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Prof. Dr. med. Markus H. Heim

Department of Biomedicine
Profiles & Affiliations

Liver Diseases

Our research is translational and focused on viral hepatitis and hepatocellular carcinoma. Most of the past and current research projects are motivated by medical needs of the patients we care for in our clinic. We use liver biopsy and blood samples from patients with liver disease and analyze them with state-of-the art technology in our laboratory. 

Selected Publications

Ng, Charlotte K. Y., Dazert, Eva, Boldanova, Tuyana, Coto-Llerena, Mairene, Nuciforo, Sandro, Ercan, Caner, Suslov, Aleksei, Meier, Marie-Anne, Bock, Thomas, Schmidt, Alexander, Ketterer, Sylvia, Wang, Xueya, Wieland, Stefan, Matter, Matthias S., Colombi, Marco, Piscuoglio, Salvatore, Terracciano, Luigi M., Hall, Michael N., & Heim, Markus H. (2022). Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages. Nature Communications, 13(1), 2436. https://doi.org/10.1038/s41467-022-29960-8

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Chen Q., Coto-Llerena M., Suslov A, Teixeira R.D., Fofana I., Nuciforo S, Hofmann M., Thimme R., Hensel N., Lohmann V., Ng C.K.Y., Rosenberger G., Wieland S, & Heim M.H. (2021). Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses. Nature Communications, 12(1), 4882. https://doi.org/10.1038/s41467-021-25218-x

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Boldanova T, Fucile G, Vosshenrich J, Suslov A, Ercan C, Coto-Llerena M, Terracciano LM, Zech CJ, Boll DT, Wieland S, & Heim MH. (2021). Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization. Cell Reports Medicine, 2(11), 100444. https://doi.org/10.1016/j.xcrm.2021.100444

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Suslov A, Meier MA, Ketterer S, Wang X, Wieland S, & Heim MH. (2021). Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity. Journal of Hepatology, 74(4), 794–800. https://doi.org/10.1016/j.jhep.2020.11.003

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