PD Dr. med. Dr. phil Stefan Schandelmaier

Taji Heravi, Ala, Gryaznov, Dmitry, Busse, Jason W., Schönenberger, Christof Manuel, von Niederhäusern, Belinda, Hausheer, Lena, Covino, Manuela, Schwenke, Johannes M., Epp, Selina, Griessbach, Alexandra, Chiaborelli, Malena, Agarwal, Arnav, Lohner, Szimonetta, Hirt, Julian, Schandelmaier, Stefan, Egli, Simon B., Makhele, Moshao Amos, Amstutz, Alain, Mertz, Dominik, et al. (2025). Metaresearch on patient-reported outcomes in trial protocols and results publications suggested large outcome reporting bias. Journal of Clinical Epidemiology, 185. https://doi.org/10.1016/j.jclinepi.2025.111822

Guyatt, G., Agoritsas, T., Brignardello-Petersen, R., Mustafa, R. A., Rylance, J., Foroutan, F., Prasad, M., Agarwal, A., De Beer, H., Murad, M. H., Schandelmaier, S., Iorio, A., Yao, L., Jaeschke, R., Vandvik, P. O., Zeng, L., Parpia, S., D’Souza, R., Rind, D., et al. (2025). Core GRADE 1: Overview of the Core GRADE approach. 389. https://doi.org/10.1136/bmj-2024-081903

Goetz, G., Schandelmaier, S., Busse, R., Wild, C., & Panteli, D. (2025). Implementation of the EU’s Health Technology Assessment regulation: Where does existing methods guidance require concretization and what are the relevant methodological options? 41(1). https://doi.org/10.1017/S0266462324004793

Guyatt, G., Schandelmaier, S., Brignardello-Petersen, R., De Beer, H., Prasad, M., Murad, M. H., Eachempati, P., Chu, D. K., D’Souza, R., Iorio, A., Agoritsas, T., Yao, L., Mustafa, R. A., Parpia, S., Santaguida, P., Vandvik, P. O., Hultcrantz, M., & Montori, V. M. (2025). Core GRADE 3: Rating certainty of evidence - Assessing inconsistency. https://doi.org/10.1136/bmj-2024-081905

Guyatt, G., Vandvik, P. O., Iorio, A., Agarwal, A., Yao, L., Eachempati, P., Zeng, L., Chu, D. K., D’Souza, R., Agoritsas, T., Murad, M. H., Schandelmaier, S., Rylance, J., Djulbegovic, B., Montori, V. M., Hultcrantz, M., & Brignardello-Petersen, R. (2025). Core GRADE 7: Principles for moving from evidence to recommendations and decisions. https://doi.org/10.1136/bmj-2024-083867

Guyatt, G., Yao, L., Murad, M. H., Hultcrantz, M., Agoritsas, T., De Beer, H., Schandelmaier, S., Iorio, A., Zeng, L., Prasad, M., Vandvik, P. O., Mustafa, R. A., Agarwal, A., Devji, T., Florez, I. D., Djulbegovic, B., Chu, D. K., Rochwerg, B., Montori, V. M., & Brignardello-Petersen, R. (2025). Core GRADE 6: presenting the evidence in summary of findings tables. https://doi.org/10.1136/bmj-2024-083866

Griessbach, Alexandra, Speich, Benjamin, Amstutz, Alain, Hausheer, Lena, Covino, Manuela, Wnfried Ramirez, Hillary, Schandelmaier, Stefan, Taji Heravi, Ala, Treweek, Shaun, Schwenkglenks, Matthias, Briel, Matthias, von Niederhäusern, Belinda, Hemkens, Lars G., Kasenda, Benjamin, Pauli-Magnus, Christiane, & McLennan, Stuart. (2024). Resource use and costs of investigator-sponsored randomized clinical trials in Switzerland, Germany, and the United Kingdom: a metaresearch study. Journal of Clinical Epidemiology, 176. https://doi.org/10.1016/j.jclinepi.2024.111536

Amstutz, Alain, Schönenberger, Christof M., Speich, Benjamin, Griessbach, Alexandra, Schwenke, Johannes M., Glasstetter, Jan, James, Sophie, Verkooijen, Helena M., Nickolls, Beverley, Relton, Clare, Hemkens, Lars G., Chammartin, Frédérique, Gerber, Felix, Labhardt, Niklaus D., Schandelmaier, Stefan, & Briel, Matthias. (2024). Characteristics, consent patterns, and challenges of randomized trials using the Trials within Cohorts (TwiCs) design - A scoping review. Journal of Clinical Epidemiology, 174. https://doi.org/10.1016/j.jclinepi.2024.111469

Wang, Ying, Parpia, Sameer, Ge, Long, Heels-Ansdell, Diane, Lai, Honghao, Esfahani, Meisam Abdar, Pan, Bei, Alhazzani, Waleed, Schandelmaier, Stefan, Lauzier, Francois, Arabi, Yaseen, Barletta, Jeffrey, Deane, Adam, Finfer, Simon, Williamson, David, Kanji, Salmaan, Møller, Morten H., Perner, Anders, Krag, Mette, et al. (2024). Proton-Pump Inhibitors to Prevent Gastrointestinal Bleeding — An Updated Meta-Analysis [Journal-article]. NEJM Evidence. https://doi.org/10.1056/evidoa2400134

Griessbach, Alexandra, Schönenberger, Christof Manuel, Taji Heravi, Ala, Gloy, Viktoria, Agarwal, Arnav, Hallenberger, Tim Jonas, Schandelmaier, Stefan, Janiaud, Perrine, Amstutz, Alain, Covino, Manuela, Mall, David, Speich, Benjamin, & Briel, Matthias. (2024). Characteristics, Progression, and Output of Randomized Platform Trials: A Systematic Review. JAMA Network Open, 7, E243109. https://doi.org/10.1001/jamanetworkopen.2024.3109

Hirt, Julian, Ewald, Hannah, Briel, Matthias, & Schandelmaier, Stefan. (2024). Searching a methods topic: practical challenges and implications for search design. Journal of Clinical Epidemiology, 166. https://doi.org/10.1016/j.jclinepi.2023.10.017

Guyatt, Gordon, Zhao, Yunli, Mayer, Martin, Briel, Matthias, Mustafa, Reem, Izcovich, Ariel, Hultcrantz, Monica, Iorio, Alfonso, Alba, Ana Carolina, Foroutan, Farid, Sun, Xin, Schunemann, Holger, DeBeer, Hans, Akl, Elie A., Christensen, Robin, & Schandelmaier, Stefan. (2023). GRADE guidance 36: updates to GRADE’s approach to addressing inconsistency. Journal of Clinical Epidemiology, 158, 70–83. https://doi.org/10.1016/j.jclinepi.2023.03.003

Hirt, Julian, Janiaud, Perrine, Gloy, Viktoria Luise, Schandelmaier, Stefan, Pereira, Tiago V., Contopoulos-Ioannidis, Despina, Goodman, Steven N., Ioannidis, John, Munkholm, Klaus, & Hemkens, Lars G. (2023). Robustness of reported postacute health outcomes in children with SARS-CoV-2 infection: A systematic review. Archives of Disease in Childhood, 108(6), 498–505. https://doi.org/10.1136/archdischild-2022-324455

Amstutz, Alain, Speich, Benjamin, Mentré, France, Rueegg, Corina Silvia, Belhadi, Drifa, Assoumou, Lambert, Burdet, Charles, Murthy, Srinivas, Dodd, Lori Elizabeth, Wang, Yeming, Tikkinen, Kari A O, Ader, Florence, Hites, Maya, Bouscambert, Maude, Trabaud, Mary Anne, Fralick, Mike, Lee, Todd C, Pinto, Ruxandra, Barratt-Due, Andreas, et al. (2023). Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials. The Lancet Respiratory Medicine, 11(5), 453–464. https://doi.org/10.1016/s2213-2600(22)00528-8

Hirt, J., Schönenberger, C. M., Ewald, H., Lawson, D. O., Papola, D., Rohner, R., Suter, K., Lin, S., Germini, F., Zeng, L., Shahabinezhad, A., Chowdhury, S. R., Gao, Y., Bhattacharjee, A., Lima, J. P., Marusic, A., Buljan, I., Agarwal, A., Guyatt, G. H., et al. (2023). Introducing the Library of Guidance for Health Scientists (LIGHTS): a living database for methods guidance. JAMA Netw Open, 6(2), e2253198. https://doi.org/10.1001/jamanetworkopen.2022.53198

Carrasco-Labra A, Devji T, Qasim A, Phillips M, Johnston BC, Devasenapathy N, Zeraatkar D, Bhatt M, Jin X, Brignardello-Petersen R, Urquhart O, Foroutan F, Schandelmaier S, Pardo-Hernandez H, Vernooij RW, Huang H, Rizwan Y, Siemieniuk R, Lytvyn L, et al. (2022). Serious reporting deficiencies exist in minimal important difference studies: current state and suggestions for improvement. Journal of Clinical Epidemiology, 150, 25–32. https://doi.org/10.1016/j.jclinepi.2022.06.010

Hirt J, Ewald H, Lawson DO, Hemkens LG, Briel M, & Schandelmaier S. (2022). A systematic survey of methods guidance suggests areas for improvement regarding access, development, and transparency. Journal of Clinical Epidemiology, 149, 217–226. https://doi.org/10.1016/j.jclinepi.2022.05.005

Gryaznov, D., von Niederhäusern, B., Speich, B., Kasenda, B., Ojeda-Ruiz, E., Blümle, A., Schandelmaier, S., Mertz, D., Odutayo, A., Tomonaga, Y., Amstutz, A., Pauli-Magnus, C., Gloy, V., Lohner, S., Bischoff, K., Wollmann, K., Rehner, L., Meerpohl, J. J., Nordmann, A., et al. (2022). Reporting quality of clinical trial protocols: a repeated cross-sectional study about the Adherence to SPIrit recommendations in Switzerland, CAnada and GErmany (ASPIRE-SCAGE). BMJ Open, 12(5), e053417. https://doi.org/10.1136/bmjopen-2021-053417

Speich, Benjamin, Gryaznov, Dmitry, Busse, Jason W., Gloy, Viktoria L., Lohner, Szimonetta, Klatte, Katharina, Taji Heravi, Ala, Ghosh, Nilabh, Lee, Hopin, Mansouri, Anita, Marian, Ioana R., Saccilotto, Ramon, Nury, Edris, Kasenda, Benjamin, Ojeda–Ruiz, Elena, Schandelmaier, Stefan, Tomonaga, Yuki, Amstutz, Alain, Pauli–Magnus, Christiane, et al. (2022). Nonregistration, discontinuation, and nonpublication of randomized trials: a repeated metaresearch analysis. PLoS Medicine, 19(4). https://doi.org/10.1371/journal.pmed.1003980

Taji Heravi A, Gryaznov D, Schandelmaier S, Kasenda B, Briel M, & Adherence to SPIRIT Recommendations (ASPIRE) Study Group. (2021). Evaluation of Planned Subgroup Analysis in Protocols of Randomized Clinical Trials. JAMA Network Open, 4(10), e2131503. https://doi.org/10.1001/jamanetworkopen.2021.31503

Scheidecker A, Green A, Syed MH, Ling CS, Fiala C, Pakkal O, Monteiro S, Schandelmaier S, & Korz L. (2021). Introducing Simulation-Based Learning for Trainees in Chronic Pain Medicine: Needs Assessment and Suggestions for Training Scenarios. Medical Science Educator, 31(4), 1463–1469. https://doi.org/10.1007/s40670-021-01335-6

Carrasco-Labra A, Devji T, Qasim A, Phillips MR, Wang Y, Johnston BC, Devasenapathy N, Zeraatkar D, Bhatt M, Jin X, Brignardello-Petersen R, Urquhart O, Foroutan F, Schandelmaier S, Pardo-Hernandez H, Hao Q, Wong V, Ye Z, Yao L, et al. (2021). Minimal important difference estimates for patient-reported outcomes: A systematic survey. Journal of Clinical Epidemiology, 133, 61–71. https://doi.org/10.1016/j.jclinepi.2020.11.024

Su N., Van Der Linden M., Van Der Heijden G.J.M.G., Listl S., Schandelmaier S., & Faggion Jr C.M. (2021). Published patterns of spin in biomedical literature: A protocol for a meta-research study. BMJ Open, 11(4). https://doi.org/10.1136/bmjopen-2020-043784

Lohner, Szimonetta, Gryaznov, Dmitry, von Niederhäusern, Belinda, Speich, Benjamin, Kasenda, Benjamin, Ojeda-Ruiz, Elena, Schandelmaier, Stefan, Mertz, Dominik, Odutayo, Ayodele, Tomonaga, Yuki, Amstutz, Alain, Pauli-Magnus, Christiane, Gloy, Viktoria, Bischoff, Karin, Wollmann, Katharina, Rehner, Laura, Meerpohl, Joerg J., Nordmann, Alain, Klatte, Katharina, et al. (2021). Reporting quality of trial protocols improved for non-regulated interventions but not regulated interventions: A repeated cross-sectional study. Journal of Clinical Epidemiology, 139, 340–349. https://doi.org/10.1016/j.jclinepi.2021.05.011

Lawson D.O., Puljak L., Pieper D, Schandelmaier S, Collins GS, Brignardello-Petersen R, Moher D., Tugwell P, Welch VA, Samaan Z., Thombs BD, Norskov A.K., Jakobsen J.C., Allison D.B., Mayo-Wilson E, Young T., Chan AW, Briel M., Guyatt G.H., et al. (2020). Reporting of methodological studies in health research: A protocol for the development of the MethodologIcal STudy reportIng Checklist (MISTIC). BMJ Open, 10(12), e040478. https://doi.org/10.1136/bmjopen-2020-040478

Schandelmaier S, Briel M, Varadhan R, Schmid CH, Devasenapathy N, Hayward RA, Gagnier J, Borenstein M, van der Heijden GJMG, Dahabreh IJ, Sun X, Sauerbrei W, Walsh M, Ioannidis JPA, Thabane L, & Guyatt GH. (2020). Development of the instrument to assess the credibility of effect modification analyses (ICEMAN) in randomized controlled trials and meta-analyses. Cmaj, 192(32), E901–E906. https://doi.org/10.1503/cmaj.200077

Devji T, Carrasco-Labra A, Qasim A, Phillips M, Johnston BC, Devasenapathy N, Zeraatkar D, Bhatt M, Jin X, Brignardello-Petersen R, Urquhart O, Foroutan F, Schandelmaier S, Pardo-Hernandez H, Vernooij RW, Huang H, Rizwan Y, Siemieniuk R, Lytvyn L, et al. (2020). Evaluating the credibility of anchor based estimates of minimal important differences for patient reported outcomes: Instrument development and reliability study. Bmj, 369, m1714. https://doi.org/10.1136/bmj.m1714

Foroutan F, Guyatt G, Zuk V, Vandvik PO, Alba AC, Mustafa R, Vernooij R, Arevalo-Rodriguez I, Munn Z, Roshanov P, Riley R, Schandelmaier S, Kuijpers T, Siemieniuk R, Canelo-Aybar C, Schunemann H, & Iorio A. (2020). GRADE Guidelines 28: Use of GRADE for the assessment of evidence about prognostic factors: rating certainty in identification of groups of patients with different absolute risks. Journal of Clinical Epidemiology, 121, 62–70. https://doi.org/10.1016/j.jclinepi.2019.12.023

Walter SD, Han H, Guyatt GH, Bassler D, Bhatnagar N, Gloy V, Schandelmaier S, & Briel M. (2020). A systematic survey of randomised trials that stopped early for reasons of futility. BMC Medical Research Methodology, 20(1), 10. https://doi.org/10.1186/s12874-020-0899-1

Gryaznov, D., Odutayo, A., von Niederhausern, B., Speich, B., Kasenda, B., Ojeda-Ruiz, E., Blumle, A., Schandelmaier, S., Mertz, D., Tomonaga, Y., Amstutz, A., Pauli-Magnus, C., Gloy, V., Bischoff, K., Wollmann, K., Rehner, L., Lohner, S., Meerpohl, J. J., Nordmann, A., et al. (2020). Rationale and design of repeated cross-sectional studies to evaluate the reporting quality of trial protocols: the Adherence to SPIrit REcommendations (ASPIRE) study and associated projects. Trials, 21(1), 896. https://doi.org/10.1186/s13063-020-04808-y

Janiaud P, Axfors C, Van’t Hooft J, Saccilotto R, Agarwal A, Appenzeller-Herzog C, Contopoulos-Ioannidis DG, Danchev V, Dirnagl U, Ewald H, Gartlehner G, Goodman SN, Haber NA, Ioannidis AD, Ioannidis JPA, Lythgoe MP, Ma W, Macleod M, Malički M, et al. (2020). The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days. F1000Research, 9, 1193. https://doi.org/10.12688/f1000research.26707.1

Kasenda, Benjamin, Liu, Junhao, Jiang, Yu, Gajewski, Byron, Wu, Cen, von Elm, Erik, Schandelmaier, Stefan, Moffa, Giusi, Trelle, Sven, Schmitt, Andreas Michael, Herbrand, Amanda K., Gloy, Viktoria, Speich, Benjamin, Hopewell, Sally, Hemkens, Lars G., Sluka, Constantin, McGill, Kris, Meade, Maureen, Cook, Deborah, et al. (2020). Prediction of RECRUITment In Randomized Clinical Trials (RECRUIT-IT) - Rationale and Design for an International Collaborative Study. Trials, 21(1), 731. https://doi.org/10.1186/s13063-020-04666-8

Schandelmaier, Stefan, Schmitt, Andreas M., Herbrand, Amanda K., Glinz, Dominik, Ewald, Hannah, Briel, Matthias, Guyatt, Gordon H., Hemkens, Lars G., & Kasenda, Benjamin. (2020). Characteristics and interpretation of subgroup analyses based on tumour characteristics in randomised trials testing target-specific anticancer drugs: design of a systematic survey. BMJ Open, 10(5), e034565. https://doi.org/10.1136/bmjopen-2019-034565

Schmitt AM, Herbrand AK, Fox CP, Bakunina K, Bromberg JEC, Cwynarski K, Doorduijn JK, Ferreri AJM, Illerhaus G, Issa S, Schorb E, Zucca E, Hemkens LG, Schandelmaier S, & Kasenda B. (2019). Rituximab in primary central nervous system lymphoma—A systematic review and meta-analysis. Hematological Oncology, 37(5), 548–557. https://doi.org/10.1002/hon.2666

Chang Y, Bhandari M, Zhu KL, Mirza RD, Ren M, Kennedy SA, Negm A, Bhatnagar N, Naji FN, Milovanovic L, Fei Y, Agarwal A, Kamran R, Cho SM, Schandelmaier S, Wang L, Jin L, Hu S, Zhao Y, et al. (2019). Antibiotic Prophylaxis in the Management of Open Fractures: A Systematic Survey of Current Practice and Recommendations. JBJS reviews, 7(2), e1. https://doi.org/10.2106/jbjs.rvw.17.00197

Speich, Benjamin, Schur, Nadine, Gryaznov, Dmitry, von Niederhäusern, Belinda, Hemkens, Lars G., Schandelmaier, Stefan, Amstutz, Alain, Kasenda, Benjamin, Pauli-Magnus, Christiane, Ojeda-Ruiz, Elena, Tomonaga, Yuki, McCord, Kimberly, Nordmann, Alain, von Elm, Erik, Briel, Matthias, Schwenkglenks, Matthias, & a collaboration of the Marta Aspire Study Groups,. (2019). Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss human research legislation. PLoS ONE, 14(1), e0210669. https://doi.org/10.1371/journal.pone.0210669

Amstutz A, Schandelmaier S, Frei R, Surina J, Agarwal A, Alturki R, von Niederhäusern B, von Elm E, Briel M, & On Behalf Of The MAking Randomized Trials Affordable Marta Group. (2018). Funding characteristics of randomised clinical trials supported by the Swiss National Science Foundation: A retrospective cohort study. Swiss Medical Weekly, 148(3-4), w14587. https://doi.org/10.4414/smw.2018.14587

Foroutan F, Guyatt GH, Otto CM, Siemieniuk RA, Schandelmaier S, Schandelmaier, Stefan, Agoritsas T, Vandvik PO, Bhagra S, & Bagur R. (2017). Structural valve deterioration after transcatheter aortic valve implantation. Heart, 103(23), 1899–1905. https://doi.org/10.1136/heartjnl-2017-311329

Amstutz A, Schandelmaier S, Frei R, Surina J, Agarwal A, Olu KK, Alturki R, Von Niederhäusern B, Von Elm E, & Briel M. (2017). Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: A retrospective cohort study. BMJ Open, 7(7), e016216. https://doi.org/10.1136/bmjopen-2017-016216

von Niederhäusern B, Schandelmaier S, Mi Bonde M, Brunner N, Hemkens LG, Rutquist M, Bhatnagar N, Guyatt GH, Pauli-Magnus C, & Briel M. (2017). Towards the development of a comprehensive framework: Qualitative systematic survey of definitions of clinical research quality. PLoS ONE, 12(7), e0180635. https://doi.org/10.1371/journal.pone.0180635

Schandelmaier, Stefan, Schandelmaier S., Briel, Matthias, Saccilotto, Ramon, Arpagaus, Armon, Arpagaus A, Hemkens L.G., & Nordmann, Alain J. (2017). Niacin for primary and secondary prevention of cardiovascular events. Cochrane Database of Systematic Reviews, 2017(6), CD009744. https://doi.org/10.1002/14651858.CD009744.pub2

Brignardello-Petersen R, Guyatt GH, Buchbinder R, Poolman RW, Schandelmaier S, Schandelmaier S, Chang Y, Sadeghirad B, Evaniew N, & Vandvik PO. (2017). Knee arthroscopy versus conservative management in patients with degenerative knee disease: A systematic review. BMJ Open, 7(5), e016114. https://doi.org/10.1136/bmjopen-2017-016114

Schandelmaier S, Kaushal A, Lytvyn L, Heels-Ansdell D, Siemieniuk RA, Agoritsas T, Guyatt GH, Vandvik PO, Couban R, Mollon B, & Busse JW. (2017). Low intensity pulsed ultrasound for bone healing: systematic review of randomized controlled trials. BMJ (Clinical research ed.), 356, j656. https://doi.org/10.1136/bmj.j656

Murad MH, Guyatt GH, Domecq JP, Vernooij RWM, Erwin PJ, Meerpohl JJ, Prutsky GJ, Akl EA, Mueller K, Bassler D, Schandelmaier S, Walter SD, Busse JW, Kasenda B, Pagano G, Pardo-Hernandez H, Montori VM, Wang Z, & Briel M. (2017). Randomized trials addressing a similar question are commonly published after a trial stopped early for benefit. Journal of Clinical Epidemiology, 82, 12–19. https://doi.org/10.1016/j.jclinepi.2016.10.006

Alturki R, Schandelmaier S, Olu KK, von Niederhäusern B, Agarwal A, Frei R, Bhatnagar N, Hooft L, von Elm E, & Briel M. (2017). Premature trial discontinuation often not accurately reflected in registries: comparison of registry records with publications. Journal of Clinical Epidemiology, 81, 56–63. https://doi.org/10.1016/j.jclinepi.2016.08.011

Ewald, Hannah, Santini-Oliveira, Marilia, Bühler, Julian-Emanuel, Vuichard, Danielle, Schandelmaier, Stefan, Stöckle, Marcel, Briel, Matthias, Bucher, Heiner C., & Hemkens, Lars G. (2017). Comparative effectiveness of tenofovir in HIV-infected treatment-experienced patients: systematic review and meta-analysis. HIV clinical trials, 18(1), 17–27. https://doi.org/10.1080/15284336.2016.1261073

Poolman RW, Agoritsas T, Siemieniuk RA, Harris IA, Schipper IB, Mollon B, Smith M, Albin A, Nador S, Sasges W, Schandelmaier S, Lytvyn L, Kuijpers T, van Beers LW, Verhofstad MH, & Vandvik PO. (2017). Low intensity pulsed ultrasound (LIPUS) for bone healing: A clinical practice guideline. BMJ (Online), 356, j576. https://doi.org/10.1136/bmj.j576

Schandelmaier S, Siemieniuk RA, Agoritsas T, Vandvik PO, Guyatt GH, & Busse JW. (2017). Authors’ reply to Farrar. BMJ (Online), 356, j1483. https://doi.org/10.1136/bmj.j1483

Briel M, Olu KK, von Elm E, Kasenda B, Alturki R, Agarwal A, Bhatnagar N, & Schandelmaier S. (2016). A systematic review of discontinued trials suggested that most reasons for recruitment failure were preventable. Journal of Clinical Epidemiology, 80, 8–15. https://doi.org/10.1016/j.jclinepi.2016.07.016

Jakob, Tobias, Nordmann, Alain J, Schandelmaier, Stefan, Schandelmaier S, Ferreira-González, Ignacio, & Briel M. (2016). Fibrates for primary prevention of cardiovascular disease events. Cochrane Database of Systematic Reviews, 2016(11), CD009753. https://doi.org/10.1002/14651858.CD009753.pub2

Blumle A., Schandelmaier S., Oeller P., Kasenda B., Briel M., von Elm E., Akl E.A., Amstutz A., Bassler D., Bengough T., Bucher H.C., Burnand B., Busse J.W., Carrasco-Labra A., Ebrahim S., Faulhaber M., Gloy V., Ferreira-Gonzalez I., Guyatt G.H., et al. (2016). Premature discontinuation of prospective clinical studies approved by a research ethics committee - A comparison of randomised and non-randomised studies. PLoS ONE, 11(10). https://doi.org/10.1371/journal.pone.0165605

Kasenda B, von Elm E, You JJ, Blümle A, Tomonaga Y, Saccilotto R, Amstutz A, Bengough T, Meerpohl JJ, Stegert M, Olu KK, Tikkinen KA, Neumann I, Carrasco-Labra A, Faulhaber M, Mulla SM, Mertz D, Akl EA, Bassler D, et al. (2016). Agreements between Industry and Academia on Publication Rights: A Retrospective Study of Protocols and Publications of Randomized Clinical Trials. PLoS Medicine, 13(6), e1002046. https://doi.org/10.1371/journal.pmed.1002046

Schandelmaier S., Von Elm E., You J.J., Blumle A., Tomonaga Y., Lamontagne F., Saccilotto R., Amstutz A., Bengough T., Meerpohl J.J., Stegert M., Olu K.K., Tikkinen K.A.O., Neumann I., Carrasco-Labra A., Faulhaber M., Mulla S.M., Mertz D., Akl E.A., et al. (2016). Premature discontinuation of randomized trials in critical and emergency care: A retrospective cohort study. Critical Care Medicine, 44(1), 130–137. https://doi.org/10.1097/CCM.0000000000001369

Vogel N, Schandelmaier S, Zumbrunn T, Ebrahim S, de Boer WEL, Busse JW, Kunz R, Schandelmaier S., Zumbrunn T., Ebrahim S., de Boer W.E.L., Mousavi S.M., Guyatt G.H., Busse J.W., & Kunz R. (2015). Return to work coordination programmes for improving return to work in workers on sick leave. Cochrane Database of Systematic Reviews, 2015(3). https://doi.org/10.1002/14651858.CD011618

Hemkens, Lars G., Ewald, Hannah, Santini-Oliveira, Marilia, Bühler, Julian-Emanuel, Vuichard, Danielle, Schandelmaier, Stefan, Stöckle, Marcel, Briel, Matthias, & Bucher, Heiner C. (2015). Comparative effectiveness of tenofovir in treatment-näive HIV-infected patients: Systematic review and meta-analysis. HIV Clinical Trials, 16(5), 178–189. https://doi.org/10.1179/1945577115y.0000000004

Kasenda, Benjamin, von Elm, Erik, You, John, Blümle, Anette, Tomonaga, Yuki, Saccilotto, Ramon, Amstutz, Alain, Bengough, Theresa, Meerpohl, Joerg J., Stegert, Mihaela, Tikkinen, Kari A. O., Neumann, Ignacio, Carrasco-Labra, Alonso, Faulhaber, Markus, Mulla, Sohail M., Mertz, Dominik, Akl, Elie A., Bassler, Dirk, Busse, Jason W., et al. (2014). Prevalence, characteristics, and publication of discontinued randomized trials. Journal of the American Medical Association, 311(10), 51–1045. https://doi.org/10.1001/jama.2014.1361

Schandelmaier S, Fischer K, Mager R, Hoffmann-Richter U, Leibold A, Bachmann MS, Kedzia S, Jeger J, Marelli R, Kunz R, & De Boer WE. (2013). Evaluation of work capacity In switzerland: A survey among psychiatristsabout practice and problems. Swiss Medical Weekly, 143, w13890. https://doi.org/10.4414/smw.2013.13890

Prutsky, Gabriela J., Domecq, Juan Pablo, Erwin, Patricia J., Briel, Matthias, Montori, Victor M., Akl, Elie A., Meerpohl, Joerg J., Bassler, Dirk, Schandelmaier, Stefan, Walter, Stephen D., Zhou, Qi, Coello, Pablo Alonso, Moja, Lorenzo, Walter, Martin, Thorlund, Kristian, Glasziou, Paul, Kunz, Regina, Ferreira-Gonzalez, Ignacio, Busse, Jason, et al. (2013). Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design. Trials, 14, 335. https://doi.org/10.1186/1745-6215-14-335

Kasenda B., Von Elm E.B., You J., Blumle A., Tomonaga Y., Saccilotto R., Amstutz A., Bengough T., Meerpohl J., Stegert M., Tikkinen K.A.O., Neumann I., Carrasco-Labra A., Faulhaber M., Mulla S., Mertz D., Akl E.A., Bassler D., Busse J.W., et al. (2012). Learning from failure - Rationale and design for a study about discontinuation of randomized trials (DISCO study). BMC Medical Research Methodology, 12. https://doi.org/10.1186/1471-2288-12-131

Kasenda, Benjamin, von Elm, Erik B., You, John, Blümle, Anette, Tomonaga, Yuki, Saccilotto, Ramon, Amstutz, Alain, Bengough, Theresa, Meerpohl, Jörg, Stegert, Mihaela, Tikkinen, Kari A. O., Neumann, Ignacio, Carrasco-Labra, Alonso, Faulhaber, Markus, Mulla, Sohail, Mertz, Dominik, Akl, Elie A., Bassler, Dirk, Busse, Jason W., et al. (2012). Learning from failure--rationale and design for a study about discontinuation of randomized trials (DISCO study). BMC Medical Research Methodology, 12, 131. https://doi.org/10.1186/1471-2288-12-131

Jung NH, Heinen F, Westhoff B, Doederlein L, Reissig A, Berweck S, Linder-Lucht M, Schandelmaier S, Mall V, & German Abo study group. (2011). Hip lateralisation in children with bilateral spastic cerebral palsy treated with botulinum toxin type A: A 2-year follow-up. Neuropediatrics, 42(1), 18–23. https://doi.org/10.1055/s-0031-1275344

Cybulla, Markus, Schaefer, Ellen, Wendt, Susanne, Ling, Hao, Kröber, Stefan M, Hövelborn, Ulrich, Schandelmaier, Stefan, Rohrbach, Rolf, & Neumann, Hartmut P H. (2005). Chronic renal failure and proteinuria in adulthood: Fabry disease predominantly affecting the kidneys. American Journal of Kidney Diseases, 45(5), e82–9. https://doi.org/10.1053/j.ajkd.2005.01.036

Amstutz, A., Schandelmaier, S., Ewald, H., Speich, B., Schwenke, J. M., Schönenberger, C. M., Schobinger, S., Agoritsas, T., Tomashek, K. M., Nayak, S., Makowski, M., Morales-Ortega, A., Bernal-Bello, D., Pomponio, G., Ferrarini, A., Ghazaeian, M., Hall, F., Bond, S., García-Morales, M. T., et al. (2025). Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials [Journal-article]. The Lancet Respiratory Medicine, 13(6), 530–544. https://doi.org/10.1016/S2213-2600(25)00055-4

Amstutz, A., Schandelmaier, S., Ewald, H., Speich, B., Schwenke, J. M., Schönenberger, C., Schobinger, S., Agoritsas, T., Tomashek, K. M., Nayak, S. U., Makowski, M., Morales-Ortega, A., Bernal-Bello, D., Pomponio, G., Ferrarini, A., Ghazaeian, M., Hall, F., Bond, S., García-Morales, M. T., et al. (2024). Effects of Jak Inhibitors in Adults Hospitalized Due to Covid-19: A Systematic Review and Individual Participant Data Meta-Analysis of Randomized Clinical Trials [Posted-content]. Elsevier BV. https://doi.org/10.2139/ssrn.4974193

Amstutz, Alain, Speich, Benjamin, Mentré, France, Rueegg, Corina Silvia, Belhadi, Drifa, Assoumou, Lambert, Burdet, Charles, Murthy, Srinivas, Dodd, Lori Elizabeth, Wang, Yeming, Tikkinen, Kari, Ader, Florence, Hites, Maya, Bouscambert-Duchamp, Maude, Trabaud, Mary-Anne, Fralick, Mike, Lee, Todd Campbell, Pinto, Ruxandra, Barratt-Due, Andreas, et al. (2023). Effects of Remdesivir in Hospitalized Patients with COVID-19: Systematic Review and Individual Patient Data Meta-Analysis of Randomized Clinical Trials. Lancet Respiratory Medicine.

Gordon Guyatt, Yunli Zhao, Martin Mayer, Matthias Briel, Reem Mustafa, Ariel Izcovich, Monica Hultcrantz, Alfonso Iorio, Ana Carolina Alba, Farid Foroutan, Xin Sun, Holger Schunemann, JJA DeBeer, Elie A. Akl, Robin Christensen, & Stefan Schandelmaier. (2023). GRADE Guidance 36: Updates to GRADE’s approach to addressing inconsistency. Journal of Clinical Epidemiology.

Julian Hirt, Christof Manuel Schönenberger, Hannah Ewald, Daeria O. Lawson, Davide Papola, Ramon Rohner, Katja Suter, Shanshan Lin, Federico Germini, Linan Zeng, Ali Shahabinezhad, Saifur Rahman Chowdhury, Ya Gao, Arunima Bhattacharjee, João Pedro Lima, Ana Marusic, Ivan Buljan, Arnav Agarwal, Gordon Guyatt, et al. (2023). Introducing the Library of Guidance for Health Scientists (LIGHTS): a living database for methods guidance. JAMA Network Open, 2(6), e2253198.

Hirt, Julian, Ewald, Hannah, Briel, Matthias, & Schandelmaier, Stefan. (2022). Library of Guidance for Health Scientists (LIGHTS): Eine neue Datenbank für methodische Leitlinien in der klinischen Forschung. GMS Medizin - Bibliothek - Information, 22(2). https://doi.org/10.3205/mbi000546

Hirt, J., Janiaud, P., Gloy, V., Schandelmaier, S., Pereira, T. V., Contopoulos-Ioannidis, D. G., Goodman, S. N., Ioannidis, J. P. A., Munkholm, K., & Hemkens, L. G. (2022). Validity of reported post-acute health outcomes in children with SARS-CoV-2 infection: a systematic review [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.03.18.22272582

Briel, Matthias, Elger, Bernice S., McLennan, Stuart, Schandelmaier, Stefan, von Elm, Erik, & Satalkar, Priya. (2022). Exploring reasons for recruitment failure in clinical trials: a qualitative study with clinical trial stakeholders in Switzerland, Germany, and Canada. Trials, 22(1), 844. https://doi.org/10.1186/s13063-021-05818-0

Janiaud, Perrine, Axfors, Cathrine, Van’t Hooft, Janneke, Saccilotto, Ramon, Agarwal, Arnav, Appenzeller-Herzog, Christian, Contopoulos-Ioannidis, Despina G., Danchev, Valentin, Dirnagl, Ulrich, Ewald, Hannah, Gartlehner, Gerald, Goodman, Steven N., Haber, Noah A., Ioannidis, Angeliki Diotima, Ioannidis, John P. A., Lythgoe, Mark P., Ma, Wenyan, Macleod, Malcolm, Malički, Mario, et al. (2020). The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days. F1000Research, 9, 1193. https://doi.org/10.12688/f1000research.26707.1

Schandelmaier, Stefan, Chang, Yaping, Bala, Malgorzata M., Devasenapathy, Niveditha, Devji, Tahira, Kwong, Joey S. W., Colunga Lozano, Luis E., Lee, Yung, Agarwal, Arnav, Bhatnagar, Neera, Ewald, Hannah, Zhang, Ying, Sun, Xin, Thabane, Lehana, Walsh, Michael, Briel, Matthias, & Guyatt, Gordon H. (2020). Erratum to “A systematic survey identified 36 criteria for assessing effect modification claims in randomized trials or meta-analyses” [J Clin Epidemiol. 2019;113:159-67]. Journal of Clinical Epidemiology, 123, 189. https://doi.org/10.1016/j.jclinepi.2020.04.003

Schandelmaier, Stefan, Chang, Yaping, Devasenapathy, Niveditha, Devji, Tahira, Kwong, Joey S. W., Colunga Lozano, Luis E., Lee, Yung, Agarwal, Arnav, Bhatnagar, Neera, Ewald, Hannah, Zhang, Ying, Sun, Xin, Thabane, Lehana, Walsh, Michael, Briel, Matthias, & Guyatt, Gordon H. (2019). A systematic survey identified 36 criteria for assessing effect modification claims in randomized trials or meta-analyses. Journal of Clinical Epidemiology, 113, 159–167. https://doi.org/10.1016/j.jclinepi.2019.05.014

Busse, J. W., Wang, L., Kamaleldin, M., Craigie, S., Riva, J. J., Montoya, L., Mulla, S. M., Lopes, L. C., Vogel, N., Chen, E., Kirmayr, K., De Oliveira, K., Olivieri, L., Kaushal, A., Chaparro, L. E., Oyberman, I., Agarwal, A., Couban, R., Tsoi, L., et al. (2018). Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis. Jama, 320(23), 2448–2460. https://doi.org/10.1001/jama.2018.18472

Dell-Kuster, S., Droeser, R. A., Schäfer, J., Gloy, V., Ewald, H., Schandelmaier, S., Schandelmaier, S., Hemkens, L. G., Bucher, H. C., Young, J., & Rosenthal, R. (2018). Systematic review and simulation study of ignoring clustered data in surgical trials. British Journal of Surgery, 105(3), 182–191. https://doi.org/10.1002/bjs.10763

Schandelmaier, Stefan, Tomonaga, Yuki, Bassler, Dirk, Meerpohl, Joerg J., von Elm, Erik, You, John J., Bluemle, Anette, Lamontagne, Francois, Saccilotto, Ramon, Amstutz, Alain, Bengough, Theresa, Stegert, Mihaela, Olu, Kelechi K., Tikkinen, Kari A. O., Neumann, Ignacio, Carrasco-Labra, Alonso, Faulhaber, Markus, Mulla, Sohail M., Mertz, Dominik, et al. (2017). Premature Discontinuation of Pediatric Randomized Controlled Trials: A Retrospective Cohort Study. The Journal of Pediatrics, 184, 209–214. https://doi.org/10.1016/j.jpeds.2017.01.071

Vogel, Nicole, Schandelmaier, Stefan, Schandelmaier, Stefan, Zumbrunn, Thomas, Ebrahim, Shanil, de Boer, Wout EL, Busse, Jason W., & Kunz, Regina. (2017). Return-to-work coordination programmes for improving return to work in workers on sick leave. Cochrane Database of Systematic Reviews, 3(3), CD011618. https://doi.org/10.1002/14651858.cd011618.pub2

Bachmann, M., de Boer, W., Schandelmaier, S., Schandelmaier, S., Leibold, A., Marelli, R., Jeger, J., Hoffmann-Richter, U., Mager, R., Schaad, H., Zumbrunn, T., Vogel, N., Banziger, O., Busse, J. W., Fischer, K., & Kunz, R. (2016). Use of a structured functional evaluation process for independent medical evaluations of claimants presenting with disabling mental illness: rationale and design for a multi-center reliability study. BMC Psychiatry, 16, 271. https://doi.org/10.1186/s12888-016-0967-6

Kasenda, B., Ferreri, A. J. M., Marturano, E., Forst, D., Bromberg, J., Ghesquieres, H., Ferlay, C., Blay, J. Y., Hoang-Xuan, K., Pulczynski, E. J., Fosså, A., Okoshi, Y., Chiba, S., Fritsch, K., Omuro, A., O’Neill, B. P., Bairey, O., Schandelmaier, S., Gloy, V., et al. (2015). First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL) - a systematic review and individual patient data meta-analysis. Annals of Oncology, 26(7), 13–1305. https://doi.org/10.1093/annonc/mdv076

Mulla, S. M., Maqbool, A., Sivananthan, L., Lopes, L. C., Schandelmaier, S., Kamaleldin, M., Hsu, S., Riva, J. J., Vandvik, P. O., Tsoi, L., Lam, T., Ebrahim, S., Johnston, B. C., Olivieri, L., Montoya, L., Kunz, R., Scheidecker, A., Buckley, D. N., Sessler, D. I., et al. (2015). Reporting of IMMPACT-recommended core outcome domains among trials assessing opioids for chronic non-cancer pain. Pain, 156(9), 9–1615. https://doi.org/10.1097/j.pain.0000000000000241

Schandelmaier, S., Conen, K., von Elm, E., You, J. J., Blümle, A., Tomonaga, Y., Saccilotto, Basel Institute for Clinical Epidemiology, Biostatistics, University Hospital of Basel, Switzerland., Amstutz, A., Bengough, T., Meerpohl, J. J., Stegert, M., Olu, K. K., Tikkinen, K. A. O., Neumann, I., Carrasco-Labra, A., Faulhaber, M., Mulla, S. M., et al. (2015). Planning and reporting of quality-of-life outcomes in cancer trials. Annals of Oncology, 26(9), 73–1966. https://doi.org/10.1093/annonc/mdv283

Schandelmaier, S., Leibold, A., Fischer, K., Mager, R., Hoffmann-Richter, U., Bachmann, M. S., Kedzia, S., Busse, J. W., Guyatt, G. H., Jeger, J., Marelli, R., De Boer, W. E., & Kunz, R. (2015). Attitudes towards evaluation of psychiatric disability claims: a survey of Swiss stakeholders. Swiss Medical Weekly, 145, w14160. https://doi.org/10.4414/smw.2015.14160

Kasenda, Benjamin, Schandelmaier, Stefan, Sun, Xin, von Elm, Erik, You, John, Blümle, Anette, Tomonaga, Yuki, Saccilotto, Ramon, Amstutz, Alain, Bengough, Theresa, Meerpohl, Joerg J., Stegert, Mihaela, Olu, Kelechi K., Tikkinen, Kari A. O., Neumann, Ignacio, Carrasco-Labra, Alonso, Faulhaber, Markus, Mulla, Sohail M., Mertz, Dominik, et al. (2014). Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications. Bmj, 349, g4539. https://doi.org/10.1136/bmj.g4539

Schandelmaier, S S, Bachmann, Kedzia, Fischer, Kunz, & Boer, de. (2013). Practice and quality of work capacity evaluations: a survey among Swiss psychiatrists [Journal-article]. Occupational and Environmental Medicine, 70(Suppl 1), A8. https://doi.org/10.1136/oemed-2013-101717.24

Busse, Jason W., Ebrahim, Shanil, Connell, Gaelan, Coomes, Eric A., Bruno, Paul, Malik, Keshena, Torrance, David, Ngo, Trung, Kirmayr, Karin, Avrahami, Daniel, Riva, John J., Struijs, Peter, Brunarski, David, Burnie, Stephen J., LeBlanc, Frances, Steenstra, Ivan A., Mahood, Quenby, Thorlund, Kristian, Montori, Victor M., et al. (2013). Systematic review and network meta-analysis of interventions for fibromyalgia: a protocol. Systematic Reviews, 2, 18. https://doi.org/10.1186/2046-4053-2-18

Busse, Jason W., Schandelmaier, Stefan, Kamaleldin, Mostafa, Hsu, Sandy, Riva, John J., Vandvik, Per Olav, Tsoi, Ludwig, Lam, Tommy, Ebrahim, Shanil, Johnston, Bradley C., Oliveri, Lori, Montoya, Luis, Kunz, Regina, Malandrino, Anna, Bhatnagar, Neera, Mulla, Sohail M., Lopes, Luciane C., Soobiah, Charlene, Wong, Anthony, et al. (2013). Opioids for chronic non-cancer pain: a protocol for a systematic review of randomized controlled trials. Systematic Reviews, 2(1), 66. https://doi.org/10.1186/2046-4053-2-66

Schandelmaier, Stefan, Ebrahim, Shanil, Burkhardt, Susan C. A., de Boer, Wout E. L., Zumbrunn, Thomas, Guyatt, Gordon H., Busse, Jason W., & Kunz, Regina. (2012). Return to work coordination programmes for work disability: a meta-analysis of randomised controlled trials. PLoS ONE, 7(11), e49760. https://doi.org/10.1371/journal.pone.0049760

Schandelmaier, Stefan, & Guyatt, Gordon. (2024). Same Old Challenges in Subgroup Analysis - Should We Do More About Methods Implementation? JAMA Network Open, 7(3), E243339. https://doi.org/10.1001/jamanetworkopen.2024.3339

Nordmann, A., Jakob, T., Schandelmaier, S., Ferreira-Gonzalez, I., & Briel, M. (2016). Fibrates for the primary prevention of cardiovascular disease. 37, 816. OXFORD UNIV PRESS.

Schandelmaier S, Conen K, von Elm E, You JJ, Blümle A, Tomonaga Y, Saccilotto R, Amstutz A, Bengough T, Meerpohl JJ, Stegert M, Olu KK, Tikkinen KA, Neumann I, Carrasco-Labra A, Faulhaber M, Mulla SM, Mertz D, Akl EA, et al. (2016). Planning and reporting of quality-of-life outcomes in cancer trials (Patent No. 1). Annals of Oncology, 27(1), Article 1. https://doi.org/10.1093/annonc/mdv559