The B cell receptor as disease driver and therapeutic target

Chronic antigen stimulation and pathological antigen receptor configurations impact the development and maintenance of lymphomas and autoimmunity. My research aims identify druggable molecules in the B cell receptor signaling axis, especially in Chronic Lymphocytic Leukemia (CLL), and to develop cellular or antibody-based approaches to target oncogenic or autoreactive antigen receptors.

Selected Publications

Schultheiß, C., Willscher, E., Paschold, L., Gottschick, C., Klee, B., Henkes, S.-S., Bosurgi, L., Dutzmann, J., Sedding, D., Frese, T., Girndt, M., Höll, J. I., Gekle, M., Mikolajczyk, R., & Binder, M. (2022). The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19. Cell Reports Medicine, 3. https://doi.org/10.1016/j.xcrm.2022.100663

URLs

Schultheiß, C., Simnica, D., Willscher, E., Oberle, A., Fanchi, L., Bonzanni, N., Wildner, N. H., Schulze Zur Wiesch, J., Weiler-Normann, C., Lohse, A. W., & Binder, M. (2021). Next-Generation Immunosequencing Reveals Pathological T-Cell Architecture in Autoimmune Hepatitis. Hepatology, 73, 1436–1448. https://doi.org/10.1002/hep.31473

URLs

Stein, A., Simnica, D., Schultheiß, C., Scholz, R., Tintelnot, J., Gökkurt, E., Von Wenserski, L., Willscher, E., Paschold, L., Sauer, M., Lorenzen, S., Riera-Knorrenschild, J., Depenbusch, R., Ettrich, T. J., Dörfel, S., Al-Batran, S.-E., Karthaus, M., Pelzer, U., Waberer, L., et al. (2021). PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer. Journal for ImmunoTherapy of Cancer, 9. https://doi.org/10.1136/jitc-2021-002844

URLs

Zhao, Y., Kilian, C., Turner, J.-E., Bosurgi, L., Roedl, K., Bartsch, P., Gnirck, A.-C., Cortesi, F., Schultheiß, C., Hellmig, M., Enk, L. U. B., Hausmann, F., Borchers, A., Wong, M. N., Paust, H.-J., Siracusa, F., Scheibel, N., Herrmann, M., Rosati, E., et al. (2021). Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients. Science Immunology, 6. https://doi.org/10.1126/sciimmunol.abf6692

URLs

Schultheiß, C., Paschold, L., Simnica, D., Mohme, M., Willscher, E., von Wenserski, L., Scholz, R., Wieters, I., Dahlke, C., Tolosa, E., Sedding, D. G., Ciesek, S., Addo, M., & Binder, M. (2020). Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease. Immunity, 53, 442–455. https://doi.org/10.1016/j.immuni.2020.06.024

URLs

Dr. rer. nat. Christoph Schultheiss

The B cell receptor as disease driver and therapeutic target

Selected Publications