Projects & Collaborations
European Collaboration for Prospective Outcome Research in Congenital Heart Disease (EPOCH)
Research Project | 1 Project Members
EPOCH is an international multicenter registry embedded in the SACHER network, designed to evaluate long-term outcomes in adults with congenital heart disease (ACHD): www.sacher-registry.com/epoch.
I serve as a Co-Investigator for the EPOCH-ASO subproject, which focuses on the prospective follow-up of patients after an arterial switch operation (ASO). This subproject is ongoing and coordinated in Switzerland by Prof. Daniel Tobler, Prof. Matthias Greutmann, and myself.
In addition to EPOCH-ASO, the EPOCH collaboration previously included the COVID-19 ACHD Tracker, which investigated outcomes of SARS-CoV-2 infection in ACHD patients. The findings were published in International Journal of Cardiology (PMID: 33685931).
A list of related peer-reviewed publications is available at:
ð https://www.sacher-registry.com/epoch/publications/accepted-manuscripts/
Effect of phosphodiesterase-5 inhibition on SystEmic Right VEntricular size and function â A multicentre, double-blind, randomized, placebo-controlled trial â SERVE
Research Project | 1 Project Members
SERVE was a double-blind, randomized, placebo-controlled, multicenter superiority trial (NCT03049540) conducted in Switzerland. The study enrolled 100 adults with a systemic right ventricle (sRV), comparing tadalafil 20â¯mg once daily versus placebo over a 3-year period. More information: www.sacher-registry.com/serve
The primary endpoint was the change in right ventricular end-systolic volume (RVESV); secondary endpoints included changes in right ventricular ejection fraction, NT-proBNP levels, and exercise capacity.
I was involved as a Co-Investigator at the Basel and Bern center, contributing to patient enrollment, follow-up, and data analysis.
Related peer-reviewed publications are available at:
ð https://www.sacher-registry.com/serve/publications/accepted-manuscripts/
SACHER â Swiss Adult Congenital HEart Disease Registry
Research Project | 1 Project Members
SACHER is a prospective national registry for adults with congenital heart disease (ACHD) in Switzerland. It systematically collects clinical, procedural, and long-term outcome data from all major Swiss ACHD centers. The aim is to support observational research, quality benchmarking, and evidence generation for this growing patient population. More information is available at: www.sacher-registry.com.
I am involved as a Co-Investigator, contributing to patient enrollment, data quality control, and scientific analysis at the Basel center. The registry serves as a platform for multiple subprojects and collaborations, including EPOCH and EPOCH-ASO.
A list of accepted peer-reviewed publications arising from SACHER can be found here:
ð https://www.sacher-registry.com/sacher/publications/accepted-manuscripts/