Dr. Jennifer Brown

Chiaborelli, Malena, Kopeka, Mamaswatsi, Sekhesa, Pontšo, Sehrt, Madeleine, Mohloanyane, Tsepang, Ballouz, Tala, Menges, Dominik, Brown, Jennifer A., Belus, Jennifer M., Gerber, Felix, Raeber, Fabian, Williams, Andréa, Jackson-Perry, David, Hyöky, Meri, Conserve, Donaldson F., Hampanda, Karen, Amstutz, Alain, Mohale, Itumeleng, Lebakeng, Thabo, et al. (2025). Hair salons as a promising space to provide HIV and sexual and reproductive health services for young women in Lesotho: a citizen scientist mixed-methods study [Journal-article]. BMC Public Health, 25(1). https://doi.org/10.1186/s12889-025-23435-3

Mbeje, Sanele S., Gounder, Lilishia, van der Molen, Johan S., Hobe, Lungile, Ngwenya, Thulani, Khanyile, Mlungisi, Tlhaku, Kwena, Chimukangara, Benjamin, Khubone, Thokozani, Sookrajh, Yukteshwar, Mahomed, Sharana, Brown, Jennifer A., Garrett, Nigel, Dorward, Jienchi, & Lewis, Lara. (2025). Trends in advanced HIV disease, treatment interruption, and viraemia in KwaZulu-Natal, South Africa. In medRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.11.06.25339741

van der Molen, Johan, Tlhaku, Kwena, Lewis, Lara, Sookrajh, Yukteshwar, Hobe, Lungile, Ngwenya, Thulani, Khanyile, Mlungisi, Khubone, Thokozani, Garrett, Nigel, Brown, Jennifer, & Dorward, Jienchi. (2025). Earlier referral to differentiated antiretroviral therapy delivery at six months after initiation: a retrospective cohort study in KwaZulu-Natal, South Africa. F1000 Research Ltd. https://doi.org/10.12688/verixiv.2341.1

Lewis, L., Sookrajh, Y., van der Molen, J., Khubone, T., Jamieson, l., Gray, A., Brown, J. A., Tlhaku, K., Little, F., Garrett, N., Dorward, J., & Kassanjee, R. (2025). Indirect effects of HIV differentiated service delivery programmes on quality of clinic care: a retrospective cohort study of clients starting antiretroviral therapy [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.09.01.25334649

Brown, Jennifer Anne, Lewis, Lara, Sookrajh, Yukteshwar, Hobe, Lungile, Ngwenya, Thulani, van der Molen, Johan, Asare, Kwabena, Tlhaku, Kwena, Khanyile, Mlungisi, Khubone, Thokozani, Bottomley, Christian, Garrett, Nigel, & Dorward, Jienchi. (2025). Uptake and 24-month outcomes of dolutegravir- versus lopinavir-based second-line antiretroviral therapy for people with HIV in South Africa: a retrospective cohort study and emulated target trial. Open Forum Infectious Diseases, 12(9). https://doi.org/10.1093/ofid/ofaf530

Dorward, J., Tlhaku, K., Sookrajh, Y., Munatsi, P., Naidoo, J., Tselana, E., Maphumulo, A., Mbambo, N., Mhlongo-Gumbi, T., Brown, J. A., Lewis, L., Moodley, P., Samsunder, N., Drain, P. K., Butler, C. C., Hayward, G., & Garrett, N. (2025). Point-of-care HIV viral load testing in a community antiretroviral therapy delivery programme: a randomised controlled trial (PHILA) [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.05.20.25327934

Dorward, J., Masombuka, X., Lewis, L., Pastellides, C., van der Molen, J., Asare, K., Tlhaku, K., Brown, J. A., Bottomley, C., Jacobs, D., Collie, S., & Garrett, N. (2025). Risk of major adverse cardiovascular events with dolutegravir versus efavirenz-based antiretroviral therapy: emulated target trials using routine, de-identified data from South Africa [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.03.07.25323562

Brown, Jennifer Anne, Lewis, Lara, Sookrajh, Yukteshwar, Hobe, Lungile, Ngwenya, Thulani, van der Molen, Johan, Asare, Kwabena, Tlhaku, Kwena, Khanyile, Mlungisi, Khubone, Thokozani, Bottomley, Christian, Garrett, Nigel, & Dorward, Jienchi. (2025). Uptake and 24-month outcomes of dolutegravir- versus lopinavir-based second-line antiretroviral therapy for people with HIV in South Africa: a retrospective cohort study and emulated target trial [Posted-content]. In veriXiv. F1000 Research Ltd. https://doi.org/10.12688/verixiv.686.1

Brown, Jennifer Anne, Motaboli, Lipontso, Lerotholi, Malebanye, Kohler, Maurus, Haenggi, Kathrin, Mokete, Moliehi, Chakela, Makobefo Gladys, Kao, Mpho, Kopo, Mathebe, Mokebe, Moleboheng, Urda, Lorena, Nsakala, Bienvenu Lengo, Lukau, Blaise, Ayakaka, Irene, Amstutz, Alain, Ehmer, Jochen, Klicpera, Anna, Klimkait, Thomas, Glass, Tracy, et al. (2025). Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2023 – cohort description, test volumes, predictors of viraemia and the road ahead [Journal-article]. BMJ Open, 15(2). https://doi.org/10.1136/bmjopen-2024-085404

Haenggi, Kathrin, Mokebe, Moleboheng, Motaboli, Lipontso, Chakela, Makobefo G., Kao, Mpho, Kopo, Mathebe, Ayakaka, Irene, Nyakane, Morongoe, Tarumbiswa, Tapiwa, Labhardt, Niklaus D., Brown, Jennifer A., & Tschumi, Nadine. (2025). The peripartum viral load cascade and outcomes of infants exposed to HIV in Lesotho [Journal-article]. HIV Medicine. https://doi.org/10.1111/hiv.70082

Tschumi, N., Lerotholi, M., Kopo, M., Kao, M., Motaboli, L., Mokebe, M., Chejane, N., Chakela, M., Nsakala, B. L., Lukau, B., van Heerden, A., Barnabas, R. V., Heitner, J., Shapiro, A. E., Urda, L., Sanchez-Samaniego, G., Lee, T., Brown, J. A., Amstutz, A., et al. (2025). Integrating Clinical Decision Support and Mobile Health for Differentiated HIV Service Delivery in Lesotho: A Cluster-Randomised Non-Inferiority Trial (Vital) [Posted-content]. Elsevier BV. https://doi.org/10.2139/ssrn.5375254

Tschumi, Nadine, Lukau, Blaise, Tlali, Katleho, Motaboli, Lipontso, Kao, Mpho, Kopo, Mathebe, Hänggi, Kathrin, Mokebe, Moleboheng, Naegele, Klaudia, Ayakaka, Irene, Leuzinger, Karoline, Brown, Jennifer A, & Labhardt, Niklaus D. (2024). Emergence of Acquired Dolutegravir Resistance in Treatment-experienced People With HIV in Lesotho [Journal-article]. Clinical Infectious Diseases, 79(5), 1208–1222. https://doi.org/10.1093/cid/ciae185

Brown, Jennifer Anne, Ringera, Isaac Kaumbuthu, Luoga, Ezekiel, Bresser, Moniek, Mothobi, Buoang, Kabundi, Lorraine, Ilunga, Mulume, Mokhele, Kuena, Isaac, Andreas Boy, Tsoaeli, Ntsepiseng, Mbaya, Thomas, Simba, Brenda, Mayogu, Kasasi, Mabula, Elizabeth, Cheleboi, Molisana, Molatelle, Mamello, Kimera, Namvua, Mollel, Getrud Joseph, Sando, David, et al. (2024). Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite, open-label randomised controlled trial [Journal-article]. The Lancet Global Health, 12(8), e1312–e1322. https://doi.org/10.1016/s2214-109x(24)00183-9

Devendra, Akash, Kohler, Maurus, Letsika, Motlatsi, Khooa, Hape, Motaboli, Lipontso, Lerotholi, Malebanye, Tschumi, Nadine, Labhardt, Niklaus D., & Brown, Jennifer A. (2024). HIV viral suppression in children and adolescents 2 years after transition to dolutegravir: A multicentre cohort study [Journal-article]. AIDS, 38(7), 1013–1023. https://doi.org/10.1097/qad.0000000000003835

Brown, Jennifer A., Motaboli, Lipontso, Lerotholi, Malebanye, Kohler, Maurus, Hänggi, Kathrin, Mokete, Moliehi, Chakely, Makobefo G., Kao, Mpho, Kopo, Mathebe, Mokebe, Moleboheng, Nsakala, Bienvenu L., Lukau, Blaise, Ayakaka, Irene, Amstutz, Alain, Ehmer, Jochen, Klimkait, Thomas, Glass, Tracy R., Muhairwe, Josephine, Chammartin, Frédérique, et al. (2024). Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2022 - cohort description, test volumes, predictors of viraemia, and the road ahead [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.03.12.24304025

Kohler, Maurus, Brown, Jennifer A., Tschumi, Nadine, Lerotholi, Malebanye, Motaboli, Lipontso, Mokete, Moliehi, Chammartin, Frédérique, & Labhardt, Niklaus D. (2024). Clinical Relevance of Human Immunodeficiency Virus Low-level Viremia in the Dolutegravir era: Data From the Viral Load Cohort North-East Lesotho (VICONEL). Open Forum Infectious Diseases, 11(2). https://doi.org/10.1093/ofid/ofae013

Tschumi, Nadine, Lukau, Blaise, Tlali, Katleho, Motaboli, Lipontso, Kao, Mpho, Kopo, Mathebe, Hänggi, Kathrin, Mokebe, Moleboheng, Naegele, Klaudia, Ayakaka, Irene, Leuzinger, Karoline, Brown, Jennifer A., & Labhardt, Niklaus Daniel. (2024). Emergence of Acquired Dolutegravir Resistance in Treatment-Experienced People with HIV in Lesotho [Posted-content]. Elsevier BV. https://doi.org/10.2139/ssrn.4683840

Tschumi N, Lerotholi M, Motaboli L, Mokete M, Labhardt ND, & Brown JA. (2023). Two-Year Outcomes of Treatment-Experienced Adults After Programmatic Transitioning to Dolutegravir: Longitudinal Data From the VICONEL Human Immunodeficiency Virus Cohort in Lesotho. Clinical Infectious Diseases, 77(9), 1318–1321. https://doi.org/10.1093/cid/ciad390

Brown JA, Hauser A, Abela IA, Pasin C, Epp S, Mohloanyane T, Nsakala BL, Trkola A, Labhardt ND, Kouyos RD, & Günthard HF. (2023). Seroprofiling of Antibodies Against Endemic Human Coronaviruses and Severe Acute Respiratory Syndrome Coronavirus 2 in a Human Immunodeficiency Virus Cohort in Lesotho: Correlates of Antibody Response and Seropositivity. Journal of Infectious Diseases, 228(8), 1042–1054. https://doi.org/10.1093/infdis/jiad197

Labhardt ND, Brown JA, Sass N, Ford N, & Rosen S. (2023). Treatment Outcomes after Offering Same-Day Initiation of Human Immunodeficiency Virus Treatment-How to Interpret Discrepancies between Different Studies. Clinical Infectious Diseases, 77(8), 1176–1184. https://doi.org/10.1093/cid/ciad317

Kopo, M., Lejone, T. I., Tschumi, N., Glass, T. R., Kao, M., Brown, J. A., Seiler, O., Muhairwe, J., Moletsane, N., Labhardt, N. D., & Amstutz, A. (2023). Effectiveness of a peer educator-coordinated preference-based differentiated service delivery model on viral suppression among young people living with HIV in Lesotho: the PEBRA cluster-randomized trial. PLOS Medicine, 20(1), e1004150. https://doi.org/10.1371/journal.pmed.1004150

Seiler, O., Kopo, M., Kao, M., Lejone, T. I., Tschumi, N., Glass, T. G., Brown, J. A., Labhardt, N. D., & Amstutz, A. (2023). HIV care preferences among young people living with HIV in Lesotho: a secondary data analysis of the PEBRA cluster randomized trial. AIDS Research and Treatment, 2023, 8124192. https://doi.org/10.1155/2023/8124192

Seiler, Olivia, Kopo, Mathebe, Kao, Mpho, Lejone, Thabo Ishmael, Tschumi, Nadine, Glass, Tracy Renée, Brown, Jennifer Anne, Labhardt, Niklaus Daniel, & Amstutz, Alain. (2022). HIV care preferences among young people living with HIV in Lesotho: A secondary data analysis of the PEBRA cluster randomized trial [Posted-content]. In medRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.07.29.22278205

Brown, J. A., Nsakala, B. L., Mokhele, K., Rakuoane, I., Muhairwe, J., Glass, T. R., Amstutz, A., Tschumi, N., Belus, J. M., Klimkait, T., & Labhardt, N. D. (2022). Dolutegravir in real life: self-reported mental and physical health outcomes after transitioning from efavirenz- to dolutegravir-based antiretroviral therapy in a prospective cohort study in Lesotho. HIV Medicine, 24(2), 153–162. https://doi.org/10.1111/hiv.13352

Brown, J. A. (2022). Towards 95% viral suppression: targeting HIV drug resistance, adherence to therapy, and access to care in southern and East Africa [Doctoral Thesis].

Brown, Jennifer A., Nsakala, Bienvenu L., Mokhele, Kuena, Rakuoane, Itumeleng, Muhairwe, Josephine, Urda, Lorena, Amstutz, Alain, Tschumi , Nadine, Klimkait, Thomas, & Labhardt, Niklaus D. (2022). Viral suppression after transition from nonnucleoside reverse transcriptase inhibitor- to dolutegravir-based antiretroviral therapy: a prospective cohort study in Lesotho (DO-REAL study). HIV medicine, 23(3), 287–293. https://doi.org/10.1111/hiv.13189

Kopo, Mathebe, Lejone, Thabo Ishmael, Tschumi, Nadine, Glass, Tracy Renée, Kao, Mpho, Brown, Jennifer Anne, Seiler, Olivia, Muhairwe, Josephine, Moletsane, Ntoli, Labhardt, Niklaus Daniel, & Amstutz, Alain. (2022). Effectiveness of a Peer Educator-Coordinated Preference-Based Differentiated Delivery Model on Viral Suppression Among Young People Living with HIV in Lesotho: The PEBRA Cluster Randomized Trial [Journal-article]. In SSRN Electronic Journal. RELX Group (Netherlands). https://doi.org/10.2139/ssrn.4019324

Muhairwe, J. A., Brown, J. A., Motaboli, L., Nsakala, B. L., Lerotholi, M., Amstutz, A., Klimkait, T., Glass, T. R., & Labhardt, N. D. (2022). The suboptimal pediatric HIV viral load cascade: multidistrict cohort study among children taking antiretroviral therapy in Lesotho, Southern Africa. Pediatric Infectious Disease Journal, 41(3), e75–e80. https://doi.org/10.1097/inf.0000000000003415

Tschumi, N., Lerotholi, M., Kopo, M., Kao, M., Lukau, B., Nsakala, B., Chejane, N., Motaboli, L., Lee, T., Barnabas, R., Shapiro, A. E., van Heerden, A., Lejone, T. I., Amstutz, A., Brown, J. A., Heitner, J., Belus, J. M., Chammartin, F., & Labhardt, N. D. (2022). Assessment of a viral load result-triggered automated differentiated service delivery model for people taking ART in Lesotho (the VITAL study): study protocol of a cluster-randomized trial. Plos One, 17(5), e0268100. https://doi.org/10.1371/journal.pone.0268100

Brown, J. A., Amstutz, A., Nsakala, B. L., Seeburg, U., Vanobberghen, F., Muhairwe, J., Klimkait, T., Daniel Labhardt, N., & Daniel Labhardt, N. (2021). Extensive drug resistance during low-level HIV viraemia while taking NNRTI-based ART supports lowering the viral load threshold for regimen switch in resource-limited settings: a pre-planned analysis from the SESOTHO trial. Journal of Antimicrobial Chemotherapy, 76(5), 1294–1298. https://doi.org/10.1093/jac/dkab025

Brown, J. A., Mbunkah, H. A., Lejone, T. I., Ringera, I., Cheleboi, M., Klimkait, T., Metzner, K. J., Gunthard, H. F., Labhardt, N. D., Kouyos, R. D., & Tschumi, N. (2021). Emergence of human immunodeficiency virus-1 drug resistance during the 3-month World Health Organization-recommended enhanced adherence counseling period in the CART-1 cohort study. Open Forum Infectious Diseases, 8(5), ofab046. https://doi.org/10.1093/ofid/ofab046

Brown, Jennifer Anne, Ringera, Isaac, Luoga, Ezekiel, Cheleboi, Molisana, Kimera, Namvua, Muhairwe, Josephine, Kayembe, Buntshi Paulin, Molapo Hlasoa, Mosa, Kabundi, Lorraine, Yav, Ching Wey David, Mothobi, Buoang, Thahane, Lineo, Amstutz, Alain, Bachmann, Nadine, Mollel, Getrud Joseph, Bresser, Moniek, Glass, Tracy Renée, Paris, Daniel Henry, Klimkait, Thomas, et al. (2020). Genotype-Informed Versus Empiric Management Of VirEmia (GIVE MOVE): study protocol of an open-label randomised clinical trial in children and adolescents living with HIV in Lesotho and Tanzania. BMC Infectious Diseases, 20(1), 773. https://doi.org/10.1186/s12879-020-05491-9

Lejone, Thabo Ishmael, Kopo, Mathebe, Bachmann, Nadine, Brown, Jennifer Anne, Glass, Tracy Renée, Muhairwe, Josephine, Matsela, Tebatso, Scherrer, Ramona, Chere, Lebohang, Namane, Tilo, Labhardt, Niklaus Daniel, & Amstutz, Alain. (2020). PEBRA trial - effect of a peer-educator coordinated preference-based ART service delivery model on viral suppression among adolescents and young adults living with HIV: protocol of a cluster-randomized clinical trial in rural Lesotho. BMC Public Health, 20(1), 425. https://doi.org/10.1186/s12889-020-08535-6

Amstutz, Alain, Brown, Jennifer Anne, Ringera, Isaac, Muhairwe, Josephine, Lejone, Thabo Ishmael, Klimkait, Thomas, Glass, Tracy Renée, & Labhardt, Niklaus Daniel. (2019). Engagement in care, viral suppression, drug resistance and reasons for non-engagement after home-based same-day ART initiation in Lesotho: a two-year follow-up of the CASCADE trial. Clinical Infectious Diseases, 71(10), 2608–2614. https://doi.org/10.1093/cid/ciz1126

Courlet, Perrine, Decosterd, Laurent Arthur, Brown, Jennifer Anne, Alves Saldanha, Susana, Marzolini, Catia, Cavassini, Matthias, Stoeckle, Marcel, Csajka, Chantal, Labhardt, Niklaus Daniel, Calmy, Alexandra, & Swiss HIV Cohort Study,,. (2019). Emtricitabine and lamivudine concentrations in saliva : a simple suitable test for treatment adherence. Journal of Antimicrobial Chemotherapy, 74(8), 2468–2470. https://doi.org/10.1093/jac/dkz181

Jawaid A, Brown JA, & Schulz PE. (2015). Diabetes mellitus in amyotrophic lateral sclerosis: Dr Jekyll or Mr Hyde? (Patent No. 11). European Journal of Neurology, 22(11), Article 11. https://doi.org/10.1111/ene.12660