· Multimodal molecular tumor profiling for early detection, improved diagnosis, and personalized treatment for ovarian cancer patients
· Novel precision medicine-driven concepts in the treatment and management of ovarian cancer
· Investigator-initiated “out-of-the-box” clinical trials: cost-effectiveness, quality of life, re-use of established medicines and digitalized trial management
· Novel treatment in homologous recombination-deficient (HRD) ovarian cancer in precision medicine
· Re-evaluation of radiotherapy in ovarian cancer
Selected Publications
Dondi, Arthur, Lischetti, Ulrike, Jacob, Francis, Singer, Franziska, Borgsmüller, Nico, Coelho, Ricardo, Aebersold, Rudolf, Ak, Melike, Al-Quaddoomi, Faisal S., Albert, Silvana I., Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beisel, Christian, Bernasconi, Lara, et al. (2023). Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer. Nature Communications, 14. https://doi.org/10.1038/s41467-023-43387-9
Dondi, Arthur, Lischetti, Ulrike, Jacob, Francis, Singer, Franziska, Borgsmüller, Nico, Coelho, Ricardo, Aebersold, Rudolf, Ak, Melike, Al-Quaddoomi, Faisal S., Albert, Silvana I., Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beisel, Christian, Bernasconi, Lara, et al. (2023). Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer. Nature Communications, 14. https://doi.org/10.1038/s41467-023-43387-9
Estermann, Manuela, Coelho, Ricardo, Jacob, Francis, Huang, Yen-Lin, Liang, Ching-Yeu, Faia-Torres, Ana Bela, Septiadi, Dedy, Drasler, Barbara, Karakocak, Bedia Begum, Dijkhoff, Irini Magdelina, Petri-Fink, Alke, Biomaterials, 294. https://doi.org/10.1016/j.biomaterials.2023.121996
, & Rothen-Rutishauser, Barbara. (2023). A 3D multi-cellular tissue model of the human omentum to study the formation of ovarian cancer metastasis.
Estermann, Manuela, Coelho, Ricardo, Jacob, Francis, Huang, Yen-Lin, Liang, Ching-Yeu, Faia-Torres, Ana Bela, Septiadi, Dedy, Drasler, Barbara, Karakocak, Bedia Begum, Dijkhoff, Irini Magdelina, Petri-Fink, Alke, Biomaterials, 294. https://doi.org/10.1016/j.biomaterials.2023.121996
, & Rothen-Rutishauser, Barbara. (2023). A 3D multi-cellular tissue model of the human omentum to study the formation of ovarian cancer metastasis.
Coelho R, Tozzi A, Disler M, Lombardo F, Fedier A, López MN, Freuler F, Jacob F, & Cell Death and Disease, 13(10), 909. https://doi.org/10.1038/s41419-022-05347-x
. (2022). Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer.
Coelho R, Tozzi A, Disler M, Lombardo F, Fedier A, López MN, Freuler F, Jacob F, & Cell Death and Disease, 13(10), 909. https://doi.org/10.1038/s41419-022-05347-x
. (2022). Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer.
Irmisch, Anja, Bonilla, Ximena, Chevrier, Stéphane, Lehmann, Kjong-Van, Singer, Franziska, Toussaint, Nora C., Esposito, Cinzia, Mena, Julien, Milani, Emanuela S., Casanova, Ruben, Stekhoven, Daniel J., Wegmann, Rebekka, Jacob, Francis, Sobottka, Bettina, Goetze, Sandra, Kuipers, Jack, Sarabia del Castillo, Jacobo, Prummer, Michael, Tuncel, Mustafa A., et al. (2021). The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support. Cancer Cell, 39(3), 288–293. https://doi.org/10.1016/j.ccell.2021.01.004
Irmisch, Anja, Bonilla, Ximena, Chevrier, Stéphane, Lehmann, Kjong-Van, Singer, Franziska, Toussaint, Nora C., Esposito, Cinzia, Mena, Julien, Milani, Emanuela S., Casanova, Ruben, Stekhoven, Daniel J., Wegmann, Rebekka, Jacob, Francis, Sobottka, Bettina, Goetze, Sandra, Kuipers, Jack, Sarabia del Castillo, Jacobo, Prummer, Michael, Tuncel, Mustafa A., et al. (2021). The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support. Cancer Cell, 39(3), 288–293. https://doi.org/10.1016/j.ccell.2021.01.004