PeRforation EVents during ENdovascular Therapy for acute ischemic stroke (PREVENT) Registry

The frequency of thrombectomy (i.e. endovascular therapy for acute ischemic stroke) is rising, but complications of thrombectomy are poorly explored. Vessel perforation with consecutive intracranial hemorrhage is a severe complication of thrombectomy. The risk factors of vessel perforation are largely unknown. There is also almost no data to guide endovascular hemostatic therapy or to decide whether thrombectomy should be continued after the event of vessel perforation.

PREVENT is a multicenter, prospective and retrospective registry with the aim to

(1) Identify risk factors of vessel perforations

(2) Explore the pathophysiology of vessel perforations

(3) Develop a classification system

(4) Compare different hemostatic treatment strategies

(5) Compare continuation of thrombectomy after vessel perforation and abortion of thrombectomy

(6) Develop a novel, safety-optimized thrombectomy technique

Anticipated study cohort: 500 patients with vessel perforation during thrombectomy and 500 matched patients without perforation during thrombectomy.