PD Dr. sc. nat. Francis Jacob

Frei, C. A., Litchfield, C., Mihic, A., Prutek, F., Fitsche, A., Wiesmann, F., Wanner, M., Sobottka, B., Mihic-Probst, D., Aebersold, R., Ak, M., Al-Quaddoomi, F. S., Albert, S. I., Albinus, J., Alborelli, I., Andani, S., Attinger, P.-O., Bacac, M., Baciu-Drăgan, M.-A., et al. (2025). The chromatin guardian ATRX is a strong prognostic biomarker in melanoma [Journal-article]. Scientific Reports. https://doi.org/10.1038/s41598-025-30842-4

Mehra, T., Menges, D., Gosztonyi, B., Miglino, N., Ring, A., Boos, L., Sobottka, B., Aebersold, R., Ak, M., Al-Quaddoomi, F. S., Albert, S. I., Albinus, J., Alborelli, I., Andani, S., Attinger, P.-O., Bacac, M., Baciu-Drăgan, M.-A., Baumhoer, D., Beck-Schimmer, B., et al. (2025). Comparative cost analysis of a diagnostic multi-omics platform for decision support in advanced cancer – results from the Tumor Profiler Melanoma project [Journal-article]. Npj Precision Oncology. https://doi.org/10.1038/s41698-025-01229-5

Lischetti, U., Liang, C.-Y., Carrara, M., Coelho, R., Hanns, A., Lombardo, F., Dondi, A., Goetze, S., Hensler, M., Kurzeder, C., Montavon, C., Fucikova, J., Singer, F., Beerenwinkel, N., Beisel, C., Heinzelmann-Schwarz, V., & Jacob, F. (2025). Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming [Journal-article]. Nature Communications. https://doi.org/10.1038/s41467-025-67557-z

De Luise, Monica, Kurelac, Ivana, Coluccelli, Sara, De Leo, Antonio, Bartoszek, Ewelina M., Iorio, Maria, Grillini, Marco, Coadă, Camelia Alexandra, de Biase, Dario, Marchio, Lorena, López, Mónica Núñez, Rimmer, Natalie, Perrone, Anna Myriam, De Iaco, Pierandrea, Porcelli, Anna Maria, Heinzelmann, Viola, Martin, Ivan, Jacob, Francis, Muraro, Manuele Giuseppe, & Gasparre, Giuseppe. (2025). Perfusion-based ex vivo culture of frozen ovarian cancer tissues with preserved tumor microenvironment. Npj Precision Oncology, 9. https://doi.org/10.1038/s41698-025-00941-6

Bollhagen, Alina, Whipman, James, Coelho, Ricardo, Heinzelmann-Schwarz, Viola, Jacob, Francis, & Bodenmiller, Bernd. (2025). High-resolution imaging mass cytometry to map subcellular structures. Nature Methods. https://doi.org/10.1038/s41592-025-02889-8

Andani, Sonali, Chen, Boqi, Ficek-Pascual, Joanna, Heinke, Simon, Casanova, Ruben, Hild, Bernard Friedrich, Sobottka, Bettina, Bodenmiller, Bernd, Zuend, Gregor, Zoche, Martin, Zimmermann, Marc, Ziegler, Johanna, Yu, Shuqing, Wollscheid, Bernd, Wildschut, Mattheus HE, Wicki, Andreas, Wey, Norbert, Wendt, Fabian, Weller, Michael, et al. (2025). Histopathology-based protein multiplex generation using deep learning. Nature Machine Intelligence, 7, 1292–1307. https://doi.org/10.1038/s42256-025-01074-y

Litchfield, Cassandra, Nienhold, Ronny, Wicki, Andreas, Schmid, Michael, Aguilera-Garcia, Domingo, Koelzer, Viktor Hendrik, Aebersold, Rudolf, Ak, Melike, Al-Quaddoomi, Faisal S., Albert, Silvana I., Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baciu-Drăgan, Monica-Andreea, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beerenwinkel, Niko, et al. (2025). Integrating Formalin-Fixed, Paraffin-Embedded–Derived Whole-Genome Sequencing into Routine Molecular Pathology: Validation and First Experiences in Metastatic Melanoma. Journal of Molecular Diagnostics, 27, 722–735. https://doi.org/10.1016/j.jmoldx.2025.04.011

Miglino, Nicola, Toussaint, Nora C., Ring, Alexander, Bonilla, Ximena, Tusup, Marina, Gosztonyi, Benedict, Mehra, Tarun, Gut, Gabriele, Jacob, Francis, Chevrier, Stephane, Lehmann, Kjong-Van, Casanova, Ruben, Jacobs, Andrea, Sivapatham, Sujana, Boos, Laura, Rahimzadeh, Parisa, Schuerch, Manuel, Sobottka, Bettina, Chicherova, Natalia, et al. (2025). Correction to: Feasibility of multiomics tumor profiling for guiding treatment of melanoma (Nature Medicine, (2025), 31, 7, (2430-2441), 10.1038/s41591-025-03715-6). Nature Medicine, 31, 2817–2818. https://doi.org/10.1038/s41591-025-03904-3

Miglino, Nicola, Toussaint, Nora C., Ring, Alexander, Bonilla, Ximena, Tusup, Marina, Gosztonyi, Benedict, Mehra, Tarun, Gut, Gabriele, Jacob, Francis, Chevrier, Stephane, Lehmann, Kjong-Van, Casanova, Ruben, Jacobs, Andrea, Sivapatham, Sujana, Boos, Laura, Rahimzadeh, Parisa, Schuerch, Manuel, Sobottka, Bettina, Chicherova, Natalia, et al. (2025). Feasibility of multiomics tumor profiling for guiding treatment of melanoma. Nature Medicine, 31, 2430–2441. https://doi.org/10.1038/s41591-025-03715-6

Todorov, Tihomir Zh., Coelho, Ricardo, Dellea, Sharon, Jacob, Francis, Heinzelmann-Schwarz, Viola, Grundler, Pascal V., van der Meulen, Nicholas P., Béhé, Martin P., Schibli, Roger, & Grünberg, Jürgen. (2025). 161Tb-Based Anti-L1CAM Radioimmunotherapy Shows Superior Efficacy in Eliminating Ovarian Cancer Stem Cells Compared with 177Lu in Preclinical Models of Ovarian Cancer. Journal of Nuclear Medicine, 66, 1091–1096. https://doi.org/10.2967/jnumed.124.269078

Casanova, Ruben, Xu, Shuhan, Bost, Pierre, Sivapatham, Sujana, Jacobs, Andrea, Engler, Stefanie, Aebersold, Rudolf, Ak, Melike, Al-Quaddoomi, Faisal S, Silvana, I Albert, Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beerenwinkel, Niko, Beisel, Christian, et al. (2025). Standardization of Suspension and Imaging Mass Cytometry Single-Cell Readouts for Clinical Decision Making. Cytometry Part A, 107, 390–403. https://doi.org/10.1002/cyto.a.24940

Todorov, Tihomir Zh, Coelho, Ricardo, Jacob, Francis, Heinzelmann-Schwarz, Viola, Schibli, Roger, Béhé, Martin, Grünberg, Jürgen, & Grzmil, Michal. (2025). Phosphoproteomics Reveals L1CAM-Associated Signaling Networks in High-Grade Serous Ovarian Carcinoma: Implications for Radioresistance and Tumorigenesis. International Journal of Molecular Sciences, 26. https://doi.org/10.3390/ijms26104585

Dondi, Arthur, Borgsmüller, Nico, Ferreira, Pedro F., Haas, Brian J., Jacob, Francis, Heinzelmann-Schwarz, Viola, & Beerenwinkel, Niko. (2025). De novo detection of somatic variants in high-quality long-read single-cell RNA sequencing data. Genome Research, 35, 900–913. https://doi.org/10.1101/gr.279281.124

Canário, Rita, Ribeiro, Ana Sofia, Morgado, Inês, Peixoto, Ana, Barbosa, Ana, Santos, Catarina, Mendes, Nuno, Lopes, Paula, Monteiro, Paula, Coelho, Ricardo, Jacob, Francis, Heinzelmann-Schwarz, Viola, Ricardo, Sara, Teixeira, Manuel R., Bartosch, Carla, & Paredes, Joana. (2025). P-cadherin overexpression is associated with early transformation of the Fallopian tube epithelium and aggressiveness of tubo-ovarian high-grade serous carcinoma. Virchows Archiv. https://doi.org/10.1007/s00428-025-04104-7

Kasikova, Lenka, Rakova, Jana, Hensler, Michal, Lanickova, Tereza, Tomankova, Jana, Pasulka, Josef, Drozenova, Jana, Mojzisova, Katerina, Fialova, Anna, Vosahlikova, Sarka, Laco, Jan, Ryska, Ales, Dundr, Pavel, Kocian, Roman, Brtnicky, Tomas, Skapa, Petr, Capkova, Linda, Kovar, Marek, Prochazka, Jan, et al. (2024). Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-46873-w

Wegmann, Rebekka, Bonilla, Ximena, Casanova, Ruben, Chevrier, Stéphane, Coelho, Ricardo, Esposito, Cinzia, Ficek-Pascual, Joanna, Goetze, Sandra, Gut, Gabriele, Jacob, Francis, Jacobs, Andrea, Kuipers, Jack, Lischetti, Ulrike, Mena, Julien, Milani, Emanuela S., Prummer, Michael, del Castillo, Jacobo Sarabia, Singer, Franziska, Sivapatham, Sujana, et al. (2024). Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia. Nature Communications , 15(1). https://doi.org/10.1038/s41467-024-53535-4

Schaefer, Thorsten, Mittal, Nitish, Wang, Hui, Ataman, Meric, Candido, Silvia, Lötscher, Jonas, Velychko, Sergiy, Tintignac, Lionel, Bock, Thomas, Börsch, Anastasiya, Baßler, Jochen, Rao, Tata Nageswara, Zmajkovic, Jakub, Roffeis, Sarah, Löliger, Jordan, Jacob, Francis, Dumlin, Alain, Schürch, Christoph, Schmidt, Alexander, et al. (2024). Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate. Cell Reports, 43(10). https://doi.org/10.1016/j.celrep.2024.114807

Labrosse, Kathrin B., Lombardo, Flavio C., Rimmer, Natalie, Núñez López, Mónica, Fedier, André, Heinzelmann-Schwarz, Viola, Coelho, Ricardo, & Jacob, Francis. (2024). Protocol for quantifying drug sensitivity in 3D patient-derived ovarian cancer models. STAR Protocols, 5(3). https://doi.org/10.1016/j.xpro.2024.103274

Cumin, Cécile, Gee, Lindsay, Litfin, Thomas, Muchabaiwa, Ropafadzo, Martin, Gael, Cooper, Oren, Heinzelmann-Schwarz, Viola, Lange, Tobias, von Itzstein, Mark, Jacob, Francis, & Everest-Dass, Arun. (2024). Highly Sensitive Spatial Glycomics at Near-Cellular Resolution by On-Slide Derivatization and Mass Spectrometry Imaging. Analytical Chemistry, 96(28), 11163–11171. https://doi.org/10.1021/acs.analchem.3c05984

Jelena, Vasilevska, Phil, Fang Cheng, Julia, Lehmann, Egle, Ramelyte, Julia, Martínez Gómez, Florentia, Dimitriou, Federica, Sella, TuPro Consortium, Daria, Ferretti, Adrian, Salas-Bastos, Whitney Shannon, Jordaan, Mitchell Paul, Levesque, Reinhard, Dummer, & Lukas, Sommer. (2024). Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance. Cell Reports Medicine, 5(7), 101611. https://doi.org/10.1016/j.xcrm.2024.101611

Vasilevska, Jelena, Cheng, Phil Fang, Lehmann, Julia, Ramelyte, Egle, Gómez, Julia Martínez, Dimitriou, Florentia, Sella, TuProConsortium, Federica, Ferretti, Daria, Salas-Bastos, Adrian, Jordaan, Whitney Shannon, Levesque, Mitchell Paul, Dummer, Reinhard, & Sommer, Lukas. (2024). Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance [Journal-article]. Cell Reports Medicine, 5(7), 101611. https://doi.org/10.1016/j.xcrm.2024.101611

Immer, Alexander, Stark, Stefan G., Jacob, Francis, Bonilla, Ximena, Thomas, Tinu, Kahles, Andre, Goetze, Sandra, Milani, Emanuela S., Wollscheid, Bernd, Ratsch, Gunnar, & Lehmann, Kjong-Van. (2024). Probabilistic pathway-based multimodal factor analysis. Bioinformatics, 40, i189–i198. https://doi.org/10.1093/bioinformatics/btae216

Dhar, Chirag, Ramachandran, Prasanna, Xu, Gege, Pickering, Chad, Čaval, Tomislav, Wong, Maurice, Rice, Rachel, Zhou, Bo, Srinivasan, Apoorva, Aiyetan, Paul, Chu, Chih-Wei, Moser, Kaitlyn, Herzog, Thomas J., Olawaiye, Alexander Babatunde, Jacob, Francis, Serie, Daniel, Lindpaintner, Klaus, & Schwarz, Flavio. (2024). Diagnosing and staging epithelial ovarian cancer by serum glycoproteomic profiling. British Journal of Cancer, 130(10), 1716–1724. https://doi.org/10.1038/s41416-024-02644-4

Dondi, A., Borgsmüller, N., Ferreira, P. F., Haas, B. J., Jacob, F., Heinzelmann-Schwarz, V., & Beerenwinkel, N. (2024). De novo detection of somatic variants in long-read single-cell RNA sequencing data [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.03.06.583775

Coelho, Ricardo, Seashore-Ludlow, Brinton, Schütz, Sarah, Lombardo Christopher, Flavio, Moussaud-Lamodière, Elisabeth, Casanova, Ruben, Ficek-Pascual, Joanna, Labrosse Brunhilde, Kathrin, Lopez-Nunez, Monica, Rimmer, Natalie, Fedier, Andre, Lima, Renata, Montavon Sartorius, Céline, Kurzeder, Christian, Singer, Franziska, Bertolini, Anne, Rätsch, Gunnar, Bodenmiller, Bernd, Kallioniemi, Olli, et al. (2024). SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.01.24.576987

Dondi, Arthur, Lischetti, Ulrike, Jacob, Francis, Singer, Franziska, Borgsmüller, Nico, Coelho, Ricardo, Aebersold, Rudolf, Ak, Melike, Al-Quaddoomi, Faisal S., Albert, Silvana I., Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beisel, Christian, Bernasconi, Lara, et al. (2023). Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-43387-9

Starzonek, Sarah, Maar, Hanna, Mereiter, Stefan, Freytag, Vera, Haider, Marie-Therese, Riecken, Kristoffer, Huang, Yen-Lin, Jacob, Francis, Wicklein, Daniel, Schumacher, Udo, & Lange, Tobias. (2023). Identification of potential classes of glycoligands mediating dynamic endothelial adhesion of human tumor cells. Glycobiology, 33(8), 637–650. https://doi.org/10.1093/glycob/cwad061

Rimmer, Natalie, Liang, Ching-Yeu, Coelho, Ricardo, Lopez, Monica Nunez, & Jacob, Francis. (2023). Generation of endogenously tagged E-cadherin cells using gene editing via non-homologous end joining. STAR Protocols, 4(2). https://doi.org/10.1016/j.xpro.2023.102305

Dhar, C., Ramachandran, P., Xu, G., Pickering, C., Čaval, T., Rice, R., Zhou, B., Srinivasan, A., Hundal, I., Cheng, R., Aiyetan, P., Chu, C.-W., Herzog, T. J., Olawaiye, A. B., Czerwieniec, G., Jacob, F., Serie, D., Lindpaintner, K., & Schwarz, F. (2023). Diagnosing and staging epithelial ovarian cancer by serum glycoproteomic profiling [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.03.20.23287422

Estermann, Manuela, Coelho, Ricardo, Jacob, Francis, Huang, Yen-Lin, Liang, Ching-Yeu, Faia-Torres, Ana Bela, Septiadi, Dedy, Drasler, Barbara, Karakocak, Bedia Begum, Dijkhoff, Irini Magdelina, Petri-Fink, Alke, Heinzelmann-Schwarz, Viola, & Rothen-Rutishauser, Barbara. (2023). A 3D multi-cellular tissue model of the human omentum to study the formation of ovarian cancer metastasis. Biomaterials, 294. https://doi.org/10.1016/j.biomaterials.2023.121996

Zwimpfer, Tibor A., Tal, Ori, Geissler, Franziska, Coelho, Ricardo, Rimmer, Natalie, Jacob, Francis, & Heinzelmann-Schwarz, Viola. (2023). Low grade serous ovarian cancer – A rare disease with increasing therapeutic options. Cancer Treatment Reviews, 112, 102497. https://doi.org/10.1016/j.ctrv.2022.102497

Dondi, A., Lischetti, U., Jacob, F., Singer, F., Borgsmüller, N., Coelho, R., Heinzelmann-Schwarz, V., Beisel, C., & Beerenwinkel, N. (2022, December 14). Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.12.12.520051

Schwab, Fabienne D., Scheidmann, Manuel C., Ozimski, Lauren L., Kling, André, Armbrecht, Lucas, Ryser, Till, Krol, Ilona, Strittmatter, Karin, Nguyen-Sträuli, Bich Doan, Jacob, Francis, Jacob, Francis, Fedier, André, Heinzelmann-Schwarz, Viola, Wicki, Andreas, Dittrich, Petra S., & Aceto, Nicola. (2022). MyCTC chip: microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies. Microsystems and Nanoengineering, 8(1). https://doi.org/10.1038/s41378-022-00467-y

Stanczak MA, Rodrigues Mantuano N, Kirchhammer N, Sanin DE, Jacob F, Coelho R, Everest-Dass AV, Wang J, Trefny MP, Monaco G, Bärenwaldt A, Gray MA, Petrone A, Kashyap AS, Glatz K, Kasenda B, Normington K, Broderick J, Peng L, et al. (2022). Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade. Science Translational Medicine, 14(669), eabj1270. https://doi.org/10.1126/scitranslmed.abj1270

Coelho, Ricardo, Tozzi, Alessandra, Disler, Muriel, Lombardo, Flavio, Fedier, André, López, Mónica Núñez, Freuler, Florian, Jacob, Francis, & Heinzelmann-Schwarz, Viola. (2022). Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer. Cell Death and Disease, 13(10), 909. https://doi.org/10.1038/s41419-022-05347-x

Cumin C, Huang YL, Rossdam C, Ruoff F, Céspedes SP, Liang CY, Lombardo FC, Coelho R, Rimmer N, Konantz M, López MN, Alam S, Schmidt A, Calabrese D, Fedier A, Vlajnic T, von Itzstein M, Templin M, Buettner FFR, et al. (2022). Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways. Cell Reports, 40(7), 111181. https://doi.org/10.1016/j.celrep.2022.111181

Fedier A, Maggi N, Tozzi A, Disler M, Coelho R, Jacob F, & Heinzelmann-Schwarz V. (2022). Exposure to escalating olaparib does not induce acquired resistance to PARPi and to other chemotherapeutic compounds in ovarian cancer cell lines. International Journal of Oncology, 61(1). https://doi.org/10.3892/ijo.2022.5379

Bertolini, Anne, Prummer, Michael, Tuncel, Mustafa Anil, Menzel, Ulrike, Rosano-González, María Lourdes, Kuipers, Jack, Stekhoven, Daniel Johannes, Beerenwinkel, Niko, Singer, Franziska, Aebersold, Rudolf, Ak, Melike, Al-Quaddoomi, Faisal S., Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, et al. (2022). scAmpi—A versatile pipeline for single-cell RNA-seq analysis from basics to clinics. PLoS Computational Biology, 18(6). https://doi.org/10.1371/journal.pcbi.1010097

Sobottka, Bettina, Nowak, Marta, Frei, Anja Laura, Haberecker, Martina, Merki, Samuel, Aebersold, Rudolf, Ak, Melike, Al-Quaddoomi, Faisal S., Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beerenwinkel, Niko, Beisel, Christian, Bernasconi, Lara, Bertolini, Anne, et al. (2021). Establishing standardized immune phenotyping of metastatic melanoma by digital pathology. Laboratory Investigation, 101(12), 1561–1570. https://doi.org/10.1038/s41374-021-00653-y

Huang, Yen-Lin, Liang, Ching-Yeu, Labitzky, Vera, Ritz, Danilo, Oliveira, Tiago, Cumin, Cécile, Estermann, Manuela, Lange, Tobias, Everest-Dass, Arun V., & Jacob, Francis. (2021). Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival. iScience, 24(10). https://doi.org/10.1016/j.isci.2021.103168

Irmisch, Anja, Bonilla, Ximena, Chevrier, Stéphane, Lehmann, Kjong-Van, Singer, Franziska, Toussaint, Nora C., Esposito, Cinzia, Mena, Julien, Milani, Emanuela S., Casanova, Ruben, Stekhoven, Daniel J., Wegmann, Rebekka, Jacob, Francis, Sobottka, Bettina, Goetze, Sandra, Kuipers, Jack, Sarabia del Castillo, Jacobo, Prummer, Michael, Tuncel, Mustafa A., et al. (2021). The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support. Cancer Cell, 39(3), 288–293. https://doi.org/10.1016/j.ccell.2021.01.004

Cumin C, Huang YL, Everest-Dass A, & Jacob F. (2021). Deciphering the importance of glycosphingolipids on cellular and molecular mechanisms associated with epithelial-to-mesenchymal transition in cancer. Biomolecules, 11(1), 1–19. https://doi.org/10.3390/biom11010062

Jacob F, Marchetti RL, Kind AB, Russell K, Schoetzau A, & Heinzelmann-Schwarz VA. (2021). High-grade serous peritoneal cancer follows a high stromal response signature and shows worse outcome than ovarian cancer. Molecular Oncology, 15(1), 91–103. https://doi.org/10.1002/1878-0261.12811

Oliveira T, Zhang M, Joo EJ, Abdel-Azim H, Chen CW, Yang L, Chou CH, Qin X, Chen J, Alagesan K, Almeida A, Jacob F, Packer NH, von Itzstein M, Heisterkamp N, & Kolarich D. (2021). Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia. Theranostics, 11(19), 9519–9537. https://doi.org/10.7150/thno.65398

Estermann, Manuela, Huang, Yen-Lin, Septiadi, Dedy, Ritz, Danilo, Liang, Ching-Yeu, Jacob, Francis, Drasler, Barbara, Petri-Fink, Alke, Heinzelmann-Schwarz, Viola, & Rothen-Rutishauser, Barbara. (2020). Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion. PLoS ONE, 15(12 December). https://doi.org/10.1371/journal.pone.0241500

Stark, Stefan G., Ficek, Joanna, Locatello, Francesco, Bonilla, Ximena, Chevrier, Stéphane, Singer, Franziska, Rätsch, Gunnar, Lehmann, Kjong-Van, Rudolf, Aebersold, Al-Quaddoomi Faisal, S., Jonas, Albinus, Ilaria, Alborelli, Sonali, Andani, Per-Olof, Attinger, Marina, Bacac, Daniel, Baumhoer, Beatrice, Beck-Schimmer, Niko, Beerenwinkel, Christian, Beisel, et al. (2020). SCIM: Universal single-cell matching with unpaired feature sets. Bioinformatics, 36, I919–I927. https://doi.org/10.1093/bioinformatics/btaa843

Coelho R, Ricardo S, Amaral AL, Huang YL, Nunes M, Neves JP, Mendes N, López MN, Bartosch C, Ferreira V, Portugal R, Lopes JM, Almeida R, Heinzelmann-Schwarz V, Jacob F, & David L. (2020). Regulation of invasion and peritoneal dissemination of ovarian cancer by mesothelin manipulation. Oncogenesis, 9(6), 61. https://doi.org/10.1038/s41389-020-00246-2

Terraneo N, Jacob F, Dubrovska A, & Grünberg J. (2020). Novel Therapeutic Strategies for Ovarian Cancer Stem Cells. Frontiers in Oncology, 10, 319. https://doi.org/10.3389/fonc.2020.00319

Irmisch, A., Bonilla, X., Chevrier, S., Lehmann, K.-V., Singer, F., Toussaint, N. C., Esposito, C., Mena, J., Milani, E. S., Casanova, R., Stekhoven, D. J., Wegmann, R., Jacob, F., Sobottka, B., Goetze, S., Kuipers, J., del Castillo, J. S., Prummer, M., Tuncel, M., et al. (2020). The Tumor Profiler Study: Integrated, multi-omic, functional tumor profiling for clinical decision support [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.02.13.20017921

Huang, Yen-Lin, Liang, Ching-Yeu, Ritz, Danilo, Coelho, Ricardo, Septiadi, Dedy, Estermann, Manuela, Cumin, Cécile, Rimmer, Natalie, Schötzau, Andreas, Núñez López, Mónica, Fedier, André, Konantz, Martina, Vlajnic, Tatjana, Calabrese, Diego, Lengerke, Claudia, David, Leonor, Rothen-Rutishauser, Barbara, Jacob, Francis, & Heinzelmann-Schwarz, Viola. (2020). Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. eLife, 9, e59442. https://doi.org/10.7554/elife.59442

Terraneo N, Jacob F, Peitzsch C, Dubrovska A, Krudewig C, Huang YL, Heinzelmann-Schwarz V, Schibli R, Béhé M, & Grünberg J. (2020). L1 cell adhesion molecule confers radioresistance to ovarian cancer and defines a new cancer stem cell population. Cancers, 12(1). https://doi.org/10.3390/cancers12010217

Montavon C, Stricker GR, Schoetzau A, Heinzelmann-Schwarz V, Jacob F, & Fedier A. (2019). Outcome in serous ovarian cancer is not associated with LATS expression. Journal of Cancer Research and Clinical Oncology, 145(11), 2737–2749. https://doi.org/10.1007/s00432-019-03037-4

Coelho R, Marcos-Silva L, Mendes N, Pereira D, Brito C, Jacob F, Steentoft C, Mandel U, Clausen H, David L, & Ricardo S. (2018). Mucins and truncated O-glycans unveil phenotypic discrepancies between serous ovarian cancer cell lines and primary tumours. International Journal of Molecular Sciences, 19(7). https://doi.org/10.3390/ijms19072045

Montavon Sartorius C, Schoetzau A, Kettelhack H, Fink D, Hacker NF, Fedier A, Jacob F, & Heinzelmann-Schwarz V. (2018). ABO blood groups as a prognostic factor for recurrence in ovarian and vulvar cancer. PLoS ONE, 13(3), e0195213. https://doi.org/10.1371/journal.pone.0195213

Heinzelmann-Schwarz V, Knipprath Mészaros A, Stadlmann S, Jacob F, Schoetzau A, Russell K, Friedlander M, Singer G, & Vetter M. (2018). Letrozole may be a valuable maintenance treatment in high-grade serous ovarian cancer patients. Gynecologic Oncology, 148(1), 79–85. https://doi.org/10.1016/j.ygyno.2017.10.036

Jacob, Francis, Alam, Shahidul, Konantz, Martina, Liang, Ching-Yeu, Kohler, Reto S., Everest-Dass, Arun V., Huang, Yen-Lin, Rimmer, Natalie, Fedier, Andre, Schötzau, Andreas, Lopez, Monica Nunez, Packer, Nicolle H., Lengerke, Claudia, & Heinzelmann-Schwarz, Viola. (2018). Transition of Mesenchymal and Epithelial Cancer Cells Depends on α1-4 Galactosyltransferase-Mediated Glycosphingolipids. Cancer Research, 78(11), 2952–2965. https://doi.org/10.1158/0008-5472.can-17-2223

Anugraham, Merrina, Jacob, Francis, Everest-Dass, Arun V., Schoetzau, Andreas, Nixdorf, Sheri, Hacker, Neville F., Fink, Daniel, Heinzelmann-Schwarz, Viola, & Packer, Nicolle H. (2017). Tissue glycomics distinguish tumour sites in women with advanced serous adenocarcinoma. Molecular Oncology, 11(11), 1595–1615. https://doi.org/10.1002/1878-0261.12134

Kohler, Reto S., Kettelhack, Henriette, Knipprath-Meszaros, Alexandra M., Fedier A, Schoetzau, Andreas, Jacob, Francis, & Heinzelmann-Schwarz, Viola. (2017). MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells. Gynecologic Oncology, 145(1), 159–166. https://doi.org/10.1016/j.ygyno.2017.02.016

Alam, Shahidul, Anugraham, Merrina, Huang, Yen-Lin, Kohler, Reto S., Hettich, Timm, Winkelbach, Katharina, Grether, Yasmin, López, Mónica Núñez, Khasbiullina, Nailia, Bovin, Nicolai V., Schlotterbeck, Götz, & Jacob, Francis. (2017). Altered (neo-) lacto series glycolipid biosynthesis impairs α2-6 sialylation on N-glycoproteins in ovarian cancer cells. Scientific Reports, 7. https://doi.org/10.1038/srep45367

Pochechueva T, Alam S, Schötzau A, Chinarev A, Bovin NV, Hacker NF, Jacob F, & Heinzelmann-Schwarz V. (2017). Naturally occurring anti-glycan antibodies binding to Globo H-expressing cells identify ovarian cancer patients. Journal of Ovarian Research, 10(1), 8. https://doi.org/10.1186/s13048-017-0305-8

Wang, Hui, Schaefer, Thorsten, Konantz, Martina, Braun, Martin, Varga, Zsuzsanna, Paczulla, Anna M., Reich, Selina, Jacob, Francis, Perner, Sven, Moch, Holger, Fehm, Tanja N., Kanz, Lothar, Schulze-Osthoff, Klaus, & Lengerke, Claudia. (2017). Prominent Oncogenic Roles of EVI1 in Breast Carcinoma. Cancer Research, 77(8), 2148–2160. https://doi.org/10.1158/0008-5472.can-16-0593

Kohler, R. S., Anugraham, M., Lopez, M. N., Xiao, C., Schoetzau, A., Hettich, T., Schlotterbeck, G., Fedier, A., Jacob, F., & Heinzelmann-Schwarz, V. (2016). Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients. Oncotarget, 7(32), 51674–51686. https://doi.org/10.18632/oncotarget.10543

Pochechueva, T., Chinarev, A., Schoetzau, A., Fedier, A., Bovin, N. V., Hacker, N. F., Jacob, F., & Heinzelmann-Schwarz, V. (2016). Blood Plasma-Derived Anti-Glycan Antibodies to Sialylated and Sulfated Glycans Identify Ovarian Cancer Patients. PLoS One, 11(10), e0164230. https://doi.org/10.1371/journal.pone.0164230

Anugraham M, Everest-Dass AV, Jacob F, & Packer NH. (2015). A platform for the structural characterization of glycans enzymatically released from glycosphingolipids extracted from tissue and cells. Rapid Communications in Mass Spectrometry, 29(7), 545–561. https://doi.org/10.1002/rcm.7130

Alam S, Fedier A, Kohler RS, & Jacob F. (2015). Glucosylceramide synthase inhibitors differentially affect expression of glycosphingolipids. Glycobiology, 25(4), 351–356. https://doi.org/10.1093/glycob/cwu187

Jacob F, Anugraham M, Pochechueva T, Tse BW, Alam S, Guertler R, Bovin NV, Fedier A, Hacker NF, Huflejt ME, Packer N, & Heinzelmann-Schwarz VA. (2014). The glycosphingolipid P1 is an ovarian cancer-associated carbohydrate antigen involved in migration. British Journal of Cancer, 111(8), 1634–1645. https://doi.org/10.1038/bjc.2014.455

Anugraham, Merrina, Jacob, Francis, Nixdorf, Sheri, Everest-Dass, Arun Vijay, Heinzelmann-Schwarz, Viola A., & Packer, Nicolle H. (2014). Specific glycosylation of membrane proteins in epithelial ovarian cancer cell lines: glycan structures reflect gene expression and DNA methylation status. Molecular and Cellular Proteomics, 13(9), 32–2213. https://doi.org/10.1074/mcp.m113.037085

Heinzelmann-Schwarz, Viola A., Kind, André B., & Jacob, Francis. (2014). Management of human papillomavirus-related gynecological malignancies. Current Problems in Dermatology, 45, 24–216. https://doi.org/10.1159/000358408

Jacob, Francis, Anugraham, M., Pochechueva, Tatiana, Tse, Brian WC, Alam, Shahidul, Guertler, Rea, Bovin, Nicolai V., Fedier, A., Hacker, N. F., Huflejt, Margaret E., Packer, Nicolle, & Heinzelmann-Schwarz, Viola A. (2014). The glycosphingolipid P(1) is an ovarian cancer-associated carbohydrate antigen involved in migration. British Journal of Cancer, 111(8), 1634–1645. https://doi.org/10.1038/bjc.2014.455

Jacob, Francis, Hitchins, Megan P., Fedier, André, Brennan, Kevin, Nixdorf, Shery, Hacker, Neville F., Ward, Robyn, & Heinzelmann-Schwarz, Viola A. (2014). Expression of GBGT1 is epigenetically regulated by DNA methylation in ovarian cancer cells. BMC Molecular Biology, 15, 24. https://doi.org/10.1186/1471-2199-15-24

Jacob, Francis, Nixdorf, Shery, Hacker, Neville F., & Heinzelmann-Schwarz, Viola A. (2014). Reliable in vitro studies require appropriate ovarian cancer cell lines. Journal of Ovarian Research, 7, 60. https://doi.org/10.1186/1757-2215-7-60

Pochechueva, Tatiana, Chinarev, Alexander A., Bovin, Nicolai V., Fedier, André, Jacob, Francis, & Heinzelmann-Schwarz, Viola. (2014). PEGylation of microbead surfaces reduces unspecific antibody binding in glycan-based suspension array. Journal of Immunological Methods, 412, 42–52. https://doi.org/10.1016/j.jim.2014.06.015

Buehler M, Tse B., Leboucq A, Jacob F, Caduff R, Fink D, Goldstein DR, & Heinzelmann-Schwarz V. (2013). Meta-analysis of microarray data identifies gas6 expression as an independent predictor of poor survival in ovarian cancer. BioMed Research International, 2013. https://doi.org/10.1155/2013/238284

Jacob, Francis, Guertler, Rea, Naim, Stephanie, Nixdorf, Sheri, Fedier, Andre, Hacker, Neville F., & Heinzelmann-Schwarz, Viola. (2013). Careful Selection of Reference Genes Is Required for Reliable Performance of RT-qPCR in Human Normal and Cancer Cell Lines. PLoS ONE, 8(3). https://doi.org/10.1371/journal.pone.0059180

Pochechueva T, Jacob F, Fedier A, & Heinzelmann-Schwarz V. (2012). Tumor-associated glycans and their role in gynecological cancers: Accelerating translational research by novel high- throughput approaches. Metabolites, 2(4), 913–939. https://doi.org/10.3390/metabo2040913

Jacob F, Ukegjini K, Nixdorf S, Ford CE, Olivier J, Caduff R, Scurry JP, Guertler R, Hornung D, Mueller R, Fink DA, Hacker NF, & Heinzelmann-Schwarz VA. (2012). Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients. PLoS ONE, 7(2), e31885. https://doi.org/10.1371/journal.pone.0031885

Jacob F, Goldstein DR, Bovin NV, Pochechueva T, Spengler M, Caduff R, Fink D, Vuskovic MI, Huflejt ME, & Heinzelmann-Schwarz V. (2012). Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array. International Journal of Cancer, 130(1), 138–146. https://doi.org/10.1002/ijc.26002

Pochechueva T, Jacob F, Goldstein DR, Huflejt ME, Chinarev A, Caduff R, Fink D, Hacker N, Bovin NV, & Heinzelmann-Schwarz V. (2011). Comparison of printed glycan array, suspension array and ELISA in the detection of human anti-glycan antibodies. Glycoconjugate Journal, 28(8-9), 507–517. https://doi.org/10.1007/s10719-011-9349-y

Jacob, Francis, Meier, Mara, Caduff, Rosmarie, Goldstein, Darlene, Pochechueva, Tatiana, Hacker, Neville, Fink, Daniel, & Heinzelmann-Schwarz, Viola. (2011). No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting. Gynecologic Oncology, 121(3), 487–491. https://doi.org/10.1016/j.ygyno.2011.02.022

Theurillat JP, Metzler SC, Henzi N, Djouder N, Helbling M, Zimmermann AK, Jacob F, Soltermann A, Caduff R, Heinzelmann-Schwarz V, Moch H, & Krek W. (2011). URI Is an Oncogene Amplified in Ovarian Cancer Cells and Is Required for Their Survival. Cancer Cell, 19(3), 317–332. https://doi.org/10.1016/j.ccr.2011.01.019

Jacob F, Goldstein DR, Fink D, & Heinzelmann-Schwarz V. (2009). Proteogenomic studies in epithelial ovarian cancer: Established knowledge and future needs. Biomarkers in Medicine, 3(6), 743–756. https://doi.org/10.2217/bmm.09.48

Wu J, Steinebrunner I, Sun Y, Butterfield T, Torres J, Arnold D, Gonzalez A, Jacob F, Reichler S, & Roux SJ. (2007). Apyrases (nucleoside triphosphate-diphosphohydrolases) play a key role in growth control in Arabidopsis. Plant Physiology, 144(2), 961–975. https://doi.org/10.1104/pp.107.097568