We are interested in pathomechanisms, diagnosis and prevention of cerebrovascular diseases. Using modern epidemiological and imaging methods, we are investigating novel approaches in diagnostics and (preventive) therapy, e.g. in order to reduce recurrent strokes and other serious adverse events. The focus of these efforts is on molecular biomarkers in peripheral blood, thrombi and atherosclerotic plaques. Furthermore, we are interested in clinical neuroepidemiological questions.
Selected Publications
, Hüsing, Anika, Stang, Andreas, Kuklik, Nils, Brinkmann, Marcus, Grond, Martin, Rollnik, Jens D., Marquardt, Lars, Kraft, Andrea, Schlemm, Eckhard, Eggers, Carsten, Eschenfelder, Christoph C., Weimar, Christian, & Diener, Hans‐Christoph. (2025). Prior Anticoagulation and Risk of Hemorrhagic Transformation in Acute Stroke: A Post Hoc Analysis of the PRODAST Study [Journal-article]. Journal of the American Heart Association , 14(3). https://doi.org/10.1161/JAHA.124.037014
, Hüsing, Anika, Stang, Andreas, Kuklik, Nils, Brinkmann, Marcus, Grond, Martin, Rollnik, Jens D., Marquardt, Lars, Kraft, Andrea, Schlemm, Eckhard, Eggers, Carsten, Eschenfelder, Christoph C., Weimar, Christian, & Diener, Hans‐Christoph. (2025). Prior Anticoagulation and Risk of Hemorrhagic Transformation in Acute Stroke: A Post Hoc Analysis of the PRODAST Study [Journal-article]. Journal of the American Heart Association , 14(3). https://doi.org/10.1161/JAHA.124.037014
Cao, Jiayu, Roth, Stefan, Zhang, Sijia, Kopczak, Anna, Mami, Samira, Asare, Yaw, Georgakis, Marios K., Messerer, Denise, Horn, Amit, Shemer, Ruth, Jacqmarcq, Charlene, Picot, Audrey, Green, Jack P., Schlegl, Christina, Li, Xinghai, Tomas, Lukas, Dutsch, Alexander, Liman, Thomas G., Endres, Matthias, et al. (2024). DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature, 633(8029), 433–441. https://doi.org/10.1038/s41586-024-07803-4
Cao, Jiayu, Roth, Stefan, Zhang, Sijia, Kopczak, Anna, Mami, Samira, Asare, Yaw, Georgakis, Marios K., Messerer, Denise, Horn, Amit, Shemer, Ruth, Jacqmarcq, Charlene, Picot, Audrey, Green, Jack P., Schlegl, Christina, Li, Xinghai, Tomas, Lukas, Dutsch, Alexander, Liman, Thomas G., Endres, Matthias, et al. (2024). DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature, 633(8029), 433–441. https://doi.org/10.1038/s41586-024-07803-4
Jochmann, Svenja L., Sievering, Esther M.W., Ernst, Johanna, Ringlstetter, Rieke, Grosshennig, Anika, Weissenborn, Karin, & (2024). Sex-Specific Risk Factors of Nonstenotic Carotid Plaque in Embolic Stroke of Unknown Source: A Case-Control Study. Stroke, 55(2), 296–300. https://doi.org/10.1161/STROKEAHA.123.044833
Jochmann, Svenja L., Sievering, Esther M.W., Ernst, Johanna, Ringlstetter, Rieke, Grosshennig, Anika, Weissenborn, Karin, & (2024). Sex-Specific Risk Factors of Nonstenotic Carotid Plaque in Embolic Stroke of Unknown Source: A Case-Control Study. Stroke, 55(2), 296–300. https://doi.org/10.1161/STROKEAHA.123.044833
, Hüsing, Anika, Stang, Andreas, Kuklik, Nils, Brinkmann, Marcus, Nabavi, Darius, Sparenberg, Paul, Weissenborn, Karin, Gröschel, Klaus, Royl, Georg, Poli, Sven, Michalski, Dominik, Eschenfelder, Christoph C, Weimar, Christian, & Diener, Hans-Christoph. (2023). Early or late initiation of dabigatran versus vitamin-K-antagonists in acute ischemic stroke or TIA: The PRODAST study. International Journal of Stroke, 18(10), 1169–1177. https://doi.org/10.1177/17474930231184366
, Hüsing, Anika, Stang, Andreas, Kuklik, Nils, Brinkmann, Marcus, Nabavi, Darius, Sparenberg, Paul, Weissenborn, Karin, Gröschel, Klaus, Royl, Georg, Poli, Sven, Michalski, Dominik, Eschenfelder, Christoph C, Weimar, Christian, & Diener, Hans-Christoph. (2023). Early or late initiation of dabigatran versus vitamin-K-antagonists in acute ischemic stroke or TIA: The PRODAST study. International Journal of Stroke, 18(10), 1169–1177. https://doi.org/10.1177/17474930231184366
Sievering, Esther MW, Grosshennig, Anika, Kottas, Martina, Ernst, Johanna, Ringlstetter, Rieke, Koch, Armin, Weissenborn, Karin, & . (2023). Diagnostic value of carotid intima-media thickness and clinical risk scores in determining etiology of ischemic stroke. European Stroke Journal, 8(3), 738–746. https://doi.org/10.1177/23969873231182492
Sievering, Esther MW, Grosshennig, Anika, Kottas, Martina, Ernst, Johanna, Ringlstetter, Rieke, Koch, Armin, Weissenborn, Karin, & . (2023). Diagnostic value of carotid intima-media thickness and clinical risk scores in determining etiology of ischemic stroke. European Stroke Journal, 8(3), 738–746. https://doi.org/10.1177/23969873231182492
Ernst, Johanna, Ehrenreich, Hannelore, Weissenborn, Karin, & (2023). Unraveling Mechanisms of Cryptogenic Stroke at the Genetic Level: A Systematic Literature Review. Journal of the American Heart Association, 12(15). https://doi.org/10.1161/JAHA.123.029843
Ernst, Johanna, Ehrenreich, Hannelore, Weissenborn, Karin, & (2023). Unraveling Mechanisms of Cryptogenic Stroke at the Genetic Level: A Systematic Literature Review. Journal of the American Heart Association, 12(15). https://doi.org/10.1161/JAHA.123.029843
de Buhr, Nicole, Baumann, Tristan, Werlein, Christopher, Fingerhut, Leonie, Imker, Rabea, Meurer, Marita, Götz, Friedrich, Bronzlik, Paul, Kühnel, Mark P., Jonigk, Danny D., Ernst, Johanna, Leotescu, Andrei, Gabriel, Maria M., Worthmann, Hans, Lichtinghagen, Ralf, Tiede, Andreas, von Köckritz-Blickwede, Maren, Falk, Christine S., Weissenborn, Karin, et al. (2022). Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.879157
de Buhr, Nicole, Baumann, Tristan, Werlein, Christopher, Fingerhut, Leonie, Imker, Rabea, Meurer, Marita, Götz, Friedrich, Bronzlik, Paul, Kühnel, Mark P., Jonigk, Danny D., Ernst, Johanna, Leotescu, Andrei, Gabriel, Maria M., Worthmann, Hans, Lichtinghagen, Ralf, Tiede, Andreas, von Köckritz-Blickwede, Maren, Falk, Christine S., Weissenborn, Karin, et al. (2022). Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.879157
, Blume, Nicole, Abu-Fares, Omar, Götz, Friedrich, Ernst, Johanna, Leotescu, Andrei, Gabriel, Maria M., Van Gemmeren, Till, Worthmann, Hans, Lichtinghagen, Ralf, Imker, Rabea, Falk, Christine S., Weissenborn, Karin, Schuppner, Ramona, & De Buhr, Nicole. (2022). Endogenous Deoxyribonuclease Activity and Cell-Free Deoxyribonucleic Acid in Acute Ischemic Stroke: A Cohort Study. Stroke, 53(4), 1235–1244. https://doi.org/10.1161/STROKEAHA.121.036299
, Blume, Nicole, Abu-Fares, Omar, Götz, Friedrich, Ernst, Johanna, Leotescu, Andrei, Gabriel, Maria M., Van Gemmeren, Till, Worthmann, Hans, Lichtinghagen, Ralf, Imker, Rabea, Falk, Christine S., Weissenborn, Karin, Schuppner, Ramona, & De Buhr, Nicole. (2022). Endogenous Deoxyribonuclease Activity and Cell-Free Deoxyribonucleic Acid in Acute Ischemic Stroke: A Cohort Study. Stroke, 53(4), 1235–1244. https://doi.org/10.1161/STROKEAHA.121.036299
, Werlein, Christopher, Blume, Nicole, Abu-Fares, Omar, Götz, Friedrich, Gabriel, Maria M., Ernst, Johanna, Leotescu, Andrei, Worthmann, Hans, Kühnel, Mark P., Jonigk, Danny D., Falk, Christine S., Weissenborn, Karin, & Schuppner, Ramona. (2022). Circulating Cytokines and Growth Factors in Acute Cerebral Large Vessel Occlusion-Association with Success of Endovascular Treatment. Thrombosis and Haemostasis, 122(4), 623–632. https://doi.org/10.1055/a-1544-5431
, Werlein, Christopher, Blume, Nicole, Abu-Fares, Omar, Götz, Friedrich, Gabriel, Maria M., Ernst, Johanna, Leotescu, Andrei, Worthmann, Hans, Kühnel, Mark P., Jonigk, Danny D., Falk, Christine S., Weissenborn, Karin, & Schuppner, Ramona. (2022). Circulating Cytokines and Growth Factors in Acute Cerebral Large Vessel Occlusion-Association with Success of Endovascular Treatment. Thrombosis and Haemostasis, 122(4), 623–632. https://doi.org/10.1055/a-1544-5431
