Prof. Dr. med. Jan Niess

Göldi, Andreas, Kaymak, Tanay, Esposito, Luca, Lehmann, Anouk, Negoias, Simona, Tamm, Michael, Niess, Jan Hendrik, & Hruz, Petr. (2025). Noninvasive Disease Assessment in Eosinophilic Esophagitis With Fractionated Exhaled Nitric Oxide, Blood, and Fecal Biomarkers. Journal of Clinical Gastroenterology, 59(8), 725–736. https://doi.org/10.1097/mcg.0000000000002068

Li, Hainan, Xu, Liping, Meda Venkata, Sai Pranathi, Minjares, Morgan, Melhem, Hassan, Kowluru, Anjaneyulu, Niess, Jan Hendrik, Milligan, Graeme, & Wang, Jie-Mei. (2025). G Protein–Coupled Receptor 35 Suppresses Oxidative Stress Responsive Kinase 1 in Diabetic Wound Healing. Diabetes, 74(7), 1233–1246. https://doi.org/10.2337/db24-0737

Woelfel, S., Dütschler, J., Junker, D., König, M., Leinenkugel, G., Krieger, C., Truniger, S., Franke, A., Koller, S., Metzger-Peter, K., Frei, N., Albrich, W. C., Friedrich, M., Niess, J. H., Schneiderhan-Marra, N., Dulovic, A., Korte, W., Bürgi, J. J., & Brand, S. (2025). XBB.1.5 COVID-19 mRNA Vaccines Induce Inadequate Mucosal Immunity in Patients with Inflammatory Bowel Disease [Journal-article]. Vaccines, 13(7), 759. https://doi.org/10.3390/vaccines13070759

Ebrahimi, Ramin, Ebrahimi, Fahim, Niess, Jan Hendrik, Mahdi, Ali, Chen, Shaojie, Di Vece, Davide, Bian, Weiwei, Kutz, Alexander, & Forss, Anders. (2025). Increased Risk of Cardiovascular Events After Coronary Interventions in Inflammatory Bowel Disease: A Nationwide Matched Cohort Study. Alimentary Pharmacology and Therapeutics, 61(12), 1904–1912. https://doi.org/10.1111/apt.70162

Rubin, D. T., Kubassova, O., Weber, C. R., Adsul, S., Freire, M., Biedermann, L., Koelzer, V. H., Bressler, B., Xiong, W., Niess, J. H., Matter, M. S., Kopylov, U., Barshack, I., Mayer, C., Magro, F., Carneiro, F., Maharshak, N., Greenberg, A., Hart, S., et al. (2025). Deployment of an Artificial Intelligence Histology Tool to Aid Qualitative Assessment of Histopathology Using the Nancy Histopathology Index in Ulcerative Colitis [Journal-article]. Inflammatory Bowel Diseases, 31(6), 1630–1636. https://doi.org/10.1093/ibd/izae204

Niess, Jan Hendrik, & Kaymak, Tanay. (2025). Eosinophilic Esophagitis Pathogenesis: All Clear? Inflamm Intest Dis, 10(1), 135–150. https://doi.org/10.1159/000546241

Mona, Robin, Göldi, Andreas, Schneider, Tobias, Panne, Isabelle, Egger, Andrea, Niess, Jan Hendrik, & Hrúz, Petr. (2025). Fatigue Is Strongly Associated with Depressive Symptoms in Patients with Inflammatory Bowel Disease. Inflammatory Intestinal Diseases, 10, 90–103. https://doi.org/10.1159/000545572

Morsy, Yasser, Walberg, Åsa, Wawrzyniak, Paulina, Hubeli, Barbara, Truscello, Luca, Mamie, Celine, Niechcial, Ania, Gueguen, Emilie, Manzini, Roberto, Gottier, Claudia, Lang, Silvia, Scharl, Sylvie, Blümel, Sena, Biedermann, Luc, Rogler, Gerhard, Turina, Matthias, Ramser, Michaela, Petrowsky, Henrik, Arnold, Isabelle C., et al. (2025). Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease. Gut Microbes, 17. https://doi.org/10.1080/19490976.2025.2530157

Woelfel, Simon, Dütschler, Joel, Junker, Daniel, König, Marius, Graf, Nicole, Krieger, Claudia, Truniger, Samuel, Oikonomou, Vasileios, Leinenkugel, Georg, Koller, Seraina, Metzger-Peter, Katline, Wyss, Jacqueline, Krupka, Niklas, Frei, Nicola, Albrich, Werner C., Friedrich, Matthias, Niess, Jan Hendrik, Schneiderhan-Marra, Nicole, Dulovic, Alex, et al. (2025). XBB.1.5-Adapted COVID-19 mRNA Vaccines but Not Infections With Previous Omicron Variants Boost Neutralisation Against the SARS-CoV-2 JN.1 Variant in Patients With Inflammatory Bowel Disease. Alimentary Pharmacology and Therapeutics, 61(2), 299–312. https://doi.org/10.1111/apt.18349

Lehmann, Anouk, Vosbeck, Juerg, Kyburz, Diego, Hruz, Petr, & Niess, Jan Hendrik. (2024). Risankizumab and Certolizumab Pegol Dual-Targeted Therapy for Crohn’s Disease and Axial Spondyloarthritis: A Case Report. Case Reports in Gastroenterology, 19(1), 22–30. https://doi.org/10.1159/000542759

Woelfel, Simon, Junker, Daniel, Bergamin, Irina, Meyer-Herbon, Pamela, Stillhard, Roman, Graf, Nicole, Leinenkugel, Georg, Dütschler, Joel, König, Marius, Kammerlander, Livia, Häuptle, Rahel, Zwyssig, Sarah, Krieger, Claudia, Truniger, Samuel, Koller, Seraina, Metzger-Peter, Katline, Frei, Nicola, Albrich, Werner C., Friedrich, Matthias, et al. (2024). STAR LIGHT Study: XBB.1.5 COVID-19 mRNA Vaccines Boost Systemic but Not Mucosal Immunity Against the SARS-CoV-2 JN.1 Variant in Patients with Chronic Liver Disease. Vaccines, 12(11). https://doi.org/10.3390/vaccines12111241

Byndloss, Mariana, Devkota, Suzanne, Duca, Frank, Niess, Jan Hendrik, Nieuwdorp, Max, Orho-Melander, Marju, Sanz, Yolanda, Tremaroli, Valentina, & Zhao, Liping. (2024). The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications—2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum. Diabetes Care, 73(9), 1391–1410. https://doi.org/10.2337/dbi24-0028

Byndloss, Mariana, Devkota, Suzanne, Duca, Frank, Niess, Jan Hendrik, Nieuwdorp, Max, Orho-Melander, Marju, Sanz, Yolanda, Tremaroli, Valentina, & Zhao, Liping. (2024). The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications—2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum. Diabetes Care, 47(9), 1491–1508. https://doi.org/10.2337/dci24-0052

Byndloss, Mariana, Devkota, Suzanne, Duca, Frank, Niess, Jan Hendrik, Nieuwdorp, Max, Orho-Melander, Marju, Sanz, Yolanda, Tremaroli, Valentina, & Zhao, Liping. (2024). The gut microbiota and diabetes: research, translation, and clinical applications – 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum. Diabetologia, 67(9), 1760–1782. https://doi.org/10.1007/s00125-024-06198-1

Melhem, H., & Niess, J. H. (2024). Eosinophilic Esophagitis and Inflammatory Bowel Disease: What Are the Differences? [Journal-article]. International Journal of Molecular Sciences, 25(15), 8534. https://doi.org/10.3390/ijms25158534

Wakim El-Khoury, Jeanine, Safroneeva, Ekaterina, Saner, Catherine, Rossel, Jean-Benoit, Trelle, Sven, Zwahlen, Marcel, Biedermann, Luc, Kreienbuehl, Andrea, Greuter, Thomas, Schreiner, Philipp, Netzer, Peter, Franke, Annett, Brand, Stephan, Hasler, Chantal, Aepli, Patrick, Burri, Emanuel, Weber, Achim, Sempoux, Christine, Biral, Ruggero, et al. (2024). Cohort Profile Update: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS). Inflammatory Intestinal Diseases, 9(1), 165–173. https://doi.org/10.1159/000539713

Woelfel, S., Dütschler, J., Junker, D., König, M., Leinenkugel, G., Graf, N., Krieger, C., Truniger, S., Franke, A., Koller, S., Metzger-Peter, K., Oberholzer, M., Frei, N., Geissler, N., Schaub, P., Albrich, W. C., Friedrich, M., Niess, J. H., Schneiderhan-Marra, N., et al. (2024). Systemic and Mucosal Immunogenicity of Monovalent XBB.1.5-Adapted COVID-19 mRNA Vaccines in Patients with Inflammatory Bowel Disease [Journal-article]. Vaccines, 12(7), 774. https://doi.org/10.3390/vaccines12070774

Kaymak, Tanay, & Niess, Jan Hendrik. (2024). Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis. Journal of Visualized Experiments , 2024(207). https://doi.org/10.3791/66503

Baldrich, Adrian, Althaus, Dominic, Menter, Thomas, Hirsiger, Julia R., Köppen, Julius, Hupfer, Robin, Juskevicius, Darius, Konantz, Martina, Bosch, Angela, Drexler, Beatrice, Gerull, Sabine, Ghosh, Adhideb, Meyer, Benedikt J., Jauch, Annaise, Pini, Katia, Poletti, Fabio, Berkemeier, Caroline M., Heijnen, Ingmar, Panne, Isabelle, et al. (2024). Post-transplant Inflammatory Bowel Disease Associated with Donor-Derived TIM-3 Deficiency. Journal of Clinical Immunology, 44(3). https://doi.org/10.1007/s10875-024-01667-z

Devan, Jan, Nosi, Vladimir, Spagnuolo, Julian, Chancellor, Andrew, Beshirova, Aisha, Loureiro, Jose Pedro, Vacchini, Alessandro, Hendrik Niess, Jan, Calogero, Raffaele, Mori, Lucia, De Libero, Gennaro, & Hruz, Petr. (2024). Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions. Clinical and Experimental Immunology, 215(1), 79–93. https://doi.org/10.1093/cei/uxad098

Lautenschlager S.A., Barry M.P., Rogler G., Biedermann L., Schreiner P., Siebenhuner A.R., Abdelrahman K., Ademi G., Aepli P., Thomas A., Anderegg C., Antonino A.-T., Archanioti E., Arrigoni E., de Jong D.B., Balsiger B., Basturk P., Bauerfeind P., Becocci A., et al. (2023). Lifestyle factors associated with inflammatory bowel disease: data from the Swiss IBD cohort study. BMC Gastroenterology, 23(1). https://doi.org/10.1186/s12876-023-02692-9

Miyamoto K, Sujino T, Harada Y, Ashida H, Yoshimatsu Y, Yonemoto Y, Nemoto Y, Tomura M, Melhem H, Niess JH, Suzuki T, Suzuki T, Suzuki S, Koda Y, Okamoto R, Mikami Y, Teratani T, Tanaka KF, Yoshimura A, et al. (2023). The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis. Cell Reports, 42(8), 113005. https://doi.org/10.1016/j.celrep.2023.113005

Kaymak, Tanay, Kaya, Berna, Wuggenig, Philipp, Nuciforo, Sandro, Göldi, Andreas, Oswald, Franz, Roux, Julien, Noti, Mario, Melhem, Hassan, Hruz, Petr, & Niess, Jan Hendrik. (2023). IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. Gut, 72(5), 821–833. https://doi.org/10.1136/gutjnl-2022-327166

Pop, Oltin-Tiberiu, Geng, Anne, Flint, Emilio, Singanayagam, Arjuna, Ercan, Caner, Possamai, Lucia, Patel, Vishal C., Kuenzler, Patrizia, Meier, Marie-Anne, Soysal, Savas, Hruz, Petr, Kollmar, Otto, Tatham, Kate C., Ward, Josie K., Müllhaupt, Beat, Weber, Achim, Wendon, Julia, Niess, Jan Hendrik, Heim, Markus, et al. (2023). AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells. Cellular and Molecular Gastroenterology and Hepatology, 16(1), 17–37. https://doi.org/10.1016/j.jcmgh.2023.03.007

Pop, Oltin-Tiberiu, Geng, Anne, Flint, Emilio, Singanayagam, Arjuna, Ercan, Caner, Possamai, Lucia, Patel, Vishal C., Kuenzler, Patrizia, Meier, Marie-Anne, Soysal, Savas, Hruz, Petr, Kollmar, Otto, Tatham, Kate C., Ward, Josie K., Müllhaupt, Beat, Weber, Achim, Wendon, Julia, Niess, Jan Hendrik, Heim, Markus, et al. (2023). AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells [Journal-article]. Cellular and Molecular Gastroenterology and Hepatology, 16(1), 17–37. https://doi.org/10.1016/j.jcmgh.2023.03.007

Rohm, Theresa V., Keller, Lena, Bosch, Angela J. T., AlAsfoor, Shefaa, Baumann, Zora, Thomas, Amandine, Wiedemann, Sophia J., Steiger, Laura, Dalmas, Elise, Wehner, Josua, Rachid, Leila, Mooser, Catherine, Yilmaz, Bahtiyar, Fernandez Trigo, Nerea, Jauch, Annaise J., Wueest, Stephan, Konrad, Daniel, Henri, Sandrine, Niess, Jan H., et al. (2022). Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03305-z

Serra, Eva Gonçalves, Schwerd, Tobias, Moutsianas, Loukas, Cavounidis, Athena, Fachal, Laura, Pandey, Sumeet, Kammermeier, Jochen, Croft, Nicholas M., Posovszky, Carsten, Rodrigues, Astor, Russell, Richard K., Barakat, Farah, Auth, Marcus K. H., Heuschkel, Robert, Zilbauer, Matthias, Fyderek, Krzysztof, Braegger, Christian, Travis, Simon P., Satsangi, Jack, et al. (2022). Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease (Nature Communications, (2020), 11, 1, (995), 10.1038/s41467-019-14275-y). Nature Communications , 13(1). https://doi.org/10.1038/s41467-022-31010-2

Jordi, Sebastian Bruno Ulrich, Lang, Brian Matthew, Wyss, Jacqueline, Auschra, Bianca, Yilmaz, Bahtiyar, Krupka, Niklas, Greuter, Thomas, Schreiner, Philipp, Biedermann, Luc, Preisig, Martin, von Känel, Roland, Rogler, Gerhard, Begré, Stefan, Misselwitz, Benjamin, Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Belli, Dominique, Bengoa, José M., et al. (2022). The personality traits activity, self-reproach, and negative affect jointly predict clinical recurrence, depressive symptoms, and low quality of life in inflammatory bowel disease patients. Journal of Gastroenterology, 57(11), 848–866. https://doi.org/10.1007/s00535-022-01902-7

Casadó-Llombart S, Velasco-de Andrés M, Català C, Leyton-Pereira A, Gutiérrez-Cózar R, Suárez B, Armiger N, Carreras E, Esteller M, Ricart E, Ordás I, Gisbert JP, Chaparro M, Esteve M, Márquez L, Busquets D, Iglesias E, García-Planella E, Martín-Arranz MD, et al. (2022). Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease. Frontiers in Immunology, 13, 966184. https://doi.org/10.3389/fimmu.2022.966184

Kaymak T, Hruz P, & Niess JH. (2022). Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases. FEBS Journal, 289(16), 4758–4772. https://doi.org/10.1111/febs.16103

Müller A, Bilger SS, Göldi A, Meinlschmidt G, Rueter F, Kappes A, Hruz P, Meier CA, & Niess JH. (2022). [The IBD-Control questionnaire: German translation and validation of the standardized questionnaire for Patient Reported Outcome Measurement in inflammatory bowel disease]. Zeitschrift Fur Gastroenterologie, 60(6), 911–926. https://doi.org/10.1055/a-1482-8642

Jordi, Sebastian Bruno Ulrich, Lang, Brian Matthew, Auschra, Bianca, Von Känel, Roland, Biedermann, Luc, Greuter, Thomas, Schreiner, Philipp, Rogler, Gerhard, Krupka, Niklas, Sulz, Michael, Misselwitz, Benjamin, Begre, Stefan, Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begre, Stefan, Belli, Dominique, Bengoa, Jose M, Biedermann, Luc, et al. (2022). Depressive Symptoms Predict Clinical Recurrence of Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 28(4), 560–571. https://doi.org/10.1093/ibd/izab136

Melhem, Hassan, Kaya, Berna, Kaymak, Tanay, Wuggenig, Philipp, Flint, Emilio, Roux, Julien, Oost, Koen C., Cavelti-Weder, Claudia, Balmer, Maria L., Walser, Jean-Claude, Morales, Rodrigo A., Riedel, Christian U., Liberali, Prisca, Villablanca, Eduardo J., & Niess, Jan Hendrik. (2022). Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity. Mucosal Immunology, 15(3), 443–458. https://doi.org/10.1038/s41385-022-00494-y

Walldorf J, Porzner M, Neumann M, Joodi G, Niess JH, von Boyen G, Mäder K, Weissbach J, Kleger A, & Seufferlein T. (2022). The Selective 5-HT1A Agonist SR57746A Protects Intestinal Epithelial Cells and Enteric Glia Cells and Promotes Mucosal Recovery in Experimental Colitis. Inflammatory Bowel Diseases, 28(3), 423–433. https://doi.org/10.1093/ibd/izab191

Lett, Martin J, Mehta, Hema, Keogh, Adrian, Jaeger, Tina, Jacquet, Maxime, Powell, Kate, Meier, Marie-Anne, Fofana, Isabel, Melhem, Hassan, Vosbeck, Jürg, Cathomas, Gieri, Heigl, Andres, Heim, Markus H, Burri, Emanuel, Mertz, Kirsten D, Niess, Jan Hendrik, Kollmar, Otto, Zech, Christoph J, Ivanek, Robert, et al. (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells [Journal-article]. Gut, 71(12), 2526–2538. https://doi.org/10.1136/gutjnl-2021-324478

Lett, Martin J, Mehta, Hema, Keogh, Adrian, Jaeger, Tina, Jacquet, Maxime, Powell, Kate, Meier, Marie-Anne, Fofana, Isabel, Melhem, Hassan, Vosbeck, Jurg, Cathomas, Gieri, Heigl, Andres, Heim, Markus H, Burri, Emanuel, Mertz, Kirsten D, Niess, Jan Hendrik, Kollmar, Otto, Zech, Christoph J, Ivanek, Robert, et al. (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells. Gut, 71(12), 2526–2538. https://doi.org/10.1136/gutjnl-2021-324478

Ledergerber, Martina, Lang, Brian M., Heinrich, Henriette, Biedermann, Luc, Begré, Stefan, Zeitz, Jonas, Krupka, Niklas, Rickenbacher, Andreas, Turina, Matthias, Greuter, Thomas, Schreiner, Philipp, Roth, René, Siebenhüner, Alexander, Vavricka, Stephan, Rogler, Gerhard, Beerenwinkel, Niko, Misselwitz, Benjamin, Anderegg, Claudia, Bauerfeind, Peter, et al. (2021). Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management. BMC Gastroenterology, 21(1). https://doi.org/10.1186/s12876-021-01622-x

Melhem H, Regan-Komito D, & Niess JH. (2021). Mucins dynamics in physiological and pathological conditions. International Journal of Molecular Sciences, 22(24). https://doi.org/10.3390/ijms222413642

Yoganathan, Priyatharsan, Rossel, Jean-Benoit, Jordi, Sebastian Bruno Ulrich, Franc, Yannick, Biedermann, Luc, Misselwitz, Benjamin, Hausmann, Martin, Rogler, Gerhard, Scharl, Michael, Frey-Wagner, Isabelle, Abdelrahman, Karim, Ademi, Gentiana, Aepli, Patrick, Thomas, Amman, Anderegg, Claudia, Antonino, Anca-Teodora, Archanioti, Eva, Arrigoni, Eviano, Bakker de Jong, Diana, et al. (2021). Genotype–phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients [Journal-article]. BMC Gastroenterology, 21(1). https://doi.org/10.1186/s12876-021-01880-9

Yoganathan P., Rossel J.-B., Jordi S.B.U., Franc Y., Biedermann L., Misselwitz B., Hausmann M., Rogler G., Scharl M., Frey-Wagner I., Abdelrahman K., Ademi G., Aepli P., Thomas A., Anderegg C., Antonino A.-T., Archanioti E., Arrigoni E., de Jong D.B., et al. (2021). Genotype–phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients. BMC Gastroenterology, 21(1). https://doi.org/10.1186/s12876-021-01880-9

Kaya B, Melhem H, & Niess JH. (2021). GPR35 in Intestinal Diseases: From Risk Gene to Function. Frontiers in Immunology, 12, 717392. https://doi.org/10.3389/fimmu.2021.717392

Sutter M, Hruz P, & Niess JH. (2021). High Serum Creatine Kinase Levels in Infliximab and Vedolizumab-Treated Inflammatory Bowel Disease Patients. Inflammatory Intestinal Diseases, 6(3), 165–174. https://doi.org/10.1159/000518264

Jordi S.B.U., Botte F., Lang B.M., Greuter T., Krupka N., Auschra B., Schreiner P., Sulz M.C., Biedermann L., von Kanel R., Rogler G., Begre S., Misselwitz B., Anderegg C., Bauerfeind P., Beglinger C., Belli D., Bengoa J.M., Bigler B., et al. (2021). Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 54(1), 53–67. https://doi.org/10.1111/apt.16365

Rohm TV, Fuchs R, Müller RL, Keller L, Baumann Z, Bosch AJT, Schneider R, Labes D, Langer I, Pilz JB, Niess JH, Delko T, Hruz P, & Cavelti-Weder C. (2021). Obesity in Humans Is Characterized by Gut Inflammation as Shown by Pro-Inflammatory Intestinal Macrophage Accumulation. Frontiers in Immunology, 12, 668654. https://doi.org/10.3389/fimmu.2021.668654

Schreiner P., Rossel J.-B., Biedermann L., Valko P.O., Baumann C.R., Greuter T., Scharl M., Vavricka S., Pittet V., Juillerat P., Rogler G., von Kanel R., Misselwitz B., Abdelrahman K., Ademi G., Aepli P., Thomas A., Anderegg C., Antonino A.-T., et al. (2021). Fatigue in inflammatory bowel disease and its impact on daily activities. Alimentary Pharmacology and Therapeutics, 53(1), 138–149. https://doi.org/10.1111/apt.16145

Herrema H, & Niess JH. (2020). Intestinal microbial metabolites in human metabolism and type 2 diabetes. Diabetologia, 63(12), 2533–2547. https://doi.org/10.1007/s00125-020-05268-4

Serra E.G., Schwerd T., Moutsianas L., Cavounidis A., Fachal L., Pandey S., Kammermeier J., Croft N.M., Posovszky C., Rodrigues A., Russell R.K., Barakat F., Auth M.K.H., Heuschkel R., Zilbauer M., Fyderek K., Braegger C., Travis S.P., Satsangi J., et al. (2020). Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease. Nature Communications, 11(1). https://doi.org/10.1038/s41467-019-14275-y

Wuggenig, Philipp, Kaya, Berna, Melhem, Hassan, Ayata, C. Korcan, Abdelrahman, Karim, Ademi, Gentiana, Aepli, Patrick, Anderegg, Claudia, Antonino, Anca-Teodora, Archanioti, Eva, Arrigoni, Eviano, de Jong, Diana Bakker, Balsiger, Bruno, Bastürk, Polat, Bauerfeind, Peter, Becocci, Andrea, Belli, Dominique, Bengoa, José M., Biedermann, Luc, et al. (2020). Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice. Communications Biology, 3(1). https://doi.org/10.1038/s42003-020-0842-3

Cernoch P.S., Fournier N., Zeitz J., Scharl M., Morell B., Greuter T., Schreiner P., Misselwitz B., Safroneeva E., Schoepfer A.M., Vavricka S., Rogler G., Biedermann L., Anderegg C., Bauerfeind P., Beglinger C., Begre S., Belli D., Bengoa J.M., et al. (2020). Lower Risk of B1-to-pB3-Stage Migration in Crohn’s Disease Upon Immunosuppressive and Anti-TNF Treatment in the Swiss IBD Cohort Study. Digestive Diseases and Sciences, 65(9), 2654–2663. https://doi.org/10.1007/s10620-019-05978-9

Kaya B, Doñas C, Wuggenig P, Diaz OE, Morales RA, Melhem H, Swiss IBD. Cohort Investigators, Hernández PP, Kaymak T, Das S, Hruz P, Franc Y, Geier F, Ayata CK, Villablanca EJ, & Niess JH. (2020). Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis. Cell Reports, 32(5), 107979. https://doi.org/10.1016/j.celrep.2020.107979

Rybinski F, Weisser M, Niess JH, & Hruz P. (2020). Amoebic Liver Abscess in Crohn Disease Treated with Ustekinumab (Patent No. 7). Inflammatory Bowel Diseases, 26(7), Article 7. https://doi.org/10.1093/ibd/izaa101

Schneider T, Caviezel D, Ayata CK, Kiss C, Niess JH, & Hruz P. (2020). The copper/zinc ratio correlates with markers of disease activity in patients with inflammatory bowel disease. Crohn’s and Colitis 360, 2(1), otaa001. https://doi.org/10.1093/crocol/otaa001

Pittet V.E.H., Maillard M.H., Simonson T., Fournier N., Rogler G., Michetti P., Anderegg C., Bauerfeind P., Beglinger C., Begre S., Belli D., Bengoa J.M., Biedermann L., Bigler B., Binek J., Blattmann M., Boehm S., Borovicka J., Braegger C.P., et al. (2019). Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals. Clinical Gastroenterology and Hepatology, 17(10), 2050–2059. https://doi.org/10.1016/j.cgh.2018.11.029

Melhem H, Kaya B, Ayata CK, Hruz P, & Niess JH. (2019). Metabolite-sensing G protein-coupled receptors connect the diet-microbiota-metabolites axis to inflammatory bowel disease. Cells, 8(5). https://doi.org/10.3390/cells8050450

Pittet V., Michetti P., Mueller C., Braegger C.P., Von Kanel R., Schoepfer A., Macpherson A.J., Rogler G., Anderegg C., Bauerfeind P., Beglinger C., Begre S., Belli D., Bengoa J.M., Biedermann L., Bigler B., Binek J., Blattmann M., Boehm S., et al. (2019). Cohort profile update: The Swiss inflammatory bowel disease cohort study (SIBDCS). International Journal of Epidemiology, 48(2), 385–386f. https://doi.org/10.1093/ije/dyy298

Yilmaz, Bahtiyar, Juillerat, Pascal, Øyås, Ove, Ramon, Charlotte, Bravo, Francisco Damian, Franc, Yannick, Fournier, Nicolas, Michetti, Pierre, Mueller, Christoph, Geuking, Markus, Pittet, Valerie E. H., Maillard, Michel H., Rogler, Gerhard, Abdelrahman, Karim, Ademi, Gentiana, Aepli, Patrick, Thomas, Amman, Anderegg, Claudia, Antonino, Anca-Teodora, et al. (2019). Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease (Nature Medicine, (2019), 25, 2, (323-336), 10.1038/s41591-018-0308-z). Nature Medicine, 25(4), 701. https://doi.org/10.1038/s41591-019-0411-9

Yilmaz, Bahtiyar, Juillerat, Pascal, Øyås, Ove, Ramon, Charlotte, Bravo, Francisco Damian, Franc, Yannick, Fournier, Nicolas, Michetti, Pierre, Mueller, Christoph, Geuking, Markus, Pittet, Valerie E. H., Maillard, Michel H., Rogler, Gerhard, Abdelrahman, Karim, Ademi, Gentiana, Aepli, Patrick, Thomas, Amman, Anderegg, Claudia, Antonino, Anca-Teodora, et al. (2019). Microbial network disturbances in relapsing refractory Crohn’s disease. Nature Medicine, 25(2), 323–336. https://doi.org/10.1038/s41591-018-0308-z

Tcymbarevich I.V., Eloranta J.J., Rossel J.-B., Obialo N., Spalinger M., Cosin-Roger J., Lang S., Kullak-Ublick G.A., Wagner C.A., Scharl M., Seuwen K., Ruiz P.A., Rogler G., De Valliere C., Misselwitz B., Abdelrahman K., Ademi G., Aepli P., Thomas A., et al. (2019). The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation. BMC Gastroenterology, 19(1). https://doi.org/10.1186/s12876-018-0922-8

Niess JH, & Francés R. (2019). Editorial: The IL-20 cytokines and related family members in immunity and diseases (Patent No. AUG). Frontiers in Immunology, 10(AUG), Article AUG. https://doi.org/10.3389/fimmu.2019.01976

Niess JH, Kaymak T, & Hruz P. (2019). [The Role of the Exposome in the Emergence of Chronic Inflammatory Bowel Diseases]. Therapeutische Umschau. Revue Therapeutique, 75(5), 261–270. https://doi.org/10.1024/0040-5930/a000998

Pillai, Nadia, Lupatsch, Judith E., Dusheiko, Mark, Schwenkglenks, Matthias, Maillard, Michel, Sutherland, C. Simone, Pittet, Valérie E. H., Swiss IBD Cohort study group, & Swiss IBD Cohort study group,. (2019). Evaluating the cost-effectiveness of early compared to late or no biologic treatment to manage Crohn’s disease using real world data. Journal of Crohn’s & Colitis, 14(4), 490–500. https://doi.org/10.1093/ecco-jcc/jjz169

Radulovic K, Ayata CK, Mak’Anyengo R, Lechner K, Wuggenig P, Kaya B, Hruz P, Gomez de Agüero M, Broz P, Weigmann B, & Niess JH. (2019). NLRP6 deficiency in CD4 T cells decreases T cell survival associated with increased cell death. Journal of Immunology, 203(2), 544–556. https://doi.org/10.4049/jimmunol.1800938

Madanchi, Matiar, Fagagnini, Stefania, Fournier, Nicolas, Biedermann, Luc, Zeitz, Jonas, Battegay, Edouard, Zimmerli, Lukas, Vavricka, Stephan R, Rogler, Gerhard, Scharl, Michael, Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M, Biedermann, Luc, Bigler, Beat, Binek, Janek, et al. (2018). The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort [Journal-article]. Inflammatory Bowel Diseases, 24(9), 1768–1779. https://doi.org/10.1093/ibd/izy054

Caviezel D, Maissen S, Niess JH, Kiss C, & Hruz P. (2018). High Prevalence of Vitamin D Deficiency among Patients with Inflammatory Bowel Disease. Inflammatory Intestinal Diseases, 2(4), 200–210. https://doi.org/10.1159/000489010

Parragi L., Fournier N., Zeitz J., Scharl M., Greuter T., Schreiner P., Misselwitz B., Safroneeva E., Schoepfer A.M., Vavricka S., Rogler G., Biedermann L., Anderegg C., Bauerfeind P., Beglinger C., Begre S., Belli D., Bengoa J.M., Bigler B., et al. (2018). Colectomy rates in ulcerative colitis are low and decreasing: 10-year follow-up data from the Swiss IBD cohort study. Journal of Crohn’s and Colitis, 12(7), 811–818. https://doi.org/10.1093/ecco-jcc/jjy040

Niess JH, Hruz P, & Kaymak T. (2018). The Interleukin-20 cytokines in intestinal diseases. Frontiers in Immunology, 9(JUN), 1373. https://doi.org/10.3389/fimmu.2018.01373

Raduolovic K, Mak’Anyengo R, Kaya B, Steinert A, & Niess JH. (2018). Injections of lipopolysaccharide into mice to mimic entrance of microbial-derived products after intestinal barrier breach (Patent No. 135). Journal of Visualized Experiments, 2018(135), Article 135. https://doi.org/10.3791/57610

Kaymak T, Moriconi F, Niess JH, Beglinger C, & Hruz P. (2018). Low Discontinuation Rate of Infliximab Treatment in Steroid-Dependent/Refractory Crohn’s Disease Patients. Inflammatory Intestinal Diseases, 2(3), 171–179. https://doi.org/10.1159/000486676

Lang B.M., Biedermann L., van Haaften W.T., de Valliere C., Schuurmans M., Begre S., Zeitz J., Scharl M., Turina M., Greuter T., Schreiner P., Heinrich H., Kuntzen T., Vavricka S., Rogler G., Beerenwinkel N., Misselwitz B., Anderegg C., Bauerfeind P., et al. (2018). Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn’s disease. Alimentary Pharmacology and Therapeutics, 47(1), 55–66. https://doi.org/10.1111/apt.14378

Radulovic, Katarina, & Niess, Jan Hendrik. (2018). CD69. In Encyclopedia of Signaling Molecules Second Edition (pp. 943–951). https://doi.org/10.1007/978-3-319-67199-4_101600

Piñero P, Juanola O, Gutiérrez A, Zapater P, Giménez P, Steinert A, Sempere L, González-Navajas JM, Niess JH, & Francés R. (2017). IL26 modulates cytokine response and anti-TNF consumption in Crohn’s disease patients with bacterial DNA. Journal of Molecular Medicine, 95(11), 1227–1236. https://doi.org/10.1007/s00109-017-1585-6

Steinert A, Linas I, Kaya B, Ibrahim M, Schlitzer A, Hruz P, Radulovic K, Terracciano L, Macpherson AJ, & Niess JH. (2017). The stimulation of macrophages with TLR ligands supports increased IL-19 expression in inflammatory bowel disease patients and in colitis models. Journal of Immunology, 199(7), 2570–2584. https://doi.org/10.4049/jimmunol.1700350

Pittet, Valerie, Vaucher, Carla, Froehlich, Florian, Burnand, Bernard, Michetti, Pierre, Maillard, Michel H., Anderegg C., Bauerfeind P., Beglinger C., Begre S., Belli D., Bengoa J.M., Biedermann L., Bigler B., Binek J., Blattmann M., Boehm S., Borovicka J., Braegger C.P., et al. (2017). Patient self-reported concerns in inflammatory bowel diseases: A genderspecific subjective quality-of-life indicator. PLoS ONE, 12(2). https://doi.org/10.1371/journal.pone.0171864

Mueller R., Ziade F., Pittet V., Fournier N., Ezri J., Schoepfer A., Schibli S., Spalinger J., Braegger C., Nydegger A., Anderegg C., Bauerfeind P., Beglinger C., Begre S., Belli D., Bengoa J., Biedermann L., Binek J., Blattmann M., et al. (2016). Quality of life in Swiss paediatric inflammatory bowel disease patients: Do patients and their parents experience disease in the same way? Journal of Crohn’s and Colitis, 10(3), 269–276. https://doi.org/10.1093/ecco-jcc/jjv199

Dawson, H., Novotny, A., Becker, K., Reim, D., Langer, R., Gullo, I., Svrcek, M., Niess, J. H., Tutuian, R., Truninger, K., Diamantis, I., Blank, A., Zlobec, I., Riddell, R. H., Carneiro, F., Flejou, J. F., Genta, R. M., & Lugli, A. (2016). Macroscopy predicts tumor progression in gastric cancer: A retrospective patho-historical analysis based on Napoleon Bonaparte’s autopsy report. Digestive and Liver Disease, 48(11), 1378–1385. https://doi.org/10.1016/j.dld.2016.07.013

Heimgartner, B., Dawson, H., De Gottardi, A., Wiest, R., & Niess, J. H. (2016). Successful Treatment of Small Intestinal Bleeding in a Crohn’s Patient with Noncirrhotic Portal Hypertension by Transjugular Portosystemic Shunt Placement and Infliximab Treatment. Case Reports in Gastroenterology, 10(3), 589–595. https://doi.org/10.1159/000450541

Li, Dalin, Achkar, Jean-Paul, Haritunians, Talin, Jacobs, Jonathan P., Hui, Ken Y., D’Amato, Mauro, Brand, Stephan, Radford-Smith, Graham, Halfvarson, Jonas, Niess, Jan-Hendrik, Kugathasan, Subra, Buning, Carsten, Schumm, Philip, Klei, Lambertus, Ananthakrishnan, Ashwin, Aumais, Guy, Baidoo, Leonardo, Dubinsky, Marla, Fiocchi, Claudio, et al. (2016). A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition. Gastroenterology, 151(4), 724–732. https://doi.org/10.1053/j.gastro.2016.06.051

Rossini, Valerio, Radulovic, Katarina, Riedel, Christian U., & Niess, Jan Hendrik. (2016). Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells. Journal of Visualized Experiments, 115, e54421. https://doi.org/10.3791/54421

Steinert, Anna, Radulovic, Katarina, & Niess, Jan. (2016). Gastro-intestinal tract: The leading role of mucosal immunity. Swiss Medical Weekly, 146, w14293. https://doi.org/10.4414/smw.2016.14293

Radulovic, K., & Niess, J. H. (2015). CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment? Journal of Immunology Research, 2015, 497056. https://doi.org/10.1155/2015/497056

Niess, Jan Hendrik, & Danese, Silvio. (2014). Anti-TNF and skin inflammation in IBD: a new paradox in gastroenterology? Gut, 63(4), 5–533. https://doi.org/10.1136/gutjnl-2013-304683

Rossini V, Zhurina D, Radulovic K, Manta C, Walther P, Riedel CU, & Niess JH. (2014). CX3CR1 cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis. Mucosal Immunology, 7(3), 533–548. https://doi.org/10.1038/mi.2013.70

Rossini, V., Zhurina, D., Radulovic, K., Manta, C., Walther, P., Riedel, C. U., & Niess, J. H. (2014). CX3CR1(+) cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis. Mucosal Immunology, 7(3), 48–533. https://doi.org/10.1038/mi.2013.70

Schulz, O., Ugur, M., Friedrichsen, M., Radulovic, K., Niess, J.-H., Jalkanen, S., Krueger, A., & Pabst, O. (2014). Hypertrophy of infected Peyer’s patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress. Mucosal Immunology, 7(4), 892–904. https://doi.org/10.1038/mi.2013.105

Radulovic K, Rossini V, Manta C, Holzmann K, Kestler HA, & Niess JH. (2013). The Early Activation Marker CD69 Regulates the Expression of Chemokines and CD4 T Cell Accumulation in Intestine. PLoS ONE, 8(6), e65413. https://doi.org/10.1371/journal.pone.0065413

Neu C, Sedlag A, Bayer C, Förster S, Crauwels P, Niess JH, van Zandbergen G, Frascaroli G, & Riedel CU. (2013). CD14-Dependent Monocyte Isolation Enhances Phagocytosis of Listeria monocytogenes by Proinflammatory, GM-CSF-Derived Macrophages. PLoS ONE, 8(6), e66898. https://doi.org/10.1371/journal.pone.0066898

Posovszky C, Pfalzer V, Lahr G, Niess JH, Klaus J, Mayer B, Debatin KM, & von Boyen GB. (2013). Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn’s disease. BMC Gastroenterology, 13(1), 77. https://doi.org/10.1186/1471-230X-13-77

Manta C, Heupel E, Radulovic K, Rossini V, Garbi N, Riedel CU, & Niess JH. (2013). CX3CR1+ macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunology, 6(1), 177–188. https://doi.org/10.1038/mi.2012.61

Grasedieck, S., Schöler, N., Bommer, M., Niess, J.H., Tumani, H., Rouhi, A., Bloehdorn, J., Liebisch, P., Mertens, D., Döhner, H., Buske, C., Langer, C., & Kuchenbauer, F. (2012). Impact of serum storage conditions on microRNA stability. Leukemia, 26(11), 2414–2416. https://doi.org/10.1038/leu.2012.106

Schlitzer, A., Heiseke, A. F., Einwächter, H., Reindl, W., Schiemann, M., Manta, C.-P., See, P., Niess, J.-H., Suter, T., Ginhoux, F., & Krug, A. B. (2012). Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor. Blood, 119(25), 6063–6071. https://doi.org/10.1182/blood-2012-03-418400

Stephani, J., Wagner, M., Breining, T., Klaus, J., & Niess, J.-H. (2012). Metabolic alkalosis, acute renal failure and epileptic seizures as unusual manifestations of an upside-down stomach. Case Reports in Gastroenterology, 6(2), 452–458. https://doi.org/10.1159/000341509

Niess, J. H., Klaus, J., Stephani, J., Pflüger, C., Degenkolb, N., Spaniol, U., Mayer, B., Lahr, G., & Von Boyen, G. B. T. (2012). NOD2 polymorphism predicts response to treatment in crohn’s disease-first steps to a personalized therapy. Digestive Diseases and Sciences, 57(4), 879–886. https://doi.org/10.1007/s10620-011-1977-3

Radulovic, K., Manta, C., Rossini, V., Holzmann, K., Kestler, H. A., Wegenka, U. M., Nakayama, T., & Niess, J. H. (2012). CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. Journal of Immunology, 188(4), 2001–2013. https://doi.org/10.4049/jimmunol.1100765

Schlitzer, A., Loschko, J., Mair, K., Vogelmann, R., Henkel, L., Einwächter, H., Schiemann, M., Niess, J.-H., Reindl, W., & Krug, A. (2011). Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs. Blood, 117(24), 6562–6570. https://doi.org/10.1182/blood-2010-12-326678

Stephani, J., Radulovic, K., & Niess, J. H. (2011). Gut microbiota, probiotics and inflammatory bowel disease. Archivum Immunologiae et Therapiae Experimentalis, 59(3), 161–177. https://doi.org/10.1007/s00005-011-0122-5

Diegelmann, J., Seiderer, J., Niess, J.-H., Haller, D., Göke, B., Reinecker, H.-C., & Brand, S. (2010). Expression and regulation of the chemokine CXCL16 in Crohns disease and models of intestinal inflammation. Inflammatory Bowel Diseases, 16(11), 1871–1881. https://doi.org/10.1002/ibd.21306

Niess, J. H. (2010). What are CX3CR1+ mononuclear cells in the intestinal mucosa? Gut Microbes, 1(6). https://doi.org/10.4161/gmic.1.6.13939

Gronbach, K., Eberle, U., Müller, M., Ölschläger, T. A., Dobrindt, U., Leithäuser, F., Niess, J. H., Döring, G., Reimann, J., Autenrieth, I. B., & Frick, J.-S. (2010). Safety of probiotic Escherichia coli strain Nissle 1917 depends on intestinal microbiota and adaptive immunity of the host. Infection and Immunity, 78(7), 3036–3046. https://doi.org/10.1128/iai.00218-10

Preising, J., Philippe, D., Gleinser, M., Wei, H., Blum, S., Eikmanns, B. J., Niess, J.-H., & Riedel, C. U. (2010). Selection of bifidobacteria based on adhesion and anti-inflammatory capacity in vitro for amelioration of murine colitis. Applied and Environmental Microbiology, 76(9), 3048–3051. https://doi.org/10.1128/AEM.03127-09

Niess, J. H., & Adler, G. (2010). Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. Journal of Immunology, 184(4), 2026–2037. https://doi.org/10.4049/jimmunol.0901936