Liver Diseases
Our research is translational and focused on viral hepatitis and hepatocellular carcinoma. Most of the past and current research projects are motivated by medical needs of the patients we care for in our clinic. We use liver biopsy and blood samples from patients with liver disease and analyze them with state-of-the art technology in our laboratory.
Selected Publications
Ng, Charlotte K. Y., Dazert, Eva, Boldanova, Tuyana, Coto-Llerena, Mairene, Nuciforo, Sandro, Ercan, Caner, Suslov, Aleksei, Meier, Marie-Anne, Bock, Thomas, Schmidt, Alexander, Ketterer, Sylvia, Wang, Xueya, Wieland, Stefan, Matter, Matthias S., Colombi, Marco, Piscuoglio, Salvatore, Terracciano, Luigi M., Hall, Michael N., & Nature Communications, 13(1), 2436. https://doi.org/10.1038/s41467-022-29960-8
(2022). Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages.
Ng, Charlotte K. Y., Dazert, Eva, Boldanova, Tuyana, Coto-Llerena, Mairene, Nuciforo, Sandro, Ercan, Caner, Suslov, Aleksei, Meier, Marie-Anne, Bock, Thomas, Schmidt, Alexander, Ketterer, Sylvia, Wang, Xueya, Wieland, Stefan, Matter, Matthias S., Colombi, Marco, Piscuoglio, Salvatore, Terracciano, Luigi M., Hall, Michael N., & Nature Communications, 13(1), 2436. https://doi.org/10.1038/s41467-022-29960-8
(2022). Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages.
Chen Q., Coto-Llerena M., Suslov A, Teixeira R.D., Fofana I., Nuciforo S, Hofmann M., Thimme R., Hensel N., Lohmann V., Ng C.K.Y., Rosenberger G., Wieland S, & Nature Communications, 12(1), 4882. https://doi.org/10.1038/s41467-021-25218-x
(2021). Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses.
Chen Q., Coto-Llerena M., Suslov A, Teixeira R.D., Fofana I., Nuciforo S, Hofmann M., Thimme R., Hensel N., Lohmann V., Ng C.K.Y., Rosenberger G., Wieland S, & Nature Communications, 12(1), 4882. https://doi.org/10.1038/s41467-021-25218-x
(2021). Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses.
Boldanova T, Fucile G, Vosshenrich J, Suslov A, Ercan C, Coto-Llerena M, Terracciano LM, Zech CJ, Boll DT, Wieland S, & Cell Reports Medicine, 2(11), 100444. https://doi.org/10.1016/j.xcrm.2021.100444
. (2021). Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization.
Boldanova T, Fucile G, Vosshenrich J, Suslov A, Ercan C, Coto-Llerena M, Terracciano LM, Zech CJ, Boll DT, Wieland S, & Cell Reports Medicine, 2(11), 100444. https://doi.org/10.1016/j.xcrm.2021.100444
. (2021). Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization.
Suslov A, Meier MA, Ketterer S, Wang X, Wieland S, & Journal of Hepatology, 74(4), 794–800. https://doi.org/10.1016/j.jhep.2020.11.003
. (2021). Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity.
Suslov A, Meier MA, Ketterer S, Wang X, Wieland S, & Journal of Hepatology, 74(4), 794–800. https://doi.org/10.1016/j.jhep.2020.11.003
. (2021). Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity.