Prof. Dr. med. Matthias Betz

Erdil, Ertunc, Becker, Anton S., Schwyzer, Moritz, Martinez-Tellez, Borja, Ruiz, Jonatan R., Sartoretti, Thomas, Vargas, H. Alberto, Burger, A. Irene, Chirindel, Alin, Wild, Damian, Zamboni, Nicola, Deplancke, Bart, Gardeux, Vincent, Maushart, Claudia Irene, Betz, Matthias Johannes, Wolfrum, Christian, & Konukoglu, Ender. (2024). Correction to: Predicting standardized uptake value of brown adipose tissue from CT scans using convolutional neural networks (Nature Communications, (2024), 15, 1, (8402), 10.1038/s41467-024-52622-w). Nature Communications, 15. https://doi.org/10.1038/s41467-024-54209-x

Wang, Tongtong, Sharma, Anand Kumar, Wu, Chunyan, Maushart, Claudia Irene, Ghosh, Adhideb, Yang, Wu, Stefanicka, Patrik, Kovanicova, Zuzana, Ukropec, Jozef, Zhang, Jing, Arnold, Myrtha, Klug, Manuel, De Bock, Katrien, Schneider, Ulrich, Popescu, Cristina, Zheng, Bo, Ding, Lianggong, Long, Fen, Dewal, Revati Sumukh, et al. (2024). Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes [Journal-article]. Cell Metabolism, 36(9), 2130–2145. https://doi.org/10.1016/j.cmet.2024.07.005

Maushart, Claudia Irene, Sun, Wenfei, Othman, Alaa, Ghosh, Adhideb, Senn, Jaël Rut, Fischer, Jonas Gabriel William, Madoerin, Philipp, Loeliger, Rahel Catherina, Benz, Robyn Melanie, Takes, Martin, Zech, Christoph Johannes, Chirindel, Alin, Beuschlein, Felix, Reincke, Martin, Wild, Damian, Bieri, Oliver, Zamboni, Nicola, Wolfrum, Christian, & Betz, Matthias Johannes. (2023). Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy men. eBioMedicine, 96. https://doi.org/10.1016/j.ebiom.2023.104771

Senn JR, Löliger RC, Fischer JGW, Bur F, Maushart CI, & Betz MJ. (2023). Acute effect of propranolol on resting energy expenditure in hyperthyroid patients. Frontiers in Endocrinology, 13, 1026998. https://doi.org/10.3389/fendo.2022.1026998

Maushart CI, Senn JR, Loeliger RC, Siegenthaler J, Bur F, Fischer JGW, & Betz MJ. (2022). Resting Energy Expenditure and Cold-induced Thermogenesis in Patients With Overt Hyperthyroidism. Journal of Clinical Endocrinology and Metabolism, 107(2), 450–461. https://doi.org/10.1210/clinem/dgab706

Betz MJ, & Zech CJ. (2022). Adrenal venous sampling in the diagnostic workup of primary aldosteronism. British Journal of Radiology, 95(1129), 20210311. https://doi.org/10.1259/bjr.20210311

Ebrahimi, Fahim, Urwyler, Sandrine Andrea, Betz, Matthias Johannes, Christ, Emanuel Remigius, Schuetz, Philipp, Müller, Beat, Donath, Marc Yves, & Christ-Crain, Mirjam. (2021). Effects of interleukin-1 antagonism and corticosteroids on fibroblast growth factor-21 in patients with metabolic syndrome. Scientific Reports, 11(1), 7911. https://doi.org/10.1038/s41598-021-87207-w

Ebrahimi F., Urwyler S.A., Betz M.J., Christ E.R., Schuetz P., Mueller B., Donath M.Y., & Christ-Crain M. (2021). Effects of interleukin-1 antagonism and corticosteroids on fibroblast growth factor-21 in patients with metabolic syndrome. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-87207-w

Felder M, Maushart CI, Gashi G, Senn JR, Becker AS, Müller J, Balaz M, Wolfrum C, Burger IA, & Betz MJ. (2021). Fluvastatin Reduces Glucose Tolerance in Healthy Young Individuals Independently of Cold Induced BAT Activity. Frontiers in Endocrinology, 12, 765807. https://doi.org/10.3389/fendo.2021.765807

Löffler MC, Betz MJ, Blondin DP, Augustin R, Sharma AK, Tseng YH, Scheele C, Zimdahl H, Mark M, Hennige AM, Wolfrum C, Langhans W, Hamilton BS, & Neubauer H. (2021). Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application. Molecular Metabolism, 51, 101237. https://doi.org/10.1016/j.molmet.2021.101237

Löffler, Mona C, Betz, Matthias J, Blondin, Denis P, Augustin, Robert, Sharma, Anand K, Tseng, Yu-Hua, Scheele, Camilla, Zimdahl, Heike, Mark, Michael, Hennige, Anita M, Wolfrum, Christian, Langhans, Wolfgang, Hamilton, Bradford S, & Neubauer, Heike. (2021). Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application. Molecular Metabolism, 51, 101237. https://doi.org/10.1016/j.molmet.2021.101237

Loeliger, Rahel Catherina, Maushart, Claudia Irene, Gashi, Gani, Senn, Jaël Rut, Felder, Martina, Becker, Anton S, Müller, Julian, Balaz, Miroslav, Wolfrum, Christian, Burger, Irene A, & Betz, Matthias Johannes. (2021). Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men. American Journal of Physiology - Endocrinology and Metabolism, 320(1), E93–E101. https://doi.org/10.1152/ajpendo.00237.2020

Loeliger RC, Maushart CI, Gashi G, Senn JR, Felder M, Becker AS, Müller J, Balaz M, Wolfrum C, Burger IA, & Betz MJ. (2021). Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men. American Journal of Physiology - Endocrinology and Metabolism, 320(1), E93–E101. https://doi.org/10.1152/AJPENDO.00237.2020

Maushart, Claudia Irene, Senn, Jaël Rut, Loeliger, Rahel Catherina, Kraenzlin, Marius E., Müller, Julian, Becker, Anton S., Balaz, Miroslav, Wolfrum, Christian, Burger, Irene A., & Betz, Matthias Johannes. (2021). Free Thyroxine Levels are Associated with Cold Induced Thermogenesis in Healthy Euthyroid Individuals. Frontiers in Endocrinology, 12, 666595. https://doi.org/10.3389/fendo.2021.666595

Fischer JGW, Maushart CI, Becker AS, Müller J, Madoerin P, Chirindel A, Wild D, Ter Voert EEGW, Bieri O, Burger I, & Betz MJ. (2020). Comparison of [18F]FDG PET/CT with magnetic resonance imaging for the assessment of human brown adipose tissue activity. EJNMMI Research, 10(1), 85. https://doi.org/10.1186/s13550-020-00665-7

Fischer, Jonas Gabriel William, Maushart, Claudia Irene, Becker, Anton S., Müller, Julian, Madoerin, Philipp, Chirindel, Alin, Wild, Damian, Ter Voert, Edwin E. G. W., Bieri, Oliver, Burger, Irene, & Betz, Matthias Johannes. (2020). Comparison of [; 18; F]FDG PET/CT with magnetic resonance imaging for the assessment of human brown adipose tissue activity. EJNMMI Research, 10(1), 85. https://doi.org/10.1186/s13550-020-00665-7

Kovaničová, Zuzana, Kurdiová, Tímea, Baláž , Miroslav, Varga, Lukáš, Kulterer, Oana C., Betz, Matthias J., Haug, Alexander R., Burger, Irene A., Kiefer, Florian W., Wolfrum, Christian, Ukropcová, Barbara, & Ukropec, Jozef. (2020). Cold Exposure Distinctively Modulates Parathyroid and Thyroid Hormones in Cold-Acclimatized and Non-Acclimatized Humans. Endocrinology, 161(7), bqaa051. https://doi.org/10.1210/endocr/bqaa051

Ter Voert, Edwin E. G. W., Svirydenka, Hanna, Müller, Julian, Becker, Anton S., Balaz, Miroslav, Efthymiou, Vissarion, Maushart, Claudia Irene, Gashi, Gani, Wolfrum, Christian, Betz, Matthias J., & Burger, Irene A. (2020). Low-dose; 18; F-FDG TOF-PET/MR for accurate quantification of brown adipose tissue in healthy volunteers. EJNMMI Research, 10(1), 5. https://doi.org/10.1186/s13550-020-0592-8

Ter Voert EEGW, Svirydenka H, Müller J, Becker AS, Balaz M, Efthymiou V, Maushart CI, Gashi G, Wolfrum C, Betz MJ, & Burger IA. (2020). Low-dose 18F-FDG TOF-PET/MR for accurate quantification of brown adipose tissue in healthy volunteers. EJNMMI Research, 10(1), 5. https://doi.org/10.1186/s13550-020-0592-8

Yoneshiro, Takeshi, Rodríguez-Rodríguez, Rosalía, Betz, Matthias Johannes, & Rensen, Patrick C. N. (2020). Editorial: Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity. Frontiers in Endocrinology, 11, 600341. https://doi.org/10.3389/fendo.2020.600341

Sukonina V, Ma H, Zhang W, Bartesaghi S, Subhash S, Heglind M, Foyn H, Betz MJ, Nilsson D, Lidell ME, Naumann J, Haufs-Brusberg S, Palmgren H, Mondal T, Beg M, Jedrychowski MP, Taskén K, Pfeifer A, Peng XR, et al. (2019). FOXK1 and FOXK2 regulate aerobic glycolysis. Nature, 566(7743), 279–283. https://doi.org/10.1038/s41586-019-0900-5

Balaz, Miroslav, Becker, Anton S., Balazova, Lucia, Straub, Leon, Müller, Julian, Gashi, Gani, Maushart, Claudia Irene, Sun, Wenfei, Dong, Hua, Moser, Caroline, Horvath, Carla, Efthymiou, Vissarion, Rachamin, Yael, Modica, Salvatore, Zellweger, Caroline, Bacanovic, Sara, Stefanicka, Patrik, Varga, Lukas, Ukropcova, Barbara, et al. (2019). Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation. Cell Metabolism, 29(4), 901–916. https://doi.org/10.1016/j.cmet.2018.11.017

Ebrahimi, Fahim, Wolffenbuttel, Carole, Blum, Claudine A., Baumgartner, Christine, Mueller, Beat, Schuetz, Philipp, Meier, Christian, Kraenzlin, Marius, Christ-Crain, Mirjam, & Betz, Matthias Johannes. (2019). Fibroblast growth factor 21 predicts outcome in community-acquired pneumonia: secondary analysis of two randomised controlled trials. European Respiratory Journal, 53(2). https://doi.org/10.1183/13993003.00973-2018

Gashi, Gani, Madoerin, Philipp, Maushart, Claudia I., Michel, Regina, Senn, Jaël-Rut, Bieri, Oliver, & Betz, Matthias J. (2019). MRI characteristics of supraclavicular brown adipose tissue in relation to cold-induced thermogenesis in healthy human adults. Journal of Magnetic Resonance Imaging, 50(4), 1160–1168. https://doi.org/10.1002/jmri.26733

Hepprich, Matthias, Lorscheider, Johannes, Peters, Nils, & Betz, Matthias Johannes. (2019). Hypothyroidism manifesting as multiple cranial neuropathies: a case report. Journal of Medical Case Reports, 13(1), 180. https://doi.org/10.1186/s13256-019-2124-6

Maushart, Claudia Irene, Loeliger, Rahel, Gashi, Gani, Christ-Crain, Mirjam, & Betz, Matthias Johannes. (2019). Resolution of Hypothyroidism Restores Cold-Induced Thermogenesis in Humans. Thyroid : Official Journal of the American Thyroid Association, 29(4), 493–501. https://doi.org/10.1089/thy.2018.0436

Meienberg, Fabian, Loher, Hannah, Bucher, Julie, Jenni, Stefan, Krüsi, Marion, Kreis, Roland, Boesch, Chris, Betz, Matthias Johannes, & Christ, Emanuel. (2019). The effect of exercise on intramyocellular acetylcarnitine (AcCtn) concentration in adult growth hormone deficiency (GHD). Scientific Reports, 9(1), 19431. https://doi.org/10.1038/s41598-019-55942-w

Trinh, Beckey, Hepprich, Matthias, Betz, Matthias J., Burkard, Thilo, Cavelti-Weder, Claudia, Seelig, Eleonora, Meienberg, Fabian, Kratschmar, Denise V., Beuschlein, Felix, Reincke, Martin, Odermatt, Alex, Hall, Michael N., Donath, Marc Y., & Swierczynska, Marta M. (2019). Treatment of Primary Aldosteronism with mTORC1 Inhibitors. The Journal of Clinical Endocrinology and Metabolism, 104(10), 4703–4714. https://doi.org/10.1210/jc.2019-00563

Ebrahimi, F., Wolffenbuttel, C., Blum, C. A., Muller, B., Schuetz, P., Christ-Crain, M., & Betz, M. J. (2018). Fibroblast growth factor-21 predicts adverse outcome in community-acquired pneumonia [Journal-article]. Endocrine Abstracts. https://doi.org/10.1530/endoabs.56.p629

Senn, J. R., Maushart, C. I., Gashi, G., Becker, A. S., Muller, J., Burger, I. A., & Betz, M. J. (2018). Cold induced thermogenesis is influenced by seasonal changes in outdoor temperature [Journal-article]. Endocrine Abstracts. https://doi.org/10.1530/endoabs.56.gp161

Nigro N, Winzeler B, Suter-Widmer I, Schuetz P, Arici B, Bally M, Refardt J, Betz M, Gashi G, Urwyler SA, Burget L, Blum CA, Bock A, Huber A, Müller B, & Christ-Crain M. (2018). Copeptin levels and commonly used laboratory parameters in hospitalised patients with severe hypernatraemia - the ‘Co-MED study’. Critical Care, 22(1), 33. https://doi.org/10.1186/s13054-018-1955-7

Betz, Matthias J., & Enerback, Sven. (2018). Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease. Nature Reviews Endocrinology, 14(2), 77–87. https://doi.org/10.1038/nrendo.2017.132

Refardt, Julie, Sailer, Clara Odilia, Winzeler, Bettina, Betz, Matthias Johannes, Chifu, Irina, Schnyder, Ingeborg, Fassnacht, Martin, Fenske, Wiebke, & Christ-Crain, Mirjam. (2018). FGF-21 levels in polyuria-polydipsia syndrome. Endocrine Connections, 7(12), 1501–1506. https://doi.org/10.1530/ec-18-0469

Senn, Jaël R., Maushart, Claudia I., Gashi, Gani, Michel, Regina, Lalive d’Epinay, Murielle, Vogt, Roland, Becker, Anton S., Müller, Julian, Baláz, Miroslav, Wolfrum, Christian, Burger, Irene A., & Betz, Matthias J. (2018). Outdoor Temperature Influences Cold Induced Thermogenesis in Humans. Frontiers in Physiology, 9, 1184. https://doi.org/10.3389/fphys.2018.01184

Swierczynska, Marta M., Betz, Matthias J., Colombi, Marco, Dazert, Eva, Jenö, Paul, Moes, Suzette, Pfaff, Cécile, Glatz, Katharina, Reincke, Martin, Beuschlein, Felix, Donath, Marc Y., & Hall, Michael N. (2018). Proteomic Landscape of Aldosterone-Producing Adenoma. Hypertension (Dallas, Tex. : 1979), 73(2), 469–480. https://doi.org/10.1161/hypertensionaha.118.11733

Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, & Pfeifer A. (2016). The G q signalling pathway inhibits brown and beige adipose tissue. Nature Communications, 7, 10895. https://doi.org/10.1038/ncomms10895

Romu T, Elander L, Leinhard OD, Lidell ME, Betz MJ, Persson A, Enerbäck S, & Borga M. (2015). Characterization of brown adipose tissue by water-fat separated magnetic resonance imaging. Journal of Magnetic Resonance Imaging, 42(6), 1639–1645. https://doi.org/10.1002/jmri.24931

Betz MJ, & Enerbäck S. (2015). Human brown adipose tissue: What we have learned so far. Diabetes, 64(7), 2352–2360. https://doi.org/10.2337/db15-0146

Degenhart C, Strube H, Betz MJ, Pallauf A, Bidlingmaier M, Fischer E, Reincke M, Reiser MF, & Wirth S. (2015). CT mapping of the vertebral level of right adrenal vein. Diagnostic and Interventional Radiology, 21(1), 60–66. https://doi.org/10.5152/dir.2014.14026

Gnad T, Scheibler S, von Kügelgen I, Scheele C, Kilić A, Glöde A, Hoffmann LS, Reverte-Salisa L, Horn P, Mutlu S, El-Tayeb A, Kranz M, Deuther-Conrad W, Brust P, Lidell ME, Betz MJ, Enerbäck S, Schrader J, Yegutkin GG, et al. (2014). Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature, 516(7531), 395–399. https://doi.org/10.1038/nature13816

Lidell ME, Betz MJ, & Enerbäck S. (2014). Brown adipose tissue and its therapeutic potential. Journal of Internal Medicine, 276(4), 364–377. https://doi.org/10.1111/joim.12255

Lidell ME, Betz MJ, & Enerbäck S. (2014). Two types of brown adipose tissue in humans. Adipocyte, 3(1), 6–63. https://doi.org/10.4161/adip.26896

Betz, Matthias Johannes, Slawik, Marc, Lidell, Martin E., Osswald, Andrea, Heglind, Mikael, Nilsson, Daniel, Lichtenauer, Urs Daniel, Mauracher, Brigitte, Mussack, Thomas, Beuschlein, Felix, & Enerbäck, Sven. (2013). Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: Relationship with outdoor temperature. Journal of Clinical Endocrinology and Metabolism, 98(10), 4097–4104. https://doi.org/10.1210/jc.2012-3535

Lidell, Martin E., Betz, Matthias J., Leinhard, Olof Dahlqvist, Heglind, Mikael, Elander, Louise, Slawik, Marc, Mussack, Thomas, Nilsson, Daniel, Romu, Thobias, Nuutila, Pirjo, Virtanen, Kirsi A., Beuschlein, Felix, Persson, Anders, Borga, Magnus, & Enerbäck, Sven. (2013). Evidence for two types of brown adipose tissue in humans. Nature Medicine, 19(5), 631–634. https://doi.org/10.1038/nm.3017

Betz,Matthias J. (2012). What dietary modification best improves insulin sensitivity and why? Clinical Endocrinology, 77(4), 508–512. https://doi.org/10.1111/j.1365-2265.2012.04450.x

Betz M.J., Hatiboglu N., Mauracher B., Hadaschik D., Sauter A., Demmelmair H., Koletzko B., Beuschlein F., & Slawik M. (2012). Mc2 receptor knockdown modulates differentiation and lipid composition in adipocytes. Hormone and Metabolic Research, 44(9), 670–675. https://doi.org/10.1055/s-0032-1314854

Betz MJ, Bielohuby M, Mauracher B, Abplanalp W, Müller HH, Pieper K, Ramisch J, Tschöp MH, Beuschlein F, Bidlingmaier M, & Slawik M. (2012). Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats. PloS One, 7(6), e38997. https://doi.org/10.1371/journal.pone.0038997

Betz MJ, & Enerbäck S. (2011). Therapeutic prospects of metabolically active brown adipose tissue in humans. Frontiers in Endocrinology, 2(NOV), 86. https://doi.org/10.3389/fendo.2011.00086

Betz MJ, Degenhart C, Fischer E, Pallauf A, Brand V, Linsenmaier U, Beuschlein F, Bidlingmaier M, & Reincke M. (2011). Adrenal vein sampling using rapid cortisol assays in primary aldosteronism is useful in centers with low success rates. European Journal of Endocrinology, 165(2), 301–306. https://doi.org/10.1530/EJE-11-0287

Tanriver Y, Betz MJ, Nibbe L, Pfluger T, Beuschlein F, & Strowski MZ. (2010). Sepsis and cardiomyopathy as rare clinical manifestations of pheochromocytoma-two case report studies. Experimental and Clinical Endocrinology and Diabetes, 118(10), 747–753. https://doi.org/10.1055/s-0030-1253413

Betz MJ, & Beuschlein F. (2009). Diagnosis: Novel molecular signatures for adrenocortical carcinoma (Patent No. 6). Nature Reviews Endocrinology, 5(6), Article 6. https://doi.org/10.1038/nrendo.2009.93

Müller AM, Betz MJ, Kromeier J, Ghanem NA, Geibel A, Imdahl A, & Frydrychowicz AP. (2006). Images in cardiovascular medicine. Acute pneumopericardium due to intestino-pericardial fistula. Circulation, 114(1), e7–9. https://doi.org/10.1161/circulationaha.105.601252

Betz MJ, Shapiro I, Fassnacht M, Hahner S, Reincke M, Beuschlein F, & German and Austrian Adrenal Network. (2005). Peroxisome proliferator-activated receptor-γ agonists suppress adrenocortical tumor cell proliferation and induce differentiation. Journal of Clinical Endocrinology and Metabolism, 90(7), 3886–3896. https://doi.org/10.1210/jc.2004-1267