[FG] Neuroradiology

The frequency of thrombectomy (i.e. endovascular therapy for acute ischemic stroke) is rising, but complications of thrombectomy are poorly explored. Vessel perforation with consecutive intracranial hemorrhage is a severe complication of thrombectomy. The risk factors of vessel perforation are largely unknown. There is also almost no data to guide endovascular hemostatic therapy or to decide whether thrombectomy should be continued after the event of vessel perforation.

PREVENT is a multicenter, prospective and retrospective registry with the aim to

(1) Identify risk factors of vessel perforations

(2) Explore the pathophysiology of vessel perforations

(3) Develop a classification system

(4) Compare different hemostatic treatment strategies

(5) Compare continuation of thrombectomy after vessel perforation and abortion of thrombectomy

(6) Develop a novel, safety-optimized thrombectomy technique

Anticipated study cohort: 500 patients with vessel perforation during thrombectomy and 500 matched patients without perforation during thrombectomy. 

The ICARUS study is a SNSF funded randomized study investigating, whether the permanent insertion of a stent in a cerebral artery improves the long-term quality of life in patients with an acute stroke due to a large vessel occlusion refractory to conventional therapy. It will allow a conclusion to be drawn as to whether this therapeutic strategy is beneficial or not.

The DISTAL study is a SNSF funded randomized study investigating, whether endovascular therapy in addition to best medical therapy improves the long-term quality of life in patients with an acute stroke due to a medium distal vessel occlusion. It will allow a conclusion to be drawn as to whether this therapeutic strategy is beneficial or not.