Development of novel LC-MS/MS-based analytical methods with a specific focus on automation and the analysis of blood microsamples
- Clinical pharmacological and forensic applications
- Automated dried blood spots analysis using DBS-MS 500 autosampler
- Blood sampling conducted under remote conditions
Conducting comprehensive DMPK (Drug Metabolism and Pharmacokinetics) studies and evaluating drug-drug interactions in human subjects
- Large scale PK studies in human clinical trials
- Cytochrome P450 phenotyping studies
- Drug metabolism studies (liver microsomes, HepRG cells)
- Biomarker analysis for forensic toxicological and physiological investigations
Development of innovative invertebrate animal models
- Advancing the 3Rs: Creation of novel preclinical models to minimize the use of sentient animals in DMPK studies.
- Investigating the effects of drugs of abuse on insect behavior to identify unknown substances in blood samples."
Selected Publications
Thomann, Jan, Kolaczynska, Karolina E., Stoeckmann, Oliver V., Rudin, Deborah, Vizeli, Patrick, Hoener, Marius C., Pryce, Christopher R., Vollenweider, Franz X., Liechti, Matthias E., & . (2024). In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin [Journal-article]. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1391689
Thomann, Jan, Kolaczynska, Karolina E., Stoeckmann, Oliver V., Rudin, Deborah, Vizeli, Patrick, Hoener, Marius C., Pryce, Christopher R., Vollenweider, Franz X., Liechti, Matthias E., & . (2024). In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin [Journal-article]. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1391689
Kern, C., Müller, P., Chaccour, C., Liechti, M. E., Hammann, F., & (2023). Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes. Malar J, 22(1), 194. https://doi.org/10.1186/s12936-023-04624-0
Kern, C., Müller, P., Chaccour, C., Liechti, M. E., Hammann, F., & (2023). Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes. Malar J, 22(1), 194. https://doi.org/10.1186/s12936-023-04624-0
Kolaczynska KE, Liechti ME, & . (2021). Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin’s main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1164, 122486. https://doi.org/10.1016/j.jchromb.2020.122486
Kolaczynska KE, Liechti ME, & . (2021). Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin’s main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1164, 122486. https://doi.org/10.1016/j.jchromb.2020.122486
, Weber, M., Hofer, L., Chaccour, C., Maia, M., Müller, P., Krähenbühl, S., & Hammann, F. (2021). The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes. PLoS Pathogens, 17(3), e1009382. https://doi.org/10.1371/journal.ppat.1009382
, Weber, M., Hofer, L., Chaccour, C., Maia, M., Müller, P., Krähenbühl, S., & Hammann, F. (2021). The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes. PLoS Pathogens, 17(3), e1009382. https://doi.org/10.1371/journal.ppat.1009382