The B cell receptor as disease driver and therapeutic target
Chronic antigen stimulation and pathological antigen receptor configurations impact the development and maintenance of lymphomas and autoimmunity. My research aims identify druggable molecules in the B cell receptor signaling axis, especially in Chronic Lymphocytic Leukemia (CLL), and to develop cellular or antibody-based approaches to target oncogenic or autoreactive antigen receptors.
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Selected Publications
Schultheiß, C., Schmidt-Barbo, P., Paschold, L., Esperanzate, C., Behn, A., Mikolajczyk, R., Kastner, D. L., Aksentijevich, I., & Binder, M. (2025). Deficiency of adenosine deaminase 2 skews adaptive immune repertoires toward specific sets of T- and B-cell receptors [Journal-article]. Journal of Allergy and Clinical Immunology, 155(5), 1664–1674. https://doi.org/10.1016/j.jaci.2025.01.032
Schultheiß, C., Schmidt-Barbo, P., Paschold, L., Esperanzate, C., Behn, A., Mikolajczyk, R., Kastner, D. L., Aksentijevich, I., & Binder, M. (2025). Deficiency of adenosine deaminase 2 skews adaptive immune repertoires toward specific sets of T- and B-cell receptors [Journal-article]. Journal of Allergy and Clinical Immunology, 155(5), 1664–1674. https://doi.org/10.1016/j.jaci.2025.01.032
Märkl, Florian, , Ali, Murtaza, Chen, Shih-Shih, Zintchenko, Marina, Egli, Lukas, Mietz, Juliane, Chijioke, Obinna, Paschold, Lisa, Spajic, Sebastijan, Holtermann, Anne, Dörr, Janina, Stock, Sophia, Zingg, Andreas, Läubli, Heinz, Piseddu, Ignazio, Anz, David, Minden, Marcus Dühren-von, Zhang, Tianjiao, et al. (2024). Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45378-w
Märkl, Florian, , Ali, Murtaza, Chen, Shih-Shih, Zintchenko, Marina, Egli, Lukas, Mietz, Juliane, Chijioke, Obinna, Paschold, Lisa, Spajic, Sebastijan, Holtermann, Anne, Dörr, Janina, Stock, Sophia, Zingg, Andreas, Läubli, Heinz, Piseddu, Ignazio, Anz, David, Minden, Marcus Dühren-von, Zhang, Tianjiao, et al. (2024). Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45378-w
Schultheiß, C., Paschold, L., Mohebiany, A. N., Escher, M., Kattimani, Y. M., Müller, M., Schmidt-Barbo, P., Mensa-Vilaró, A., Aróstegui, J. I., Boursier, G., de Moreuil, C., Hautala, T., Willscher, E., Jonas, H., Chinchuluun, N., Grosser, B., Märkl, B., Klapper, W., Oommen, P. T., et al. (2024). A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors [Journal-article]. Science Advances, 10(34). https://doi.org/10.1126/sciadv.adl3975
Schultheiß, C., Paschold, L., Mohebiany, A. N., Escher, M., Kattimani, Y. M., Müller, M., Schmidt-Barbo, P., Mensa-Vilaró, A., Aróstegui, J. I., Boursier, G., de Moreuil, C., Hautala, T., Willscher, E., Jonas, H., Chinchuluun, N., Grosser, B., Märkl, B., Klapper, W., Oommen, P. T., et al. (2024). A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors [Journal-article]. Science Advances, 10(34). https://doi.org/10.1126/sciadv.adl3975
Schultheiß, C., Willscher, E., Paschold, L., Gottschick, C., Klee, B., Henkes, S.-S., Bosurgi, L., Dutzmann, J., Sedding, D., Frese, T., Girndt, M., Höll, J. I., Gekle, M., Mikolajczyk, R., & Binder, M. (2022). The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19. Cell Reports Medicine, 3(6). https://doi.org/10.1016/j.xcrm.2022.100663
Schultheiß, C., Willscher, E., Paschold, L., Gottschick, C., Klee, B., Henkes, S.-S., Bosurgi, L., Dutzmann, J., Sedding, D., Frese, T., Girndt, M., Höll, J. I., Gekle, M., Mikolajczyk, R., & Binder, M. (2022). The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19. Cell Reports Medicine, 3(6). https://doi.org/10.1016/j.xcrm.2022.100663
Schultheiß, C., Paschold, L., Simnica, D., Mohme, M., Willscher, E., von Wenserski, L., Scholz, R., Wieters, I., Dahlke, C., Tolosa, E., Sedding, D. G., Ciesek, S., Addo, M., & Binder, M. (2020). Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease. Immunity, 53(2), 442–455. https://doi.org/10.1016/j.immuni.2020.06.024
Schultheiß, C., Paschold, L., Simnica, D., Mohme, M., Willscher, E., von Wenserski, L., Scholz, R., Wieters, I., Dahlke, C., Tolosa, E., Sedding, D. G., Ciesek, S., Addo, M., & Binder, M. (2020). Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease. Immunity, 53(2), 442–455. https://doi.org/10.1016/j.immuni.2020.06.024