Genome dynamics in cell programming, aging and human disease
DNA in our cells is continuously damaged through its exposure to reactive agents of endogenous or environmental origin. Damage to DNA, however, does not only occur randomly by chemical reactions, but also on purpose, by the action of enzymes, to increase genetic variance or alter cell fate determining epigenetic marks, i.e., DNA methylation. Modifications of either kind occur thousands of times in our DNA every day and need to be controlled if genome integrity is to be maintained. We investigate molecular mechanisms underlying this structural and functional dynamics of genomes.
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Selected Publications
Schwarz, Simon D., Xu, Jianming, Gunasekera, Kapila, Schürmann, David, Vågbø, Cathrine B., Ferrari, Elena, Slupphaug, Geir, Hottiger, Michael O., , & Steinacher, Roland. (2024). Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation [Journal-article]. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44209-8
Schwarz, Simon D., Xu, Jianming, Gunasekera, Kapila, Schürmann, David, Vågbø, Cathrine B., Ferrari, Elena, Slupphaug, Geir, Hottiger, Michael O., , & Steinacher, Roland. (2024). Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation [Journal-article]. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44209-8
Noreen F, Küng T, Tornillo L, Parker H, Silva M, Weis S, Marra G, Rad R, Truninger K, & . (2019). DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways. Clinical Epigenetics, 11(1), 196. https://doi.org/10.1186/s13148-019-0791-1
Noreen F, Küng T, Tornillo L, Parker H, Silva M, Weis S, Marra G, Rad R, Truninger K, & . (2019). DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways. Clinical Epigenetics, 11(1), 196. https://doi.org/10.1186/s13148-019-0791-1
Steinacher, Roland, Barekati, Zeinab, Botev, Petar, Kuśnierczyk, Anna, Slupphaug, Geir, & . (2019). SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation. EMBO Journal, 38(1). https://doi.org/10.15252/embj.201899242
Steinacher, Roland, Barekati, Zeinab, Botev, Petar, Kuśnierczyk, Anna, Slupphaug, Geir, & . (2019). SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation. EMBO Journal, 38(1). https://doi.org/10.15252/embj.201899242
Weber, A. R., Krawczyk, C., Robertson, A. B., Kusnierczyk, A., Vagbo, C. B., Schuermann, D., Klungland, A., & (2016). Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun, 7, 10806. https://doi.org/10.1038/ncomms10806
Weber, A. R., Krawczyk, C., Robertson, A. B., Kusnierczyk, A., Vagbo, C. B., Schuermann, D., Klungland, A., & (2016). Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun, 7, 10806. https://doi.org/10.1038/ncomms10806
Cortázar, Daniel, Kunz, Christophe, Selfridge, Jim, Lettieri, Teresa, Saito, Yusuke, MacDougall, Eilidh, Wirz, Annika, Schuermann, David, Jacobs, Angelika L, Siegrist, Fredy, Steinacher, Roland, Jiricny, Josef, Bird, Adrian, & . (2011). Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature, 470(7334), 419–423. https://doi.org/10.1038/nature09672
Cortázar, Daniel, Kunz, Christophe, Selfridge, Jim, Lettieri, Teresa, Saito, Yusuke, MacDougall, Eilidh, Wirz, Annika, Schuermann, David, Jacobs, Angelika L, Siegrist, Fredy, Steinacher, Roland, Jiricny, Josef, Bird, Adrian, & . (2011). Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature, 470(7334), 419–423. https://doi.org/10.1038/nature09672
Valencia, M, Bentele, M, Vaze, M B, Herrmann, G, Kraus, E, Lee, S E, , & Haber, J E. (2001). NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature, 414(6864), 666–669. https://doi.org/10.1038/414666a
Valencia, M, Bentele, M, Vaze, M B, Herrmann, G, Kraus, E, Lee, S E, , & Haber, J E. (2001). NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature, 414(6864), 666–669. https://doi.org/10.1038/414666a
