Macrophages and microbial metabolites in intestinal diseases

Humans with inflammatory bowel disease, such as Crohn’s disease or eosinophilic esophagitis, have an altered gut microbiome. Emerging evidence indicates that microbial metabolites and not only the microorganisms and their structural components modulate mucosal immune responses and metabolism. These microbial metabolites may influence the development of inflammatory bowel disease and eosinophilic esophagitis. Our research group aims to unravel some mechanisms of how the host recognizes microbial metabolites in inflammatory bowel disease. We focus on studies in which we genetically delete metabolite-sensing receptors in macrophages and intestinal epithelial cells. Our studies suggest microbial metabolites possibly fuel inflammatory bowel disease and eosinophilic esophagitis.

Prof. Dr. med. Jan Hendrik Niess

Profiles & Affiliations

Department of Biomedicine

Faculty of Medicine > Forschung > Department of Biomedicine > Niess Lab / Gastroenterology | Professorship / Head of Research Group

Department of Clinical Research

Faculty of Medicine > Forschung > Department of Clinical Research > [FG] Niess Jan | Professorship / Head of Research Group

Faculty of Medicine >
Forschung >
Department of Biomedicine >
Niess Lab / Gastroenterology | Professorship / Head of Research Group

Faculty of Medicine >
Forschung >
Department of Clinical Research >
[FG] Niess Jan | Professorship / Head of Research Group