Prof. Dr. med. Marc Pfister

Bräm, D., Bachmann, F., Schropp, J., Gotta, V., Steffens, B., van den Anker, J., Pfister, M., & Koch, G. (2025). Understanding and Streamlining Dose Finding: From Dose Simulation to Dose Estimation [Journal-article]. Journal of Clinical Pharmacology, 65(6), 731–741. https://doi.org/10.1002/jcph.6188

Ravix, A., Gotta, V., Pfister, M., Berger, C., Glauser, A., Paioni, P., Csajka, C., & Guidi, M. (2025). Dose Evaluation and Optimization of Amoxicillin in Children Treated for Lyme Disease [Journal-article]. Journal of Clinical Pharmacology, 65(6), 742–750. https://doi.org/10.1002/jcph.6190

Gotta, V., Csajka, C., Glauser, A., Berger, C., Pfister, M., & Paioni, P. (2025). Risk of Potentially Neurotoxic Exposure in Infants Under High-Dose Cefepime Treatment—A Pharmacometric Simulation Study [Journal-article]. Pharmaceutics, 17(5), 544. https://doi.org/10.3390/pharmaceutics17050544

Ajayi, David T., Orherhe, Ochuko M., Pillai, Goonaseelan (Colin), Mouksassi, Samer, Steffens, Britta, Bräm, Dominic, Sprecher, Viviane, Hofmann, Daniela, Buettcher, Michael, Coulibaly, Jean T., Ali, Said M., Keiser, Jennifer, & Pfister, Marc. (2025). Pharmacometric Analysis to Describe Pharmacokinetics and Exposure-Efficacy Response of Ivermectin in Adolescents Infected with Trichuris trichiura [Journal-article]. Journal of Clinical Pharmacology, 65(4), 433–440. https://doi.org/10.1002/jcph.6158

Bräm, D. S., Steiert, B., Pfister, M., Steffens, B., & Koch, G. (2025). Low-dimensional neural ordinary differential equations accounting for inter-individual variability implemented in Monolix and NONMEM [Journal-article]. CPT: Pharmacometrics and Systems Pharmacology, 14(1), 5–16. https://doi.org/10.1002/psp4.13265

Golhen, Klervi, Welzel, Tatjana, Atkinson, Andrew, Koch, Gilbert, Braem, Dominic, van den Anker, Johannes, Woerner, Andreas, Pfister, Marc, & Gotta, Verena. (2025). Influence of Disease Type and Activity on Adalimumab Exposure in Children with Inflammatory Rheumatic Diseases. Journal of Clinical Pharmacology. https://doi.org/10.1002/jcph.70045

Bachmann, Freya, Koch, Gilbert, Bauer, Robert J., Steffens, Britta, Szinnai, Gabor, Pfister, Marc, & Schropp, Johannes. (2024). Computing optimal drug dosing regarding efficacy and safety: the enhanced OptiDose method in NONMEM [Journal-article]. Journal of Pharmacokinetics and Pharmacodynamics, 51(6), 919–934. https://doi.org/10.1007/s10928-024-09940-9

Welzel, Tatjana, Golhen, Klervi, Atkinson, Andrew, Gotta, Verena, Ternant, David, Kuemmerle-Deschner, Jasmin B., Michler, Christine, Koch, Gilbert, van den Anker, Johannes N., Pfister, Marc, & Woerner, Andreas. (2024). Prospective study to characterize adalimumab exposure in pediatric patients with rheumatic diseases. Pediatric Rheumatology, 22(1). https://doi.org/10.1186/s12969-023-00930-8

Gavel, Gil, Koch, Gilbert, Terrier, Axel, Atkinson, Andrew, Pfister, Marc, & Erb, Thomas. (2024). Understanding time to peak effect of propofol as sole agent on bispectral index in children aged 2–12 years [Journal-article]. Paediatric Anaesthesia, 34(10), 1019–1028. https://doi.org/10.1111/pan.14972

Bräm, D. S., Koch, G., Allegaert, K., van den Anker, J., & Pfister, M. (2024). Applying Neural ODEs to Derive a Mechanism-Based Model for Characterizing Maturation-Related Serum Creatinine Dynamics in Preterm Newborns. Journal of Clinical Pharmacology, 64(9), 1141–1149. https://doi.org/10.1002/jcph.2460

Golhen, Klervi, Buettcher, Michael, Huwyler, Jörg, van den Anker, John, Gotta, Verena, Dao, Kim, Rothuizen, Laura E., Kobylinski, Kevin, & Pfister, Marc. (2024). Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg [Journal-article]. Pharmaceutics, 16(9), 1186. https://doi.org/10.3390/pharmaceutics16091186

Anliker‐Ort, Marion, Rodieux, Frédérique, Ziesenitz, Victoria C., Atkinson, Andrew, Bielicki, Julia A., Erb, Thomas O., Gürtler, Nicolas, Holland‐Cunz, Stefan, Duthaler, Urs, Rudin, Deborah, Haschke, Manuel, van den Anker, John, Pfister, Marc, & Gotta, Verena. (2024). Pharmacokinetics-Based Pediatric Dose Evaluation and Optimization Using Saliva – A Case Study [Journal-article]. Journal of Clinical Pharmacology, 64(7), 810–819. https://doi.org/10.1002/jcph.2428

Pillay-Fuentes Lorente, Veshni, Nwogu-Attah, Jacinta N., Steffens, Britta, Bräm, Dominic, Sprecher, Viviane, Hofmann, Daniela, Buettcher, Michael, Pillai, Goonaseelan, Mouksassi, Samer, Coulibaly, Jean, Pfister, Marc, & Keiser, Jennifer. (2024). Understanding Drug Exposure and Trichuris trichiura Cure Rates: A Pharmacometric Approach for Albendazole-Ivermectin Co-medication in Tanzania and Côte d’Ivoire [Journal-article]. Drugs in R and D, 24(2), 331–340. https://doi.org/10.1007/s40268-024-00476-4

Dao, Kim, Buettcher, Michael, Golhen, Klervi, Kost, Jonas, Schittny, Andreas, Duthaler, Urs, Atkinson, Andrew, Haefliger, David, Guidi, Monia, Bardinet, Carine, Chtioui, Haithem, Boulekbache, Abdelwahab, Buclin, Thierry, Huwyler, Jörg, Pfister, Marc, & Rothuizen, Laura E. (2024). Novel Patient‐Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced Palatability, Controlled Absorption, and Less Variability: High Potential for Pediatric Use [Journal-article]. The Journal of Clinical Pharmacology, 64(10), 1295–1303. https://doi.org/10.1002/jcph.2462

Bräm, Dominic Stefan, Nahum, Uri, Schropp, Johannes, Pfister, Marc, & Koch, Gilbert. (2024). Low-dimensional neural ODEs and their application in pharmacokinetics. Journal of Pharmacokinetics and Pharmacodynamics, 51(2), 123–140. https://doi.org/10.1007/s10928-023-09886-4

Gotta, Verena, Bielicki, Julia Anna, Paioni, Paolo, Csajka, Chantal, Bräm, Dominic Stefan, Berger, Christoph, Giger, Elisabeth, Buettcher, Michael, Posfay-Barbe, Klara M., Van den Anker, John, & Pfister, Marc. (2024). Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology - application to amikacin [Journal-article]. Swiss Medical Weekly, 154(4), 3632. https://doi.org/10.57187/s.3632

Lass, Jana, Leroux, Stephanie, Kõrgvee, Lenne-Triin, Varendi, Heili, Kipper, Karin, Takkis, Kalev, Aro, Rudolf, Metsvaht, Tuuli, Oselin, Kersti, Pfister, Marc, Soeorg, Hiie, van den Anker, Johannes, & Lutsar, Irja. (2024). Pharmacokinetics of oral spironolactone in infants up to 2 years of age. European Journal of Clinical Pharmacology, 80(2), 239–248. https://doi.org/10.1007/s00228-023-03599-w

Leutheuser, Heike, Bartholet, Marc, Marx, Alexander, Pfister, Marc, Burckhardt, Marie-Anne, Bachmann, Sara, & Vogt, Julia E. (2024). Predicting risk for nocturnal hypoglycemia after physical activity in children with type 1 diabetes [Journal-article]. Frontiers in Medicine, 11. https://doi.org/10.3389/fmed.2024.1439218

Gotta, Verena, Bachmann, Sara, Pfister, Marc, & Donner, Birgit. (2023). Characterizing Associations of QTc Interval with Nocturnal Glycemic Control in Children with Type 1 Diabetes. Journal of Clinical Pharmacology, 63(10), 1147–1155. https://doi.org/10.1002/jcph.2301

Anliker-Ort, Marion, Hsin, Chih-hsuan, Krause, Andreas, Pfister, Marc, van den Anker, John, Dingemanse, Jasper, & Kaufmann, Priska. (2023). Modeling time-delayed concentration-QT effects with ACT-1014-6470, a novel oral complement factor 5a receptor 1 (C5a1 receptor) antagonist. Pharmacology Research and Perspectives, 11(4). https://doi.org/10.1002/prp2.1112

Bachmann, Freya, Koch, Gilbert, Bauer, Robert J., Steffens, Britta, Szinnai, Gabor, Pfister, Marc, & Schropp, Johannes. (2023). Computing optimal drug dosing with OptiDose: implementation in NONMEM. Journal of Pharmacokinetics and Pharmacodynamics, 50(3), 173–188. https://doi.org/10.1007/s10928-022-09840-w

Golhen K, Buettcher M, Kost J, Huwyler J, & Pfister M. (2023). Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children. Pharmaceutics, 15(4). https://doi.org/10.3390/pharmaceutics15041033

Golhen, Klervi, Buettcher, Michael, Kost, Jonas, Huwyler, Jörg, & Pfister, Marc. (2023). Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children. Pharmaceutics, 15(4), 1033. https://doi.org/10.3390/pharmaceutics15041033

Smit, C., Engbers, A. G. J., Samiee-Zafarghandy, S., Van Donge, T., Simons, S. H. P., Flint, R. B., Pfister, M., Knibbe, C. A. J., & Van Den Anker, J. N. (2023). Oral Ibuprofen Is More Effective than Intravenous Ibuprofen for Closure of a Patent Ductus Arteriosus: Can Pharmacokinetic Modeling Help Us to Understand Why? Neonatology, 120(1), 81–89. https://doi.org/10.1159/000526210

Marx, Alexander, Di Stefano, Francesco, Leutheuser, Heike, Chin-Cheong, Kieran, Pfister, Marc, Burckhardt, Marie-Anne, Bachmann, Sara, & Vogt, Julia E. (2023). Blood glucose forecasting from temporal and static information in children with T1D. Frontiers in Pediatrics, 11. https://doi.org/10.3389/fped.2023.1296904

Deichmann, Julia, Bachmann, Sara, Burckhardt, Marie-Anne, Pfister, Marc, Szinnai, Gabor, & Kaltenbach, Hans-Michael. (2023). New model of glucose-insulin regulation characterizes effects of physical activity and facilitates personalized treatment evaluation in children and adults with type 1 diabetes. PLoS Computational Biology, 19(2). https://doi.org/10.1371/journal.pcbi.1010289

Otto, Marije E., Burckhardt, Marie-Anne, Szinnai, Gabor, Pfister, Marc, & Gotta, Verena. (2023). Semimechanistic modeling of copeptin and aldosterone kinetics and dynamics in response to rehydration treatment for diabetic ketoacidosis in children. CPT: Pharmacometrics and Systems Pharmacology, 12(2), 207–220. https://doi.org/10.1002/psp4.12891

Buettcher, Michael, Stebler, Anita K., Theiler, Martin, Kobylinski, Kevin, & Pfister, Marc. (2023). National survey in Switzerland calls for improved diagnosis and treatment in children with scabies. Swiss Medical Weekly, 153(11). https://doi.org/10.57187/SMW.2023.40129

Steffens, Britta, Koch, Gilbert, Gächter, Pascal, Claude, Fabien, Gotta, Verena, Bachmann, Freya, Schropp, Johannes, Janner, Marco, l’Allemand, Dagmar, Konrad, Daniel, Welzel, Tatjana, Szinnai, Gabor, & Pfister, Marc. (2023). Clinically practical pharmacometrics computer model to evaluate and personalize pharmacotherapy in pediatric rare diseases: application to Graves’ disease. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1099470

Otto M, Burckhardt MA, Szinnai G, Pfister M, & Gotta V. (2022). Semi- Mechanistic Modeling of Copeptin and Aldosterone Kinetics and Dynamics in Response to Rehydration Treatment for Diabetic Ketoacidosis in Children. CPT: Pharmacometrics & Systems Pharmacology , PSP -2022-0079R1.

Bräm DS, Nahum U, Atkinson A, Koch G, & Pfister M. (2022). Evaluation of machine learning methods for covariate data imputation in pharmacometrics. CPT: Pharmacometrics and Systems Pharmacology, 11(12), 1638–1648. https://doi.org/10.1002/psp4.12874

Nahum U, Refardt J, Chifu I, Fenske WK, Fassnacht M, Szinnai G, Christ-Crain M, & Pfister M. (2022). Machine learning-based algorithm as an innovative approach for the differentiation between diabetes insipidus and primary polydipsia in clinical practice. European Journal of Endocrinology, 187(6), 777–786. https://doi.org/10.1530/EJE-22-0368

Welzel T, Oefelein L, Twilt M, Pfister M, Kuemmerle-Deschner JB, & Benseler SM. (2022). Tapering of biological treatment in autoinflammatory diseases: a scoping review. Pediatric Rheumatology, 20(1), 67. https://doi.org/10.1186/s12969-022-00725-3

Qin L, Zhang N, Ishigami J, Miller ER 3rd, Pfister M, Moran AE, & Cox E. (2022). Dyskalemia risk associated with fixed-dose anti-hypertensive medication combinations. Journal of Human Hypertension, 36(11), 989–995. https://doi.org/10.1038/s41371-021-00600-w

Golhen K, Winskill C, Theiler M, Buettcher M, Yeh YH, Zhang N, Welzel T, & Pfister M. (2022). Understanding efficacy-safety balance of biologics in moderate-to-severe pediatric psoriasis. Frontiers in Medicine, 9, 944208. https://doi.org/10.3389/fmed.2022.944208

Pfiffner, Miriam, Gotta, Verena, Pfister, Marc, Vonbach, Priska, & Berger-Olah, Eva. (2022). Pharmacokinetics and tolerability of intranasal or intravenous administration of nalbuphine in infants. Archives of Disease in Childhood, 108(1), 56–61. https://doi.org/10.1136/archdischild-2022-323807

Koch G, Wilbaux M, Kasser S, Schumacher K, Steffens B, Wellmann S, & Pfister M. (2022). Leveraging Predictive Pharmacometrics-Based Algorithms to Enhance Perinatal Care—Application to Neonatal Jaundice. Frontiers in Pharmacology, 13, 842548. https://doi.org/10.3389/fphar.2022.842548

Royston, Léna, Masouridi-Levrat, Stavroula, Gotta, Verena, Royston, Eva, Pressacco-Brossier, Caroline, Aad, Yasmine Abi, Tonoli, David, Karmime, Abderrahim, Jayo, Murielle, Van Delden, Christian, Lescuyer, Pierre, Pfister, Marc, Chalandon, Yves, & Neofytos, Dionysios. (2022). Therapeutic Drug Monitoring of Orally Administered Letermovir Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplant Recipients. Antimicrobial Agents and Chemotherapy, 66(8). https://doi.org/10.1128/aac.00657-22

Golhen K, Winskill C, Yeh C, Zhang N, Welzel T, & Pfister M. (2022). Value of Literature Review to Inform Development and Use of Biologics in Juvenile Idiopathic Arthritis [Frontiers Media S.A.]. Frontiers in Pediatrics, 10, 909118. https://doi.org/10.3389/fped.2022.909118

Pfiffner, Miriam, Berger-Olah, Eva, Vonbach, Priska, Pfister, Marc, & Gotta, Verena. (2022). Pharmacometric Analysis of Intranasal and Intravenous Nalbuphine to Optimize Pain Management in Infants. Frontiers in Pediatrics, 10. https://doi.org/10.3389/fped.2022.837492

Dao K, Fuchs A, André P, Giannoni E, Decosterd LA, Marchetti O, Asner SA, Pfister M, Widmer N, Buclin T, Csajka C, & Guidi M. (2022). Dosing strategies of imipenem in neonates based on pharmacometric modelling and simulation. Journal of Antimicrobial Chemotherapy, 77(2), 457–465. https://doi.org/10.1093/jac/dkab394

Eugster NS, Corminboeuf F, Koch G, Vogt JE, Sutter T, van Donge T, Pfister M, & Gerull R. (2022). Vaginale Geburt und niedriges Gestationsalter sind Hauptrisikofaktoren für Hypernatriämie bei Frühgeborenen < 32 SSW. Klinische Padiatrie, 234(1), 20–25. https://doi.org/10.1055/a-1443-6208

Hofmann, D., Brussee, J. M., Schulz, J. D., Coulibaly, J. T., Pfister, M., & Keiser, J. (2022). Pharmacokinetic modelling and simulation to optimize albendazole dosing in hookworm- or Trichuris trichiura-infected infants to adults. J Antimicrob Chemother, 77(4), 1082–1093. https://doi.org/10.1093/jac/dkac020

Hofmann, D., Smit, C., Sayasone, S., Pfister, M., & Keiser, J. (2022). Optimizing moxidectin dosing for Strongyloides stercoralis infections: insights from pharmacometric modeling. Clin Transl Sci, 15(3), 700–708. https://doi.org/10.1111/cts.13189

Manduchi, Laura, Marcinkevičs, Ričards, Massi, Michela C., Weikert, Thomas, Sauter, Alexander, Gotta, Verena, Müller, Timothy, Vasella, Flavio, Neidert, Marian C., Pfister, Marc, Stieltjes, Bram, & Vogt, Julia E. (2022). A DEEP VARIATIONAL APPROACH TO CLUSTERING SURVIVAL DATA. ICLR 2022 - 10th International Conference on Learning Representations, null.

Samiee-Zafarghandy S, van Donge T, Fusch G, Pfister M, Jacob G, Atkinson A, Rieder MJ, Smit C, & Van Den Anker J. (2022). Novel strategy to personalise use of ibuprofen for closure of patent ductus arteriosus in preterm neonates. Archives of Disease in Childhood, 107(1), 86–91. https://doi.org/10.1136/archdischild-2020-321381

Smit, C., Hofmann, D., Sayasone, S., Keiser, J., & Pfister, M. (2022). Characterization of the population pharmacokinetics of moxidectin in adults infected with strongyloides stercoralis: support for a fixed-dose treatment regimen. Clinical Pharmacokinetics, 61(1), 123–132. https://doi.org/10.1007/s40262-021-01048-4

Smit, C., Sen, S., von Dach, E., Karmime, A., Lescuyer, P., Tonoli, D., Bielicki, J., Huttner, A., & Pfister, M. (2022). Steering away from current amoxicillin dose reductions in hospitalized patients with impaired kidney function to avoid subtherapeutic drug exposure. Antibiotics (Basel), 11(9), 1190. https://doi.org/10.3390/antibiotics11091190

Ternant D, Pfister M, Le Tilly O, Mulleman D, Picon L, Willot S, Passot C, Bejan-Angoulvant T, Lecomte T, Paintaud G, & Koch G. (2022). Infliximab Treatment Does Not Lead to Full TNF-α Inhibition: A Target-Mediated Drug Disposition Model. Clinical Pharmacokinetics, 61(1), 143–154. https://doi.org/10.1007/s40262-021-01057-3

Tamara Van Donge, Karel Allegaert, Marc Pfister, Anne Smits, & Johannes Nicolaas Van Den Anker. (2021). Creatinine trends to detect ibuprofen-related maturational adverse drug events in neonatal life: a simulation study for the ELBW newborn Creatinine trends during ibuprofen exposure in ELBW newborns. Frontiers in Pharmacology, section Obstetric and Pediatric Pharmacology.

Welzel T, Winskill C, Zhang N, Woerner A, & Pfister M. (2021). Biologic disease modifying antirheumatic drugs and Janus kinase inhibitors in paediatric rheumatology – what we know and what we do not know from randomized controlled trials. Pediatric Rheumatology, 19(1), 46. https://doi.org/10.1186/s12969-021-00514-4

Welzel T, Winskill C, Zhang N, Woerner A, & Pfister M. (2021). Correction to: Biologic disease modifying antirheumatic drugs and Janus kinase inhibitors in paediatric rheumatology – what we know and what we do not know from randomized controlled trials (Pediatric Rheumatology, (2021), 19, 1, (46), 10.1186/s12969-021-00514-4) (Patent No. 1). Pediatric Rheumatology, 19(1), Article 1. https://doi.org/10.1186/s12969-021-00593-3

Koch, Gilbert, Steffens, Britta, Leroux, Stephanie, Gotta, Verena, Schropp, Johannes, Gächter, Pascal, Bachmann, Freya, Welzel, Tatjana, Janner, Marco, L’Allemand, Dagmar, Konrad, Daniel, Szinnai, Gabor, & Pfister, Marc. (2021). Modeling of levothyroxine in newborns and infants with congenital hypothyroidism: challenges and opportunities of a rare disease multi-center study. Journal of Pharmacokinetics and Pharmacodynamics, 48(5), 711–723. https://doi.org/10.1007/s10928-021-09765-w

Gotta V, Marsenic O, Atkinson A, & Pfister M. (2021). Hemodialysis (HD) dose and ultrafiltration rate are associated with survival in pediatric and adolescent patients on chronic HD—a large observational study with follow-up to young adult age. Pediatric Nephrology, 36(8), 2421–2432. https://doi.org/10.1007/s00467-021-04972-6

Tortorici MA, Yuraszeck T, Cornblath D, Bril V, Hartung HP, Sobue G, Lewis RA, Merkies ISJ, Lawo JP, Praus M, Durn BL, Mielke O, Ma X, Jauslin P, Pfister M, van Schaik IN, & PATH study group. (2021). Pharmacometric analysis linking immunoglobulin exposure to clinical efficacy outcomes in chronic inflammatory demyelinating polyneuropathy. CPT: Pharmacometrics and Systems Pharmacology, 10(8), 839–850. https://doi.org/10.1002/psp4.12647

Deichmann, J., Bachmann, S., Pfister, M., Szinnai, G., & Kaltenbach, H.-M. (2021, June 10). A Comprehensive Model of Glucose-Insulin Regulation Including Acute and Prolonged Effects of Physical Activity in Type 1 Diabetes [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.06.09.447693

Koch G, Jost K., Schulzke S.M., Koch R., Pfister M, & Datta AN. (2021). The rhythm of a preterm neonate’s life: ultradian oscillations of heart rate, body temperature and sleep cycles. Journal of Pharmacokinetics and Pharmacodynamics, 48(3), 401–410. https://doi.org/10.1007/s10928-020-09735-8

Maringwa J, Sardu ML, Hang Y, Czerniak R, Vishnubhotla M, Vakilynejad M, & Pfister M. (2021). Characterizing Effects of Antidiabetic Drugs on Heart Rate, Systolic and Diastolic Blood Pressure. Clinical Pharmacology and Therapeutics, 109(6), 1583–1592. https://doi.org/10.1002/cpt.2130

Zheng B, Duffy D, Tricoci P, Kastrissios H, Pfister M, Wright SD, Gille A, & Tortorici MA. (2021). Pharmacometric analyses to characterize the effect of CSL112 on apolipoprotein A-I and cholesterol efflux capacity in acute myocardial infarction patients. British Journal of Clinical Pharmacology, 87(6), 2558–2571. https://doi.org/10.1111/bcp.14666

Bachmann F, Koch G, Pfister M, Szinnai G, & Schropp J. (2021). OptiDose: Computing the Individualized Optimal Drug Dosing Regimen Using Optimal Control. Journal of Optimization Theory and Applications, 189(1), 46–65. https://doi.org/10.1007/s10957-021-01819-w

Leroux S, Biran V, van den Anker J, Gotta V, Zhao W, Zhang D, Jacqz-Aigrain E, & Pfister M. (2021). Serum Creatinine and Serum Cystatin C are Both Relevant Renal Markers to Estimate Vancomycin Clearance in Critically Ill Neonates. Frontiers in Pharmacology, 12, 634686. https://doi.org/10.3389/fphar.2021.634686

van Donge T, Staub E, Atkinson A, Gotta V, van den Anker J, Risch L, Welzel T, & Pfister M. (2021). Corrigendum to: Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents. (Patent No. 5). 59(5), Article 5. https://doi.org/10.1515/cclm-2021-0232

Gotta V, Tancev G, Marsenic O, Vogt JE, & Pfister M. (2021). Identifying key predictors of mortality in young patients on chronic haemodialysis - A machine learning approach. Nephrology Dialysis Transplantation, 36(3), 519–528. https://doi.org/10.1093/ndt/gfaa128

van Donge T, Allegaert K., Gotta V, Smits A, Levtchenko E, Mekahli D, van den Anker J., & Pfister M. (2021). Characterizing dynamics of serum creatinine and creatinine clearance in extremely low birth weight neonates during the first 6 weeks of life. Pediatric Nephrology, 36(3), 649–659. https://doi.org/10.1007/s00467-020-04749-3

van Donge T, Staub E, Atkinson A, Gotta V, van den Anker J, Risch L, Welzel T, & Pfister M. (2021). Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents. Clinical Chemistry and Laboratory Medicine, 59(2), 373–382. https://doi.org/10.1515/cclm-2020-0781

van Donge T, Allegaert K, Pfister M, Smits A, & van den Anker J. (2021). Creatinine Trends to Detect Ibuprofen-Related Maturational Adverse Drug Events in Neonatal Life: A Simulation Study for the ELBW Newborn. Frontiers in Pharmacology, 11, 610294. https://doi.org/10.3389/fphar.2020.610294

Brussee, Janneke M., Hiroshige, Noemi, Neodo, Anna, Coulibaly, Jean T., Pfister, Marc, & Keiser, Jennifer. (2021). Population pharmacokinetics and exposure-response analysis of tribendimidine to improve treatment for children with hookworm infection. Antimicrobial Agents and Chemotherapy, 65(2), e01778–20. https://doi.org/10.1128/aac.01778-20

Brussee, Janneke M., Neodo, Anna, Schulz, Jessica D., Coulibaly, Jean T., Pfister, Marc, & Keiser, Jennifer. (2021). Pharmacometric analysis of tribendimidine mono- and combination therapies to achieve high cure rates in patients with hookworm infections. Antimicrobial Agents and Chemotherapy, 65(2), e00714–20. https://doi.org/10.1128/aac.00714-20

van Donge T, Fuchs A., Leroux S., Pfister M, Rodieux F., Atkinson A, Giannoni E., Van Den Anker J., & Bielicki J. (2021). Amoxicillin Dosing Regimens for the Treatment of Neonatal Sepsis: Balancing Efficacy and Neurotoxicity. Neonatology, 117(5), 619–627. https://doi.org/10.1159/000509751

Wagner-Hattler, Leonie, Kiene, Klara, Bielicki, Julia, Pfister, Marc, Puchkov, Maxim, & Huwyler, Jörg. (2021). High Acceptability of an Orally Dispersible Tablet Formulation by Children. Children, 8(3), 194. https://doi.org/10.3390/children8030194

Burckhardt MA, Gotta V, Beglinger S, Renggli L, Bachmann S, Hess M, Rentsch K, Pfister M, Koch G, Davis EA, Zumsteg U, Jones TW, & Szinnai G. (2020). Copeptin Kinetics and Its Relationship to Osmolality during Rehydration for Diabetic Ketoacidosis in Children. Journal of Clinical Endocrinology and Metabolism, 105(11). https://doi.org/10.1210/clinem/dgaa568

Sarode R, Fukutake K, Yasaka M, Tortorici MA, Mangione A, Pfister M, & Cuker A. (2020). Pharmacometric modeling to explore 4F-PCC dosing strategies for VKA reversal in patients with INR below 2. Blood Advances, 4(17), 4208–4216. https://doi.org/10.1182/BLOODADVANCES.2020002267

Staub E, Urfer-Maurer N, Lemola S, Risch L, Evers KS, Welzel T, & Pfister M. (2020). Comparison of blood pressure and kidney markers between adolescent former preterm infants and term controls. Children, 7(9). https://doi.org/10.3390/children7090141

Mian P, Allegaert K, Conings S, Annaert P, Tibboel D, Pfister M, van Calsteren K, van den Anker JN, & Dallmann A. (2020). Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus. Clinical Pharmacokinetics, 59(7), 911–925. https://doi.org/10.1007/s40262-020-00861-7

Angehrn Z, Haldna L, Zandvliet AS, Gil Berglund E, Zeeuw J, Amzal B, Cheung SYA, Polasek TM, Pfister M, Kerbusch T, & Heckman NM. (2020). Artificial Intelligence and Machine Learning Applied at the Point of Care. Frontiers in Pharmacology, 11, 759. https://doi.org/10.3389/fphar.2020.00759

Gotta V, Leuppi-Taegtmeyer A, Gessler M., Pfister M., Muller D., & Jehle AW. (2020). Intensive Hemodiafiltration Successfully Removes Ganciclovir Overdose and Largely Exceeds Reported Elimination During Hemodialysis—A Case Report and Review of the Literature [Frontiers Media S.A.info@frontiersin.org]. Frontiers in Pharmacology, 11, 882. https://doi.org/10.3389/fphar.2020.00882

Koch G, Schönfeld N, Jost K, Atkinson A, Schulzke SM, Pfister M, & Datta AN. (2020). Caffeine preserves quiet sleep in preterm neonates. Pharmacology Research and Perspectives, 8(3), e00596. https://doi.org/10.1002/prp2.596

Dao K, Guidi M, André P, Giannoni E, Basterrechea S, Zhao W, Fuchs A, Pfister M, Buclin T, & Csajka C. (2020). Optimisation of vancomycin exposure in neonates based on the best level of evidence. Pharmacological Research, 154, 104278. https://doi.org/10.1016/j.phrs.2019.104278

Koch G, Pfister M, Daunhawer I, Wilbaux M, Wellmann S, & Vogt JE. (2020). Pharmacometrics and Machine Learning Partner to Advance Clinical Data Analysis. Clinical Pharmacology and Therapeutics, 107(4), 926–933. https://doi.org/10.1002/cpt.1774

Gotta, Verena, Marsenic, Olivera, & Pfister, Marc. (2020). Understanding the effects of kidney disease and dialysis treatment on pharmacotherapy in children. In Handbook of Experimental Pharmacology (Vol. 261, pp. 209–229). Springer. https://doi.org/10.1007/164_2019_224

Gotta V, Marsenic O, & Pfister M. (2020). Understanding urea kinetic factors that enhance personalized hemodialysis prescription in children. ASAIO Journal, 66(1), 115–123. https://doi.org/10.1097/mat.0000000000000941

Mian P, van den Anker JN, van Calsteren K, Annaert P, Tibboel D, Pfister M, Allegaert K, & Dallmann A. (2020). Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women. Clinical Pharmacokinetics, 59(1), 97–110. https://doi.org/10.1007/s40262-019-00799-5

van Donge T, Evers K, Koch G, van den Anker J, & Pfister M. (2020). Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life. Handbook of Experimental Pharmacology, 261, 325–337. https://doi.org/10.1007/164_2019_210

Ziesenitz VC, Rodieux F, Atkinson A, Borter C, Bielicki JA, Haschke M, Duthaler U, Bachmann F, Erb TO, Gürtler N, Holland-Cunz S, van den Anker JN, Gotta V, & Pfister M. (2019). Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study. European Journal of Clinical Pharmacology, 75(11), 1491–1502. https://doi.org/10.1007/s00228-019-02720-2

Burckhardt, Marie-Anne, Beglinger, Svetlana, Gotta, Verena, Renggli, Luzia, Bachmann, Sara, Hess, Melanie, Rentsch, Katharina, Koch, Gilbert, Zumsteg, Urs, Jones, Timothy, Pfister, Marc, & Szinnai, Gabor. (2019). Copeptin kinetics and its relationship to osmolality during rehydration for diabetic ketoacidosis in children: an observational study. 91, 41–42. KARGER.

van Donge T, Welzel T, Atkinson A, van den Anker J, & Pfister M. (2019). Age-Dependent Changes of Kidney Injury Biomarkers in Pediatrics. Journal of Clinical Pharmacology, 59(S1), S21–S32. https://doi.org/10.1002/jcph.1487

Daunhawer I, Kasser S, Koch G, Sieber L, Cakal H, Tütsch J, Pfister M, Wellmann S, & Vogt JE. (2019). Enhanced early prediction of clinically relevant neonatal hyperbilirubinemia with machine learning. Pediatric Research, 86(1), 122–127. https://doi.org/10.1038/s41390-019-0384-x

van Donge T, Samiee-Zafarghandy S, Pfister M, Koch G, Kalani M, Bordbar A, & van den Anker J. (2019). Methadone dosing strategies in preterm neonates can be simplified. British Journal of Clinical Pharmacology, 85(6), 1348–1356. https://doi.org/10.1111/bcp.13906

Leroux S, van den Anker JN, Smits A, Pfister M, & Allegaert K. (2019). Maturational changes in vancomycin protein binding affect vancomycin dosing in neonates (Patent No. 5). British Journal of Clinical Pharmacology, 85(5), Article 5. https://doi.org/10.1111/bcp.13899

Wilbaux, Mélanie, Kasser, Severin, Gromann, Julia, Mancino, Isabella, Coscia, Tania, Lapaire, Olav, van den Anker, Johannes N, Pfister, Marc, & Wellmann, Sven. (2019). Personalized weight change prediction in the first week of life. Clinical Nutrition, 38(2), 689–696. https://doi.org/10.1016/j.clnu.2018.04.001

Mian, P., Dallmann, A., Conings, S., Annaert, P., Tibboel, D., Pfister, M., van Calsteren, K., van den Anker, J., & Allegaert, K. (2019). PREDICTION FETAL EXPOSURE TO ACETAMINOPHEN AND ITS METABOLITES USING PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING. 105, S26–S26. WILEY.

Mian, P., van den Anker, J., van Calsteren, K., Annaert, P., Tibboel, D., Pfister, M., Allegaert, K., & Dallmann, A. (2019). PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING TO CHARACTERIZE ACETAMINOPHEN TARGET ATTAINMENT AND HEPATOTOXICITY IN NON-PREGNANT AND PREGNANT WOMEN. [WILEY]. 105, S106–S106. https://doi.org/10.1136/archdischild-2019-esdppp.5

Brussee, Janneke M., Schulz, Jessica D., Coulibaly, Jean T., Keiser, Jennifer, & Pfister, Marc. (2019). Ivermectin dosing strategy to achieve equivalent exposure coverage in children and adults. Clinical Pharmacology and Therapeutics, 106(3), 661–667. https://doi.org/10.1002/cpt.1456

Dallmann A, van den Anker J, Pfister M, & Koch G. (2019). Characterization of Maternal and Neonatal Pharmacokinetic Behavior of Ceftazidime. Journal of Clinical Pharmacology, 59(1), 74–82. https://doi.org/10.1002/jcph.1294

Gotta V, Pfister M, & Marsenic O. (2019). Ultrafiltration rates in children on chronic hemodialysis routinely exceed weight based adult limit (Patent No. 1). Hemodialysis International, 23(1), Article 1. https://doi.org/10.1111/hdi.12727

• Bachmann F, Pfister M, Schropp J, & Koch G. (2018). OptiDose: An advanced approach to compute optimal drug dosing schemes for a PKPD model using optimal control theory . American Conference of Pharmacometrics 2018.

• Daunhawer I, Kasser S, Koch G, Pfister M, Wellmann S, Vogt . (2018). Apply machine learning to predict the need for phototherapy in neonates. American Conference of Pharmacometrics 2018.

Imant Daunhawer, Severin Kasser, Gilbert Koch, Marc Pfister, Sven Wellmann, Julia E. Vogt. (2018). Apply machine learning to predict the need for photherapy in neonates . Acop 2018.

• Koch G, Corminboeuf F, Eugster N, Pfister M, Gerull R . (2018). Characterization of postnatal sodium fluctuation in very preterm neonates . Approach Group Europe 2018.

• Verena Gotta, Olivera Marsenic, Marc Pfister. (2018). Modelling of urea clearance in pediatric and young adult patients on chronic hemodialysis. Population Approach Group Europe (PAGE) Meeting, Montreux (Switzerland), 29 May – 1st June, 2018.