Prof. Dr. med. Markus H. Heim

Chancellor, Andrew, Constantin, Daniel, Berloffa, Giuliano, Yang, Qinmei, Nosi, Vladimir, Loureiro, José Pedro, Colombo, Rodrigo, Jakob, Roman P., Joss, Daniel, Pfeffer, Michael, De Simone, Giulia, Morabito, Aurelia, Schaefer, Verena, Vacchini, Alessandro, Brunelli, Laura, Montagna, Daniela, Heim, Markus, Zippelius, Alfred, Davoli, Enrico, et al. (2024). The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells [Journal-article]. Immunity, Online ahead of print. https://doi.org/10.1016/j.immuni.2024.11.019

Pu, W., Zhu, H., Zhang, M., Pikiolek, M., Ercan, C., Li, J., Huang, X., Han, X., Zhang, Z., Lv, Z., Li, Y., Liu, K., He, L., Liu, X., Heim, M. H., Terracciano, L. M., Tchorz, J. S., & Zhou, B. (2023). Bipotent transitional liver progenitor cells contribute to liver regeneration. Nature Genetics, 55(4), 651–664. https://doi.org/10.1038/s41588-023-01335-9

Borisov, Angel N., Kutz, Alexander, Christ, Emanuel R., Heim, Markus H., & Ebrahimi, Fahim. (2023). Canagliflozin and Metabolic Associated Fatty Liver Disease in Patients With Diabetes Mellitus: New Insights From CANVAS. Journal of Clinical Endocrinology and Metabolism, 108, 2940–2949. https://doi.org/10.1210/clinem/dgad249

Nikolaou, Kostas C., Godbersen, Svenja, Manoharan, Muthiah, Wieland, Stefan, Heim, Markus H., & Stoffel, Markus. (2023). Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators. JCI Insight, 8. https://doi.org/10.1172/jci.insight.164694

Pop, Oltin-Tiberiu, Geng, Anne, Flint, Emilio, Singanayagam, Arjuna, Ercan, Caner, Possamai, Lucia, Patel, Vishal C., Kuenzler, Patrizia, Meier, Marie-Anne, Soysal, Savas, Hruz, Petr, Kollmar, Otto, Tatham, Kate C., Ward, Josie K., Müllhaupt, Beat, Weber, Achim, Wendon, Julia, Niess, Jan Hendrik, Heim, Markus, et al. (2023). AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells [Journal-article]. Cellular and Molecular Gastroenterology and Hepatology, 16(1), 17–37. https://doi.org/10.1016/j.jcmgh.2023.03.007

Lett, Martin J, Mehta, Hema, Keogh, Adrian, Jaeger, Tina, Jacquet, Maxime, Powell, Kate, Meier, Marie-Anne, Fofana, Isabel, Melhem, Hassan, Vosbeck, Jürg, Cathomas, Gieri, Heigl, Andres, Heim, Markus H, Burri, Emanuel, Mertz, Kirsten D, Niess, Jan Hendrik, Kollmar, Otto, Zech, Christoph J, Ivanek, Robert, et al. (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells [Journal-article]. Gut, 71(12), 2526–2538. https://doi.org/10.1136/gutjnl-2021-324478

Suslov A, Heim MH, & Wieland S. (2022). Studying Hepatitis Virus-Host Interactions in Patient Liver Biopsies. Viruses, 14(11). https://doi.org/10.3390/v14112490

Ebrahimi F, Semela D, & Heim M. (2022). Impact of propofol sedation on the diagnostic accuracy of hepatic venous pressure gradient measurements in patients with cirrhosis. Hepatology International, 16(4), 817–823. https://doi.org/10.1007/s12072-021-10261-z

Donners R, Zaugg C, Gehweiler JE, Boldanova T, Heim MH, Terracciano LM, & Boll DT. (2022). Computed tomography (CT) and magnetic resonance imaging (MRI) of diffuse liver disease: a multiparametric predictive modelling algorithm can aid categorization of liver parenchyma. Quantitative Imaging in Medicine and Surgery, 12(2), 1186–1197. https://doi.org/10.21037/qims-21-384

Gallon J, Coto-Llerena M, Ercan C, Bianco G, Paradiso V, Nuciforo S, Taha-Melitz S, Meier MA, Boldanova T, Pérez-Del-Pulgar S, Rodríguez-Tajes S, von Flüe M, Soysal SD, Kollmar O, Llovet JM, Villanueva A, Terracciano LM, Heim MH, Ng CKY, & Piscuoglio S. (2022). Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma. Molecular Oncology, 16(3), 665–682. https://doi.org/10.1002/1878-0261.13154

Ercan, Caner, Coto-Llerena, Mairene, Gallon, John, Fourie, Lana, Marinucci, Mattia, Hess, Gabriel F., Vosbeck, Jürg, Taha-Mehlitz, Stephanie, Boldanova, Tuyana, Meier, Marie-Anne, Tzankov, Alexandar, Matter, Matthias S., Hoffmann, Martin H. K., Di Tommaso, Luca, von Flüe, Markus, Ng, Charlotte K. Y., Heim, Markus H., Soysal, Savas D., Terracciano, Luigi M., et al. (2022). Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report. Communications Medicine, 2. https://doi.org/10.1038/s43856-022-00074-y

Lett, Martin J, Mehta, Hema, Keogh, Adrian, Jaeger, Tina, Jacquet, Maxime, Powell, Kate, Meier, Marie-Anne, Fofana, Isabel, Melhem, Hassan, Vosbeck, Jurg, Cathomas, Gieri, Heigl, Andres, Heim, Markus H, Burri, Emanuel, Mertz, Kirsten D, Niess, Jan Hendrik, Kollmar, Otto, Zech, Christoph J, Ivanek, Robert, et al. (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells. Gut, 71, 2526–2538. https://doi.org/10.1136/gutjnl-2021-324478

Meier, Marie-Anne, Nuciforo, Sandro, Coto-Llerena, Mairene, Gallon, John, Matter, Matthias S., Ercan, Caner, Vosbeck, Jürg, Terracciano, Luigi M., Soysal, Savas D., Boll, Daniel, Kollmar, Otto, Delaloye, Raphaël, Piscuoglio, Salvatore, & Heim, Markus H. (2022). Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report. Communications Medicine, 2. https://doi.org/10.1038/s43856-022-00150-3

Ng, Charlotte K. Y., Dazert, Eva, Boldanova, Tuyana, Coto-Llerena, Mairene, Nuciforo, Sandro, Ercan, Caner, Suslov, Aleksei, Meier, Marie-Anne, Bock, Thomas, Schmidt, Alexander, Ketterer, Sylvia, Wang, Xueya, Wieland, Stefan, Matter, Matthias S., Colombi, Marco, Piscuoglio, Salvatore, Terracciano, Luigi M., Hall, Michael N., & Heim, Markus H. (2022). Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages. Nature Communications, 13(1), 2436. https://doi.org/10.1038/s41467-022-29960-8

Park, Sujin, Mossmann, Dirk, Chen, Qian, Wang, Xueya, Dazert, Eva, Colombi, Marco, Schmidt, Alexander, Ryback, Brendan, Ng, Charlotte K. Y., Terracciano, Luigi M., Heim, Markus H., & Hall, Michael N. (2022). Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Molecular Cell, 82(22), 4246–4261. https://doi.org/10.1016/j.molcel.2022.10.027

Suter, Polina, Dazert, Eva, Kuipers, Jack, Ng, Charlotte K. Y., Boldanova, Tuyana, Hall, Michael N., Heim, Markus H., & Beerenwinkel, Niko. (2022). Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model. PLoS Computational Biology, 18(9), e1009767. https://doi.org/10.1371/journal.pcbi.1009767

Chen Q., Coto-Llerena M., Suslov A, Teixeira R.D., Fofana I., Nuciforo S, Hofmann M., Thimme R., Hensel N., Lohmann V., Ng C.K.Y., Rosenberger G., Wieland S, & Heim M.H. (2021). Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses. Nature Communications, 12(1), 4882. https://doi.org/10.1038/s41467-021-25218-x

Ding L, Sun W., Balaz M, He A, Klug M, Wieland S, Caiazzo R, Raverdy V, Pattou F, Lefebvre P, Lodhi IJ, Staels B., Heim M., & Wolfrum C. (2021). Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis. Nature Metabolism, 3(12), 1648–1661. https://doi.org/10.1038/s42255-021-00489-2

Boldanova T, Fucile G, Vosshenrich J, Suslov A, Ercan C, Coto-Llerena M, Terracciano LM, Zech CJ, Boll DT, Wieland S, & Heim MH. (2021). Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization. Cell Reports Medicine, 2(11), 100444. https://doi.org/10.1016/j.xcrm.2021.100444

Meier MA, Meier MA, Calabrese D, Suslov A, Terracciano LM, Heim MH, & Wieland S. (2021). Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load. Journal of Hepatology, 75(4), 840–847. https://doi.org/10.1016/j.jhep.2021.04.051

Vosshenrich J, Zech CJ, Heye T, Boldanova T, Fucile G, Wieland S, Heim MH, & Boll DT. (2021). Response prediction of hepatocellular carcinoma undergoing transcatheter arterial chemoembolization: unlocking the potential of CT texture analysis through nested decision tree models. European Radiology, 31(6), 4367–4376. https://doi.org/10.1007/s00330-020-07511-3

Suslov A, Meier MA, Ketterer S, Wang X, Wieland S, & Heim MH. (2021). Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity. Journal of Hepatology, 74(4), 794–800. https://doi.org/10.1016/j.jhep.2020.11.003

Nuciforo S, & Heim MH. (2021). Organoids to model liver disease. JHEP Reports, 3(1), 100198. https://doi.org/10.1016/j.jhepr.2020.100198

Coto-Llerena M, Lepore M, Spagnuolo J, Di Blasi D, Calabrese D, Suslov A, Bantug G, Duong FH, Terracciano LM, De Libero G, & Heim MH. (2021). Interferon lambda 4 can directly activate human CD19+ B cells and CD8+ T cells. Life Science Alliance, 4(1). https://doi.org/10.26508/LSA.201900612

Gao, Ruize, Buechel, David, Kalathur, Ravi K. R., Morini, Marco F., Coto-Llerena, Mairene, Ercan, Caner, Piscuoglio, Salvatore, Chen, Qian, Blumer, Tanja, Wang, Xueya, Dazert, Eva, Heim, Markus H., Hall, Michael N., Tang, Fengyuan, & Christofori, Gerhard. (2021). USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis. Oncogenesis, 10(7), 52. https://doi.org/10.1038/s41389-021-00338-7

Sorrentino G, Rezakhani S, Yildiz E, Nuciforo S, Heim MH, Lutolf MP, & Schoonjans K. (2020). Mechano-modulatory synthetic niches for liver organoid derivation. Nature Communications, 11(1), 3416. https://doi.org/10.1038/s41467-020-17161-0

Hess, Gabriel Fridolin, Terracciano, Luigi, Heim, Markus, Soysal, Savas Deniz, & Kollmar, Otto. (2020). Hepatectomy of a Hepatocellular Carcinoma after SIRT in a Cirrhotic Liver. Archives of Surgery and Clinical Case Reports, 3(3). https://doi.org/10.29011/2689-0526.100129

Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJP, Boldanova T, Zhang Y, Brüggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR, Heim MH, Sitek B, Bartenschlager R, Pietschmann T, & Steinmann E. (2020). C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle. Journal of Hepatology, 73(3), 549–558. https://doi.org/10.1016/j.jhep.2020.03.047

Goossens N, Toso C, & Heim MH. (2020). Management of hepatocellular carcinoma: SASL expert opinion statement. Swiss Medical Weekly, 150(32), w20296. https://doi.org/10.4414/smw.2020.20296

Andreozzi M, Quintavalle C, Benz D, Quagliata L, Matter M, Calabrese D, Tosti N, Ruiz C, Trapani F, Tornillo L, Fusco A, Heim MH, Ng CKY, Pallante P, Terracciano LM, & Piscuoglio S. (2020). Corrigendum to “HMGA1 expression in human hepatocellular carcinoma correlates with poor prognosis and promotes tumor growth and migration in in vitro models” [Neoplasia 18 (2016) 724–731] (Neoplasia (2016) 18(12) (724–731), (S1476558616301634), (10.1016/j.neo.2016.10.002)) (Patent No. 7). 22(7), Article 7. https://doi.org/10.1016/j.neo.2020.04.004

Tran HTL, Morikawa K, Anggakusuma, Zibi R, Thi VLD, Penin F, Heim MH, Quadroni M, Pietschmann T, Gouttenoire J, & Moradpour D. (2020). OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease. PLoS ONE, 15(7 July), e0236447. https://doi.org/10.1371/journal.pone.0236447

Bertisch, B., Brezzi, M., Negro, F., Müllhaupt, B., Ottiger, C., Künzler-Heule, P., Schmid, P., Giudici, F., Clerc, O., Moriggia, A., Roelens, M., Marinucci, F., Zehnder, C., Moradpour, D., Keiser, O., Kaiser, L., Kaiser, L., Heim, M., Hirsch, H., et al. (2020). Very Low Hepatitis C Viral Loads in Treatment-naive Persons: Do They Compromise Hepatitis C Virus Antigen Testing? Clinical Infectious Diseases, 70(4), 653–659. https://doi.org/10.1093/cid/ciz270

Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Künzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, & Bernsmeier C. (2020). Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Life Science Alliance, 3(1). https://doi.org/10.26508/lsa.201900465

Di Blasi D., Boldanova T, Mori L, Terracciano L., Heim M.H., & De Libero G. (2020). Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma. Cellular and Molecular Gastroenterology and Hepatology, 9(2), 195–218. https://doi.org/10.1016/j.jcmgh.2019.08.004

Roelens, Maroussia, Bertisch, Barbara, Moradpour, Darius, Cerny, Andreas, Semmo, Nasser, Schmid, Patrick, Müllhaupt, Beat, Clerc, Olivier, Semela, David, Junker, Christoph, Negro, Francesco, Keiser, Olivia, Negro, Francesco, Kaiser, Laurent, Heim, Markus, Hirsch, Hans, Semmo, Nasser, Suter, Franziska, Moradpour, Darius, et al. (2020). All-cause mortality and causes of death in the swiss hepatitis C cohort study (SCCS). Open Forum Infectious Diseases, 7. https://doi.org/10.1093/ofid/ofaa308

Blumer T., Fofana I., Matter M.S., Wang X, Montazeri H., Calabrese D, Coto-Llerena M., Boldanova T, Nuciforo S, Kancherla V., Tornillo L, Piscuoglio S, Wieland S, Terracciano LM, Ng C.K.Y., & Heim MH. (2019). Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors. Hepatology Communications, 3(7), 971–986. https://doi.org/10.1002/hep4.1365

Flecken T, Meier MA, Skewes-Cox P, Barkan DT, Heim MH, Wieland SF, & Holdorf MM. (2019). Mapping the heterogeneity of histone modifications on hepatitis B virus DNA using liver needle biopsies obtained from chronically infected patients. Journal of Virology, 93(9). https://doi.org/10.1128/JVI.02036-18

Wieland SF, & Heim MH. (2019). The IFN-λ Pony Express (Patent No. 5). 20(5), Article 5. https://doi.org/10.1038/s41590-019-0362-9

Calabrese D, Roma G, Bergling S, Carbone W, Mele V, Nuciforo S, Fofana I, Campana B, Szkolnicka D, Hay DC, Tchorz J, Bouwmeester T, Wieland S, & Heim MH. (2019). Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells. PloS One, 14(8), e0221762. https://doi.org/10.1371/journal.pone.0221762

Ruperti-Repilado, Francisco Javier, Haefliger, Simon, Rehm, Sophia, Zweier, Markus, Rentsch, Katharina M., Rentsch, Katharina M., Blum, Johannes, Jetter, Alexander, Heim, Markus, Leuppi-Taegtmeyer, Anne, Terracciano, Luigi, & Bernsmeier, Christine. (2019). Danger of Herbal Tea: A Case of Acute Cholestatic Hepatitis Due to; Artemisia annua; Tea. Frontiers in medicine, 6, 221. https://doi.org/10.3389/fmed.2019.00221

Tang, Fengyuan, Gao, Ruize, Jeevan-Raj, Beena, Wyss, Christof B., Kalathur, Ravi K. R., Piscuoglio, Salvatore, Ng, Charlotte K. Y., Hindupur, Sravanth K., Nuciforo, Sandro, Dazert, Eva, Bock, Thomas, Song, Shuang, Buechel, David, Morini, Marco F., Hergovich, Alexander, Matthias, Patrick, Lim, Dae-Sik, Terracciano, Luigi M., Heim, Markus H., et al. (2019). LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function. Nature Communications, 10(1), 5755. https://doi.org/10.1038/s41467-019-13591-7

Broguiere N, Isenmann L, Hirt C, Ringel T, Placzek S, Cavalli E, Ringnalda F, Villiger L, Züllig R, Lehmann R, Rogler G, Heim MH, Schüler J, Zenobi-Wong M, & Schwank G. (2018). Growth of Epithelial Organoids in a Defined Hydrogel. Advanced Materials (Deerfield Beach, Fla.), 30(43), e1801621. https://doi.org/10.1002/adma.201801621

Goossens N, de Vito C, Mangia A, Clément S, Cenderello G, Barrera F, D’Ambrosio R, Coppola N, Zampino R, Stanzione M, Adinolfi LE, Wedemeyer H, Semmo N, Müllhaupt B, Semela D, Malinverni R, Moradpour D, Heim M, Trincucci G, et al. (2018). Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects: A multi-centre study and systematic review. Journal of Viral Hepatitis, 25(8), 920–929. https://doi.org/10.1111/jvh.12891

Suslov A, Heim MH, & Wieland S. (2018). New insights into HDV-induced innate immunity: MDA5 senses HDV replication. (Patent No. 1). 69(1), Article 1. https://doi.org/10.1016/j.jhep.2018.03.030

Suslov A, Boldanova T, Wang X, Wieland S, & Heim MH. (2018). Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver. Gastroenterology, 154(6), 1778–1790. https://doi.org/10.1053/j.gastro.2018.01.034

Allgaier, H.-P., Arnold, C., Baumert, T. F., Becker, G., Geiβler, M., Hafkemeyer, P., Harder, J., Heim, M. H., Huber, R., Kern, W. V., Mohr, L., Moradpour, D., Offensperger, S., Offensperger, W.-B., Spangenberg, H. C., Thimme, R., Walter, E., & Von Weizsäcker, F. (2018). From Molecuar to Natural Medicine Von der molekularen Medizin bis zur Naturheilkunde 1. Deutsche Medizinische Wochenschrift, 143(1), 40–45. https://doi.org/10.1055/s-0043-123263

Hindupur, Sravanth K., Colombi, Marco, Fuhs, Stephen R., Matter, Matthias S., Guri, Yakir, Adam, Kevin, Cornu, Marion, Piscuoglio, Salvatore, Ng, Charlotte K. Y., Betz, Charles, Liko, Dritan, Quagliata, Luca, Moes, Suzette, Jenoe, Paul, Terracciano, Luigi M., Heim, Markus H., Hunter, Tony, & Hall, Michael N. (2018). The protein histidine phosphatase LHPP is a tumour suppressor. Nature, 555(7698), 678–+. https://doi.org/10.1038/nature26140

Ng, C. K. Y., Ng, C. K. Y., Di Costanzo, G. G., Tosti, N., Paradiso, V., Coto-Llerena, M., Roscigno, G., Perrina, V., Quintavalle, C., Boldanova, T., Wieland, S., Marino-Marsilia, G., Lanzafame, M., Quagliata, L., Condorelli, G., Matter, M. S., Tortora, R., Heim, M. H., Terracciano, L. M., & Piscuoglio, S. (2018). Genetic profiling using plasma-derived cell-free DNA in therapy-naïve hepatocellular carcinoma patients: a pilot study. Annals of Oncology, 29(5), 1286–1291. https://doi.org/10.1093/annonc/mdy083

Nuciforo, Sandro, Fofana, Isabel, Matter, Matthias S., Blumer, Tanja, Calabrese, Diego, Boldanova, Tujana, Piscuoglio, Salvatore, Wieland, Stefan, Ringnalda, Femke, Schwank, Gerald, Terracciano, Luigi M., Ng, Charlotte K. Y., & Heim, Markus H. (2018). Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies. Cell reports, 24(5), 1363–1376. https://doi.org/10.1016/j.celrep.2018.07.001

Paradiso, Viola, Garofoli, Andrea, Tosti, Nadia, Lanzafame, Manuela, Perrina, Valeria, Quagliata, Luca, Matter, Matthias S., Wieland, Stefan, Heim, Markus H., Piscuoglio, Salvatore, Ng, Charlotte K. Y., & Terracciano, Luigi M. (2018). Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening. The Journal of molecular diagnostics : JMD, 20(6), 836–848. https://doi.org/10.1016/j.jmoldx.2018.07.003

Gauthiez E, Habfast-Robertson I, Rüeger S, Kutalik Z, Aubert V, Berg T, Cerny A, Gorgievski M, George J, Heim MH, Malinverni R, Moradpour D, Müllhaupt B, Negro F, Semela D, Semmo N, Villard J, Bibert S, Bochud PY, & Swiss Hepatitis C Cohort Study. (2017). A systematic review and meta-analysis of HCV clearance. Liver International : Official Journal of the International Association for the Study of the Liver, 37(10), 1431–1445. https://doi.org/10.1111/liv.13401

Juhling, Frank, Hamdane, Nourdine, Thumann, Christine, Oudot, Marine A., El Saghire, Hussein, Bandiera, Simonetta, Saviano, Antonio, Schmidl, Christian, Bock, Christoph, Davidson, Irwin, Pessaux, Patrick, Habersetzer, FranOois, Wieland, Stefan, Heim, Markus H., Piardi, Tullio, Sommacale, Daniele, Fuchs, Bryan C., Bardeesy, Nabeel, Hoshida, Yujin, et al. (2017). Hepatitis C virus-induced epigenetic changes associated with hepatocarcinogenesis persist following viral cure. 66, 120A–120A. WILEY.

Blumer, Tanja, Coto-Llerena, Mairene, Duong, Francois H. T., & Heim, Markus H. (2017). SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)-induced gene expression in vivo. Journal of Biological Chemistry, 292(43), 17928–17938. https://doi.org/10.1074/jbc.m117.788877

Boldanova, T., Suslov, A., Heim, M. H., & Necsulea, A. (2017). Transcriptional response to hepatitis C virus infection in the human liver. 66, S324–S324. ELSEVIER SCIENCE BV.

Boldanova, Tujana, Suslov, Aleksei, Heim, Markus H., & Necsulea, Anamaria. (2017). Transcriptional response to hepatitis C virus infection and interferon-alpha treatment in the human liver. EMBO Molecular Medicine, 9(6), 816–834. https://doi.org/10.15252/emmm.201607006

Campana, B., Calabrese, Diego, Matter, M. S., Terracciano, L. M., Wieland, Stefan F., & Heim, Markus H. (2017). In vivo analysis at the cellular level reveals similar steatosis induction in both hepatitis C virus genotype 1 and 3 infections. Journal of Viral Hepatitis, 25(3), 262–271. https://doi.org/10.1111/jvh.12816

Gauthiez, Emeline, Habfast-Robertson, Ines, Rüeger, Sina, Kutalik, Zoltan, Aubert, Vincent, Berg, Thomas, Cerny, Andreas, Gorgievski, Meri, George, Jacob, Heim, Markus H., Malinverni, Raffaele, Moradpour, Darius, Müllhaupt, Beat, Negro, Francesco, Semela, David, Semmo, Nasser, Villard, Jean, Bibert, Stéphanie, Bochud, Pierre-Yves, & Swiss Hepatitis C. Cohort Study. (2017). A systematic review and meta‐analysis of HCV clearance. Liver International, 37(10), 1431–1445. https://doi.org/10.1111/liv.13401

Guri, Y., Colombi, M., Dazert, E., Hindupur, S. K., Roszik, J., Moes, S., Jenoe, P., Heim, M. H., Riezman, I., Riezman, H., & Hall, M. N. (2017). mTORC2 Promotes Tumorigenesis via Lipid Synthesis. Cancer Cell, 32(6), 807–823. https://doi.org/10.1016/j.ccell.2017.11.011

Keiser, O., Giudici, F., Bruggmann, P., Dufour, J. -F., Moradpour, D., Semela, D., Heim, M., Mullhaupt, B., Beretta-Piccoli, B. T., Malinverni, R., Negro, F., & Sporri, A. (2017). Trends in Hepatitis C-related mortality in Switzerland. 66, S498–S498. ELSEVIER SCIENCE BV.

Meier, M.-A., Suslov, A., Ketterer, S., Heim, M. H., & Wieland, S. F. (2017). Hepatitis B virus covalently closed circular DNA homeostasis is independent of the lymphotoxin pathway during chronic HBV infection. Journal of Viral Hepatitis, 24(8), 662–671. https://doi.org/10.1111/jvh.12689

Quintavalle, Cristina, Hindupur, Sravanth Kumar, Quagliata, Luca, Pallante, Pierlorenzo, Nigro, Cecilia, Condorelli, Gerolama, Andersen, Jesper Bøje, Tagscherer, Katrin Elisabeth, Roth, Wilfried, Beguinot, Francesco, Heim, Markus Hermann, Ng, Charlotte Kiu Yan, Piscuoglio, Salvatore, & Matter, Matthias Sebastian. (2017). Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib. Cell death & disease, 8(10), e3138. https://doi.org/10.1038/cddis.2017.512

Rey, Silvia, Quintavalle, Cristina, Burmeister, Katharina, Calabrese, Diego, Schlageter, Manuel, Quagliata, Luca, Cathomas, Gieri, Diebold, Joachim, Molinolo, Alfredo, Heim, Markus H., Terracciano, Luigi M., & Matter, Matthias S. (2017). Liver damage and senescence increases in patients developing hepatocellular carcinoma. Journal of Gastroenterology and Hepatology, 32(8), 1480–1486. https://doi.org/10.1111/jgh.13717

Suslov, A., Calabrese, D., Boldanova, T., Wieland, S., & Heim, M. (2017). Hepatitis B virus does not suppress the innate immune responses in the liver. 66, S28–S28. ELSEVIER SCIENCE BV.

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Mobin, M. B., Gerstberger, S., Teupser, D., Campana, B., Charisse, K., Heim, M. H., Manoharan, M., Tuschl, T., & Stoffel, M. (2016). The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation. Nat Commun, 7, 12848. https://doi.org/10.1038/ncomms12848

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Bernsmeier, Christine, Weisskopf, Diego M., Pflueger, Marlon O., Mosimann, Jan, Campana, Benedetta, Terracciano, Luigi, Beglinger, Christoph, Heim, Markus H., & Cajochen, Christian. (2015). Sleep Disruption and Daytime Sleepiness Correlating with Disease Severity and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: A Comparison with Healthy Controls. PLoS ONE, 10(11), e0143293. https://doi.org/10.1371/journal.pone.0143293

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Rothweiler, Sonja, Dill, Michael T., Terracciano, Luigi, Makowska, Zuzanna, Quagliata, Luca, Hlushchuk, Ruslan, Djonov, Valentin, Heim, Markus H., & Semela, David. (2015). Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model. Laboratory Investigation, 95(3), 351–362. https://doi.org/10.1038/labinvest.2014.141

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Bernsmeier C, Meyer-Gerspach AC, Blaser LS, Jeker L, Steinert RE, Heim MH, & Beglinger C. (2014). Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic fatty liver disease. PloS one, 9(1), e87488. https://doi.org/10.1371/journal.pone.0087488

de Bruyn Ouboter, Dirk, Schuster, Thomas B., Shanker, Vijay, Heim, Markus H., & Meier, Wolfgang. (2014). Multicompartment micelle-structured peptide nanoparticles: a new biocompatible gene- and drug-delivery tool. Journal of Biomedical Materials Research Part A, 102(4), 1155–1163. https://doi.org/10.1002/jbm.a.34778

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Duong, François H T, Dill, Michael T, Matter, Matthias S, Makowska, Zuzanna, Calabrese, Diego, Dietsche, Tanja, Ketterer, Sylvia, Terracciano, Luigi, & Heim, Markus H. (2014). Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53. Carcinogenesis, 35(1), 114–122. https://doi.org/10.1093/carcin/bgt258

Duong, Francois H. T., Trincucci, Gaia, Boldanova, Tujana, Calabrese, Diego, Campana, Benedetta, Krol, Ilona, Durand, Sarah C., Heydmann, Laura, Zeisel, Mirjam B., Baumert, Thomas F., & Heim, Markus H. (2014). IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies. Journal of Experimental Medicine, 211(5), 857–868. https://doi.org/10.1084/jem.20131557

Frei, Pascal, Leucht, Anna-Kathrin, Held, Ulrike, Kofmehl, Reto, Manser, Christine N, Schmitt, Johannes, Mertens, Joachim, Rau, Monika, Baur, Katharina, Gerlach, Tilman, Negro, Francesco, Heim, Markus, Moradpour, Darius, Cerny, Andreas, Dufour, Jean-François, Müllhaupt, Beat, Geier, Andreas, & Swiss Hepatitis C Cohort Study Group. (2014). Elderly age is not a negative predictive factor for virological response to therapy with pegylated interferon-alpha and ribavirin in chronic hepatitis C virus patients. Liver International, 34(4), 551–557. https://doi.org/10.1111/liv.12279