Prof. Dr. med. Markus H. Heim

Chancellor, Andrew, Constantin, Daniel, Berloffa, Giuliano, Yang, Qinmei, Nosi, Vladimir, Loureiro, José Pedro, Colombo, Rodrigo, Jakob, Roman P., Joss, Daniel, Pfeffer, Michael, De Simone, Giulia, Morabito, Aurelia, Schaefer, Verena, Vacchini, Alessandro, Brunelli, Laura, Montagna, Daniela, Heim, Markus, Zippelius, Alfred, Davoli, Enrico, et al. (2024). The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells [Journal-article]. Immunity, Online ahead of print. https://doi.org/10.1016/j.immuni.2024.11.019

Pu, W., Zhu, H., Zhang, M., Pikiolek, M., Ercan, C., Li, J., Huang, X., Han, X., Zhang, Z., Lv, Z., Li, Y., Liu, K., He, L., Liu, X., Heim, M. H., Terracciano, L. M., Tchorz, J. S., & Zhou, B. (2023). Bipotent transitional liver progenitor cells contribute to liver regeneration. Nature Genetics, 55(4), 651–664. https://doi.org/10.1038/s41588-023-01335-9

Borisov, Angel N., Kutz, Alexander, Christ, Emanuel R., Heim, Markus H., & Ebrahimi, Fahim. (2023). Canagliflozin and Metabolic Associated Fatty Liver Disease in Patients With Diabetes Mellitus: New Insights From CANVAS. Journal of Clinical Endocrinology and Metabolism, 108, 2940–2949. https://doi.org/10.1210/clinem/dgad249

Nikolaou, Kostas C., Godbersen, Svenja, Manoharan, Muthiah, Wieland, Stefan, Heim, Markus H., & Stoffel, Markus. (2023). Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators. JCI Insight, 8. https://doi.org/10.1172/jci.insight.164694

Pop, Oltin-Tiberiu, Geng, Anne, Flint, Emilio, Singanayagam, Arjuna, Ercan, Caner, Possamai, Lucia, Patel, Vishal C., Kuenzler, Patrizia, Meier, Marie-Anne, Soysal, Savas, Hruz, Petr, Kollmar, Otto, Tatham, Kate C., Ward, Josie K., Müllhaupt, Beat, Weber, Achim, Wendon, Julia, Niess, Jan Hendrik, Heim, Markus, et al. (2023). AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells [Journal-article]. Cellular and Molecular Gastroenterology and Hepatology, 16(1), 17–37. https://doi.org/10.1016/j.jcmgh.2023.03.007

Lett, Martin J, Mehta, Hema, Keogh, Adrian, Jaeger, Tina, Jacquet, Maxime, Powell, Kate, Meier, Marie-Anne, Fofana, Isabel, Melhem, Hassan, Vosbeck, Jürg, Cathomas, Gieri, Heigl, Andres, Heim, Markus H, Burri, Emanuel, Mertz, Kirsten D, Niess, Jan Hendrik, Kollmar, Otto, Zech, Christoph J, Ivanek, Robert, et al. (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells [Journal-article]. Gut, 71(12), 2526–2538. https://doi.org/10.1136/gutjnl-2021-324478

Suslov A, Heim MH, & Wieland S. (2022). Studying Hepatitis Virus-Host Interactions in Patient Liver Biopsies. Viruses, 14(11). https://doi.org/10.3390/v14112490

Ebrahimi F, Semela D, & Heim M. (2022). Impact of propofol sedation on the diagnostic accuracy of hepatic venous pressure gradient measurements in patients with cirrhosis. Hepatology International, 16(4), 817–823. https://doi.org/10.1007/s12072-021-10261-z

Donners R, Zaugg C, Gehweiler JE, Boldanova T, Heim MH, Terracciano LM, & Boll DT. (2022). Computed tomography (CT) and magnetic resonance imaging (MRI) of diffuse liver disease: a multiparametric predictive modelling algorithm can aid categorization of liver parenchyma. Quantitative Imaging in Medicine and Surgery, 12(2), 1186–1197. https://doi.org/10.21037/qims-21-384

Gallon J, Coto-Llerena M, Ercan C, Bianco G, Paradiso V, Nuciforo S, Taha-Melitz S, Meier MA, Boldanova T, Pérez-Del-Pulgar S, Rodríguez-Tajes S, von Flüe M, Soysal SD, Kollmar O, Llovet JM, Villanueva A, Terracciano LM, Heim MH, Ng CKY, & Piscuoglio S. (2022). Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma. Molecular Oncology, 16(3), 665–682. https://doi.org/10.1002/1878-0261.13154

Ercan, Caner, Coto-Llerena, Mairene, Gallon, John, Fourie, Lana, Marinucci, Mattia, Hess, Gabriel F., Vosbeck, Jürg, Taha-Mehlitz, Stephanie, Boldanova, Tuyana, Meier, Marie-Anne, Tzankov, Alexandar, Matter, Matthias S., Hoffmann, Martin H. K., Di Tommaso, Luca, von Flüe, Markus, Ng, Charlotte K. Y., Heim, Markus H., Soysal, Savas D., Terracciano, Luigi M., et al. (2022). Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report. Communications Medicine, 2. https://doi.org/10.1038/s43856-022-00074-y

Lett, Martin J, Mehta, Hema, Keogh, Adrian, Jaeger, Tina, Jacquet, Maxime, Powell, Kate, Meier, Marie-Anne, Fofana, Isabel, Melhem, Hassan, Vosbeck, Jurg, Cathomas, Gieri, Heigl, Andres, Heim, Markus H, Burri, Emanuel, Mertz, Kirsten D, Niess, Jan Hendrik, Kollmar, Otto, Zech, Christoph J, Ivanek, Robert, et al. (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells. Gut, 71, 2526–2538. https://doi.org/10.1136/gutjnl-2021-324478

Meier, Marie-Anne, Nuciforo, Sandro, Coto-Llerena, Mairene, Gallon, John, Matter, Matthias S., Ercan, Caner, Vosbeck, Jürg, Terracciano, Luigi M., Soysal, Savas D., Boll, Daniel, Kollmar, Otto, Delaloye, Raphaël, Piscuoglio, Salvatore, & Heim, Markus H. (2022). Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report. Communications Medicine, 2. https://doi.org/10.1038/s43856-022-00150-3

Chen Q., Coto-Llerena M., Suslov A, Teixeira R.D., Fofana I., Nuciforo S, Hofmann M., Thimme R., Hensel N., Lohmann V., Ng C.K.Y., Rosenberger G., Wieland S, & Heim M.H. (2021). Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses. Nature Communications, 12(1), 4882. https://doi.org/10.1038/s41467-021-25218-x

Ding L, Sun W., Balaz M, He A, Klug M, Wieland S, Caiazzo R, Raverdy V, Pattou F, Lefebvre P, Lodhi IJ, Staels B., Heim M., & Wolfrum C. (2021). Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis. Nature Metabolism, 3(12), 1648–1661. https://doi.org/10.1038/s42255-021-00489-2

Boldanova T, Fucile G, Vosshenrich J, Suslov A, Ercan C, Coto-Llerena M, Terracciano LM, Zech CJ, Boll DT, Wieland S, & Heim MH. (2021). Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization. Cell Reports Medicine, 2(11), 100444. https://doi.org/10.1016/j.xcrm.2021.100444

Meier MA, Meier MA, Calabrese D, Suslov A, Terracciano LM, Heim MH, & Wieland S. (2021). Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load. Journal of Hepatology, 75(4), 840–847. https://doi.org/10.1016/j.jhep.2021.04.051

Vosshenrich J, Zech CJ, Heye T, Boldanova T, Fucile G, Wieland S, Heim MH, & Boll DT. (2021). Response prediction of hepatocellular carcinoma undergoing transcatheter arterial chemoembolization: unlocking the potential of CT texture analysis through nested decision tree models. European Radiology, 31(6), 4367–4376. https://doi.org/10.1007/s00330-020-07511-3

Suslov A, Meier MA, Ketterer S, Wang X, Wieland S, & Heim MH. (2021). Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity. Journal of Hepatology, 74(4), 794–800. https://doi.org/10.1016/j.jhep.2020.11.003

Nuciforo S, & Heim MH. (2021). Organoids to model liver disease. JHEP Reports, 3(1), 100198. https://doi.org/10.1016/j.jhepr.2020.100198

Coto-Llerena M, Lepore M, Spagnuolo J, Di Blasi D, Calabrese D, Suslov A, Bantug G, Duong FH, Terracciano LM, De Libero G, & Heim MH. (2021). Interferon lambda 4 can directly activate human CD19+ B cells and CD8+ T cells. Life Science Alliance, 4(1). https://doi.org/10.26508/LSA.201900612

Sorrentino G, Rezakhani S, Yildiz E, Nuciforo S, Heim MH, Lutolf MP, & Schoonjans K. (2020). Mechano-modulatory synthetic niches for liver organoid derivation. Nature Communications, 11(1), 3416. https://doi.org/10.1038/s41467-020-17161-0

Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJP, Boldanova T, Zhang Y, Brüggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR, Heim MH, Sitek B, Bartenschlager R, Pietschmann T, & Steinmann E. (2020). C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle. Journal of Hepatology, 73(3), 549–558. https://doi.org/10.1016/j.jhep.2020.03.047

Goossens N, Toso C, & Heim MH. (2020). Management of hepatocellular carcinoma: SASL expert opinion statement. Swiss Medical Weekly, 150(32), w20296. https://doi.org/10.4414/smw.2020.20296

Tran HTL, Morikawa K, Anggakusuma, Zibi R, Thi VLD, Penin F, Heim MH, Quadroni M, Pietschmann T, Gouttenoire J, & Moradpour D. (2020). OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease. PLoS ONE, 15(7 July), e0236447. https://doi.org/10.1371/journal.pone.0236447

Bertisch, B., Brezzi, M., Negro, F., Müllhaupt, B., Ottiger, C., Künzler-Heule, P., Schmid, P., Giudici, F., Clerc, O., Moriggia, A., Roelens, M., Marinucci, F., Zehnder, C., Moradpour, D., Keiser, O., Kaiser, L., Kaiser, L., Heim, M., Hirsch, H., et al. (2020). Very Low Hepatitis C Viral Loads in Treatment-naive Persons: Do They Compromise Hepatitis C Virus Antigen Testing? Clinical Infectious Diseases, 70(4), 653–659. https://doi.org/10.1093/cid/ciz270

Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Künzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, & Bernsmeier C. (2020). Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Life Science Alliance, 3(1). https://doi.org/10.26508/lsa.201900465

Di Blasi D., Boldanova T, Mori L, Terracciano L., Heim M.H., & De Libero G. (2020). Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma. Cellular and Molecular Gastroenterology and Hepatology, 9(2), 195–218. https://doi.org/10.1016/j.jcmgh.2019.08.004

Roelens, Maroussia, Bertisch, Barbara, Moradpour, Darius, Cerny, Andreas, Semmo, Nasser, Schmid, Patrick, Müllhaupt, Beat, Clerc, Olivier, Semela, David, Junker, Christoph, Negro, Francesco, Keiser, Olivia, Negro, Francesco, Kaiser, Laurent, Heim, Markus, Hirsch, Hans, Semmo, Nasser, Suter, Franziska, Moradpour, Darius, et al. (2020). All-cause mortality and causes of death in the swiss hepatitis C cohort study (SCCS). Open Forum Infectious Diseases, 7. https://doi.org/10.1093/ofid/ofaa308

Blumer T., Fofana I., Matter M.S., Wang X, Montazeri H., Calabrese D, Coto-Llerena M., Boldanova T, Nuciforo S, Kancherla V., Tornillo L, Piscuoglio S, Wieland S, Terracciano LM, Ng C.K.Y., & Heim MH. (2019). Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors. Hepatology Communications, 3(7), 971–986. https://doi.org/10.1002/hep4.1365

Wieland SF, & Heim MH. (2019). The IFN-λ Pony Express (Patent No. 5). 20(5), Article 5. https://doi.org/10.1038/s41590-019-0362-9

Calabrese D, Roma G, Bergling S, Carbone W, Mele V, Nuciforo S, Fofana I, Campana B, Szkolnicka D, Hay DC, Tchorz J, Bouwmeester T, Wieland S, & Heim MH. (2019). Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells. PloS One, 14(8), e0221762. https://doi.org/10.1371/journal.pone.0221762

Broguiere N, Isenmann L, Hirt C, Ringel T, Placzek S, Cavalli E, Ringnalda F, Villiger L, Züllig R, Lehmann R, Rogler G, Heim MH, Schüler J, Zenobi-Wong M, & Schwank G. (2018). Growth of Epithelial Organoids in a Defined Hydrogel. Advanced Materials (Deerfield Beach, Fla.), 30(43), e1801621. https://doi.org/10.1002/adma.201801621

Goossens N, de Vito C, Mangia A, Clément S, Cenderello G, Barrera F, D’Ambrosio R, Coppola N, Zampino R, Stanzione M, Adinolfi LE, Wedemeyer H, Semmo N, Müllhaupt B, Semela D, Malinverni R, Moradpour D, Heim M, Trincucci G, et al. (2018). Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects: A multi-centre study and systematic review. Journal of Viral Hepatitis, 25(8), 920–929. https://doi.org/10.1111/jvh.12891

Suslov A, Boldanova T, Wang X, Wieland S, & Heim MH. (2018). Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver. Gastroenterology, 154(6), 1778–1790. https://doi.org/10.1053/j.gastro.2018.01.034

Allgaier, H.-P., Arnold, C., Baumert, T. F., Becker, G., Geiβler, M., Hafkemeyer, P., Harder, J., Heim, M. H., Huber, R., Kern, W. V., Mohr, L., Moradpour, D., Offensperger, S., Offensperger, W.-B., Spangenberg, H. C., Thimme, R., Walter, E., & Von Weizsäcker, F. (2018). From Molecuar to Natural Medicine Von der molekularen Medizin bis zur Naturheilkunde 1. Deutsche Medizinische Wochenschrift, 143(1), 40–45. https://doi.org/10.1055/s-0043-123263

Gauthiez E, Habfast-Robertson I, Rüeger S, Kutalik Z, Aubert V, Berg T, Cerny A, Gorgievski M, George J, Heim MH, Malinverni R, Moradpour D, Müllhaupt B, Negro F, Semela D, Semmo N, Villard J, Bibert S, Bochud PY, & Swiss Hepatitis C Cohort Study. (2017). A systematic review and meta-analysis of HCV clearance. Liver International : Official Journal of the International Association for the Study of the Liver, 37(10), 1431–1445. https://doi.org/10.1111/liv.13401

Gauthiez, Emeline, Habfast-Robertson, Ines, Rüeger, Sina, Kutalik, Zoltan, Aubert, Vincent, Berg, Thomas, Cerny, Andreas, Gorgievski, Meri, George, Jacob, Heim, Markus H., Malinverni, Raffaele, Moradpour, Darius, Müllhaupt, Beat, Negro, Francesco, Semela, David, Semmo, Nasser, Villard, Jean, Bibert, Stéphanie, Bochud, Pierre-Yves, & Swiss Hepatitis C. Cohort Study. (2017). A systematic review and meta‐analysis of HCV clearance. Liver International, 37(10), 1431–1445. https://doi.org/10.1111/liv.13401

Giudici, F., Bertisch, B., Negro, F., Stirnimann, G., Müllhaupt, B., Moradpour, D., Cerny, A., Keiser, O., Kaiser, L., Heim, M., Hirsch, H., Dufour, J.-F., Gorgievski, M., Aubert, V., Siegrist, H. H., Lucchini, G. M., Malinverni, R., Semela, D., Schmid, P., et al. (2016). Access to therapy and therapy outcomes in the Swiss Hepatitis C Cohort Study: a person-centred approach. Journal of Viral Hepatitis, 23(9), 697–707. https://doi.org/10.1111/jvh.12535

Bertisch, Barbara, Giudici, Fabio, Negro, Francesco, Moradpour, Darius, Müllhaupt, Beat, Moriggia, Alberto, Estill, Janne, Keiser, Olivia, Kaiser, Laurent, Heim, Markus, Hirsch, Hans, Dufour, Jean-François, Gorgievski, Meri, Aubert, Vincent, Siegrist, Hans H., Cerny, Andreas, Lucchini, Gladys Martinetti, Malinverni, Raffaele, Semela, David, et al. (2016). Characteristics of foreign-born persons in the Swiss hepatitis C cohort study: Implications for screening recommendations. PLoS ONE, 11. https://doi.org/10.1371/journal.pone.0155464

Bernsmeier C, Meyer-Gerspach AC, Blaser LS, Jeker L, Steinert RE, Heim MH, & Beglinger C. (2014). Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic fatty liver disease. PloS one, 9(1), e87488. https://doi.org/10.1371/journal.pone.0087488

de Bruyn Ouboter, Dirk, Schuster, Thomas B., Shanker, Vijay, Heim, Markus H., & Meier, Wolfgang. (2014). Multicompartment micelle-structured peptide nanoparticles: a new biocompatible gene- and drug-delivery tool. Journal of Biomedical Materials Research Part A, 102(4), 1155–1163. https://doi.org/10.1002/jbm.a.34778

Shanker V, Trincucci G., Heim H.M., & Duong HT. (2013). Protein phosphatase 2A impairs IFNα-induced antiviral activity against the hepatitis C virus through the inhibition of STAT1 tyrosine phosphorylation. Journal of Viral Hepatitis, 20(9), 612–621. https://doi.org/10.1111/jvh.12083

Heim M, & Wertli M. (2013). [Severe hypertriglyceridemia]. Praxis, 102(17), 1023–1032. https://doi.org/10.1024/1661-8157/a001400

Heim MH. (2013). Innate immunity and HCV. Journal of hepatology, 58(3), 564–574. https://doi.org/10.1016/j.jhep.2012.10.005

Heim, Markus H. (2013). Innate immunity and HCV. Journal of Hepatology, 58(3), 564–574. https://doi.org/10.1016/j.jhep.2012.10.005

Zeuzem S, Asselah T, Angus P, Zarski JP, Larrey D, Müllhaupt B, Gane E, Schuchmann M, Lohse AW, Pol S, Bronowicki JP, Roberts S, Arasteh K, Zoulim F, Heim M, Stern JO, Nehmiz G, Kukolj G, Böcher WO, & Mensa FJ. (2013). Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results. Antiviral therapy, 18(8), 1015–1019. https://doi.org/10.3851/imp2567

Zeuzem, Stefan, Asselah, Tarik, Angus, Peter, Zarski, Jean-Pierre, Larrey, Dominique, Müllhaupt, Beat, Gane, Ed, Schuchmann, Marcus, Lohse, Ansgar W, Pol, Stanislas, Bronowicki, Jean-Pierre, Roberts, Stuart, Arasteh, Keikawus, Zoulim, Fabien, Heim, Markus, Stern, Jerry O, Nehmiz, Gerhard, Kukolj, George, Böcher, Wulf O, & Mensa, Federico J. (2013). Faldaprevir (BI 201335), BI 207127 and ribavirin oral therapy for treatment-naive HCV genotype 1 : SOUND-C1 final results. Antiviral Therapy, 18(8), 1015–1019. https://doi.org/10.3851/imp2567

Manns M.P., Gane E., Rodriguez-Torres M., Stoehr A., Yeh C.-T., Marcellin P., Wiedmann R.T., Hwang P.M., Caro L., Barnard R.J., Lee A.W., Baruch Y., Benhamou Y., Cave M., Davis, Faruqui S., Fried M., Godofsky E., Gschwantler M., et al. (2012). Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naïve patients with chronic hepatitis C: A randomized phase II study. Hepatology, 56(3), 884–893. https://doi.org/10.1002/hep.25743

Dill, Michael T, Makowska, Zuzanna, Duong, Francois H T, Merkofer, Franzisca, Filipowicz, Magdalena, Baumert, Thomas F, Tornillo, Luigi, Terracciano, Luigi, & Heim, Markus H. (2012). Interferon-gamma-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C. Gastroenterology, 143(3), 777–786. https://doi.org/10.1053/j.gastro.2012.05.044

Dill, Michael T, Makowska Z, Duong, Francois H T, Merkofer F, Filipowicz, Magdalena, Baumert, Thomas F, Tornillo L, Terracciano L, & Heim MH. (2012). Interferon-γstimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C. Gastroenterology, 143(3), 777–786. https://doi.org/10.1053/j.gastro.2012.05.044

Müllhaupt B, Durand F, Roskams T, Dutkowski P, & Heim M. (2011). Is tumor biopsy necessary? Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 17 Suppl 2(12), S14–25. https://doi.org/10.1002/lt.22374

Semela D, & Heim M. (2011). [Hepatocellular carcinoma]. Therapeutische Umschau. Revue Therapeutique, 68(4), 213–217. https://doi.org/10.1024/0040-5930/a000153

Muellhaupt, Beat, Durand, Francois, Roskams, Tanja, Dutkowski, Philipp, & Heim, Markus. (2011). Is tumor biopsy necessary? Liver Transplantation, 17, S14–S25. https://doi.org/10.1002/lt.22374

Semela, David, & Heim, Markus. (2011). Hepatozelluläres Karzinom. Therapeutische Umschau, 68(4), 213–217. https://doi.org/10.1024/0040-5930/a000153

Semela,David, & Heim,Markus. (2011). [Hepatocellular carcinoma]. Ther Umsch, 68(5), 213–217.

Sarasin-Filipowicz M., & Heim M.H. (2010). Interferon-induced gene expression in chronic hepatitis C. Future Virology, 5(1), 25–31. https://doi.org/10.2217/fvl.09.67

Heim MH. (2009). HCV innate immune responses. Viruses, 1(3), 1073–1088. https://doi.org/10.3390/v1031073

Bernsmeier C, & Heim MH. (2009). Insulin resistance in chronic hepatitis C: mechanisms and clinical relevance. Swiss medical weekly, 139(47-48), 678–684. https://doi.org/10.4414/smw.2009.12765

Bernsmeier C., & Heim M.H. (2009). Insulin resistance in chronic hepatitis C: Mechanisms and clinical relevance. Swiss Medical Weekly, 139(47-48), 678–684.

Bernsmeier, Christine, & Heim, Markus H. (2009). Insulin resistance in chronic hepatitis C : mechanisms and clinical relevance. Swiss Medical Weekly : Official Journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology, 139(47-48), 678–684. https://doi.org/smw-12765

Dill,Michael T, Makowska,Zuzanna, Duong,Francois H T, Merkofer,Franzisca, Filipowicz,Magdalena, Baumert,Thomas F, Tornillo,Luigi, Terracciano,Luigi, Heim,Markus H, Dong X, Zhang X, Zhang X, Yao Z, Shen Y, Qiang B, Wang Y, & He F. (2008). Regulatory polymorphisms in the promoter of CXCL10 gene and disease progression in male hepatitis B virus carriers. Gastroenterology, 134(3), 716–726. https://doi.org/10.1053/j.gastro.2007.12.044

Gilgen-Anner Y, Heim M, Ledermann HP, & Bircher AJ. (2007). Iodide mumps after contrast media imaging: a rare adverse effect to iodine. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 99(1), 93–98. https://doi.org/10.1016/s1081-1206(10)60628-x

Sawatzki M, & Heim M. (2007). [Delayed upper abdominal pain and tarry stool after transjugular liver biopsy. A 24-old man with hemophilia]. Praxis, 96(13), 509–511. https://doi.org/10.1024/1661-8157.96.13.509

Christen V, Duong F, Bernsmeier C, Sun D, Nassal M, & Heim MH. (2007). Inhibition of alpha interferon signaling by hepatitis B virus. Journal of virology, 81(1), 159–165. https://doi.org/10.1128/jvi.01292-06

Heim MH, Jacob L, & Beglinger C. (2007). The angiotensin II receptor antagonist candesartan is not effective in reducing portal hypertension in patients with cirrhosis. Digestion, 75(2-3), 122–123. https://doi.org/10.1159/000104819

Rendi-Wagner P, Shouval D, Genton B, Lurie Y, Rümke H, Boland G, Cerny A, Heim M, Bach D, Schroeder M, & Kollaritsch H. (2006). Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine. Vaccine, 24(15), 2781–2789. https://doi.org/10.1016/j.vaccine.2006.01.007

Duong,Francois H T, Christen,Verena, Filipowicz,Magdalena, & Heim,Markus H. (2006). S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro. Hepatology (Baltimore, Md.), 43(4), 796–806. https://doi.org/10.1002/hep.21116

Duong FH, Christen V, Berke JM, Penna SH, Moradpour D, & Heim MH. (2005). Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1. Journal of virology, 79(24), 15342–15350. https://doi.org/10.1128/jvi.79.24.15342-15350.2005

Schnyder B, Schnyder-Candrian S, Pansky A, Schmitz ML, Heim M, Ryffel B, & Moser R. (2005). IL-17 reduces TNF-induced Rantes and VCAM-1 expression. Cytokine, 31(3), 191–202. https://doi.org/10.1016/j.cyto.2005.02.012

Croquelois A, Blindenbacher A, Terracciano L, Wang X, Langer I, Radtke F, & Heim MH. (2005). Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology (Baltimore, Md.), 41(3), 487–496. https://doi.org/10.1002/hep.20571

Heim MH. (2005). RIG-I: an essential regulator of virus-induced interferon production. Journal of hepatology, 42(3), 431–433. https://doi.org/10.1016/j.jhep.2004.12.016

Sadallah, Salima, Heim, Markus, Hess, Christoph, Klimkait, Thomas, Battegay, Manuel, & Schifferli, Jürg A. (2005). Contrary to HIV, hepatitis C virus is not associated with erythrocytes in vivo [4]. Journal of Hepatology, 42(1), 150–152. https://doi.org/10.1016/j.jhep.2004.07.027

Heim MH. (2004). [Autoimmune hepatitis]. Therapeutische Umschau. Revue therapeutique, 61(8), 499–504. https://doi.org/10.1024/0040-5930.61.8.499

Blanchard C, Durual S, Estienne M, Bouzakri K, Heim MH, Blin N, & Cuber JC. (2004). IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis. Journal of immunology (Baltimore, Md. : 1950), 172(6), 3775–3783. https://doi.org/10.4049/jimmunol.172.6.3775

Duong FH, Filipowicz M, Tripodi M, La Monica N, & Heim MH. (2004). Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology, 126(1), 263–277. https://doi.org/10.1053/j.gastro.2003.10.076

Heim MH. (2003). A new survival trick of hepatitis C virus: blocking the activation of interferon regulatory factor-3. Hepatology (Baltimore, Md.), 38(6), 1582–1584. https://doi.org/10.1002/hep.510380632

Zimmers T.A., Pierce R.H., McKillop I.H., Koniaris L.G., & Heim M.H. (2003). Resolving the Role of IL-6 in Liver Regeneration [2] (multiple letters). Hepatology, 38(6), 1590–1591. https://doi.org/10.1016/j.hep.2003.09.021

Blindenbacher A, Wang X, Langer I, Savino R, Terracciano L, & Heim MH. (2003). Interleukin 6 is important for survival after partial hepatectomy in mice. Hepatology (Baltimore, Md.), 38(3), 674–682. https://doi.org/10.1053/jhep.2003.50378

Wiederkehr-Adam M, Ernst P, Müller K, Bieck E, Gombert FO, Ottl J, Graff P, Grossmüller F, & Heim MH. (2003). Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3. The Journal of biological chemistry, 278(18), 16117–16128. https://doi.org/10.1074/jbc.m300261200

Blindenbacher A, Duong FH, Hunziker L, Stutvoet ST, Wang X, Terracciano L, Moradpour D, Blum HE, Alonzi T, Tripodi M, La Monica N, & Heim MH. (2003). Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology, 124(5), 1465–1475. https://doi.org/10.1016/s0016-5085(03)00290-7

Tietz A, Heim MH, Eriksson U, Marsch S, Terracciano L, & Krähenbühl S. (2003). Fulminant liver failure associated with clarithromycin. The Annals of pharmacotherapy, 37(1), 57–60. https://doi.org/10.1345/aph.1c171

Schnyder B, Schnyder-Candrian S, Panski A, Bömmel H, Heim M, Duschl A, & Moser R. (2002). Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1. Biochemical and biophysical research communications, 292(4), 841–847. https://doi.org/10.1006/bbrc.2002.6754

Staedele H, Wiesner W, Heim M., & Bongartz G. (2002). Potentially misleading CT findings in fatty liver cirrhosis [1]. European Radiology, 12(4), 946–947. https://doi.org/10.1007/s003300101101

Wiesner W, Kocher T, Heim M, & Bongartz G. (2002). CT findings in eosinophilic enterocolitis with predominantly serosal and muscular bowel wall infiltration. JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR), 85(1), 4–6.

Moradpour D, Wölk B, Cerny A, Heim MH, & Blum HE. (2001). Hepatitis C: a concise review. Minerva medica, 92(5), 329–339.

Moradpour D, Cerny A, Heim MH, & Blum HE. (2001). Hepatitis C: an update. Swiss medical weekly, 131(21-22), 291–298. https://doi.org/10.4414/smw.2001.06097

Donda A, Mori L, Shamshiev A, Carena I, Mottet C, Heim MH, Beglinger C, Grunert F, Rochlitz C, Terracciano L, Jantscheff P, & De Libero G. (2000). Locally inducible CD66a (CEACAM1) as an amplifier of the human intestinal T cell response. European Journal of Immunology, 30(9), 2593–2603. https://doi.org/10.1002/1521-4141(200009)30:9<2593::aid-immu2593>3.0.co;2-0

Heim MH. (2000). Intracellular signalling and antiviral effects of interferons. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 32(3), 257–263. https://doi.org/10.1016/s1590-8658(00)80831-2

Pansky A, Hildebrand P, Fasler-Kan E, Baselgia L, Ketterer S, Beglinger C, & Heim MH. (2000). Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha. International journal of cancer, 85(5), 720–725. https://doi.org/10.1002/(sici)1097-0215(20000301)85:5<720::aid-ijc20>3.0.co;2-o

Heim MH, Moradpour D, & Blum HE. (1999). Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. Journal of virology, 73(10), 8469–8475. https://doi.org/10.1128/jvi.73.10.8469-8475.1999

Heim MH. (1999). The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. Journal of receptor and signal transduction research, 19(1-4), 75–120. https://doi.org/10.3109/10799899909036638

Heuss LT, Heim MH, Schultz U, Wissmann D, Offensperger WB, Staeheli P, & Blum HE. (1998). Biological efficacy and signal transduction through STAT proteins of recombinant duck interferon in duck hepatitis B virus infection. The Journal of general virology, 79 ( Pt 8), 2007–2012. https://doi.org/10.1099/0022-1317-79-8-2007

Steiger JU, Nickerson PW, Hermle M, Thiel G, & Heim MH. (1998). Interferon-gamma receptor signaling is not required in the effector phase of the alloimmune response. Transplantation, 65(12), 1649–1652. https://doi.org/10.1097/00007890-199806270-00019

Fasler-Kan E, Pansky A, Wiederkehr M, Battegay M, & Heim MH. (1998). Interferon-alpha activates signal transducers and activators of transcription 5 and 6 in Daudi cells. European journal of biochemistry, 254(3), 514–519. https://doi.org/10.1046/j.1432-1327.1998.2540514.x

Feng N, Lugli SM, Schnyder B, Gauchat JF, Graber P, Schlagenhauf E, Schnarr B, Wiederkehr-Adam M, Duschl A, Heim MH, Lutz RA, & Moser R. (1998). The interleukin-4/interleukin-13 receptor of human synovial fibroblasts: overexpression of the nonsignaling interleukin-13 receptor alpha2. Laboratory investigation; a journal of technical methods and pathology, 78(5), 591–602.

Pansky A, Hildebrand P, Heim MH, Eberhard M, Kissel T, & Beglinger C. (1998). Growth effects of alpha-interferon but not of bombesin or angiotensin II are mediated by activation of STAT proteins. European journal of clinical investigation, 28(5), 398–406. https://doi.org/10.1046/j.1365-2362.1998.00300.x

Heim MH, Gamboni G, Beglinger C, & Gyr K. (1997). Specific activation of AP-1 but not Stat3 in regenerating liver in mice. European journal of clinical investigation, 27(11), 948–955. https://doi.org/10.1046/j.1365-2362.1997.2100770.x

Moriggl R, Berchtold S, Friedrich K, Standke GJ, Kammer W, Heim M, Wissler M, Stöcklin E, Gouilleux F, & Groner B. (1997). Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells. Molecular and cellular biology, 17(7), 3663–3678. https://doi.org/10.1128/mcb.17.7.3663

Pless M, Norga K, Carroll M, Heim MH, D’Andrea AD, & Mathey-Prevot B. (1997). Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding. Blood, 89(9), 3175–3185.