PD Dr. Dr. Gerrit M. Grosse

Jendretzky, K. F., Bajor, A., Lezius, L.-M., Hümmert, M. W., Konen, F. F., Grosse, G. M., Schwenkenbecher, P., Sühs, K.-W., Trebst, C., Framme, C., Wattjes, M. P., Meuth, S. G., Gingele, S., & Skripuletz, T. (2024). Clinical and paraclinical characteristics of optic neuritis in the context of the McDonald criteria 2017. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-57199-4

Cao, J., Roth, S., Zhang, S., Kopczak, A., Mami, S., Asare, Y., Georgakis, M. K., Messerer, D., Horn, A., Shemer, R., Jacqmarcq, C., Picot, A., Green, J. P., Schlegl, C., Li, X., Tomas, L., Dutsch, A., Liman, T. G., Endres, M., et al. (2024). DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature, 633(8029), 433–441. https://doi.org/10.1038/s41586-024-07803-4

Diener, H.-C., Grosse, G. M., Hüsing, A., Stang, A., Kuklik, N., Brinkmann, M., Maurer, G. D., Soda, H., Pohlmann, C., Hilker-Roggendorf, R., Popovic, N., Kraft, P., Mackert, B.-M., Eschenfelder, C. C., & Weimar, C. (2024). Efficacy and safety of oral factor Xa inhibitors versus vitamin-K antagonists in the early phase after acute ischemic stroke or TIA in the real-world setting: The PRODAST study. European Stroke Journal, 9(3), 696–703. https://doi.org/10.1177/23969873241242239

Jochmann, S. L., Sievering, E. M. W., Ernst, J., Ringlstetter, R., Grosshennig, A., Weissenborn, K., & Grosse, G. M. (2024). Sex-Specific Risk Factors of Nonstenotic Carotid Plaque in Embolic Stroke of Unknown Source: A Case-Control Study. Stroke, 55(2), 296–300. https://doi.org/10.1161/STROKEAHA.123.044833

Dirks, M., Hennemann, A.-K., Grosse, Gerrit M., Beer, A., Pflugrad, H., Haag, K., Schuppner, R., Deterding, K., Cornberg, M., Wedemeyer, H., & Weissenborn, K. (2024). Long-Term Follow-Up of Neuropsychiatric Symptoms After Sustained Virological Response to Interferon-Free and Interferon-Based Hepatitis C Virus Treatment. Journal of Viral Hepatitis. https://doi.org/10.1111/jvh.14033

Grosse, G. M., Hüsing, A., Stang, A., Kuklik, N., Brinkmann, M., Nabavi, D., Sparenberg, P., Weissenborn, K., Gröschel, K., Royl, G., Poli, S., Michalski, D., Eschenfelder, C. C., Weimar, C., & Diener, H.-C. (2023). Early or late initiation of dabigatran versus vitamin-K-antagonists in acute ischemic stroke or TIA: The PRODAST study. International Journal of Stroke, 18(10), 1169–1177. https://doi.org/10.1177/17474930231184366

Hupe, J., Worthmann, H., Ravenberg, K. K., Grosse, G. M., Ernst, J., Haverich, A., Bengel, F. M., Weissenborn, K., Schmitto, J. D., Hanke, J. S., Derlin, T., & Gabriel, M. M. (2023). Interplay between driveline infection, vessel wall inflammation, cerebrovascular events and mortality in patients with left ventricular assist device. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-45110-6

Worthmann, H., Ernst, J., & Grosse, G. M. (2023). What is confirmed in the treatment of ischemic stroke Was ist gesichert in der Therapie des ischämischen Schlaganfalls? Innere Medizin (Germany), 64(12), 1143–1153. https://doi.org/10.1007/s00108-023-01622-x

Sievering, E. M., Grosshennig, A., Kottas, M., Ernst, J., Ringlstetter, R., Koch, A., Weissenborn, K., & Grosse, G. M. (2023). Diagnostic value of carotid intima-media thickness and clinical risk scores in determining etiology of ischemic stroke. European Stroke Journal, 8(3), 738–746. https://doi.org/10.1177/23969873231182492

Ernst, J., Ehrenreich, H., Weissenborn, K., & Grosse, G. M. (2023). Unraveling Mechanisms of Cryptogenic Stroke at the Genetic Level: A Systematic Literature Review. Journal of the American Heart Association, 12(15). https://doi.org/10.1161/JAHA.123.029843

Ravenberg, K. K., Gabriel, M. M., Leotescu, A., Tran, A. T., Grosse, G. M., Schuppner, R., Ernst, J., Lichtinghagen, R., Tiede, A., Werwitzke, S., Bara, C. L., Schmitto, J. D., Weissenborn, K., Hanke, J. S., & Worthmann, H. (2023). Microembolic signal monitoring in patients with HeartMate 3 and HeartWare left ventricular assist devices: Association with antithrombotic treatment and cerebrovascular events. Artificial Organs, 47(2), 370–379. https://doi.org/10.1111/aor.14409

Grosse, G. M., Leotescu, A., Sieweke, J.-T., Schneppenheim, S., Budde, U., Ziegler, N. L., Biber, S., Gabriel, M. M., Ernst, J., Schuppner, R., Lichtinghagen, R., Bavendiek, U., Widder, J., & Weissenborn, K. (2023). ADAMTS-13 activity in stroke of known and unknown cause: Relation to vascular risk factor burden. Frontiers in Neurology, 13. https://doi.org/10.3389/fneur.2022.1045478

Döring, K., Aburub, A., Krauss, J. K., Lang, J. M., Al-Afif, S., Polemikos, M., Weissenborn, K., Grosse, G., Grieb, D., Lanfermann, H., Götz, F., & Abu-Fares, O. (2023). Early clinical experience with the new generation Pipeline Vantage flow diverter in the treatment of unruptured saccular aneurysms using short-term dual antiplatelet therapy. Interventional Neuroradiology. https://doi.org/10.1177/15910199231205047

Sieweke, J.-T., Grosse, G. M., Weissenborn, K., Derda, A. A., Biber, S., Bauersachs, J., Bavendiek, U., & Tillmanns, J. (2022). Circulating fibroblast activation protein α is reduced in acute ischemic stroke. Frontiers in Cardiovascular Medicine, 9. https://doi.org/10.3389/fcvm.2022.1064157

Faber, D., Grosse, G. M., Klietz, M., Petri, S., Schwenkenbecher, P., Sühs, K.-W., & Kopp, B. (2022). Towards the Validation of Executive Functioning Assessments: A Clinical Study. Journal of Clinical Medicine, 11(23). https://doi.org/10.3390/jcm11237138

Hasse, I. M. C., Grosse, G. M., Schuppner, R., Van Gemmeren, T., Gabriel, M. M., Weissenborn, K., Lichtinghagen, R., & Worthmann, H. (2022). Circulating Inflammatory Biomarkers in Early Prediction of Stroke-Associated Infections. International Journal of Molecular Sciences, 23(22). https://doi.org/10.3390/ijms232213747

de Buhr, N., Baumann, T., Werlein, C., Fingerhut, L., Imker, R., Meurer, M., Götz, F., Bronzlik, P., Kühnel, M. P., Jonigk, D. D., Ernst, J., Leotescu, A., Gabriel, M. M., Worthmann, H., Lichtinghagen, R., Tiede, A., von Köckritz-Blickwede, M., Falk, C. S., Weissenborn, K., et al. (2022). Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.879157

Grosse, G. M., Blume, N., Abu-Fares, O., Götz, F., Ernst, J., Leotescu, A., Gabriel, M. M., Van Gemmeren, T., Worthmann, H., Lichtinghagen, R., Imker, R., Falk, C. S., Weissenborn, K., Schuppner, R., & De Buhr, N. (2022). Endogenous Deoxyribonuclease Activity and Cell-Free Deoxyribonucleic Acid in Acute Ischemic Stroke: A Cohort Study. Stroke, 53(4), 1235–1244. https://doi.org/10.1161/STROKEAHA.121.036299

Grosse, G. M., Werlein, C., Blume, N., Abu-Fares, O., Götz, F., Gabriel, M. M., Ernst, J., Leotescu, A., Worthmann, H., Kühnel, M. P., Jonigk, D. D., Falk, C. S., Weissenborn, K., & Schuppner, R. (2022). Circulating Cytokines and Growth Factors in Acute Cerebral Large Vessel Occlusion-Association with Success of Endovascular Treatment. Thrombosis and Haemostasis, 122(4), 623–632. https://doi.org/10.1055/a-1544-5431

Sieweke, J.-T., Hagemus, J., Biber, S., Berliner, D., Grosse, G. M., Schallhorn, S., Pfeffer, T. J., Derda, A. A., Neuser, J., Bauersachs, J., & Bavendiek, U. (2022). Echocardiographic Parameters to Predict Atrial Fibrillation in Clinical Routine—The EAHsy-AF Risk Score. Frontiers in Cardiovascular Medicine, 9. https://doi.org/10.3389/fcvm.2022.851474

Ernst, J., Storch, K. F., Tran, A. T., Gabriel, M. M., Leotescu, A., Boeck, A.-L., Huber, M. K., Abu-Fares, O., Bronzlik, P., Götz, F., Worthmann, H., Schuppner, R., Grosse, G. M., & Weissenborn, K. (2022). Advancement of door-to-needle times in acute stroke treatment after repetitive process analysis: never give up! Therapeutic Advances in Neurological Disorders, 15. https://doi.org/10.1177/17562864221122491

Dirks, M., Buchert, R., Wirries, A.-K., Pflugrad, H., Grosse, G. M., Petrusch, C., Schütze, C., Wilke, F., Mamach, M., Hamann, L., Langer, L. B. N., Ding, X.-Q., Barg-Hock, H., Klempnauer, J., Wetzel, C. H., Lukacevic, M., Janssen, E., Kessler, M., Bengel, F. M., et al. (2021). Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation. European Journal of Nuclear Medicine and Molecular Imaging, 49(1), 234–245. https://doi.org/10.1007/s00259-021-05398-w

Grosse, G. M., Weimar, C., Kuklik, N., Hüsing, A., Stang, A., Brinkmann, M., Eschenfelder, C. C., & Diener, H.-C. (2021). Rationale, Design and Methods of the Prospective Record of the Use of Dabigatran in Patients with Acute Stroke or TIA (PRODAST) Study. European Stroke Journal, 6(4), 438–444. https://doi.org/10.1177/23969873211060219

Grosse, G. M., Derda, A. A., Stauss, R. D., Neubert, L., Jonigk, D. D., Kühnel, M. P., Gabriel, M. M., Schuppner, R., Wilhelmi, M., Bär, C., Bauersachs, J., Schrimpf, C., Thum, T., & Weissenborn, K. (2021). Circulating microRNAs in Symptomatic and Asymptomatic Carotid Stenosis. Frontiers in Neurology, 12. https://doi.org/10.3389/fneur.2021.755827

Deutsch, N. R., Worthmann, H., Steixner-Kumar, A. A., Schuppner, R., Grosse, G. M., Pan, H., Gabriel, M. M., Hasse, I., van Gemmeren, T., Lichtinghagen, R., Ehrenreich, H., & Weissenborn, K. (2021). Autoantibodies against the NMDAR subunit NR1 are associated with neuropsychiatric outcome after ischemic stroke. Brain, Behavior, and Immunity, 96, 73–79. https://doi.org/10.1016/j.bbi.2021.05.011

Weissenborn, K., Gruber, S., Grosse, G. M., Gabriel, M., Schuppner, R., Worthmann, H., Abu-Fares, O., & Götz, F. (2021). Endovascular Treatment of Acute Ischemic Stroke in Clinical Practice: Analysis of Workflow and Outcome in a Tertiary Care Center. Frontiers in Neurology, 12. https://doi.org/10.3389/fneur.2021.657345

Grosse, G. M., Sieweke, J.-T., Biber, S., Ziegler, N. L., Gabriel, M. M., Schuppner, R., Worthmann, H., Bavendiek, U., & Weissenborn, K. (2020). Nonstenotic Carotid Plaque in Embolic Stroke of Undetermined Source: Interplay of Arterial and Atrial Disease. Stroke, 51(12), 3737–3741. https://doi.org/10.1161/STROKEAHA.120.030537

Stauss, R. D., Grosse, G. M., Neubert, L., Falk, C. S., Jonigk, D., Kühnel, M. P., Gabriel, M. M., Schuppner, R., Lichtinghagen, R., Wilhelmi, M., Weissenborn, K., & Schrimpf, C. (2020). Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-78941-8

Sieweke, J.-T., Pfeffer, T. J., Biber, S., Chatterjee, S., Weissenborn, K., Grosse, G. M., Hagemus, J., Derda, A. A., Berliner, D., Lichtinghagen, R., Hilfiker-Kleiner, D., Bauersachs, J., Bär, C., Thum, T., & Bavendiek, U. (2020). MiR−21 and nt-probnp correlate with echocardiographic parameters of atrial dysfunction and predict atrial fibrillation. Journal of Clinical Medicine, 9(4). https://doi.org/10.3390/jcm9041118

Grosse, G. M., Bauer, C., Kopp, B., Schrader, C., & Osmanovic, A. (2020). Identification of a rare SEPT9 variant in a family with autosomal dominant Charcot-Marie-Tooth disease. BMC Medical Genetics, 21(1). https://doi.org/10.1186/s12881-020-0984-7

Grosse, G. M., Schwedhelm, E., Worthmann, H., & Choe, C.-U. (2020). Arginine derivatives in cerebrovascular diseases: Mechanisms and clinical implications. International Journal of Molecular Sciences, 21(5). https://doi.org/10.3390/ijms21051798

van Gemmeren, T., Schuppner, R., Grosse, G. M., Fering, J., Gabriel, M. M., Huber, R., Worthmann, H., Lichtinghagen, R., & Weissenborn, K. (2020). Early post-stroke infections are associated with an impaired function of neutrophil granulocytes. Journal of Clinical Medicine, 9(3). https://doi.org/10.3390/jcm9030872

Sieweke, J.-T., Biber, S., Weissenborn, K., Heuschmann, P. U., Akin, M., Zauner, F., Gabriel, M. M., Schuppner, R., Berliner, D., Bauersachs, J., Grosse, G. M., & Bavendiek, U. (2020). Septal total atrial conduction time for prediction of atrial fibrillation in embolic stroke of unknown source: a pilot study. Clinical Research in Cardiology, 109(2), 205–214. https://doi.org/10.1007/s00392-019-01501-2

Putzer, A.-S., Worthmann, H., Grosse, G. M., Goetz, F., Martens-Lobenhoffer, J., Dirks, M., Kielstein, J. T., Lichtinghagen, R., Budde, U., Bode-Böger, S. M., Weissenborn, K., & Schuppner, R. (2020). ADAMTS13 activity is associated with early neurological improvement in acute ischemic stroke patients treated with intravenous thrombolysis. Journal of Thrombosis and Thrombolysis, 49(1), 67–74. https://doi.org/10.1007/s11239-019-01941-7

Ziegler, N. L., Sieweke, J.-T., Biber, S., Gabriel, M. M., Schuppner, R., Worthmann, H., Martens-Lobenhoffer, J., Lichtinghagen, R., Bode-Böger, S. M., Bavendiek, U., Weissenborn, K., & Grosse, G. M. (2019). Markers of endothelial pathology to support detection of atrial fibrillation in embolic stroke of undetermined source. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-55943-9

Grosse, G. M., Biber, S., Sieweke, J.-T., Martens-Lobenhoffer, J., Gabriel, M. M., Putzer, A.-S., Hasse, I., Gemmeren, T. V., Schuppner, R., Worthmann, H., Lichtinghagen, R., Bode-Böger, S. M., Bavendiek, U., & Weissenborn, K. (2019). Plasma dimethylarginine levels and carotid intima–media thickness are related to atrial fibrillation in patients with embolic stroke. International Journal of Molecular Sciences, 20(3). https://doi.org/10.3390/ijms20030730

Kasner S.E., Swaminathan B., Lavados P., Sharma M., Muir K.W., Veltkamp R., Ameriso S.F., Endres M., Lutsep H., Messe S.R., Spence J.D., Nedeltechev K., Perera K., Santo G., Olavarria V., Lindgren A., Bangdiwala S., Shoamanesh A., Berkowitz S.D., et al. (2018). Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial. The Lancet Neurology, 17(12), 1053–1060. https://doi.org/10.1016/s1474-4422(18)30319-3

Schuppner, R., Dirks, M., Grosse, G. M., Böckmann, M., Goetz, F., Pasedag, T., Bode-Böger, S. M., Martens-Lobenhoffer, J., Budde, U., Lanfermann, H., Lichtinghagen, R., Weissenborn, K., & Worthmann, H. (2018). ADAMTS-13 Activity Predicts Outcome in Acute Ischaemic Stroke Patients Undergoing Endovascular Treatment. Thrombosis and Haemostasis, 118(4), 758–767. https://doi.org/10.1055/s-0038-1637732

Grosse, G. M., Bascuñana, P., Schulz-Schaeffer, W. J., Teebken, O. E., Wilhelmi, M., Worthmann, H., Ross, T. L., Wester, H.-J., Kropf, S., Derlin, T., Bengel, F. M., Bankstahl, J. P., & Weissenborn, K. (2018). Targeting chemokine receptor CXCR4 and translocator protein for characterization of high-risk plaque in carotid stenosis ex vivo. Stroke, 49(8), 1988–1991. https://doi.org/10.1161/STROKEAHA.118.021070

Grosse, G. M., Schulz-Schaeffer, W. J., Teebken, O. E., Schuppner, R., Dirks, M., Worthmann, H., Lichtinghagen, R., Maye, G., Limbourg, F. P., & Weissenborn, K. (2016). Monocyte subsets and related chemokines in carotid artery stenosis and ischemic stroke. International Journal of Molecular Sciences, 17(4). https://doi.org/10.3390/ijms17040433

Grosse, G.M., Teebken, O.E., Worthmann, H., Schulz-Schaeffer, W.J., Limbourg, F.P., & Weissenborn, K. (2014). Re. ‘identification of patients with a histologically unstable carotid plaque using ultrasonic plaque image analysis’. European Journal of Vascular and Endovascular Surgery, 48(6), 714–715. https://doi.org/10.1016/j.ejvs.2014.09.013

Grosse, G. M., Tryc, A. B., Dirks, M., Schuppner, R., Pflugrad, H., Lichtinghagen, R., Weissenborn, K., & Worthmann, H. (2014). The temporal dynamics of plasma fractalkine levels in ischemic stroke: Association with clinical severity and outcome. Journal of Neuroinflammation, 11. https://doi.org/10.1186/1742-2094-11-74