Prof. Dr. Mariana Borsa

Borsa, M., Lechuga-Vieco, A. V., Kayvanjoo, A. H., Jenkins, E., Yazicioglu, Y., Compeer, E. B., Richter, F. C., Rapp, S., Mitchell, R., Youdale, T., Bui, H., Kuuluvainen, E., Dustin, M. L., Sinclair, L. V., Katajisto, P., & Simon, A. K. (2025). Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment [Journal-article]. Nature Cell Biology. https://doi.org/10.1038/s41556-025-01835-2

Piletic, K., Kayvanjoo, A. H., Richter, F. C., Borsa, M., Lechuga-Vieco, A. V., Popp, O., Grenet, S., Ko, J. K. L., Luo, L., Zec, K., Kyriazi, M., Haysom, H. K., Koneva, L., Sansom, S., Mertins, P., Powrie, F., Alsaleh, G., & Simon, A. K. (2025). Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling. 16. https://doi.org/10.1038/s41467-025-64266-5

Kandasamy, M., Andrew, H. F., Raza, I. G., Mitchell, R., Borsa, M., Valvo, S., Ali, M., Kronsteiner, B., Attar, M., & Clarke, A. J. (2025). Glycogen synthase kinase-3 is essential for Treg development and function. 44. https://doi.org/10.1016/j.celrep.2025.116256

Luo, L., Lechuga-Vieco, A. V., Sattentau, C., Borsa, M., & Simon, A. K. (2025). Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms. 26. https://doi.org/10.1038/s44319-025-00536-z

Yazicioglu, Y. F., Marin, E., Andrew, H. F., Bentkowska, K., Johnstone, J. C., Mitchell, R., Wong, Z. Y., Zec, K., Fergusson, J., Borsa, M., Raza, I. G. A., Attar, M., Ali, M., Kronsteiner, B., Furlani, I. L., MacRae, J. I., Devine, M. J., Coles, M., Buckley, C. D., et al. (2024). Asparagine availability controls germinal center B cell homeostasis. 9. https://doi.org/10.1126/sciimmunol.adl4613

Piletic, K., Kayvanjoo, A. H., Richter, F. C., Borsa, M., Lechuga-Vieco, A. V., Popp, O., Grenet, S., Long Ko, J. K., Zec, K., Kyriazi, M., Koneva, L., Sansom, S., Mertins, P., Powrie, F., Alsaleh, G., & Simon, A. K. (2024). Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.09.17.613382

Borsa, M., Lechuga-Vieco, A. V., Kayvanjoo, A. H., Yazicioglu, Y., Compeer, E. B., Richter, F. C., Bui, H., Dustin, M. L., Katajisto, P., & Simon, A. K. (2024). Inheritance of old mitochondria controls early CD8 + T cell fate commitment and is regulated by autophagy [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.01.29.577412

Borsa, M., Obba, S., Richter, F. C., Zhang, H., Riffelmacher, T., Carrelha, J., Alsaleh, G., Jacobsen, S. E. W., & Simon, A. K. (2024). Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism. 20. https://doi.org/10.1080/15548627.2023.2247310

Borsa, M., & Gerlach, C. (2023). Heterologous immunity: innate function of memory CD4+ T cells. 23. https://doi.org/10.1038/s41577-023-00923-4

Gräbnitz, F., Stark, D., Shlesinger, D., Petkidis, A., Borsa, M., Yermanos, A., Carr, A., Barandun, N., Wehling, A., Balaz, M., Schroeder, T., & Oxenius, A. (2023). Asymmetric cell division safeguards memory CD8 T cell development. 42. https://doi.org/10.1016/j.celrep.2023.112468

Richter, F. C., Friedrich, M., Kampschulte, N., Piletic, K., Alsaleh, G., Zummach, R., Hecker, J., Pohin, M., Ilott, N., Guschina, I., Wideman, S. K., Johnson, E., Borsa, M., Hahn, P., Morriseau, C., Hammock, B. D., Schipper, H. S., Edwards, C. M., Zechner, R., et al. (2023). Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10. 42. https://doi.org/10.15252/embj.2022112202

Zhou, D., Borsa, M., Puleston, D. J., Zellner, S., Capera, J., Sanderson, S., Schifferer, M., Hester, S. S., Ge, X., Fischer, R., Jostins, L., Behrends, C., Alsaleh, G., & Simon, A. K. (2022). Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation. 13. https://doi.org/10.1038/s41467-022-32718-x

Gräbnitz, F., Stark, D., Shlesinger, D., Petkidis, A., Borsa, M., Yermanos, A., Carr, A., Barandun, N., Wehling, A., Balaz, M., Schroeder, T., & Oxenius, A. (2022). Asymmetric cell division safeguards memory CD8 T cell development [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.11.08.515624

Zhou, D., Borsa, M., Puleston, D. J., Zellner, S., Capera, J., Sanderson, S., Jostins, L., Behrends, C., Alsaleh, G., & Simon, A. K. (2021). Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.12.08.471825

Borsa, M., Barandun, N., Gräbnitz, F., Barnstorf, I., Baumann, N. S., Pallmer, K., Baumann, S., Stark, D., Balaz, M., Oetiker, N., Wagen, F., Wolfrum, C., Simon, A. K., Joller, N., Barral, Y., Spörri, R., & Oxenius, A. (2021). Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing. 12. https://doi.org/10.1038/s41467-021-22954-y

Richter, F. C., Friedrich, M., Kampschulte, N., Pohin, M., Alsaleh, G., Guschina, I., Wideman, S. K., Johnson, E., Borsa, M., Piletic, K., Hahn, P., Schipper, H. S., Edwards, C. M., Zechner, R., Schebb, N. H., Powrie, F., & Simon, A. K. (2021). Adipocyte autophagy limits gut inflammation by controlling oxylipin levels [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.10.25.465200

Zhou, D., & Borsa, M. (2021). Sensing extracellular ATP boosts memory T cell commitment. 21. https://doi.org/10.1038/s41577-021-00586-z

Stoycheva, D., Sandu, I., Gräbnitz, F., Amorim, A., Borsa, M., Weber, S., Becher, B., & Oxenius, A. (2021). Non-neutralizing antibodies protect against chronic LCMV infection by promoting infection of inflammatory monocytes in mice. 51. https://doi.org/10.1002/eji.202049068

Yermanos, A., Neumeier, D., Sandu, I., Borsa, M., Waindok, A. C., Merkler, D., Oxenius, A., & Reddy, S. T. (2021). Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice. 288. https://doi.org/10.1098/rspb.2020.2793

Zhou, D., Borsa, M., & Simon, A. K. (2021). Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells. 20. https://doi.org/10.1111/acel.13316

Hanna, S. J., Codd, A. S., Gea-Mallorqui, E., Scourfield, D. O., Richter, F. C., Ladell, K., Borsa, M., Compeer, E. B., Moon, O. R., Galloway, S. A. E., Dimonte, S., Capitani, L., Shepherd, F. R., Wilson, J. D., Uhl, L. F. K., Ahern, D. J., Almuttaqi, H., Alonzi, D. S., Alrubayyi, A., et al. (2021). T cell phenotypes in COVID-19 - a living review [Journal-article]. Oxford Open Immunology, 2(1). https://doi.org/10.1093/oxfimm/iqaa007

Scourfield, D. O., Reed, S. G., Quastel, M., Alderson, J., Bart, V. M. T., Teijeira Crespo, A., Jones, R., Pring, E., Richter, F. C., Ahern, D. J., Almuttaqi, H., Alonzi, D. S., Alrubayyi, A., Alsaleh, G., Bart, V. M. T., Batchelor, V., Bayliss, R., Berthold, D. L., Bezbradica, J. S., et al. (2021). The role and uses of antibodies in COVID-19 infections: a living review [Journal-article]. Oxford Open Immunology, 2(1). https://doi.org/10.1093/oxfimm/iqab003

Borsa, M., & Mazet, J. M. (2020). Attacking the defence: SARS-CoV-2 can infect immune cells. 20. https://doi.org/10.1038/s41577-020-00439-1

Richter, F. C., & Borsa, M. (2020). Getting to the (germinal) centre of SARS-CoV-2. 20. https://doi.org/10.1038/s41577-020-00424-8

Barnstorf, I., Welten, S. P. M., Borsa, M., Baumann, N. S., Pallmer, K., Joller, N., Spörri, R., & Oxenius, A. (2020). Chronic viral infections impinge on naive bystander CD8 T cells. 8. https://doi.org/10.1002/iid3.300

Sandu, I., Cerletti, D., Oetiker, N., Borsa, M., Wagen, F., Spadafora, I., Welten, S. P. M., Stolz, U., Oxenius, A., & Claassen, M. (2020). Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection. 32. https://doi.org/10.1016/j.celrep.2020.108078

Borsa, M., & Simon, A. K. (2020). Fine-tuning stemness. 369. https://doi.org/10.1126/science.abd1431

Bösch, N. M., Borsa, M., Greczmiel, U., Morinaka, B. I., Gugger, M., Oxenius, A., Vagstad, A. L., & Piel, J. (2020). Landornamides: Antiviral Ornithine-Containing Ribosomal Peptides Discovered through Genome Mining. 59. https://doi.org/10.1002/anie.201916321

Yermanos, A., Sandu, I., Pedrioli, A., Borsa, M., Wagen, F., Oetiker, N., Welten, S. P. M., Pallmer, K., Reddy, S. T., & Oxenius, A. (2020). Profiling Virus-Specific Tcf1+ T Cell Repertoires During Acute and Chronic Viral Infection. 11. https://doi.org/10.3389/fimmu.2020.00986

Yermanos, A., Neumeier, D., Sandu, I., Borsa, M., Waindok, A. C., Merkler, D., Oxenius, A., & Reddy, S. T. (2020). Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.05.04.077081

Greczmiel, U., Kräutler, N. J., Borsa, M., Pedrioli, A., Bartsch, I., Richter, K., Agnellini, P., Bedenikovic, G., & Oxenius, A. (2020). LCMV-specific CD4 T cell dependent polyclonal B-cell activation upon persistent viral infection is short lived and extrafollicular. 50. https://doi.org/10.1002/eji.201948286

Baumann, N. S., Welten, S. P. M., Torti, N., Pallmerid, K., Borsa, M., Barnstorf, I., Oduro, J. D., Cicin-Sain, L., & Oxenius, A. (2019). Early primed KLRG1- CMV-specific t cells determine the size of the inflationary t cell pool. 15. https://doi.org/10.1371/journal.ppat.1007785

Borsa, M., Barnstorf, I., Baumann, N. S., Pallmer, K., Yermanos, A., Gräbnitz, F., Barandun, N., Hausmann, A., Sandu, I., Barral, Y., & Oxenius, A. (2019). Modulation of asymmetric cell division as a mechanism to boost CD8+ T cell memory. 4. https://doi.org/10.1126/sciimmunol.aav1730

Barnstorf, I., Borsa, M., Baumann, N., Pallmer, K., Yermanos, A., Joller, N., Spörri, R., Welten, S. P. M., Kräutler, N. J., & Oxenius, A. (2019). Chronic virus infection compromises memory bystander T cell function in an IL-6/ STAT1-dependent manner. 216. https://doi.org/10.1084/jem.20181589

Pallmer, K., Barnstorf, I., Baumann, N. S., Borsa, M., Jonjic, S., & Oxenius, A. (2019). NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection. 15. https://doi.org/10.1371/journal.ppat.1007725

Baumann, N. S., Torti, N., Welten, S. P. M., Barnstorf, I., Borsa, M., Pallmer, K., Oduro, J. D., Cicin-Sain, L., Ikuta, K., Ludewig, B., & Oxenius, A. (2018). Tissue maintenance of CMV-specific inflationary memory T cells by IL-15. 14. https://doi.org/10.1371/journal.ppat.1006993

Borsa, M., Ferreira, P. L. C., Petry, A., Ferreira, L. G. E., Camargo, M. M., Bou-Habib, D. C., & Pinto, A. R. (2015). HIV infection and antiretroviral therapy lead to unfolded protein response activation Retroviruses. 12. https://doi.org/10.1186/s12985-015-0298-0

Borsa, M., Seibert, C. H., Rosa, R. D., Stoco, P. H., Cargnin-Ferreira, E., Pereira, A. M. L., Grisard, E. C., Zanetti, C. R., & Pinto, A. R. (2011). Detection of infectious myonecrosis virus in penaeid shrimps using immunoassays: Usefulness of monoclonal antibodies directed to the viral major capsid protein. 156. https://doi.org/10.1007/s00705-010-0810-1

Seibert, C. H., Borsa, M., Rosa, R. D., Cargnin-Ferreira, E., Pereira, A. M. L., Grisard, E. C., Zanetti, C. R., & Pinto, A. R. (2010). Detection of major capsid protein of infectious myonecrosis virus in shrimps using monoclonal antibodies. 169. https://doi.org/10.1016/j.jviromet.2010.07.020