I trained as a physician and health research methodologist. In my research, I am exploring new ways to improve the quality of health research. Starting in February 2025, I will lead an international consortium to develop STandards for developing ResEArch Methods guidance (STREAM) funded by an SNSF Ambizione grant. Previously, I founded the Library of Guidance for Health Scientists (LIGHTS, www.lights.science) to support searchability and dissemination of methods guidance. To improve the interpretation of subgroup analyses in randomized trials and meta-analyses, I developed the Instrument to assess the Credibility of Effect Modification ANalyses (ICEMAN, www.iceman.help). My areas of expertise include clinical trials, meta-analyses, clinical practice guidelines, meta-research, methods research, and qualitative research. I teach research methods to medical students, PhD students, and postgraduates at the University Basel and the University College Cork and mentor doctoral students Nikita Sass, Marta Moreno-Sole, and Malena Chiaborelli.
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Selected Publications
Hirt, Julian, Ewald, Hannah, Briel, Matthias, & . (2024). Searching a methods topic: practical challenges and implications for search design. Journal of Clinical Epidemiology, 166. https://doi.org/10.1016/j.jclinepi.2023.10.017
Hirt, Julian, Ewald, Hannah, Briel, Matthias, & . (2024). Searching a methods topic: practical challenges and implications for search design. Journal of Clinical Epidemiology, 166. https://doi.org/10.1016/j.jclinepi.2023.10.017
Guyatt, Gordon, Zhao, Yunli, Mayer, Martin, Briel, Matthias, Mustafa, Reem, Izcovich, Ariel, Hultcrantz, Monica, Iorio, Alfonso, Alba, Ana Carolina, Foroutan, Farid, Sun, Xin, Schunemann, Holger, DeBeer, Hans, Akl, Elie A., Christensen, Robin, & . (2023). GRADE guidance 36: updates to GRADE’s approach to addressing inconsistency. Journal of Clinical Epidemiology, 158, 70–83. https://doi.org/10.1016/j.jclinepi.2023.03.003
Guyatt, Gordon, Zhao, Yunli, Mayer, Martin, Briel, Matthias, Mustafa, Reem, Izcovich, Ariel, Hultcrantz, Monica, Iorio, Alfonso, Alba, Ana Carolina, Foroutan, Farid, Sun, Xin, Schunemann, Holger, DeBeer, Hans, Akl, Elie A., Christensen, Robin, & . (2023). GRADE guidance 36: updates to GRADE’s approach to addressing inconsistency. Journal of Clinical Epidemiology, 158, 70–83. https://doi.org/10.1016/j.jclinepi.2023.03.003
Hirt, J., Schönenberger, C. M., Ewald, H., Lawson, D. O., Papola, D., Rohner, R., Suter, K., Lin, S., Germini, F., Zeng, L., Shahabinezhad, A., Chowdhury, S. R., Gao, Y., Bhattacharjee, A., Lima, J. P., Marusic, A., Buljan, I., Agarwal, A., Guyatt, G. H., et al. (2023). Introducing the Library of Guidance for Health Scientists (LIGHTS): a living database for methods guidance. JAMA Netw Open, 6(2), e2253198. https://doi.org/10.1001/jamanetworkopen.2022.53198
Hirt, J., Schönenberger, C. M., Ewald, H., Lawson, D. O., Papola, D., Rohner, R., Suter, K., Lin, S., Germini, F., Zeng, L., Shahabinezhad, A., Chowdhury, S. R., Gao, Y., Bhattacharjee, A., Lima, J. P., Marusic, A., Buljan, I., Agarwal, A., Guyatt, G. H., et al. (2023). Introducing the Library of Guidance for Health Scientists (LIGHTS): a living database for methods guidance. JAMA Netw Open, 6(2), e2253198. https://doi.org/10.1001/jamanetworkopen.2022.53198
, Briel M, Varadhan R, Schmid CH, Devasenapathy N, Hayward RA, Gagnier J, Borenstein M, van der Heijden GJMG, Dahabreh IJ, Sun X, Sauerbrei W, Walsh M, Ioannidis JPA, Thabane L, & Guyatt GH. (2020). Development of the instrument to assess the credibility of effect modification analyses (ICEMAN) in randomized controlled trials and meta-analyses. Cmaj, 192(32), E901–E906. https://doi.org/10.1503/cmaj.200077
, Briel M, Varadhan R, Schmid CH, Devasenapathy N, Hayward RA, Gagnier J, Borenstein M, van der Heijden GJMG, Dahabreh IJ, Sun X, Sauerbrei W, Walsh M, Ioannidis JPA, Thabane L, & Guyatt GH. (2020). Development of the instrument to assess the credibility of effect modification analyses (ICEMAN) in randomized controlled trials and meta-analyses. Cmaj, 192(32), E901–E906. https://doi.org/10.1503/cmaj.200077