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Prof. Dr. med. Marios-Nikos Psychogios

Department of Clinical Research
Profiles & Affiliations

Acute Stroke, Aneurysms and diagnostic Neuroradiology

Marios-Nikos Psychogios is a physician and clinical researcher with a strong interest in improving patient outcomes and validating new treatment approaches with randomized-controlled trials. He received his Dr. med. and PD from the University of Göttingen for his pioneer work on the usage of flat panel CT in the diagnostic of stroke patients. He is the Sponsor-PI of multiple high profile randomized controlled stroke trials including the DISTAL (NCT05029414), ICARUS (NCT06472336) and SPINNERS (NCT05458908) trial.


As a clinician he is highly active in the interventional treatment of stroke patients and has developed multiple techniques to improve the outcomes of patients with an acute ischemic stroke. He has mentored multiple fellows and is very passionate about sharing his knowledge with the upcoming generation of doctors.

Selected Publications

Psychogios, Marios, Brehm, Alex, López-Cancio, Elena, Marco De Marchis, Gian, Meseguer, Elena, Katsanos, Aristeidis H, Kremer, Christine, Sporns, Peter, Zedde, Marialuisa, Kobayashi, Adam, Caroff, Jildaz, Bos, Daniel, Lémeret, Sabrina, Lal, Avtar, & Arenillas, Juan F. (2022). European Stroke Organisation guidelines on treatment of patients with intracranial atherosclerotic disease. European Stroke Journal, 7, III–IIV. https://doi.org/10.1177/23969873221099715

URLs
URLs

Maus V, Behme D, Kabbasch C, Borggrefe J, Tsogkas I, Nikoubashman O, Wiesmann M, Knauth M, Mpotsaris A, & Psychogios MN. (2018). Maximizing First-Pass Complete Reperfusion with SAVE. Clinical Neuroradiology, 28(3), 327–338. https://doi.org/10.1007/s00062-017-0566-z

URLs
URLs

Psychogios MN, Behme D, Schregel K, Tsogkas I, Maier IL, Leyhe JR, Zapf A, Tran J, Bähr M, Liman J, & Knauth M. (2017). One-Stop Management of Acute Stroke Patients: Minimizing Door-to-Reperfusion Times. Stroke, 48(11), 3152–3155. https://doi.org/10.1161/strokeaha.117.018077

URLs
URLs

Selected Projects & Collaborations

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PeRforation EVents during ENdovascular Therapy for acute ischemic stroke (PREVENT) Registry

Research Project  | 2 Project Members

The frequency of thrombectomy (i.e. endovascular therapy for acute ischemic stroke) is rising, but complications of thrombectomy are poorly explored. Vessel perforation with consecutive intracranial hemorrhage is a severe complication of thrombectomy. The risk factors of vessel perforation are largely unknown. There is also almost no data to guide endovascular hemostatic therapy or to decide whether thrombectomy should be continued after the event of vessel perforation.


PREVENT is a multicenter, prospective and retrospective registry with the aim to

(1) Identify risk factors of vessel perforations

(2) Explore the pathophysiology of vessel perforations

(3) Develop a classification system

(4) Compare different hemostatic treatment strategies

(5) Compare continuation of thrombectomy after vessel perforation and abortion of thrombectomy

(6) Develop a novel, safety-optimized thrombectomy technique


Anticipated study cohort: 500 patients with vessel perforation during thrombectomy and 500 matched patients without perforation during thrombectomy. 


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ProSPective Evaluation of Non-contrast sINe spiN Flat-dEtectoR CT for the Detection of Intracranial hemorrhageS (SPINNERS)

Research Project  | 3 Project Members

Stroke is one of the leading causes of mortality and disability worldwide. Optimization of intra-hospital pathways is as of today one of the most promising research topics in stroke treatment. A potential solution to shorten the time needed for current workflows, and therefore reperfusion, is to do both imaging and subsequent endovascular therapy (EVT) in the angiography suite using non-contrast syngo DynaCT Sine Spin (FDCT) for the exclusion of intracranial hemorrhage and flat detector CT angiography (FDCTA) or digital subtraction angiography for diagnosis of LVO. It is still a matter of debate if FDCT can reliably differentiate between ischemic and hemorrhagic stroke.

This study aims to investigate if non-contrast syngo DynaCT Sine Spin imaging is non-inferior to non-contrast MDCT imaging regarding its sensitivity and specificity for the detection of intracranial hemorrhages.