PD Dr. Urs Duthaler

Monti, Manuela Carla, Stoll, Anna, Schlotterbeck, Götz, & Duthaler, Urs. (2025). Miniaturized one-step extraction for the analysis of tetrahydrocannabinol ∆9- and ∆8- isomers, phytocannabinoids, and hexahydrocannabinol in whole blood using liquid chromatography tandem mass spectrometry. Journal of Chromatography A, 1760. https://doi.org/10.1016/j.chroma.2025.466276

Guessoum, Adrian, Vogt, Severin B., Meyer, Maximilian, Westenberg, Jean Nicolas, Klemperer, Benjamin, Dürsteler, Kenneth M., Liechti, Matthias E., Thomann, Jan, Luethi, Dino, Duthaler, Urs, & Vogel, Marc. (2025). Pharmacokinetics and Pharmacodynamics of Intranasal Diacetylmorphine in Heroin-Assisted Treatment for Severe Opioid Use Disorder. CNS Drugs, 39(8), 807–817. https://doi.org/10.1007/s40263-025-01189-1

Kamau, Yvonne, Tuwei, Mercy, Wanjiku, Caroline, Ominde, Kelly, Ngama, Mwanajuma, Karisa, Jonathan, Babu, Lawrence, Muturi, Martha, Mwatasa, Mwaganyuma, Adetifa, Jane, Kern, Charlotte, Duthaler, Urs, Hammann, Felix, Rabinovich, Regina, Chaccour, Carlos, & Maia, Marta Ferreira. (2024). Mosquitocidal efficacy and pharmacokinetics of single-dose ivermectin versus three-day dose regimen for malaria vector control compared with albendazole and no treatment: An open-label randomized controlled trial. International Journal of Infectious Diseases, 148, 107236. https://doi.org/10.1016/j.ijid.2024.107236

Müller-Durovic, Bojana, Jäger, Jessica, Engelmann, Christine, Schuhmachers, Patrick, Altermatt, Sabine, Schlup, Yannick, Duthaler, Urs, Makowiec, Celia, Unterstab, Gunhild, Roffeis, Sarah, Xhafa, Erta, Assmann, Nadine, Trulsson, Fredrik, Steiner, Rebekah, Edwards-Hicks, Joy, West, James, Turner, Lorinda, Develioglu, Leyla, Ivanek, Robert, et al. (2024). A metabolic dependency of EBV can be targeted to hinder B cell transformation [Journal-article]. Science, 385(6704). https://doi.org/10.1126/science.adk4898

Anliker‐Ort, Marion, Rodieux, Frédérique, Ziesenitz, Victoria C., Atkinson, Andrew, Bielicki, Julia A., Erb, Thomas O., Gürtler, Nicolas, Holland‐Cunz, Stefan, Duthaler, Urs, Rudin, Deborah, Haschke, Manuel, van den Anker, John, Pfister, Marc, & Gotta, Verena. (2024). Pharmacokinetics-Based Pediatric Dose Evaluation and Optimization Using Saliva – A Case Study [Journal-article]. Journal of Clinical Pharmacology, 64(7), 810–819. https://doi.org/10.1002/jcph.2428

Walz, Annabelle, Lehmann, Ursula, Duthaler, Urs, Mäser, Pascal, & Wittlin, Sergio. (2024). In vivo antimalarial efficacy of Artemisia afra powder suspensions. Phytomedicine, 129. https://doi.org/10.1016/j.phymed.2024.155644

Dao, Kim, Buettcher, Michael, Golhen, Klervi, Kost, Jonas, Schittny, Andreas, Duthaler, Urs, Atkinson, Andrew, Haefliger, David, Guidi, Monia, Bardinet, Carine, Chtioui, Haithem, Boulekbache, Abdelwahab, Buclin, Thierry, Huwyler, Jörg, Pfister, Marc, & Rothuizen, Laura E. (2024). Novel Patient‐Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced Palatability, Controlled Absorption, and Less Variability: High Potential for Pediatric Use [Journal-article]. The Journal of Clinical Pharmacology, 64(10), 1295–1303. https://doi.org/10.1002/jcph.2462

Blukacz, Lauriane, Nuciforo, Sandro, Fucile, Geoffrey, Trulsson, Fredrik, Duthaler, Urs, Wieland, Stefan, & Heim, Markus H. (2024). Inhibition of the transmembrane transporter ABCB1 overcomes resistance to doxorubicin in patient-derived organoid models of HCC. Hepatology Communications, 8(5). https://doi.org/10.1097/hc9.0000000000000437

Luethi, Dino, Rudin, Deborah, Straumann, Isabelle, Thomann, Jan, Avedisian, Isidora, Liechti, Matthias E., & Duthaler, Urs. (2024). Derivatization-free determination of chiral plasma pharmacokinetics of MDMA and its enantiomers. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1238. https://doi.org/10.1016/j.jchromb.2024.124123

Thomann, Jan, Vogt, Severin B., Guessoum, Adrian, Meyer, Maximilian, Vogel, Marc, Liechti, Matthias E., Luethi, Dino, & Duthaler, Urs. (2024). Development and validation of an LC-MS/MS method for quantifying diamorphine and its major metabolites 6-monoacetylmorphine, morphine, morphine-3-glucuronide, and morphine-6-glucuronide in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1237. https://doi.org/10.1016/j.jchromb.2024.124104

Abegg, Vanessa Fabienne, Panajatovic, Miljenko Valentin, Mancuso, Riccardo Vincenzo, Allard, Julien Arthur, Duthaler, Urs, Odermatt, Alex, Krähenbühl, Stephan, & Bouitbir, Jamal. (2024). Mechanisms of hepatocellular toxicity associated with the components of St. John’s Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. Toxicology Letters, 393, 1–13. https://doi.org/10.1016/j.toxlet.2024.01.008

Holze, Friederike, Erne, Livio, Duthaler, Urs, & Liechti, Matthias E. (2024). Pharmacokinetics, pharmacodynamics and urinary recovery of oral lysergic acid diethylamide administration in healthy participants. British Journal of Clinical Pharmacology, 90(1), 200–208. https://doi.org/10.1111/bcp.15887

Thomann, Jan, Kolaczynska, Karolina E., Stoeckmann, Oliver V., Rudin, Deborah, Vizeli, Patrick, Hoener, Marius C., Pryce, Christopher R., Vollenweider, Franz X., Liechti, Matthias E., & Duthaler, Urs. (2024). In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin [Journal-article]. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1391689

Straumann, Isabelle, Ley, Laura, Holze, Friederike, Becker, Anna M., Klaiber, Aaron, Wey, Kathrin, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants. Neuropsychopharmacology, 48(13), 1840–1848. https://doi.org/10.1038/s41386-023-01609-0

Vogt, Severin B., Ley, Laura, Erne, Livio, Straumann, Isabelle, Becker, Anna M., Klaiber, Aaron, Holze, Friederike, Vandersmissen, Anja, Mueller, Lorenz, Duthaler, Urs, Rudin, Deborah, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants. Translational Psychiatry, 13(1). https://doi.org/10.1038/s41398-023-02477-4

Ley, Laura, Holze, Friederike, Arikci, Denis, Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, Coviello, Fabio, Dierbach, Sophie, Thomann, Jan, Duthaler, Urs, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants. Neuropsychopharmacology, 48(11), 1659–1667. https://doi.org/10.1038/s41386-023-01607-2

Duthaler U, Bachmann F, Ozbey AC, Umehara K, Parrott N, Fowler S, & Krähenbühl S. (2023). The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis. Clinical Pharmacokinetics, 62(8), 1141–1155. https://doi.org/10.1007/s40262-023-01261-3

Ozbey AC, Bachmann F, Duthaler U, Annaert P, Fowler S, Umehara K, Parrott N, & Krähenbühl S. (2023). Dose Adjustment in Patients with Liver Cirrhosis – Comparison of Two Different Modeling Approaches. Clinical Pharmacology and Therapeutics, 113(6), 1346–1358. https://doi.org/10.1002/cpt.2897

Mancuso RV, Schneider G, Hürzeler M, Gut M, Zurflüh J, Breitenstein W, Bouitbir J, Reisen F, Atz K, Ehrhardt C, Duthaler U, Gygax D, Schmidt AG, Krähenbühl S, & Weitz-Schmidt G. (2023). Allosteric targeting resolves limitations of earlier LFA-1 directed modalities. Biochemical Pharmacology, 211, 115504. https://doi.org/10.1016/j.bcp.2023.115504

Holze, Friederike, Becker, Anna M., Kolaczynska, Karolina E., Duthaler, Urs, & Liechti, Matthias E. (2023). Pharmacokinetics and Pharmacodynamics of Oral Psilocybin Administration in Healthy Participants. Clinical Pharmacology and Therapeutics, 113(4), 822–831. https://doi.org/10.1002/cpt.2821

Becker, Anna M., Klaiber, Aaron, Holze, Friederike, Istampoulouoglou, Ioanna, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Ketanserin Reverses the Acute Response to LSD in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Participants. International Journal of Neuropsychopharmacology, 26(2), 97–106. https://doi.org/10.1093/ijnp/pyac075

Luethi, Dino, Kolaczynska, Karolina E., Vogt, Severin B., Ley, Laura, Erne, Livio, Liechti, Matthias E., & Duthaler, Urs. (2022). Liquid chromatography–tandem mass spectrometry method for the bioanalysis of N,N-dimethyltryptamine (DMT) and its metabolites DMT-N-oxide and indole-3-acetic acid in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1213. https://doi.org/10.1016/j.jchromb.2022.123534

Thomann J, Ley L, Klaiber A, Liechti ME, & Duthaler U. (2022). Development and validation of an LC-MS/MS method for the quantification of mescaline and major metabolites in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 220, 114980. https://doi.org/10.1016/j.jpba.2022.114980

Vizeli P, Straumann I, Duthaler U, Varghese N, Eckert A, Paulus MP, Risbrough V, & Liechti ME. (2022). Effects of 3,4-Methylenedioxymethamphetamine on Conditioned Fear Extinction and Retention in a Crossover Study in Healthy Subjects. Frontiers in Pharmacology, 13, 906639. https://doi.org/10.3389/fphar.2022.906639

Duthaler, Urs, Bachmann, Fabio, Suenderhauf, Claudia, Grandinetti, Tanja, Pfefferkorn, Florian, Haschke, Manuel, Hruz, Petr, Bouitbir, Jamal, & Krähenbühl, Stephan. (2022). Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently. Clinical Pharmacokinetics, 61(7), 1039–1055. https://doi.org/10.1007/s40262-022-01119-0

Ruiz A, Benucci S, Duthaler U, Bachmann C, Franchini M, Noreen F, Pietrangelo L, Protasi F, Treves S, & Zorzato F. (2022). Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors. eLife, 11. https://doi.org/10.7554/elife.73718

Bachmann F, Meyer Zu Schwabedissen HE, Duthaler U, & Krähenbühl S. (2022). Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine. British Journal of Clinical Pharmacology, 88(4), 1885–1896. https://doi.org/10.1111/bcp.15108

Kasenda, B., König, D., Manni, M., Ritschard, R., Duthaler, U., Bartoszek, E., Bärenwaldt, A., Deuster, S., Hutter, G., Cordier, D., Mariani, L., Hench, J., Frank, S., Krähenbühl, S., Zippelius, A., Rochlitz, C., Mamot, C., Wicki, A., & Läubli, H. (2022). Targeting immunoliposomes to EGFR-positive glioblastoma. ESMO Open, 7(1). https://doi.org/10.1016/j.esmoop.2021.100365

Lett, Martin J, Mehta, Hema, Keogh, Adrian, Jaeger, Tina, Jacquet, Maxime, Powell, Kate, Meier, Marie-Anne, Fofana, Isabel, Melhem, Hassan, Vosbeck, Jurg, Cathomas, Gieri, Heigl, Andres, Heim, Markus H, Burri, Emanuel, Mertz, Kirsten D, Niess, Jan Hendrik, Kollmar, Otto, Zech, Christoph J, Ivanek, Robert, et al. (2022). Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells. Gut, 71(12), 2526–2538. https://doi.org/10.1136/gutjnl-2021-324478

Bachmann F, Duthaler U, & Krähenbühl S. (2021). Effect of deglucuronidation on the results of the Basel phenotyping cocktail. British Journal of Clinical Pharmacology, 87(12), 4608–4618. https://doi.org/10.1111/bcp.14874

Nicolas P, Kiuru C, Wagah MG, Muturi M, Duthaler U, Hammann F, Maia M, & Chaccour C. (2021). Potential metabolic resistance mechanisms to ivermectin in Anopheles gambiae: a synergist bioassay study. Parasites and Vectors, 14(1), 172. https://doi.org/10.1186/s13071-021-04675-9

Berger B, Dingemanse J, Sabattini G, Delahaye S, Duthaler U, Muehlan C, & Krähenbühl S. (2021). Effect of Liver Cirrhosis on the Pharmacokinetics, Metabolism, and Tolerability of Daridorexant, A Novel Dual Orexin Receptor Antagonist. Clinical Pharmacokinetics, 60(10), 1349–1360. https://doi.org/10.1007/s40262-021-01028-8

Holze, Friederike, Liechti, Matthias E., Hutten, Nadia R.P.W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., Duthaler, Urs, Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P.C. (2021). Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants. Clinical Pharmacology and Therapeutics, 109(3), 658–666. https://doi.org/10.1002/cpt.2057

Schittny, Andreas, Waldner, Samuel, Duthaler, Urs, Vorobyev, Alexander, Abramovich, Rimma, Krähenbühl, Stephan, Puchkov, Maxim, & Huwyler, Jörg. (2021). Particle forming amorphous solid dispersions: A mechanistic randomized pharmacokinetic study in humans. Pharmaceutics, 13(3), 1–17. https://doi.org/10.3390/pharmaceutics13030401

Schittny A, Waldner S, Duthaler U, Vorobyev A, Abramovich R, Krähenbühl S, Puchkov M, & Huwyler J. (2021). Particle forming amorphous solid dispersions: A mechanistic randomized pharmacokinetic study in humans. Pharmaceutics, 13(3). https://doi.org/10.3390/pharmaceutics13030401

Scholz I, Liakoni E, Hammann F, Grafinger KE, Duthaler U, Nagler M, Krähenbühl S, & Haschke M. (2021). Effects of Hypericum perforatum (St John’s wort) on the pharmacokinetics and pharmacodynamics of rivaroxaban in humans. British Journal of Clinical Pharmacology, 87(3), 1466–1474. https://doi.org/10.1111/bcp.14553

Holze, Friederike, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2021). Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 46(3), 537–544. https://doi.org/10.1038/s41386-020-00883-6

Kolaczynska KE, Liechti ME, & Duthaler U. (2021). Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin’s main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1164, 122486. https://doi.org/10.1016/j.jchromb.2020.122486

Blaser, Lea S., Duthaler, Urs, Bouitbir, Jamal, Leuppi-Taegtmeyer, Anne B., Liakoni, Evangelia, Dolf, Reto, Mayr, Michael, Drewe, Jürgen, Krähenbühl, Stephan, & Haschke, Manuel. (2021). Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study. Frontiers in Pharmacology, 12, 620635. https://doi.org/10.3389/fphar.2021.620635

Bachmann F, Blaser L, Haschke M, Krähenbühl S, & Duthaler U. (2020). Development and validation of an LC-MS/MS method for the bioanalysis of the major metamizole metabolites in human plasma. Bioanalysis, 12(3), 175–189. https://doi.org/10.4155/bio-2019-0251

Duthaler U, Leisegang R, Karlsson MO, Krähenbühl S, & Hammann F. (2020). The effect of food on the pharmacokinetics of oral ivermectin. Journal of Antimicrobial Chemotherapy, 75(2), 438–440. https://doi.org/10.1093/jac/dkz466

Rudin D, Roos NJ, Duthaler U, & Krähenbühl S. (2019). Toxicity of metamizole on differentiating HL60 cells and human neutrophil granulocytes. Toxicology, 426, 152254. https://doi.org/10.1016/j.tox.2019.152254

Duthaler U, Suenderhauf C, Gaugler S, Vetter B, Krähenbühl S, & Hammann F. (2019). Development and validation of an LC-MS/MS method for the analysis of ivermectin in plasma, whole blood, and dried blood spots using a fully automatic extraction system. Journal of Pharmaceutical and Biomedical Analysis, 172, 18–25. https://doi.org/10.1016/j.jpba.2019.04.007

Holze, Friederike, Duthaler, Urs, Vizeli, Patrick, Müller, Felix, Borgwardt, Stefan, & Liechti, Matthias E. (2019). Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects. British Journal of Clinical Pharmacology, 85(7), 1474–1483. https://doi.org/10.1111/bcp.13918

Luethi D, Hoener MC, Krähenbühl S, Liechti ME, & Duthaler U. (2019). Cytochrome P450 enzymes contribute to the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD: Implications for clinical LSD use. Biochemical Pharmacology, 164, 129–138. https://doi.org/10.1016/j.bcp.2019.04.013

Duthaler U, Sayasone S, Vanobbergen F, Penny MA, Odermatt P, Huwyler J, & Keiser J. (2016). Single-ascending-dose pharmacokinetic study of tribendimidine in opisthorchis viverrini-infected patients. Antimicrobial Agents and Chemotherapy, 60(10), 5705–5715. https://doi.org/10.1128/aac.00992-16

Duthaler, Urs, Sayasone, Somphou, Vanobbergen, Fiona, Penny, Melissa A., Odermatt, Peter, Huwyler, Jörg, & Keiser, Jennifer. (2016). Single ascending dose pharmacokinetic study of tribendimidine in Opisthorchis viverrini-infected patients. Antimicrobial Agents and Chemotherapy, 60(10), 15–5705. https://doi.org/10.1128/aac.00992-16

Saric, Jasmina, Want, Elizabeth J., Duthaler, Urs, Lewis, Matthew, Keiser, Jennifer, Shockcor, John P., Ross, Gordon A., Nicholson, Jeremy K., Holmes, Elaine, & Tavares, Marina F. M. (2012). Systematic evaluation of extraction methods for multi-platform based metabotyping : application to the Fasciola hepatica metabolome. Analytical Chemistry, 84(16), 6963–6972. https://doi.org/10.1021/ac300586m

Bouitbir, J., Sanvee, G. M., Panajatovic, M. V., Fehrenbach, N. B., Fréchard, T., Manivannan, M., Duthaler, U., & Krähenbühl, S. (2025). Relationship between simvastatin pharmacokinetics and muscle toxicity in male mice [Journal-article]. Food and Chemical Toxicology, 205. https://doi.org/10.1016/j.fct.2025.115688

Velpen, V. v. d., Liakoni, E., Hirt, M. B., Vonwyl, C. M., Christen, S. E., Duthaler, U., Jacob, P., & Haschke, M. (2025). A validated single-step saliva and serum sample extraction LC-MS/MS method for the analysis of nicotine, cotinine and 3’-hydroxycotinine for clinical vaping studies [Journal-article]. Journal of Pharmaceutical and Biomedical Analysis, 258, 116703. https://doi.org/10.1016/j.jpba.2025.116703

Hutten, N. R. P. W., Quaedflieg, C. W. E. M., Mason, N. L., Theunissen, E. L., Liechti, M. E., Duthaler, U., Kuypers, K. P. C., Bonnelle, V., Feilding, A., & Ramaekers, J. G. (2024). Inter-individual variability in neural response to low doses of LSD [Journal-article]. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-03013-8

Duthaler, U., Chapuisat, F., Hanimann, R., & Krähenbühl, S. (2024). Effect of protein binding on the pharmacokinetics of the six substrates in the Basel phenotyping cocktail in healthy subjects and patients with liver cirrhosis [Journal-article]. European Journal of Pharmaceutical Sciences, 202, 106885. https://doi.org/10.1016/j.ejps.2024.106885

Holze, F., Madsen, M. K., Svarer, C., Gillings, N., Stenbaek, D. S., Rudin, D., Duthaler, U., Liechti, M. E., Fisher, P. M., & Knudsen, G. M. (2024). Ketanserin exhibits dose- and concentration-proportional serotonin 2A receptor occupancy in healthy individuals: Relevance for psychedelic research [Journal-article]. European Neuropsychopharmacology, 88, 43–48. https://doi.org/10.1016/j.euroneuro.2024.07.003

Chaccour C, Casellas A, Hammann F, Ruiz-Castillo P, Nicolas P, Montaña J, Mael M, Selvaraj P, Duthaler U, Mrema S, Kakolwa M, Lyimo I, Okumu F, Marathe A, Schürch R, Elobolobo E, Sacoor C, Saute F, Xia K, et al. (2023). BOHEMIA: Broad One Health Endectocide-based Malaria Intervention in Africa—a phase III cluster-randomized, open-label, clinical trial to study the safety and efficacy of ivermectin mass drug administration to reduce malaria transmission in two African settings. Trials, 24(1), 128. https://doi.org/10.1186/s13063-023-07098-2

Kern, C., Müller, P., Chaccour, C., Liechti, M. E., Hammann, F., & Duthaler, U. (2023). Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes. Malar J, 22(1), 194. https://doi.org/10.1186/s12936-023-04624-0

Becker, Anna M., Holze, Friederike, Grandinetti, Tanja, Klaiber, Aaron, Toedtli, Vanja E., Kolaczynska, Karolina E., Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Grünblatt, Edna, & Liechti, Matthias E. (2022). Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects. Clinical Pharmacology & Therapeutics, 111(4), 886–895. https://doi.org/10.1002/cpt.2487

Holze, Friederike, Ley, Laura, Müller, Felix, Becker, Anna M., Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A., Duthaler, Urs, Kolaczynska, Karolina E., Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2022). Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2

Ruiz, A., Benucci, S., Duthaler, U., Bachmann, C., Franchini, M., Noreen, F., Pietrangelo, L., Protasi, F., Treves, S., & Zorzato, F. (2021, November 9). Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.11.09.467894

Bachmann, F., Duthaler, U., Meyerzuschwabidissen, H., & Krahenbuhl, S. (2021). Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine [Posted-content]. Authorea, Inc. https://doi.org/10.22541/au.162544273.38681801/v1

Bachmann, Fabio, Duthaler, Urs, Meyer Zu Schwabedissen, Henriette E., Puchkov, Maxim, Huwyler, Jörg, Haschke, Manuel, & Krähenbühl, Stephan. (2021). Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2. Clinical Pharmacology and Therapeutics, 109(6), 1505–1516. https://doi.org/10.1002/cpt.2141

Duthaler, U., Weber, M., Hofer, L., Chaccour, C., Maia, M., Müller, P., Krähenbühl, S., & Hammann, F. (2021). The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes. PLoS Pathogens, 17(3), e1009382. https://doi.org/10.1371/journal.ppat.1009382

Nicolas, P., Kiuru, C., Wagah, M., Muturi, M., Duthaler, U., Hammann, F., Maia, M., & Chaccour, C. (2020). Potential Metabolic Resistance Mechanisms to Ivermectin in Anopheles Gambiae: A Synergist Bioassay Study [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-121991/v1

Panajatovic, Miljenko Valentin, Singh, François, Roos, Noëmi Johanna, Duthaler, Urs, Handschin, Christoph, Krähenbühl, Stephan, & Bouitbir, Jamal. (2020). PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice. Acta physiologica (Oxford, England), 228(4), e13402. https://doi.org/10.1111/apha.13402

Panajatovic, Miljenko V., Singh, François, Duthaler, Urs, Krähenbühl, Stephan, & Bouitbir, Jamal. (2020). Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced Myotoxicity. European Cardiology, 15, e35. https://doi.org/10.15420/ecr.2020.15.1.po12

Roos, Noëmi Johanna, Duthaler, Urs, Bouitbir, Jamal, & Krähenbühl, Stephan. (2020). The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells. Free Radical Biology and Medicine, 152, 216–226. https://doi.org/10.1016/j.freeradbiomed.2020.03.009

Suenderhauf, Claudia, Berger, Benjamin, Puchkov, Maxim, Schmid, Yasmin, Müller, Sabine, Huwyler, Jörg, Haschke, Manuel, Krähenbühl, Stephan, & Duthaler, Urs. (2020). Pharmacokinetics and phenotyping properties of the “Basel” phenotyping cocktail combination capsule in healthy male adults. British Journal of Clinical Pharmacology, 86(2), 352–361. https://doi.org/10.1111/bcp.14157

Ziesenitz VC, Rodieux F, Atkinson A, Borter C, Bielicki JA, Haschke M, Duthaler U, Bachmann F, Erb TO, Gürtler N, Holland-Cunz S, van den Anker JN, Gotta V, & Pfister M. (2019). Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study. European Journal of Clinical Pharmacology, 75(11), 1491–1502. https://doi.org/10.1007/s00228-019-02720-2

Leuppi-Taegtmeyer, Anne, Duthaler, Urs, Hammann, Felix, Schmid, Yasmin, Dickenmann, Michael, Amico, Patricia, Jehle, Andreas W., Kalbermatter, Stefan, Lenherr, Christoph, Meyer Zu Schwabedissen, Henriette E., Haschke, Manuel, Liechti, Matthias E., & Krähenbühl, Stephan. (2019). Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions. Nephrology, Dialysis, Transplantation, 34(4), 692–702. https://doi.org/10.1093/ndt/gfy285

Malagnino, Vanessa, Duthaler, Urs, Seibert, Isabell, Krähenbühl, Stephan, & Meyer Zu Schwabedissen, Henriette E. (2019). OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe. Molecular Pharmacology, 96(2), 128–137. https://doi.org/10.1124/mol.118.114934

Singh, François, Zoll, Joffrey, Duthaler, Urs, Charles, Anne-Laure, Panajatovic, Miljenko V., Laverny, Gilles, McWilliams, Thomas G., Metzger, Daniel, Geny, Bernard, Krähenbühl, Stephan, & Bouitbir, Jamal. (2019). PGC-1β modulates statin-associated myotoxicity in mice. Archives of Toxicology, 93(2), 487–504. https://doi.org/10.1007/s00204-018-2369-7

Bachmann, Fabio, Duthaler, Urs, Rudin, Deborah, Krähenbühl, Stephan, & Haschke, Manuel. (2018). N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 120, 172–180. https://doi.org/10.1016/j.ejps.2018.05.003

Berger, Benjamin, Bachmann, Fabio, Duthaler, Urs, Krähenbühl, Stephan, & Haschke, Manuel. (2018). Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug. Frontiers in Pharmacology, 9, 774. https://doi.org/10.3389/fphar.2018.00774

Duthaler, Urs, Berger, Benjamin, Erb, Stefan, Battegay, Manuel, Letang, Emili, Gaugler, Stefan, Natamatungiro, Alex, Mnzava, Dorcas, Donzelli, Massimiliano, Krähenbühl, Stephan, & Haschke, Manuel. (2018). Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions. Journal of Antimicrobial Chemotherapy, 73(10), 2729–2737. https://doi.org/10.1093/jac/dky254

Duthaler, Urs, Suenderhauf, Claudia, Karlsson, Mats O., Hussner, Janine, Meyer Zu Schwabedissen, Henriette, Krähenbühl, Stephan, & Hammann, Felix. (2018). Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers. British Journal of Clinical Pharmacology, 85(3), 626–633. https://doi.org/10.1111/bcp.13840

Grünig, David, Duthaler, Urs, & Krähenbühl, Stephan. (2018). Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells. Frontiers in Pharmacology, 9, 257. https://doi.org/10.3389/fphar.2018.00257

Grünig, David, Felser, Andrea, Duthaler, Urs, Bouitbir, Jamal, & Krähenbühl, Stephan. (2018). Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicological Sciences, 164(2), 477–488. https://doi.org/10.1093/toxsci/kfy101

Paech, Franziska, Abegg, Vanessa F., Duthaler, Urs, Terracciano, Luigi, Bouitbir, Jamal, & Krähenbühl, Stephan. (2018). Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology, 409, 13–23. https://doi.org/10.1016/j.tox.2018.07.009

Singh, F., Zoll, J., Duthaler, U., Charles, A.-L., Laverny, G., Metzger, D., Geny, B., Krähenbühl, S., & Bouitbir, J. (2017). PGC-1β prevents statin-associated myotoxicity in oxidative skeletal muscle [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/218636

Duthaler, Urs, Berger, Benjamin, Erb, Stefan, Battegay, Manuel, Letang, Emilio, Gaugler, Stefan, Krähenbühl, Stephan, & Haschke, Manuel. (2017). Automated high throughput analysis of antiretroviral drugs in dried blood spots. Journal of Mass Spectrometry, 52(8), 534–542. https://doi.org/10.1002/jms.3952

Erb, S., Letang, E., Glass, T. R., Natamatungiro, A., Mnzava, D., Mapesi, H., Haschke, M., Duthaler, U., Berger, B., Muri, L., Bader, J., Marzolini, C., Elzi, L., Klimkait, T., Langewitz, W., Battegay, M., & Kilombero Ulanga Antiretroviral Cohort study group. (2017). Health care provider communication training in rural Tanzania empowers HIV-infected patients on antiretroviral therapy to discuss adherence problems. HIV Medicine, 18(9), 623–634. https://doi.org/10.1111/hiv.12499

Bouitbir, Jamal, Haegler, Patrizia, Singh, François, Joerin, Lorenz, Felser, Andrea, Duthaler, Urs, & Krähenbühl, Stephan. (2016). Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency. Frontiers in Physiology, 7, 345. https://doi.org/10.3389/fphys.2016.00345

Meister, Isabel, Kovac, Jana, Duthaler, Urs, Odermatt, Peter, Huwyler, Jörg, Vanobberghen, Fiona, Sayasone, Somphou, & Keiser, Jennifer. (2016). Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients. PLoS Neglected Tropical Diseases, 10(5), e0004700. https://doi.org/10.1371/journal.pntd.0004700

Meister, Isabel, Leonidova, Anna, Kovač, Jana, Duthaler, Urs, Keiser, Jennifer, & Huwyler, Jörg. (2016). Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots. Journal of Pharmaceutical and Biomedical Analysis, 118, 81–88. https://doi.org/10.1016/j.jpba.2015.10.011

Sayasone, Somphou, Odermatt, Peter, Vonghachack, Youthanavanh, Xayavong, Syda, Senggnam, Kanpaseuth, Duthaler, Urs, Akkhavong, Kongsap, Hattendorf, Jan, & Keiser, Jennifer. (2016). Efficacy and safety of tribendimidine against Opisthorchis viverrini : two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials. Lancet Infectious Diseases, 16(10), 53–1145. https://doi.org/10.1016/s1473-3099(16)30198-0

Vanobberghen, Fiona, Penny, Melissa A, Duthaler, Urs, Odermatt, Peter, Sayasone, Somphou, Keiser, Jennifer, & Tarning, Joel. (2016). Population pharmacokinetic modeling of tribendimidine metabolites in opisthorchis viverrini-Infected adults. Antimicrobial Agents and Chemotherapy, 60(10), 704–5695. https://doi.org/10.1128/aac.00655-16

Duthaler, Urs, Keiser, Jennifer, & Huwyler, Jörg. (2015). LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots. Journal of Pharmaceutical and Biomedical Analysis, 105, 163–173. https://doi.org/10.1016/j.jpba.2014.12.006

Schmid, Yasmin, Rickli, Anna, Schaffner, Antonia, Duthaler, Urs, Grouzmann, Eric, Hysek, Cédric M., & Liechti, Matthias E. (2015). Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects. Journal of Pharmacology and Experimental Therapeutics, 353(1), 102–111. https://doi.org/10.1124/jpet.114.222356

Panic, Gordana, Duthaler, Urs, Speich, Benjamin, & Keiser, Jennifer. (2014). Repurposing drugs for the treatment and control of helminth infections. International Journal of Parasitology : Drugs and Drug Resistance, 4(3), 185–200. https://doi.org/10.1016/j.ijpddr.2014.07.002

Ingram, Katrin, Duthaler, Urs, Vargas, Mireille, Ellis, William, & Keiser, Jennifer. (2013). Disposition of mefloquine and enpiroline is highly influenced by a chronic Schistosoma mansoni infection. Antimicrobial Agents and Chemotherapy, 57(9), 11–4506. https://doi.org/10.1128/aac.01129-13

Meister, Isabel, Duthaler, Urs, Huwyler, Jörg, Rinaldi, Laura, Bosco, Antonio, Cringoli, Giuseppe, & Keiser, Jennifer. (2013). Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep. Veterinary Parasitology, 198(1-2), 10–102. https://doi.org/10.1016/j.vetpar.2013.08.007

Duthaler, Urs, Huwyler, Jörg, Rinaldi, Laura, Cringoli, Giuseppe, & Keiser, Jennifer. (2012). Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica. Veterinary Parasitology, 186(3-4), 80–270. https://doi.org/10.1016/j.vetpar.2011.11.076

Fürst, T., Duthaler, U., Sripa, B., Utzinger, J., & Keiser, J. (2012). Trematode infections : liver and lung flukes. Infectious Disease Clinics of North America, 26(2), 399–419. https://doi.org/10.1016/j.idc.2012.03.008

Duthaler, Urs, Keiser, Jennifer, & Huwyler, Jörg. (2011). Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether, and their major metabolites dihydroartemisinin and dihydroartemisininglucuronide in sheep plasma. Journal of Mass Spectrometry, 46(2), 81–172. https://doi.org/10.1002/jms.1883

Duthaler, Urs, Rinaldi, Laura, Maurelli, Maria P, Vargas, Mireille, Utzinger, Jürg, Cringoli, Giuseppe, & Keiser, Jennifer. (2010). Fasciola hepatica: comparison of the sedimentation and FLOTAC techniques for the detection and quantification of faecal egg counts in rats. Experimental Parasitology : EP, 126(2), 6–161. https://doi.org/10.1016/j.exppara.2010.04.020

Duthaler, Urs, Smith, Thomas A, & Keiser, Jennifer. (2010). In vivo and in vitro sensitivity of Fasciola hepatica to combinations of triclabendazole and artesunate, artemether or OZ78. Antimicrobial Agents and Chemotherapy : AAC, 54(11), 604–4596. https://doi.org/10.1128/aac.00828-10

Keiser, Jennifer, Duthaler, Urs, & Utzinger, Jürg. (2010). Update on the diagnosis and treatment of food-borne trematode infections. Current Opinion in Infectious Diseases, 23(5), 20–513. https://doi.org/10.1097/qco.0b013e32833de06a

Keiser, Jennifer, Veneziano, Vincenzo, Rinaldi, Laura, Mezzino, Laura, Duthaler, Urs, & Cringoli, Giuseppe. (2010). Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep. Research in Veterinary Science, 88(1), 10–107. https://doi.org/10.1016/j.rvsc.2009.05.007