Prof. Dr. Mariana Borsa

Piletic, K., Kayvanjoo, A. H., Richter, F. C., Borsa, M., Lechuga-Vieco, A. V., Popp, O., Grenet, S., Ko, J. K. L., Luo, L., Zec, K., Kyriazi, M., Haysom, H. K., Koneva, L., Sansom, S., Mertins, P., Powrie, F., Alsaleh, G., & Simon, A. K. (2025). Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling. Nature Communications , 16. https://doi.org/10.1038/s41467-025-64266-5

Kandasamy, M., Andrew, H. F., Raza, I. G., Mitchell, R., Borsa, M., Valvo, S., Ali, M., Kronsteiner, B., Attar, M., & Clarke, A. J. (2025). Glycogen synthase kinase-3 is essential for Treg development and function. Cell Reports, 44. https://doi.org/10.1016/j.celrep.2025.116256

Luo, L., Lechuga-Vieco, A. V., Sattentau, C., Borsa, M., & Simon, A. K. (2025). Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms. EMBO Reports, 26. https://doi.org/10.1038/s44319-025-00536-z

Yazicioglu, Y. F., Marin, E., Andrew, H. F., Bentkowska, K., Johnstone, J. C., Mitchell, R., Wong, Z. Y., Zec, K., Fergusson, J., Borsa, M., Raza, I. G. A., Attar, M., Ali, M., Kronsteiner, B., Furlani, I. L., MacRae, J. I., Devine, M. J., Coles, M., Buckley, C. D., et al. (2024). Asparagine availability controls germinal center B cell homeostasis. Science Immunology, 9. https://doi.org/10.1126/sciimmunol.adl4613

Borsa, M., Obba, S., Richter, F. C., Zhang, H., Riffelmacher, T., Carrelha, J., Alsaleh, G., Jacobsen, S. E. W., & Simon, A. K. (2024). Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism. Autophagy, 20. https://doi.org/10.1080/15548627.2023.2247310

Borsa, M., & Gerlach, C. (2023). Heterologous immunity: innate function of memory CD4+ T cells. Nature Reviews Immunology, 23. https://doi.org/10.1038/s41577-023-00923-4

Gräbnitz, F., Stark, D., Shlesinger, D., Petkidis, A., Borsa, M., Yermanos, A., Carr, A., Barandun, N., Wehling, A., Balaz, M., Schroeder, T., & Oxenius, A. (2023). Asymmetric cell division safeguards memory CD8 T cell development. Cell Reports, 42. https://doi.org/10.1016/j.celrep.2023.112468

Richter, F. C., Friedrich, M., Kampschulte, N., Piletic, K., Alsaleh, G., Zummach, R., Hecker, J., Pohin, M., Ilott, N., Guschina, I., Wideman, S. K., Johnson, E., Borsa, M., Hahn, P., Morriseau, C., Hammock, B. D., Schipper, H. S., Edwards, C. M., Zechner, R., et al. (2023). Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10. EMBO Journal, 42. https://doi.org/10.15252/embj.2022112202

Zhou, D., Borsa, M., Puleston, D. J., Zellner, S., Capera, J., Sanderson, S., Schifferer, M., Hester, S. S., Ge, X., Fischer, R., Jostins, L., Behrends, C., Alsaleh, G., & Simon, A. K. (2022). Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation. Nature Communications , 13. https://doi.org/10.1038/s41467-022-32718-x

Borsa, M., Barandun, N., Gräbnitz, F., Barnstorf, I., Baumann, N. S., Pallmer, K., Baumann, S., Stark, D., Balaz, M., Oetiker, N., Wagen, F., Wolfrum, C., Simon, A. K., Joller, N., Barral, Y., Spörri, R., & Oxenius, A. (2021). Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing. Nature Communications , 12. https://doi.org/10.1038/s41467-021-22954-y

Zhou, D., & Borsa, M. (2021). Sensing extracellular ATP boosts memory T cell commitment. Nature Reviews Immunology, 21. https://doi.org/10.1038/s41577-021-00586-z

Stoycheva, D., Sandu, I., Gräbnitz, F., Amorim, A., Borsa, M., Weber, S., Becher, B., & Oxenius, A. (2021). Non-neutralizing antibodies protect against chronic LCMV infection by promoting infection of inflammatory monocytes in mice. European Journal of Immunology, 51. https://doi.org/10.1002/eji.202049068

Yermanos, A., Neumeier, D., Sandu, I., Borsa, M., Waindok, A. C., Merkler, D., Oxenius, A., & Reddy, S. T. (2021). Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice. Proceedings of the Royal Society B: Biological Sciences, 288. https://doi.org/10.1098/rspb.2020.2793

Zhou, D., Borsa, M., & Simon, A. K. (2021). Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells. Aging Cell, 20. https://doi.org/10.1111/acel.13316

Borsa, M., & Mazet, J. M. (2020). Attacking the defence: SARS-CoV-2 can infect immune cells. Nature Reviews Immunology, 20. https://doi.org/10.1038/s41577-020-00439-1

Richter, F. C., & Borsa, M. (2020). Getting to the (germinal) centre of SARS-CoV-2. Nature Reviews Immunology, 20. https://doi.org/10.1038/s41577-020-00424-8

Barnstorf, I., Welten, S. P. M., Borsa, M., Baumann, N. S., Pallmer, K., Joller, N., Spörri, R., & Oxenius, A. (2020). Chronic viral infections impinge on naive bystander CD8 T cells. Immunity, Inflammation and Disease, 8. https://doi.org/10.1002/iid3.300

Sandu, I., Cerletti, D., Oetiker, N., Borsa, M., Wagen, F., Spadafora, I., Welten, S. P. M., Stolz, U., Oxenius, A., & Claassen, M. (2020). Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection. Cell Reports, 32. https://doi.org/10.1016/j.celrep.2020.108078

Borsa, M., & Simon, A. K. (2020). Fine-tuning stemness. Science, 369. https://doi.org/10.1126/science.abd1431

Bösch, N. M., Borsa, M., Greczmiel, U., Morinaka, B. I., Gugger, M., Oxenius, A., Vagstad, A. L., & Piel, J. (2020). Landornamides: Antiviral Ornithine-Containing Ribosomal Peptides Discovered through Genome Mining. Angewandte Chemie - International Edition, 59. https://doi.org/10.1002/anie.201916321

Yermanos, A., Sandu, I., Pedrioli, A., Borsa, M., Wagen, F., Oetiker, N., Welten, S. P. M., Pallmer, K., Reddy, S. T., & Oxenius, A. (2020). Profiling Virus-Specific Tcf1+ T Cell Repertoires During Acute and Chronic Viral Infection. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.00986

Greczmiel, U., Kräutler, N. J., Borsa, M., Pedrioli, A., Bartsch, I., Richter, K., Agnellini, P., Bedenikovic, G., & Oxenius, A. (2020). LCMV-specific CD4 T cell dependent polyclonal B-cell activation upon persistent viral infection is short lived and extrafollicular. European Journal of Immunology, 50. https://doi.org/10.1002/eji.201948286

Baumann, N. S., Welten, S. P. M., Torti, N., Pallmerid, K., Borsa, M., Barnstorf, I., Oduro, J. D., Cicin-Sain, L., & Oxenius, A. (2019). Early primed KLRG1- CMV-specific t cells determine the size of the inflationary t cell pool. PLoS Pathogens, 15. https://doi.org/10.1371/journal.ppat.1007785

Borsa, M., Barnstorf, I., Baumann, N. S., Pallmer, K., Yermanos, A., Gräbnitz, F., Barandun, N., Hausmann, A., Sandu, I., Barral, Y., & Oxenius, A. (2019). Modulation of asymmetric cell division as a mechanism to boost CD8+ T cell memory. Science Immunology, 4. https://doi.org/10.1126/sciimmunol.aav1730

Barnstorf, I., Borsa, M., Baumann, N., Pallmer, K., Yermanos, A., Joller, N., Spörri, R., Welten, S. P. M., Kräutler, N. J., & Oxenius, A. (2019). Chronic virus infection compromises memory bystander T cell function in an IL-6/ STAT1-dependent manner. Journal of Experimental Medicine, 216. https://doi.org/10.1084/jem.20181589

Pallmer, K., Barnstorf, I., Baumann, N. S., Borsa, M., Jonjic, S., & Oxenius, A. (2019). NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection. PLoS Pathogens, 15. https://doi.org/10.1371/journal.ppat.1007725

Baumann, N. S., Torti, N., Welten, S. P. M., Barnstorf, I., Borsa, M., Pallmer, K., Oduro, J. D., Cicin-Sain, L., Ikuta, K., Ludewig, B., & Oxenius, A. (2018). Tissue maintenance of CMV-specific inflationary memory T cells by IL-15. PLoS Pathogens, 14. https://doi.org/10.1371/journal.ppat.1006993

Borsa, M., Ferreira, P. L. C., Petry, A., Ferreira, L. G. E., Camargo, M. M., Bou-Habib, D. C., & Pinto, A. R. (2015). HIV infection and antiretroviral therapy lead to unfolded protein response activation Retroviruses. Virology Journal, 12. https://doi.org/10.1186/s12985-015-0298-0

Borsa, M., Seibert, C. H., Rosa, R. D., Stoco, P. H., Cargnin-Ferreira, E., Pereira, A. M. L., Grisard, E. C., Zanetti, C. R., & Pinto, A. R. (2011). Detection of infectious myonecrosis virus in penaeid shrimps using immunoassays: Usefulness of monoclonal antibodies directed to the viral major capsid protein. Archives of Virology, 156. https://doi.org/10.1007/s00705-010-0810-1

Seibert, C. H., Borsa, M., Rosa, R. D., Cargnin-Ferreira, E., Pereira, A. M. L., Grisard, E. C., Zanetti, C. R., & Pinto, A. R. (2010). Detection of major capsid protein of infectious myonecrosis virus in shrimps using monoclonal antibodies. Journal of Virological Methods, 169. https://doi.org/10.1016/j.jviromet.2010.07.020

Borsa, M., Lechuga-Vieco, A. V., Kayvanjoo, A. H., Jenkins, E., Yazicioglu, Y., Compeer, E. B., Richter, F. C., Rapp, S., Mitchell, R., Youdale, T., Bui, H., Kuuluvainen, E., Dustin, M. L., Sinclair, L. V., Katajisto, P., & Simon, A. K. (2026). Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment [Journal-article]. Nature Cell Biology, 28. https://doi.org/10.1038/s41556-025-01835-2

Piletic, K., Kayvanjoo, A. H., Richter, F. C., Borsa, M., Lechuga-Vieco, A. V., Popp, O., Grenet, S., Long Ko, J. K., Zec, K., Kyriazi, M., Koneva, L., Sansom, S., Mertins, P., Powrie, F., Alsaleh, G., & Simon, A. K. (2024). Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.09.17.613382

Borsa, M., Lechuga-Vieco, A. V., Kayvanjoo, A. H., Yazicioglu, Y., Compeer, E. B., Richter, F. C., Bui, H., Dustin, M. L., Katajisto, P., & Simon, A. K. (2024). Inheritance of old mitochondria controls early CD8 + T cell fate commitment and is regulated by autophagy [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.01.29.577412

Gräbnitz, F., Stark, D., Shlesinger, D., Petkidis, A., Borsa, M., Yermanos, A., Carr, A., Barandun, N., Wehling, A., Balaz, M., Schroeder, T., & Oxenius, A. (2022). Asymmetric cell division safeguards memory CD8 T cell development [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.11.08.515624

Zhou, D., Borsa, M., Puleston, D. J., Zellner, S., Capera, J., Sanderson, S., Jostins, L., Behrends, C., Alsaleh, G., & Simon, A. K. (2021). Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.12.08.471825

Richter, F. C., Friedrich, M., Kampschulte, N., Pohin, M., Alsaleh, G., Guschina, I., Wideman, S. K., Johnson, E., Borsa, M., Piletic, K., Hahn, P., Schipper, H. S., Edwards, C. M., Zechner, R., Schebb, N. H., Powrie, F., & Simon, A. K. (2021). Adipocyte autophagy limits gut inflammation by controlling oxylipin levels [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.10.25.465200

Hanna, S. J., Codd, A. S., Gea-Mallorqui, E., Scourfield, D. O., Richter, F. C., Ladell, K., Borsa, M., Compeer, E. B., Moon, O. R., Galloway, S. A. E., Dimonte, S., Capitani, L., Shepherd, F. R., Wilson, J. D., Uhl, L. F. K., Ahern, D. J., Almuttaqi, H., Alonzi, D. S., Alrubayyi, A., et al. (2021). T cell phenotypes in COVID-19 - a living review [Journal-article]. Oxford Open Immunology, 2(1). https://doi.org/10.1093/oxfimm/iqaa007

Scourfield, D. O., Reed, S. G., Quastel, M., Alderson, J., Bart, V. M. T., Teijeira Crespo, A., Jones, R., Pring, E., Richter, F. C., Ahern, D. J., Almuttaqi, H., Alonzi, D. S., Alrubayyi, A., Alsaleh, G., Bart, V. M. T., Batchelor, V., Bayliss, R., Berthold, D. L., Bezbradica, J. S., et al. (2021). The role and uses of antibodies in COVID-19 infections: a living review [Journal-article]. Oxford Open Immunology, 2(1). https://doi.org/10.1093/oxfimm/iqab003

Yermanos, A., Neumeier, D., Sandu, I., Borsa, M., Waindok, A. C., Merkler, D., Oxenius, A., & Reddy, S. T. (2020). Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.05.04.077081