UNIverse - Public Research Portal
Profile Photo

PD Dr. Dr. Gerrit M. Grosse

Department of Clinical Research
Profiles & Affiliations

We are interested in pathomechanisms, diagnosis and prevention of cerebrovascular diseases. Using modern epidemiological and imaging methods, we are investigating novel approaches in diagnostics and (preventive) therapy, e.g. in order to reduce recurrent strokes and other serious adverse events. The focus of these efforts is on molecular biomarkers in peripheral blood, thrombi and atherosclerotic plaques. Furthermore, we are interested in clinical neuroepidemiological questions.

Selected Publications

Cao, J., Roth, S., Zhang, S., Kopczak, A., Mami, S., Asare, Y., Georgakis, M. K., Messerer, D., Horn, A., Shemer, R., Jacqmarcq, C., Picot, A., Green, J. P., Schlegl, C., Li, X., Tomas, L., Dutsch, A., Liman, T. G., Endres, M., et al. (2024). DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature, 633(8029), 433–441. https://doi.org/10.1038/s41586-024-07803-4

URLs
URLs

Jochmann, S. L., Sievering, E. M. W., Ernst, J., Ringlstetter, R., Grosshennig, A., Weissenborn, K., & Grosse, G. M. (2024). Sex-Specific Risk Factors of Nonstenotic Carotid Plaque in Embolic Stroke of Unknown Source: A Case-Control Study. Stroke, 55(2), 296–300. https://doi.org/10.1161/STROKEAHA.123.044833

URLs
URLs

Grosse, G. M., Hüsing, A., Stang, A., Kuklik, N., Brinkmann, M., Nabavi, D., Sparenberg, P., Weissenborn, K., Gröschel, K., Royl, G., Poli, S., Michalski, D., Eschenfelder, C. C., Weimar, C., & Diener, H.-C. (2023). Early or late initiation of dabigatran versus vitamin-K-antagonists in acute ischemic stroke or TIA: The PRODAST study. International Journal of Stroke, 18(10), 1169–1177. https://doi.org/10.1177/17474930231184366

URLs
URLs

Sievering, E. M., Grosshennig, A., Kottas, M., Ernst, J., Ringlstetter, R., Koch, A., Weissenborn, K., & Grosse, G. M. (2023). Diagnostic value of carotid intima-media thickness and clinical risk scores in determining etiology of ischemic stroke. European Stroke Journal, 8(3), 738–746. https://doi.org/10.1177/23969873231182492

URLs
URLs

Ernst, J., Ehrenreich, H., Weissenborn, K., & Grosse, G. M. (2023). Unraveling Mechanisms of Cryptogenic Stroke at the Genetic Level: A Systematic Literature Review. Journal of the American Heart Association, 12(15). https://doi.org/10.1161/JAHA.123.029843

URLs
URLs

de Buhr, N., Baumann, T., Werlein, C., Fingerhut, L., Imker, R., Meurer, M., Götz, F., Bronzlik, P., Kühnel, M. P., Jonigk, D. D., Ernst, J., Leotescu, A., Gabriel, M. M., Worthmann, H., Lichtinghagen, R., Tiede, A., von Köckritz-Blickwede, M., Falk, C. S., Weissenborn, K., et al. (2022). Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.879157

URLs
URLs

Grosse, G. M., Blume, N., Abu-Fares, O., Götz, F., Ernst, J., Leotescu, A., Gabriel, M. M., Van Gemmeren, T., Worthmann, H., Lichtinghagen, R., Imker, R., Falk, C. S., Weissenborn, K., Schuppner, R., & De Buhr, N. (2022). Endogenous Deoxyribonuclease Activity and Cell-Free Deoxyribonucleic Acid in Acute Ischemic Stroke: A Cohort Study. Stroke, 53(4), 1235–1244. https://doi.org/10.1161/STROKEAHA.121.036299

URLs
URLs

Grosse, G. M., Werlein, C., Blume, N., Abu-Fares, O., Götz, F., Gabriel, M. M., Ernst, J., Leotescu, A., Worthmann, H., Kühnel, M. P., Jonigk, D. D., Falk, C. S., Weissenborn, K., & Schuppner, R. (2022). Circulating Cytokines and Growth Factors in Acute Cerebral Large Vessel Occlusion-Association with Success of Endovascular Treatment. Thrombosis and Haemostasis, 122(4), 623–632. https://doi.org/10.1055/a-1544-5431

URLs
URLs

Selected Projects & Collaborations

Project cover

CRESCENDO - CiRculating mEdiators of Stroke reCurrENce anD aetiOlogies

Research Networks (Institutional Membership)  | 1 Project Members

Patients who suffered ischaemic stroke are at high risk for a recurrent cerebrovascular event. Despite all efforts in secondary prevention, stroke is still among the top causes for invalidity and death. Traditionally, risks for stroke recurrence are thought to be based on categorized stroke aetiologies and the amount of vascular risk factors. This concept however does not sufficiently reflect the complex pathophysiology and thus comes along with substantial issues. Rather, it appears probable that circulating mediators related to the extent of acute and chronic brain damage in concert with aetiological mechanisms and underlying comorbidities influence the risk for recurrent cerebrovascular events. With the CiRculating mEdiators of Stroke reCurrENce anD aetiOlogies (CRESCENDO) consortium, we aim to address this hypothesis. CRESCENDO will utilize existing biosample collections from a total of over 5,000 thoroughly evaluated patients at the three study sites in Hannover, Seville and Basel/Zrich. We on the one hand will investigate well-characterized biomarkers of cerebral damage, inflammation, immunothrombosis and stress in a hypothesis-driven approach and on the other hand explore predictive targets via a data-driven approach applying proteomics. The objective of this collaboration is to initiate a paradigm shift towards an integrated pathophysiology-based evaluation of individual cerebrovascular risks and to identify innovative approaches for secondary stroke prevention.