Prof. Dr. med. Beat Hintermann Department of Clinical Research Profiles & Affiliations OverviewResearch Publications Projects & Collaborations Projects & Collaborations OverviewResearch Publications Projects & Collaborations Profiles & Affiliations Projects & Collaborations 12 foundShow per page10 10 20 50 Shifting demand for public transport across time and modes Research Project | 1 Project MembersImported from Grants Tool 4705037 FV-23 Wirksamkeit klima- und energiepolitischer Massnahmen - eine empirische Analyseun Research Project | 4 Project MembersSeit 2005 befindet sich die Klima- und Energiepolitik in der Schweiz und der EU im Umbruch. Marktbasierte Instrumente (Emissionsabgaben, Emissionshandel) finden zunehmend Anwendung und werden häufig durch weitere Instrumente (Einspeisevergütungen, Technologieförderung, Labels) ergänzt. Dabei wird die Wirksamkeit der einzelnen Instrumente sowie der eingesetzten Instrumentkombinationen sehr kontrovers diskutiert. Insbesondere ist unklar, ob ein Einsatz ergänzender Instrumente (z.B. Einspeisevergütung, Technologieförderung) im Kontext eines Emissionshandels sinnvoll ist. Empirische Untersuchungen zu diesem Thema fehlen fast vollständig. Für die Schweiz sind zur Zeit keine hierfür nutzbaren Daten verfügbar. Die EU Kommission veröffentlicht aber mit 5 Jahren Verzögerung die Transaktionsdaten des Europäischen Emissionshandels. Anfang 2013 werden vollständige Daten für die erste Handelsphase (2005-2007) vorliegen. Aufgrund vorhandener Unterschiede in den ergänzenden Instrumente in der EU, kann mit diesen Daten die Wirkung von einzelnen Instrumenten und Instrumentkombinationen untersucht werden. Da fast alle in der Schweizer Politik eingesetzten Instrumente auch in der EU verwendet werden und weitgehend die gleichen Branchen betroffen sind, erlaubt eine solche Untersuchung direkte Rückschlüsse auf die Schweizer Klima- und Energiepolitik. Der mini-open Sinus-Tarsi-Zugang beim operativen Verfahren von Calcaneusfrakturen: eine klinisch prospektive, CT-kontrollierte Studie Research Project | 1 Project MembersDas Ziel unserer Studie ist bei dem minimal invasiven Sinus-Tarsi-Zugang für die operative Behandlung von intraartikulären Calcaneusfrakturen: 1) die Qualität der Reposition der posterioren Facette des unteren Sprunggelenkes auf einem postoperativen CT zu beurteilen; 2) zu evaluieren, mit CT nach minimal 1 Jahr, ob die erreichte Reposition ausreichend stabil bleiben konnte um allfällige Deformationskräfte aushalten zu können 3) die längerfristige klinische Ergebnisse zu erfassen. Follow-UP Study of Patients undergoing supramalleolar osteotomy Research Project | 1 Project MembersRecent studies have indicated that supramalleolar osteotomies are a valuable treatment option for early to midstage asymmetric osteoarthritis of the ankle joint. In the present study, we assessed the intermediate to long term effects of a supramalleolar osteotomy on the ankle and the neighbouring joints. For this study we evaluated a consecutive serie of patients with supramalleolar osteotomy. Long-term follow up of total ankle replacements Research Project | 1 Project MembersThe HINTEGRA ankle was developed as an attempt to specifically address the needs of minimal bone resection, extended bone support, proper ligament balancing, and minimal contact stresses within and around the prosthesis. The purpose of this project si to analyze the results after a minimal follow-up time of 4 years for a consecutive series of patients in whom symptomatic ankle arthritis was treated with the HINTEGRA total ankle prosthesis. The Influence of Implant Positioning and Design on Biomechanical Properties of the Replaced Ankle Research Project | 1 Project MembersIn recent decades, total ankle replacement (TAR) has become a valuable treatment option for end-stage ankle osteoarthritis. Although TAR continues to gain a greater clinical acceptance, postoperative complications such as prosthesis loosening and persistent pain remains much more prevalent than arthroplasties of other joints such as the hip or knee. One possible factor responsible for higher failure rates is the difficulty in obtaining the correct placement of the talar component such that the joint center of rotation is maintained. It is possible that differences in the pre- and postoperative joint center leads to abnormal articulation, increased joint contact and shear stresses, and the onset/advancement of osteoarthritis. Adding of a second interface between the polyethylene (PE) insert ant the tibial prosthesis component of the three-component TAR may permit the prosthesis components to adapt more physiological articulation. This may prevent deleterious loading of ankle soft tissues and reduce PE wear. Therefore, it is generally believed that a three-component TAR is superior to a two-component design. However, there are no data in literature to directly support this notion. To address the aforementioned issues, the proposed research project will answer the following questions: 1) To which extent does the PE inlay move with regard to the tibial component; 2) How and to what extent do changes in the position of the talar/tibial component influence biomechanics; 3) How and to what extent does supra- and inframalleolar misalignement influence biomechanics; 4) How and to what extent do the biomechanics of the hindfoot change if the PE inlay is fixed to the tibial component. The Infected Bone Graft. An in-vitro Study Comparing Staphylococcal Biofilm Formation on Fresh, Fresh-Frozen and Processed Human and Bovine Cancellous Bone Grafts Research Project | 1 Project MembersWe studied the initial adherence and biofilm formation of Staphylococcus aureus on different cancellous bone grafts used for filling of bone defects: fresh (fr) and fresh-frozen (ff) human bone grafts and commercial available bone grafts of processed human (ph) and processed bovine (pb) cancellous bone under standardized in-vitro conditions. Our data show that despite an initially increased adhesion a quantitatively reduced increase in bacterial density on fr and ff bone grafts within 24 h compared to ph and pb. The use of fr and ff bone grafts therefore seems to be favorable to ph and pb bone grafts regarding the risk of a peri-operative infection. Insert Position in Three-Component Total Ankle: Observing Study in 368 Consecutive Patients Research Project | 1 Project MembersTotal ankle replacement has become a valuable treatment option for end-stage osteoarthritis in recent decades. The most recent generation of implants comprises a second interface between the polyethylene insert and the tibial prosthesis component. To date, no data are available indicating the interindividual difference in the relative position of talar and tibial implant components and their position change over time. We assessed the radiographs of 368 ankles that underwent primary arthroplasty with a HINTEGRA ankle to determine the spatial relationship between talar and tibial components at the time of surgery and during followup. Examination of the data suggests that the latest three-component prosthesis functions similar to the two-component prosthesis, but with an added advantage of allowing an individualized position of the polyethylene insert in response to the individual soft tissue load. The Effect of Supramalleolar Varus and Valgus Deformities on the Tibiotalar Joint - an ex vivo Study Research Project | 1 Project MembersDistal tibia coronal plane malalignment predisposes to asymmetric ankle joint load. The purpose of this ex vivo study was to quantify the changes of pressure and force transfer in an ankle with a supramalleolar deformity. Two groups were assessed: isolated frontal plane deformity and deformities with an impaired containment of the ankle joint. Long-term outcome after supination-external rotation type-4 fractures of the ankle Research Project | 1 Project MembersAt a mean follow-up of 13 years after operative treatment of a supination-external rotation type-4 ankle fracture patients with partial or complete rupture of the medial deltoid ligament tended to have a better result than those with a medial malleolar fracture. 12 12 OverviewResearch Publications Projects & Collaborations
Projects & Collaborations 12 foundShow per page10 10 20 50 Shifting demand for public transport across time and modes Research Project | 1 Project MembersImported from Grants Tool 4705037 FV-23 Wirksamkeit klima- und energiepolitischer Massnahmen - eine empirische Analyseun Research Project | 4 Project MembersSeit 2005 befindet sich die Klima- und Energiepolitik in der Schweiz und der EU im Umbruch. Marktbasierte Instrumente (Emissionsabgaben, Emissionshandel) finden zunehmend Anwendung und werden häufig durch weitere Instrumente (Einspeisevergütungen, Technologieförderung, Labels) ergänzt. Dabei wird die Wirksamkeit der einzelnen Instrumente sowie der eingesetzten Instrumentkombinationen sehr kontrovers diskutiert. Insbesondere ist unklar, ob ein Einsatz ergänzender Instrumente (z.B. Einspeisevergütung, Technologieförderung) im Kontext eines Emissionshandels sinnvoll ist. Empirische Untersuchungen zu diesem Thema fehlen fast vollständig. Für die Schweiz sind zur Zeit keine hierfür nutzbaren Daten verfügbar. Die EU Kommission veröffentlicht aber mit 5 Jahren Verzögerung die Transaktionsdaten des Europäischen Emissionshandels. Anfang 2013 werden vollständige Daten für die erste Handelsphase (2005-2007) vorliegen. Aufgrund vorhandener Unterschiede in den ergänzenden Instrumente in der EU, kann mit diesen Daten die Wirkung von einzelnen Instrumenten und Instrumentkombinationen untersucht werden. Da fast alle in der Schweizer Politik eingesetzten Instrumente auch in der EU verwendet werden und weitgehend die gleichen Branchen betroffen sind, erlaubt eine solche Untersuchung direkte Rückschlüsse auf die Schweizer Klima- und Energiepolitik. Der mini-open Sinus-Tarsi-Zugang beim operativen Verfahren von Calcaneusfrakturen: eine klinisch prospektive, CT-kontrollierte Studie Research Project | 1 Project MembersDas Ziel unserer Studie ist bei dem minimal invasiven Sinus-Tarsi-Zugang für die operative Behandlung von intraartikulären Calcaneusfrakturen: 1) die Qualität der Reposition der posterioren Facette des unteren Sprunggelenkes auf einem postoperativen CT zu beurteilen; 2) zu evaluieren, mit CT nach minimal 1 Jahr, ob die erreichte Reposition ausreichend stabil bleiben konnte um allfällige Deformationskräfte aushalten zu können 3) die längerfristige klinische Ergebnisse zu erfassen. Follow-UP Study of Patients undergoing supramalleolar osteotomy Research Project | 1 Project MembersRecent studies have indicated that supramalleolar osteotomies are a valuable treatment option for early to midstage asymmetric osteoarthritis of the ankle joint. In the present study, we assessed the intermediate to long term effects of a supramalleolar osteotomy on the ankle and the neighbouring joints. For this study we evaluated a consecutive serie of patients with supramalleolar osteotomy. Long-term follow up of total ankle replacements Research Project | 1 Project MembersThe HINTEGRA ankle was developed as an attempt to specifically address the needs of minimal bone resection, extended bone support, proper ligament balancing, and minimal contact stresses within and around the prosthesis. The purpose of this project si to analyze the results after a minimal follow-up time of 4 years for a consecutive series of patients in whom symptomatic ankle arthritis was treated with the HINTEGRA total ankle prosthesis. The Influence of Implant Positioning and Design on Biomechanical Properties of the Replaced Ankle Research Project | 1 Project MembersIn recent decades, total ankle replacement (TAR) has become a valuable treatment option for end-stage ankle osteoarthritis. Although TAR continues to gain a greater clinical acceptance, postoperative complications such as prosthesis loosening and persistent pain remains much more prevalent than arthroplasties of other joints such as the hip or knee. One possible factor responsible for higher failure rates is the difficulty in obtaining the correct placement of the talar component such that the joint center of rotation is maintained. It is possible that differences in the pre- and postoperative joint center leads to abnormal articulation, increased joint contact and shear stresses, and the onset/advancement of osteoarthritis. Adding of a second interface between the polyethylene (PE) insert ant the tibial prosthesis component of the three-component TAR may permit the prosthesis components to adapt more physiological articulation. This may prevent deleterious loading of ankle soft tissues and reduce PE wear. Therefore, it is generally believed that a three-component TAR is superior to a two-component design. However, there are no data in literature to directly support this notion. To address the aforementioned issues, the proposed research project will answer the following questions: 1) To which extent does the PE inlay move with regard to the tibial component; 2) How and to what extent do changes in the position of the talar/tibial component influence biomechanics; 3) How and to what extent does supra- and inframalleolar misalignement influence biomechanics; 4) How and to what extent do the biomechanics of the hindfoot change if the PE inlay is fixed to the tibial component. The Infected Bone Graft. An in-vitro Study Comparing Staphylococcal Biofilm Formation on Fresh, Fresh-Frozen and Processed Human and Bovine Cancellous Bone Grafts Research Project | 1 Project MembersWe studied the initial adherence and biofilm formation of Staphylococcus aureus on different cancellous bone grafts used for filling of bone defects: fresh (fr) and fresh-frozen (ff) human bone grafts and commercial available bone grafts of processed human (ph) and processed bovine (pb) cancellous bone under standardized in-vitro conditions. Our data show that despite an initially increased adhesion a quantitatively reduced increase in bacterial density on fr and ff bone grafts within 24 h compared to ph and pb. The use of fr and ff bone grafts therefore seems to be favorable to ph and pb bone grafts regarding the risk of a peri-operative infection. Insert Position in Three-Component Total Ankle: Observing Study in 368 Consecutive Patients Research Project | 1 Project MembersTotal ankle replacement has become a valuable treatment option for end-stage osteoarthritis in recent decades. The most recent generation of implants comprises a second interface between the polyethylene insert and the tibial prosthesis component. To date, no data are available indicating the interindividual difference in the relative position of talar and tibial implant components and their position change over time. We assessed the radiographs of 368 ankles that underwent primary arthroplasty with a HINTEGRA ankle to determine the spatial relationship between talar and tibial components at the time of surgery and during followup. Examination of the data suggests that the latest three-component prosthesis functions similar to the two-component prosthesis, but with an added advantage of allowing an individualized position of the polyethylene insert in response to the individual soft tissue load. The Effect of Supramalleolar Varus and Valgus Deformities on the Tibiotalar Joint - an ex vivo Study Research Project | 1 Project MembersDistal tibia coronal plane malalignment predisposes to asymmetric ankle joint load. The purpose of this ex vivo study was to quantify the changes of pressure and force transfer in an ankle with a supramalleolar deformity. Two groups were assessed: isolated frontal plane deformity and deformities with an impaired containment of the ankle joint. Long-term outcome after supination-external rotation type-4 fractures of the ankle Research Project | 1 Project MembersAt a mean follow-up of 13 years after operative treatment of a supination-external rotation type-4 ankle fracture patients with partial or complete rupture of the medial deltoid ligament tended to have a better result than those with a medial malleolar fracture. 12 12
Shifting demand for public transport across time and modes Research Project | 1 Project MembersImported from Grants Tool 4705037
FV-23 Wirksamkeit klima- und energiepolitischer Massnahmen - eine empirische Analyseun Research Project | 4 Project MembersSeit 2005 befindet sich die Klima- und Energiepolitik in der Schweiz und der EU im Umbruch. Marktbasierte Instrumente (Emissionsabgaben, Emissionshandel) finden zunehmend Anwendung und werden häufig durch weitere Instrumente (Einspeisevergütungen, Technologieförderung, Labels) ergänzt. Dabei wird die Wirksamkeit der einzelnen Instrumente sowie der eingesetzten Instrumentkombinationen sehr kontrovers diskutiert. Insbesondere ist unklar, ob ein Einsatz ergänzender Instrumente (z.B. Einspeisevergütung, Technologieförderung) im Kontext eines Emissionshandels sinnvoll ist. Empirische Untersuchungen zu diesem Thema fehlen fast vollständig. Für die Schweiz sind zur Zeit keine hierfür nutzbaren Daten verfügbar. Die EU Kommission veröffentlicht aber mit 5 Jahren Verzögerung die Transaktionsdaten des Europäischen Emissionshandels. Anfang 2013 werden vollständige Daten für die erste Handelsphase (2005-2007) vorliegen. Aufgrund vorhandener Unterschiede in den ergänzenden Instrumente in der EU, kann mit diesen Daten die Wirkung von einzelnen Instrumenten und Instrumentkombinationen untersucht werden. Da fast alle in der Schweizer Politik eingesetzten Instrumente auch in der EU verwendet werden und weitgehend die gleichen Branchen betroffen sind, erlaubt eine solche Untersuchung direkte Rückschlüsse auf die Schweizer Klima- und Energiepolitik.
Der mini-open Sinus-Tarsi-Zugang beim operativen Verfahren von Calcaneusfrakturen: eine klinisch prospektive, CT-kontrollierte Studie Research Project | 1 Project MembersDas Ziel unserer Studie ist bei dem minimal invasiven Sinus-Tarsi-Zugang für die operative Behandlung von intraartikulären Calcaneusfrakturen: 1) die Qualität der Reposition der posterioren Facette des unteren Sprunggelenkes auf einem postoperativen CT zu beurteilen; 2) zu evaluieren, mit CT nach minimal 1 Jahr, ob die erreichte Reposition ausreichend stabil bleiben konnte um allfällige Deformationskräfte aushalten zu können 3) die längerfristige klinische Ergebnisse zu erfassen.
Follow-UP Study of Patients undergoing supramalleolar osteotomy Research Project | 1 Project MembersRecent studies have indicated that supramalleolar osteotomies are a valuable treatment option for early to midstage asymmetric osteoarthritis of the ankle joint. In the present study, we assessed the intermediate to long term effects of a supramalleolar osteotomy on the ankle and the neighbouring joints. For this study we evaluated a consecutive serie of patients with supramalleolar osteotomy.
Long-term follow up of total ankle replacements Research Project | 1 Project MembersThe HINTEGRA ankle was developed as an attempt to specifically address the needs of minimal bone resection, extended bone support, proper ligament balancing, and minimal contact stresses within and around the prosthesis. The purpose of this project si to analyze the results after a minimal follow-up time of 4 years for a consecutive series of patients in whom symptomatic ankle arthritis was treated with the HINTEGRA total ankle prosthesis.
The Influence of Implant Positioning and Design on Biomechanical Properties of the Replaced Ankle Research Project | 1 Project MembersIn recent decades, total ankle replacement (TAR) has become a valuable treatment option for end-stage ankle osteoarthritis. Although TAR continues to gain a greater clinical acceptance, postoperative complications such as prosthesis loosening and persistent pain remains much more prevalent than arthroplasties of other joints such as the hip or knee. One possible factor responsible for higher failure rates is the difficulty in obtaining the correct placement of the talar component such that the joint center of rotation is maintained. It is possible that differences in the pre- and postoperative joint center leads to abnormal articulation, increased joint contact and shear stresses, and the onset/advancement of osteoarthritis. Adding of a second interface between the polyethylene (PE) insert ant the tibial prosthesis component of the three-component TAR may permit the prosthesis components to adapt more physiological articulation. This may prevent deleterious loading of ankle soft tissues and reduce PE wear. Therefore, it is generally believed that a three-component TAR is superior to a two-component design. However, there are no data in literature to directly support this notion. To address the aforementioned issues, the proposed research project will answer the following questions: 1) To which extent does the PE inlay move with regard to the tibial component; 2) How and to what extent do changes in the position of the talar/tibial component influence biomechanics; 3) How and to what extent does supra- and inframalleolar misalignement influence biomechanics; 4) How and to what extent do the biomechanics of the hindfoot change if the PE inlay is fixed to the tibial component.
The Infected Bone Graft. An in-vitro Study Comparing Staphylococcal Biofilm Formation on Fresh, Fresh-Frozen and Processed Human and Bovine Cancellous Bone Grafts Research Project | 1 Project MembersWe studied the initial adherence and biofilm formation of Staphylococcus aureus on different cancellous bone grafts used for filling of bone defects: fresh (fr) and fresh-frozen (ff) human bone grafts and commercial available bone grafts of processed human (ph) and processed bovine (pb) cancellous bone under standardized in-vitro conditions. Our data show that despite an initially increased adhesion a quantitatively reduced increase in bacterial density on fr and ff bone grafts within 24 h compared to ph and pb. The use of fr and ff bone grafts therefore seems to be favorable to ph and pb bone grafts regarding the risk of a peri-operative infection.
Insert Position in Three-Component Total Ankle: Observing Study in 368 Consecutive Patients Research Project | 1 Project MembersTotal ankle replacement has become a valuable treatment option for end-stage osteoarthritis in recent decades. The most recent generation of implants comprises a second interface between the polyethylene insert and the tibial prosthesis component. To date, no data are available indicating the interindividual difference in the relative position of talar and tibial implant components and their position change over time. We assessed the radiographs of 368 ankles that underwent primary arthroplasty with a HINTEGRA ankle to determine the spatial relationship between talar and tibial components at the time of surgery and during followup. Examination of the data suggests that the latest three-component prosthesis functions similar to the two-component prosthesis, but with an added advantage of allowing an individualized position of the polyethylene insert in response to the individual soft tissue load.
The Effect of Supramalleolar Varus and Valgus Deformities on the Tibiotalar Joint - an ex vivo Study Research Project | 1 Project MembersDistal tibia coronal plane malalignment predisposes to asymmetric ankle joint load. The purpose of this ex vivo study was to quantify the changes of pressure and force transfer in an ankle with a supramalleolar deformity. Two groups were assessed: isolated frontal plane deformity and deformities with an impaired containment of the ankle joint.
Long-term outcome after supination-external rotation type-4 fractures of the ankle Research Project | 1 Project MembersAt a mean follow-up of 13 years after operative treatment of a supination-external rotation type-4 ankle fracture patients with partial or complete rupture of the medial deltoid ligament tended to have a better result than those with a medial malleolar fracture.
