Immune Selection and Dysfunction in Cancer Evolution and Treatment Resistance
We investigate how immune selection, signaling, and cellular interactions drive cancer development and therapeutic resistance, focusing on mutation–antigen receptor networks in lymphoma and suppressive immune environments in head and neck squamous cell carcinoma.
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Selected Publications
Paschold, L., Schultheiss, C., Schmidt-Barbo, P., Klinghammer, K., Hahn, D., Tometten, M., Schafhausen, P., Blaurock, M., Brandt, A., Westgaard, I., Kowoll, S., Stein, A., Hinke, A., & Binder, M. (2025). Inflammation and limited adaptive immunity predict worse outcomes on immunotherapy in head and neck cancer [Journal-article]. Npj Precision Oncology, 9(1). https://doi.org/10.1038/s41698-025-01020-6
Paschold, L., Schultheiss, C., Schmidt-Barbo, P., Klinghammer, K., Hahn, D., Tometten, M., Schafhausen, P., Blaurock, M., Brandt, A., Westgaard, I., Kowoll, S., Stein, A., Hinke, A., & Binder, M. (2025). Inflammation and limited adaptive immunity predict worse outcomes on immunotherapy in head and neck cancer [Journal-article]. Npj Precision Oncology, 9(1). https://doi.org/10.1038/s41698-025-01020-6
Schultheiß, C., Schmidt-Barbo, P., Paschold, L., Esperanzate, C., Behn, A., Mikolajczyk, R., Kastner, D. L., Aksentijevich, I., & Binder, M. (2025). Deficiency of adenosine deaminase 2 skews adaptive immune repertoires toward specific sets of T- and B-cell receptors [Journal-article]. Journal of Allergy and Clinical Immunology, 155(5), 1664–1674. https://doi.org/10.1016/j.jaci.2025.01.032
Schultheiß, C., Schmidt-Barbo, P., Paschold, L., Esperanzate, C., Behn, A., Mikolajczyk, R., Kastner, D. L., Aksentijevich, I., & Binder, M. (2025). Deficiency of adenosine deaminase 2 skews adaptive immune repertoires toward specific sets of T- and B-cell receptors [Journal-article]. Journal of Allergy and Clinical Immunology, 155(5), 1664–1674. https://doi.org/10.1016/j.jaci.2025.01.032
Märkl, Florian, , Ali, Murtaza, Chen, Shih-Shih, Zintchenko, Marina, Egli, Lukas, Mietz, Juliane, Chijioke, Obinna, Paschold, Lisa, Spajic, Sebastijan, Holtermann, Anne, Dörr, Janina, Stock, Sophia, Zingg, Andreas, Läubli, Heinz, Piseddu, Ignazio, Anz, David, Minden, Marcus Dühren-von, Zhang, Tianjiao, et al. (2024). Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45378-w
Märkl, Florian, , Ali, Murtaza, Chen, Shih-Shih, Zintchenko, Marina, Egli, Lukas, Mietz, Juliane, Chijioke, Obinna, Paschold, Lisa, Spajic, Sebastijan, Holtermann, Anne, Dörr, Janina, Stock, Sophia, Zingg, Andreas, Läubli, Heinz, Piseddu, Ignazio, Anz, David, Minden, Marcus Dühren-von, Zhang, Tianjiao, et al. (2024). Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45378-w
Schultheiß, C., Paschold, L., Mohebiany, A. N., Escher, M., Kattimani, Y. M., Müller, M., Schmidt-Barbo, P., Mensa-Vilaró, A., Aróstegui, J. I., Boursier, G., de Moreuil, C., Hautala, T., Willscher, E., Jonas, H., Chinchuluun, N., Grosser, B., Märkl, B., Klapper, W., Oommen, P. T., et al. (2024). A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors [Journal-article]. Science Advances, 10(34). https://doi.org/10.1126/sciadv.adl3975
Schultheiß, C., Paschold, L., Mohebiany, A. N., Escher, M., Kattimani, Y. M., Müller, M., Schmidt-Barbo, P., Mensa-Vilaró, A., Aróstegui, J. I., Boursier, G., de Moreuil, C., Hautala, T., Willscher, E., Jonas, H., Chinchuluun, N., Grosser, B., Märkl, B., Klapper, W., Oommen, P. T., et al. (2024). A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors [Journal-article]. Science Advances, 10(34). https://doi.org/10.1126/sciadv.adl3975
Schultheiß, C., Paschold, L., Simnica, D., Mohme, M., Willscher, E., von Wenserski, L., Scholz, R., Wieters, I., Dahlke, C., Tolosa, E., Sedding, D. G., Ciesek, S., Addo, M., & Binder, M. (2020). Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease. Immunity, 53(2), 442–455. https://doi.org/10.1016/j.immuni.2020.06.024
Schultheiß, C., Paschold, L., Simnica, D., Mohme, M., Willscher, E., von Wenserski, L., Scholz, R., Wieters, I., Dahlke, C., Tolosa, E., Sedding, D. G., Ciesek, S., Addo, M., & Binder, M. (2020). Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease. Immunity, 53(2), 442–455. https://doi.org/10.1016/j.immuni.2020.06.024