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The Infected Bone Graft. An in-vitro Study Comparing Staphylococcal Biofilm Formation on Fresh, Fresh-Frozen and Processed Human and Bovine Cancellous Bone Grafts

Research Project
 | 
01.04.2009
 - 31.03.2010

We studied the initial adherence and biofilm formation of Staphylococcus aureus on different cancellous bone grafts used for filling of bone defects: fresh (fr) and fresh-frozen (ff) human bone grafts and commercial available bone grafts of processed human (ph) and processed bovine (pb) cancellous bone under standardized in-vitro conditions. Our data show that despite an initially increased adhesion a quantitatively reduced increase in bacterial density on fr and ff bone grafts within 24 h compared to ph and pb. The use of fr and ff bone grafts therefore seems to be favorable to ph and pb bone grafts regarding the risk of a peri-operative infection.

Members (1)

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Beat Hintermann

Principal Investigator