Prof. Dr. Primo Leo Schär

Künstle, Noëmi, Gorlanova, Olga, Marten, Andrea, Müller, Loretta, Sharma, Pawan, Röösli, Martin, Sinues, Pablo, Schär, Primo, Schürmann, David, Rüttimann, Céline, Da Silva Sena, Carla Rebeca, Nahum, Uri, Usemann, Jakob, Steinberg, Ruth, Yammine, Sophie, Schulzke, Sven, Latzin, Philipp, Frey, Urs, & , on behalf of the BILD study group. (2024). Differences in autophagy marker levels at birth in preterm vs. term infants [Journal-article]. Pediatric Research. https://doi.org/10.1038/s41390-024-03273-6

Schwarz, Simon D., Xu, Jianming, Gunasekera, Kapila, Schürmann, David, Vågbø, Cathrine B., Ferrari, Elena, Slupphaug, Geir, Hottiger, Michael O., Schär, Primo, & Steinacher, Roland. (2024). Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation [Journal-article]. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44209-8

Krawczyk, C., Bentele, M., Latypov, V., Woolcock, K., Noreen, F., Fritsch, O., & Schär, P. (2023, March 7). Uracil Repair - A Source of DNA Glycosylase Dependent Genome Instability [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.03.07.530818

Fischer, V., Kretschmer, M., Germain, P.-L., Kaur, J., Mompart-Barrenechea, S., Pelczar, P., Schürmann, D., Schär, P., & Gapp, K. (2023). Sperm chromatin accessibility’s involvement in the intergenerational effects of stress hormone receptor activation. Translational Psychiatry, 13. https://doi.org/10.1038/s41398-023-02684-z

Kim, Jihee, Nath, Kirti, Schmidlin, Kurt, Schaufelberger, Helen, Quattropani, Christiana, Vannini, Simone., Mossi, Sandro, Thumshirn, Miriam, Manz, Michael, Litichevskiy, Lev, Fan, Jiaxin, Dmitrieva-Posocco, Oxana, Li, Mingyao, Levy, Maayan, Schär, Primo, Zwahlen, Marcel, Thaiss, Christoph A., & Truninger, Kaspar. (2023). Hierarchical contribution of individual lifestyle factors and their interactions on adenomatous and serrated polyp risk. Journal of Gastroenterology, 58, 856–867. https://doi.org/10.1007/s00535-023-02004-8

Noreen F, Chaber-Ciopinska A, Regula J, Schär P, & Truninger K. (2020). Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging. Clinical Epigenetics, 12(1), 164. https://doi.org/10.1186/s13148-020-00956-9

Schwarz, Simon D., Grundbacher, Eliane, Hrovat, Alexandra M., Xu, Jianming, Kuśnierczyk, Anna, Vågbø, Cathrine B., Schär, Primo, & Schuermann, David. (2020). Inducible TDG knockout models to study epigenetic regulation [Journal-article]. In F1000Research (Vol. 9). https://doi.org/10.12688/f1000research.25637.1

Schuermann, David, Ziemann, Christina, Barekati, Zeinab, Capstick, Myles, Oertel, Antje, Focke, Frauke, Murbach, Manuel, Kuster, Niels, Dasenbrock, Clemens, & Schär, Primo. (2020). Assessment of genotoxicity in human cells exposed to modulated electromagnetic fields of wireless communication devices. Genes, 11(4). https://doi.org/10.3390/genes11040347

Schwarz Simon D., Grundbacher Elieane, Hrovat Alexandra M., Xu Jianming, Kuśnierczyk Anna, Vågbø Cathrine B, Schär Primo, & Schuermann David. (2020). Inducible TDG knockout models to study epigenetic regulation. F1000Research, 9, 1112. https://doi.org/10.12688/f1000research.25637.2

Noreen F, Küng T, Tornillo L, Parker H, Silva M, Weis S, Marra G, Rad R, Truninger K, & Schär P. (2019). DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways. Clinical Epigenetics, 11(1), 196. https://doi.org/10.1186/s13148-019-0791-1

Bachmann C, Noreen F, Voermans NC, Schär PL, Vissing J, Fock JM, Bulk S, Kusters B, Moore SA, Beggs AH, Mathews KD, Meyer M, Genetti CA, Meola G, Cardani R, Mathews E, Jungbluth H, Muntoni F, Zorzato F, & Treves S. (2019). Aberrant regulation of epigenetic modifiers contributes to the pathogenesis in patients with selenoprotein N-related myopathies. Human Mutation, 40(7), 962–974. https://doi.org/10.1002/humu.23745

Tièche CC, Gao Y, Bührer ED, Hobi N, Berezowska SA, Wyler K, Froment L, Weis S, Peng RW, Bruggmann R, Schär P, Amrein MA, Hall SRR, Dorn P, Kocher G, Riether C, Ochsenbein A, Schmid RA, & Marti TM. (2019). Tumor Initiation Capacity and Therapy Resistance Are Differential Features of EMT-Related Subpopulations in the NSCLC Cell Line A549. Neoplasia (United States), 21(2), 185–196. https://doi.org/10.1016/j.neo.2018.09.008

Steinacher, Roland, Barekati, Zeinab, Botev, Petar, Kuśnierczyk, Anna, Slupphaug, Geir, & Schär, Primo. (2019). SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation. EMBO Journal, 38(1). https://doi.org/10.15252/embj.201899242

Manser, Melissa, Sater, Mohamad R. Abdul, Schmid, Christoph D., Noreen, Faiza, Murbach, Manuel, Kuster, Niels, Schuermann, David, & Schär, Primo. (2017). ELF-MF exposure affects the robustness of epigenetic programming during granulopoiesis. Scientific Reports, 7, 43345. https://doi.org/10.1038/srep43345

Weber, Alain R, Schär,Primo Leo, & Schuermann, David. (2017). Base Excision Repair and Epigenetic Regulation. In David M Wilson III (ed.), The Base Excision Repair Pathway (pp. 391–419). World Scientific. https://doi.org/10.1142/9789814719735_0011

Weber A.R., Schar P., & Schuermann D. (2016). Base excision repair and epigenetic regulation (pp. 391–419). Taylor and Francis Inc.

Liu, Y., Duong, W., Krawczyk, C., Bretschneider, N., Borbely, G., Varshney, M., Zinser, C., Schar, P., & Ruegg, J. (2016). Oestrogen receptor beta regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase. Epigenetics Chromatin, 9, 7. https://doi.org/10.1186/s13072-016-0055-7

Liu Y, Duong W, Krawczyk C, Bretschneider N, Borbély G, Varshney M, Zinser C, Schär P, & Rüegg J. (2016). Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase. Epigenetics & chromatin, 9, 7. https://doi.org/10.1186/s13072-016-0055-7

Schuermann, David., Weber, Alain R., & Schar, Primo. (2016). Active DNA demethylation by DNA repair: Facts and uncertainties. DNA Repair, 44, 92–102. https://doi.org/10.1016/j.dnarep.2016.05.013

Schuermann, D., Scheidegger, S. P., Weber, A. R., Bjoras, M., Leumann, C. J., & Schar, P. (2016). 3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair. Nucleic Acids Res, 44(5), 2187–2198. https://doi.org/10.1093/nar/gkv1520

Schüz, J., Dasenbrock, C., Ravazzani, P., Röösli, M., Schär, P., Bounds, P. L., Erdmann, F., Borkhardt, A., Cobaleda, C., Fedrowitz, M., Hamnerius, Y., Sanchez-Garcia, I., Seger, R., Schmiegelow, K., Ziegelberger, G., Capstick, M., Manser, M., Müller, M., SChmid, C. D., et al. (2016). Extremely low-frequency magnetic fields and risk of childhood leukemia : a risk assessment by the ARIMMORA consortium. Bioelectromagnetics, 37(3), 183–189. https://doi.org/10.1002/bem.21963

Weber, A. R., Krawczyk, C., Robertson, A. B., Kusnierczyk, A., Vagbo, C. B., Schuermann, D., Klungland, A., & Schar, P. (2016). Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun, 7, 10806. https://doi.org/10.1038/ncomms10806

Li, Zheng, Gu, Tian-Peng, Weber, Alain R., Shen, Jia-Zhen, Li, Bin-Zhong, Xie, Zhi-Guo, Yin, Ruichuan, Guo, Fan, Liu, Xiaomeng, Tang, Fuchou, Wang, Hailin, Schär, Primo, & Xu, Guo-Liang. (2015). Gadd45a promotes DNA demethylation through TDG. Nucleic Acids Research, 43(8), 3986–3997. https://doi.org/10.1093/nar/gkv283

Krawczyk, C., Dion, V., Schär, P., & Fritsch, O. (2014). Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability. Nucleic Acids Research, 42(8), 4985–4995. https://doi.org/10.1093/nar/gku148

Noreen, Faiza, Röösli, Martin, Gaj, Pawel, Pietrzak, Jakub, Weis, Stefan, Urfer, Patric, Regula, Jaroslaw, Schär, Primo, & Truninger, Kaspar. (2014). Modulation of age- and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle. Journal of the National Cancer Institute, 106(7), dju161. https://doi.org/10.1093/jnci/dju161

Pfaffeneder, Toni, Spada, Fabio, Wagner, Mirko, Brandmayr, Caterina, Laube, Silvia K, Eisen, David, Truss, Matthias, Steinbacher, Jessica, Hackner, Benjamin, Kotljarova, Olga, Schuermann, David, Michalakis, Stylianos, Kosmatchev, Olesea, Schiesser, Stefan, Steigenberger, Barbara, Raddaoui, Nada, Kashiwazaki, Gengo, Müller, Udo, Spruijt, Cornelia G, et al. (2014). Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA. Nature Chemical Biology, 10(7), 574–581. https://doi.org/10.1038/nchembio.1532

Weber, A. R., Schuermann, D., & Schär, P. (2014). Versatile recombinant SUMOylation system for the production of SUMO-modified protein. PLoS ONE, 9(7), e102157. https://doi.org/10.1371/journal.pone.0102157

Capstick, Myles, Schär, Primo, Schuermann, David, Romann, Albert, & Kuster, Niels. (2013). ELF exposure system for live cell imaging. Bioelectromagnetics, 34(3), 231–239. https://doi.org/10.1002/bem.21751

Talhaoui, Ibtissam, Couve, Sophie, Ishchenko, Alexander A., Kunz, Christophe, Schär, Primo, & Saparbaev, Murat. (2013). 7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases. Nucleic Acids Research, 41(2), 912–923. https://doi.org/10.1093/nar/gks1149

Jacobs, Angelika L, & Schär, Primo. (2012). DNA glycosylases: in DNA repair and beyond. Chromosoma, 121(1), 1–20. https://doi.org/10.1007/s00412-011-0347-4

Wilson, Gareth A, Dhami, Pawandeep, Feber, Andrew, Cortázar, Daniel, Suzuki, Yuka, Schulz, Reiner, Schär, Primo, & Beck, Stephan. (2012). Resources for methylome analysis suitable for gene knockout studies of potential epigenome modifiers. GigaScience, 1(1), 3. https://doi.org/10.1186/2047-217x-1-3

Cortázar, Daniel, Kunz, Christophe, Selfridge, Jim, Lettieri, Teresa, Saito, Yusuke, MacDougall, Eilidh, Wirz, Annika, Schuermann, David, Jacobs, Angelika L, Siegrist, Fredy, Steinacher, Roland, Jiricny, Josef, Bird, Adrian, & Schär, Primo. (2011). Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature, 470(7334), 419–423. https://doi.org/10.1038/nature09672

Schär, Primo, & Fritsch, Olivier. (2011). DNA repair and the control of DNA methylation. Progress in Drug Research, 67, 51–68. https://doi.org/10.1007/978-3-7643-8989-5_3

Schär, P. (2010). Reply to the Letter to the Editor. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 692(1-2), 63–64. https://doi.org/10.1016/j.mrfmmm.2010.08.002

Focke, Frauke, Schuermann, David, Kuster, Niels, & Schär, Primo. (2010). DNA fragmentation in human fibroblasts under extremely low frequency electromagnetic field exposure. Mutation Research, 683(1-2), 74–83. https://doi.org/10.1016/j.mrfmmm.2009.10.012

Fritsch, Olivier, Burkhalter, Martin D, Kais, Sanja, Sogo, José M, & Schär, Primo. (2010). DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier. DNA Repair, 9(8), 879–888. https://doi.org/10.1016/j.dnarep.2010.05.003

Kunz, Christophe, Focke, Frauke, Saito, Yusuke, Schuermann, David, Lettieri, Teresa, Selfridge, Jim, & Schär, Primo. (2009). Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil. PLoS Biology, 7(4). https://doi.org/10.1371/journal.pbio.1000091

Kunz, C, Saito, Y, & Schär, P. (2009). DNA Repair in mammalian cells: mismatched repair : variations on a theme [Review of DNA Repair in mammalian cells: mismatched repair : variations on a theme]. Cellular and Molecular Life Sciences, 66, Article 6. https://doi.org/10.1007/s00018-009-8739-9

Menigatti, M, Truninger, K, Gebbers, J-O, Marbet, U, Marra, G, & Schär, P. (2009). Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters. Oncogene, 28(6), 899–909. https://doi.org/10.1038/onc.2008.444

Messner, Simon, Schuermann, David, Altmeyer, Matthias, Kassner, Ingrid, Schmidt, Darja, Schär, Primo, Müller, Stefan, & Hottiger, Michael O. (2009). Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function. The FASEB Journal, 23(11), 3978–3989. https://doi.org/10.1096/fj.09-137695

Menigatti M, Pedroni M, Verrone AM, Borghi F, Scarselli A, Benatti P, Losi L, Di Gregorio C, Schär P, Marra G, Ponz de Leon M, & Roncucci L. (2007). O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis. Oncology reports, 17(6), 1421–1427.

Cortázar, Daniel, Kunz, Christophe, Saito, Yusuke, Steinacher, Roland, & Schär, Primo. (2007). The enigmatic thymine DNA glycosylase. DNA Repair, 6(4), 489–504. https://doi.org/10.1016/j.dnarep.2006.10.013

Hardeland, Ulrike, Kunz, Christophe, Focke, Frauke, Szadkowski, Marta, & Schär, Primo. (2007). Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2. Nucleic Acids Research, 35(11), 3859–3867. https://doi.org/10.1093/nar/gkm337

Herrmann, Gernot, Kais, Sanja, Hoffbauer, Jan, Shah-Hosseini, Kijwasch, Brüggenolte, Nicole, Schober, Heiko, Fäsi, Margaret, & Schär, Primo. (2007). Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism. Nucleic Acids Research, 35(7), 2321–2332. https://doi.org/10.1093/nar/gkm127

Menigatti, Mirco, Pedroni, Monica, Verrone, Anna Maria, Borghi, Francesca, Scarselli, Alessandra, Benatti, Piero, Losi, Lorena, Di Gregorio, Carmela, Schär, Primo, Marra, Giancarlo, Ponz de Leon, Maurizio, & Roncucci, Luca. (2007). O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis. Oncology Reports, 17(6), 1421–1427. https://doi.org/10.3892/or.17.6.1421

Menigatti M., Pedroni M., Verrone A.M., Borghi F., Scarselli A., Benatti P., Losi L., Di Gregorio C., Schar P., Marra G., Ponz De Leon M., & Roncucci L. (2007). O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis. Oncology Reports, 17(6), 1421–1427. https://doi.org/10.3892/or.17.6.1421

El-Andaloussi, Nazim, Valovka, Taras, Toueille, Magali, Steinacher, Roland, Focke, Frauke, Gehrig, Peter, Covic, Marcela, Hassa, Paul O, Schär, Primo, Hübscher, Ulrich, & Hottiger, Michael O. (2006). Arginine methylation regulates DNA polymerase beta. Molecular Cell, 22(1), 51–62. https://doi.org/10.1016/j.molcel.2006.02.013

Borys-Brzywczy E, Arczewska KD, Saparbaev M, Hardeland U, Schär P, & Kuśmierek JT. (2005). Mismatch dependent uracil/thymine-DNA glycosylases excise exocyclic hydroxyethano and hydroxypropano cytosine adducts. Acta biochimica Polonica, 52(1), 149–165. https://doi.org/055201149

Cejka, Petr, Mojas, Nina, Gillet, Ludovic, Schär, Primo, & Jiricny, Josef. (2005). Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae. Current Biology, 15(15), 1395–1400. https://doi.org/10.1016/j.cub.2005.07.032

Lucey, Marie J., Chen, Dongsheng, Lopez-Garcia, Jorge, Hart, Stephen M., Phoenix, Fladia, Al-Jehani, Rajai, Alao, John P., White, Roger, Kindle, Karin B., Losson, Régine, Chambon, Pierre, Parker, Malcolm G., Schär, Primo, Heery, David M., Buluwela, Lakjaya, & Ali, Simak. (2005). T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif. Nucleic Acids Research, 33(19), 6393–6404. https://doi.org/10.1093/nar/gki940

Steinacher, Roland, & Schär, Primo. (2005). Functionality of human thymine DNA glycosylase requires SUMO-regulated changes in protein conformation. Current Biology, 15(7), 616–623. https://doi.org/10.1016/j.cub.2005.02.054

Truninger, Kaspar, Menigatti, Mirco, Luz, Judith, Russell, Anna, Haider, Ritva, Gebbers, Jan-Olaf, Bannwart, Fridolin, Yurtsever, Hueseyin, Neuweiler, Joerg, Riehle, Hans-Martin, Cattaruzza, Maria Sofia, Heinimann, Karl, Schär, Primo, Jiricny, Josef, & Marra, Giancarlo. (2005). Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer. Gastroenterology, 128(5), 1160–1171. https://doi.org/10.1053/j.gastro.2005.01.056

Fleck, Oliver, & Schär, Primo. (2004). Translesion DNA synthesis : little fingers teach tolerance. Current Biology, 14(10), R389–91. https://doi.org/10.1016/j.cub.2004.05.014

Kunz, Christophe, & Schär, Primo. (2004). Meiotic recombination: sealing the partnership at the junction. Current Biology, 14(22), R962–4. https://doi.org/10.1016/j.cub.2004.10.043

Schär, Primo, Fäsi, Margaret, & Jessberger, Rolf. (2004). SMC1 coordinates DNA double-strand break repair pathways. Nucleic Acids Research, 32(13), 3921–3929. https://doi.org/10.1093/nar/gkh716

Springer, Burkhard, Sander, Peter, Sedlacek, Ludwig, Hardt, Wolf-Dietrich, Mizrahi, Valerie, Schär, Primo, & Böttger, Erik C. (2004). Lack of mismatch correction facilitates genome evolution in mycobacteria. Molecular Microbiology, 53(6), 1601–1609. https://doi.org/10.1111/j.1365-2958.2004.04231.x

Chen, Dongsheng, Lucey, Marie J, Phoenix, Fladia, Lopez-Garcia, Jorge, Hart, Stephen M, Losson, Régine, Buluwela, Lakjaya, Coombes, R Charles, Chambon, Pierre, Schär, Primo, & Ali, Simak. (2003). T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. Journal of Biological Chemistry, 278(40), 38586–38592. https://doi.org/10.1074/jbc.m304286200

Hardeland, Ulrike, Bentele, Marc, Jiricny, Josef, & Schär, Primo. (2003). The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs. Nucleic Acids Research, 31(9), 2261–2271. https://doi.org/10.1093/nar/gkg344

Wellinger, Ralf Erik, Schär, Primo, & Sogo, Jose M. (2003). Rad52-independent accumulation of joint circular minichromosomes during S phase in Saccharomyces cerevisiae. Molecular and Cellular Biology, 23(18), 6363–6372. https://doi.org/10.1128/mcb.23.18.6363-6372.2003

Hardeland, Ulrike, Steinacher, Roland, Jiricny, Josef, & Schär, Primo. (2002). Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. The EMBO Journal, 21(6), 1456–1464. https://doi.org/10.1093/emboj/21.6.1456

Hasan, Sameez, El-Andaloussi, Nazim, Hardeland, Ulrike, Hassa, Paul O, Bürki, Christine, Imhof, Ralph, Schär, Primo, & Hottiger, Michael O. (2002). Acetylation regulates the DNA end-trimming activity of DNA polymerase beta. Molecular Cell, 10(5), 1213–1222. https://doi.org/10.1016/s1097-2765(02)00745-1

Schar, P. (2001). Spontaneous DNA damage, genome instability, and cancer - When DNA replication escapes control. CELL, 104, 329–332.

Hardeland U, Bentele M, Lettieri T, Steinacher R, Jiricny J, & Schär P. (2001). Thymine DNA glycosylase. Progress in nucleic acid research and molecular biology, 68, 235–253. https://doi.org/10.1016/s0079-6603(01)68103-0

Hardeland, U, Bentele, M, Lettieri, T, Steinacher, R, Jiricny, J, & Schär, P. (2001). Thymine DNA glycosylase. Progress in Nucleic Acid Research and Molecular Biology, 68, 235–253. https://doi.org/10.1016/s0079-6603(01)68103-0

Sartori, A A, Schär, P, Fitz-Gibbon, S, Miller, J H, & Jiricny, J. (2001). Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum. Journal of Biological Chemistry, 276(32), 29979–29986. https://doi.org/10.1074/jbc.m102985200

Schär, P. (2001). Spontaneous DNA damage, genome instability, and cancer - when DNA replication escapes control [Review of Spontaneous DNA damage, genome instability, and cancer - when DNA replication escapes control]. Cell, 104, Article 3. https://doi.org/10.1016/s0092-8674(01)00220-3

Valencia, M, Bentele, M, Vaze, M B, Herrmann, G, Kraus, E, Lee, S E, Schär, P, & Haber, J E. (2001). NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature, 414(6864), 666–669. https://doi.org/10.1038/414666a

Hardeland, U, Bentele, M, Jiricny, J, & Schär, P. (2000). Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis. Journal of Biological Chemistry, 275(43), 33449–33456. https://doi.org/10.1074/jbc.m005095200

Marra G, & Schär P. (1999). Recognition of DNA alterations by the mismatch repair system. The Biochemical journal, 338 ( Pt 1)(Pt 1), 1–13.

Fleck, O, Lehmann, E, Schär, P, & Kohli, J. (1999). Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair. Nature Genetics, 21(3), 314–317. https://doi.org/10.1038/6838

Marra, G, & Schär, P. (1999). Recognition of DNA alterations by the mismatch repair system. The Biochemical Journal, 338 ( Pt 1), 1–13.

Räschle, M, Marra, G, Nyström-Lahti, M, Schär, P, & Jiricny, J. (1999). Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. Journal of Biological Chemistry, 274(45), 32368–32375. https://doi.org/10.1074/jbc.274.45.32368

Herrmann G, Lindahl T, & Schär P. (1998). Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4. The EMBO journal, 17(14), 4188–4198. https://doi.org/10.1093/emboj/17.14.4188

Schär P, Baur M, Schneider C, & Kohli J. (1997). Mismatch repair in Schizosaccharomyces pombe requires the mutL homologous gene pms1: molecular cloning and functional analysis. Genetics, 146(4), 1275–1286. https://doi.org/10.1093/genetics/146.4.1275

Schär P, Herrmann G, Daly G, & Lindahl T. (1997). A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks. Genes & development, 11(15), 1912–1924. https://doi.org/10.1101/gad.11.15.1912

Jessberger R, Schär P, Robins P, Ferrari E, Riwar B, & Hübscher U. (1997). Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: up-regulation of DNA polymerase delta. Nucleic acids research, 25(2), 289–296. https://doi.org/10.1093/nar/25.2.289

Lindahl T, Barnes DE, Klungland A, Mackenney VJ, & Schär P. (1997). Repair and processing events at DNA ends. Ciba Foundation symposium, 211, 198–205; discussion 205–8. https://doi.org/10.1002/9780470515433.ch13

Kubota Y, Nash RA, Klungland A, Schär P, Barnes DE, & Lindahl T. (1996). Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. The EMBO journal, 15(23), 6662–6670.

Wei YF, Robins P, Carter K, Caldecott K, Pappin DJ, Yu GL, Wang RP, Shell BK, Nash RA, & Schär P. (1995). Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Molecular and cellular biology, 15(6), 3206–3216. https://doi.org/10.1128/mcb.15.6.3206

Fleck O, Schär P, & Kohli J. (1994). Identification of two mismatch-binding activities in protein extracts of Schizosaccharomyces pombe. Nucleic acids research, 22(24), 5289–5295. https://doi.org/10.1093/nar/22.24.5289

Fleck O, Rudolph C, Albrecht A, Lorentz A, Schär P, & Schmidt H. (1994). The mutator gene swi8 effects specific mutations in the mating-type region of Schizosaccharomyces pombe. Genetics, 138(3), 621–632. https://doi.org/10.1093/genetics/138.3.621

Schär P, & Kohli J. (1994). Preferential strand transfer and hybrid DNA formation at the recombination hotspot ade6-M26 of Schizosaccharomyces pombe. The EMBO journal, 13(21), 5212–5219. https://doi.org/10.1002/j.1460-2075.1994.tb06852.x

Schär, P, & Kohli, J. (1993). Marker effects of G to C transversions on intragenic recombination and mismatch repair in Schizosaccharomyces pombe. Genetics, 133(4), 825–835. https://doi.org/10.1093/genetics/133.4.825

Schär, P., Munz, P., & Kohli, J. (1993). Meiotic mismatch repair quantified on the basis of segregation patterns in Schizosaccharomyces pombe. Genetics, 133(4), 815–824. https://doi.org/10.1093/genetics/133.4.815

Grimm, C., Schaer, P., Munz, P., & Kohli, J. (1991). The strong ADH1 promoter stimulates mitotic and meiotic recombination at the ADE6 gene of Schizosaccharomyces pombe. Molecular and cellular biology, 11(1), 289–298. https://doi.org/10.1128/mcb.11.1.289-298.1991