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Prof. Dr. med. Ludwig Kappos

Department of Clinical Research
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Publications

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Martina, Greselin, Po-Jui, Lu, Magdalena, Mroczek, Nuria, Cerdá-Fuertes, Anastasios, Demirtzoglou, Athina, Papadopoulou, Jens, Kuhle, David, Leppert, Sophie, Arnould, Manar, Aoun, Ludwig, Kappos, Cristina, Granziera, & Marcus, D’Souza. (2025). AI-assisted identification of disability patterns within identical EDSS grades. Mult Scler ., 31(6), 677–688. https://doi.org/10.1177/13524585251327300

Kappos, Ludwig, Yiu, Sean, Dahlke, Frank, Coetzee, Timothy, Cutter, Gary R., Yuen, Steven, Bonati, Ulrike, & Lublin, Fred D. (2025). Composite Confirmed Disability Worsening/Progression Is a Useful Clinical Endpoint for Multiple Sclerosis Clinical Trials. Neurology, 104(10). https://doi.org/10.1212/wnl.0000000000213558

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Géraldine, Androdias, Jan D, Lünemann, Elisabeth, Maillart, Maria Pia, Amato, Bertrand, Audoin, Arlette L, Bruijstens, Gabriel, Bsteh, Helmut, Butzkueven, Olga, Ciccarelli, Alvaro, Cobo-Calvo, Tobias, Derfuss, Franziska, Di Pauli, Gilles, Edan, Christian, Enzinger, Ruth, Geraldes, Cristina, Granziera, Yael, Hacohen, Hans-Peter, Hartung, Sinéad, Hynes, et al. (2025). De-escalating and discontinuing disease-modifying therapies in multiple sclerosis. Brain, 148(5), 1459–1478. https://doi.org/10.1093/brain/awae409

Özgür, Yaldizli, Pascal, Benkert, Lutz, Achtnichts, Amit, Bar-Or, Viviane, Bohner-Lang, Claire, Bridel, Manuel, Comabella, Oliver, Findling, Giulio, Disanto, Sebastian, Finkener, Claudio, Gobbi, Cristina, Granziera, Marina, Herwerth, Robert, Hoepner, Dana, Horakova, Nicole, Kamber, Michael, Khalil, Philipp, Kunz, Patrice, Lalive, et al. (2025). Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in multiple sclerosis: A modified Delphi Study. Mult Scler . . https://doi.org/10.1177/13524585251335466

Mario, Ocampo-Pineda, Alessandro, Cagol, Pascal, Benkert, Muhamed, Barakovic, Po-Jui, Lu, Jannis, Müller, Sabine Anna, Schaedelin, Lester, Melie-Garcia, Matthias, Weigel, Maria Pia, Sormani, Ludwig, Kappos, Jens, Kuhle, & Cristina, Granziera. (2025). White Matter Tract Degeneration in Multiple Sclerosis Patients With Progression Independent of Relapse Activity. Neurol Neuroimmunol Neuroinflamm . , 12(3), e200388. https://doi.org/10.1212/NXI.0000000000200388

Jannis, Müller, Sifat, Sharmin, Johannes, Lorscheider, Serkan, Ozakbas, Rana, Karabudak, Dana, Horakova, Bianca, Weinstock-Guttman, Vahid, Shaygannejad, Masoud, Etemadifar, Raed, Alroughani, Francesco, Patti, Sara, Eichau, Alexandre, Prat, Alessandra, Lugaresi, Valentina, Tomassini, Allan G, Kermode, Maria Pia, Amato, Recai, Turkoglu, Ayse, Altintas, et al. (2025). Standardized Definition of Progression Independent of Relapse Activity (PIRA) in Relapsing-Remitting Multiple Sclerosis. JAMA Neurol . , e250495. https://doi.org/10.1001/jamaneurol.2025.0495

Riccardo, Galbusera, Matthias, Weigel, Erik, Bahn, Sabine, Schaedelin, Alessandro, Cagol, Po-Jui, Lu, Muhamed, Barakovic, Lester, Melie-Garcia, Jonas, Franz, Peter, Dechent, Govind, Nair, Ludwig, Kappos, Wolfgang, Brück, Christine, Stadelmann, & Cristina, Granziera. (2025). Quantitative T1 is sensitive to cortical remyelination in multiple sclerosis: A postmortem MRI study. Brain Pathol ., e70010. https://doi.org/10.1111/bpa.70010

Mallucci, Giulia, Zimmer, Andrea, Sfikas, Nikolaos, Cerdá-Fuertes, Nuria, Wunderlin, Simon, Athanasopoulou, Ioanna, Mroczek, Magdalena, Phavanh, Vanny, Sanak, Lisa, Suter, Jolanda, Friedli, Bernadette, Kel, Jakob, Trouillet, Thomas, Simmen, Sarah, Ocampo, Alex, Wei, Wenjia, Kieseier, Bernd, Kamm, Christian P, Kappos, Ludwig, & D’Souza, Marcus. (2025). Neurostatus-SMARTCARE clinical trial: Enabling health care professionals to assess EDSS for decentralized trials in multiple sclerosis. Multiple Sclerosis Journal, 31(4), 497–501. https://doi.org/10.1177/13524585241305966

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Giulio, Disanto, Sabine, Schaedelin, Johanna, Oechtering, Johannes, Lorscheider, Riccardo, Galbusera, Sebastian, Finkener, Lutz, Achtnichts, Patrice, Lalive, Stefanie, Müller, Caroline, Pot, Robert, Hoepner, Anke, Salmen, Chiara, Zecca, Lars G, Hemkens, Marcus, D’Souza, Bettina, Fischer-Barnicol, Renaud, Du Pasquier, Patrick, Roth, Özgür, Yaldizli, et al. (2025). Treatment persistence and clinical outcomes in patients starting B cell depleting therapies within the Swiss MS Cohort. Mult Scler J Exp Transl Clin ., 11(1), 20552173251315457. https://doi.org/10.1177/20552173251315457

Jannis, Müller, Sifat, Sharmin, Johannes, Lorscheider, Dana, Horakova, Eva, Kubala Havrdova, Sara, Eichau, Francesco, Patti, Pierre, Grammond, Katherine, Buzzard, Olga, Skibina, Alexandre, Prat, Marc, Girard, Francois, Grand’Maison, Raed, Alroughani, Jeannette, Lechner-Scott, Daniele, Spitaleri, Michael, Barnett, Elisabetta, Cartechini, Maria Jose, Sa, et al. (2025). Treatment De-escalation in Relapsing-Remitting Multiple Sclerosis: An Observational Study. CNS Drugs ., 39(4), 403–416. https://doi.org/10.1007/s40263-025-01164-w

Ralph, Hb Benedict, Ludwig, Kappos, Aaron, Miller, Hans-Peter, Hartung, James, Overell, Jinglan, Pei, Frank, Dahlke, Corrado, Bernasconi, Harold, Koendgen, Qing, Wang, Ulrike, Bonati, & Stanley, Cohan. (2025). Cognitive effects of ocrelizumab vs interferon β-1a in relapsing multiple sclerosis: A post hoc analysis of the OPERA I/II trials. Mult Scler Relat Disord . . https://doi.org/10.1016/j.msard.2025.106310

Paolo A, Muraro, Alice, Mariottini, Raffaella, Greco, Joachim, Burman, Ellen, Iacobaeus, Matilde, Inglese, John A, Snowden, Tobias, Alexander, Maria Pia, Amato, Lars, Bø, Giacomo, Boffa, Olga, Ciccarelli, Jeffrey A, Cohen, Tobias, Derfuss, Dominique, Farge, Mark S, Freedman, Maria, Gaughan, Christoph, Heesen, Majid, Kazmi, et al. (2025). Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder - recommendations from ECTRIMS and the EBMT. Nat Rev Neurol . , 21(3), 140–158. https://doi.org/10.1038/s41582-024-01050-x

Silvan, Pless, Tim, Woelfle, Johannes, Lorscheider, Andrea, Wiencierz, Óscar, Reyes, Carlos, Luque, Pasquale, Calabrese, Cristina, Granziera, & Ludwig, Kappos. (2025). CoGames: Development of an adaptive smartphone-based and gamified monitoring tool for cognitive function in Multiple Sclerosis. J Neurol . , 272(2), 119. https://doi.org/doi: 10.1007/s00415-024-12818-y

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Patrick, Vermersch, Ralf, Gold, Amit, Bar-Or, Bruce A C, Cree, Robert J, Fox, Gavin, Giovannoni, Friedemann, Paul, Sebastian, Wolf, Bingbing, Li, Marie-Catherine, Mousseau, Tina, Maio-Twofoot, Xiaofang, Shi, & Ludwig, Kappos. (2025). Effect of siponimod on retinal thickness, a marker of neurodegeneration, in participants with SPMS: Findings from the EXPAND OCT substudy. Mult Scler Relat Disord . , 94, 106259. https://doi.org/10.1016/j.msard.2025.106259

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Oechtering, Johanna, Schaedelin, Sabine Anna, Stein, Kerstin, Maleska Maceski, Aleksandra, Melie-Garcia, Lester, Benkert, Pascal, Cagol, Alessandro, Leber, Selina, Galbusera, Riccardo, Ruberte, Esther, Hu, Wayne, Qureshi, Ferhan, Orleth, Annette, Demuth, Lilian, Willemse, Eline, Heijnen, Ingmar, Regeniter, Axel, Derfuss, Tobias J., Fischer-Barnicol, Bettina, et al. (2025). Aberrant Complement Activation Is Associated With Structural Brain Damage in Multiple Sclerosis [Journal-article]. Neurology: Neuroimmunology and NeuroInflammation, 12(2). https://doi.org/10.1212/nxi.0000000000200361

Benkert, Pascal, Maleska Maceski, Aleksandra, Schaedelin, Sabine, Oechtering, Johanna, Zadic, Amar, Vilchez Gomez, Juan Francisco, Melie-Garcia, Lester, Cagol, Alessandro, Galbusera, Riccardo, Subramaniam, Suvitha, Lorscheider, Johannes, Galli, Edoardo, Mueller, Jannis, Fischer-Barnicol, Bettina, Achtnichts, Lutz, Findling, Oliver, Lalive, Patrice H., Bridel, Claire, Uginet, Marjolaine, et al. (2025). Serum Glial Fibrillary Acidic Protein and Neurofilament Light Chain Levels Reflect Different Mechanisms of Disease Progression under B-Cell Depleting Treatment in Multiple Sclerosis. Annals of Neurology, 97(1), 104–115. https://doi.org/10.1002/ana.27096

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Damiano, Marastoni, Elisa, Colato, Matteo, Foschi, Agnese, Tamanti, Stefano, Ziccardi, Chiara, Eccher, Francesco, Crescenzo, Albulena, Bajrami, Gian Marco, Schiavi, Valentina, Camera, Daniela Anni, Federica, Virla, Maddalena, Guandalini, Ermanna, Turano, Francesca Benedetta, Pizzini, Stefania, Montemezzi, Bruno, Bonetti, Owain, Howell, Roberta, Magliozzi, et al. (2025). Intrathecal Inflammatory Profile and Gray Matter Damage Predict Progression Independent of Relapse Activity in Early Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm . , 12(4), e200399. https://doi.org/10.1212/NXI.0000000000200399

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Douglas L, Arnold, Shannon, Kolind, Haz-Edine, Assemlal, Amit, Bar-Or, Matilde, Inglese, Ludwig, Kappos, Katrin, Parmar, Till, Sprenger, Anthony, Traboulsee, Irene M, Vavasour, Jerry S, Wolinsky, Corrado, Bernasconi, Ulrike, Bonati, Stefano, Magon, Björn, Tackenberg, & Laura, Gaetano. (2025). Short- and long-term effects of early versus delayed treatment with ocrelizumab on cerebellar volume loss in patients with RMS and PPMS. Mult Scler . . https://doi.org/10.1177/13524585251325086

Pontillo, G., Prados, F., Wink, A. M., Kanber, B., Bisecco, A., Broeders, T. A. A., Brunetti, A., Cagol, A., Calabrese, M., Castellaro, M., Cocozza, S., Colato, E., Collorone, S., Cortese, R., De Stefano, N., Douw, L., Enzinger, C., Filippi, M., Foster, M. A., et al. (2025). More Than the Sum of Its Parts: Disrupted Core Periphery of Multiplex Brain Networks in Multiple Sclerosis. Human Brain Mapping, 46(1). https://doi.org/10.1002/hbm.70107

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Sanabria-Diaz, Gretel, Cagol, Alessandro, Lu, Po-Jui, Barakovic, Muhamed, Ocampo-Pineda, Mario, Chen, Xinjie, Weigel, Matthias, Ruberte, Esther, Siebenborn, Nina de Oliveira S., Galbusera, Riccardo, Schädelin, Sabine, Benkert, Pascal, Kuhle, Jens, Kappos, Ludwig, Melie-Garcia, Lester, & Granziera, Cristina. (2025). Advanced MRI Measures of Myelin and Axon Volume Identify Repair in Multiple Sclerosis. Annals of Neurology, 97(1), 134–148. https://doi.org/10.1002/ana.27102

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Gomes, Ana Beatriz Ayroza Galvão Ribeiro, Kim, Su-Hyun, Pretzsch, Roxanne, Kulsvehagen, Laila, Schaedelin, Sabine, Lerner, Jasmine, Wetzel, Nora Sandrine, Benkert, Pascal, Maceski, Aleksandra Maleska, Hyun, Jae-Won, Lecourt, Anne-Catherine, Lipps, Patrick, Schoeps, Vinicius Andreoli, De Moura Brasil Matos, Aline, Mendes, Natalia Trombini, Apóstolos-Pereira, Samira Luisa, Mehling, Matthias, Derfuss, Tobias, Kappos, Ludwig, et al. (2024). Neurofilament Light Chain as a Discriminator of Disease Activity Status in MOG Antibody-Associated Disease [Journal-article]. Neurology: Neuroimmunology and NeuroInflammation, 12(1). https://doi.org/10.1212/NXI.0000000000200347

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Barakovic, Muhamed, Weigel, Matthias, Cagol, Alessandro, Schaedelin, Sabine, Galbusera, Riccardo, Lu, Po-Jui, Chen, Xinjie, Melie-Garcia, Lester, Ocampo-Pineda, Mario, Bahn, Erik, Stadelmann, Christine, Palombo, Marco, Kappos, Ludwig, Kuhle, Jens, Magon, Stefano, & Granziera, Cristina. (2024). A novel imaging marker of cortical “cellularity” in multiple sclerosis patients [Journal-article]. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-60497-6

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Janiaud, Perrine, Zecca, Chiara, Salmen, Anke, Benkert, Pascal, Schädelin, Sabine, Orleth, Annette, Demuth, Lilian, Maceski, Aleksandra Maleska, Granziera, Cristina, Oechtering, Johanna, Leppert, David, Derfuss, Tobias, Achtnichts, Lutz, Findling, Oliver, Roth, Patrick, Lalive, Patrice, Uginet, Marjolaine, Müller, Stefanie, Pot, Caroline, et al. (2024). MultiSCRIPT-Cycle 1—a pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in multiple sclerosis: a study protocol for a randomized clinical trial. Trials, 25(1). https://doi.org/10.1186/s13063-024-08454-6

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Oh, J., Capezzuto, L., Kriara, L., Schjodt-Eriksen, J., van Beek, J., Bernasconi, C., Montalban, X., Butzkueven, H., Kappos, L., Giovannoni, G., Bove, R., Julian, L., Baker, M., Gossens, C., & Lindemann, M. (2024). Use of smartphone-based remote assessments of multiple sclerosis in Floodlight Open, a global, prospective, open-access study. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-023-49299-4

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Pontillo, Giuseppe, Prados, Ferran, Colman, Jordan, Kanber, Baris, Abdel-Mannan, Omar, Al-Araji, Sarmad, Bellenberg, Barbara, Bianchi, Alessia, Bisecco, Alvino, Brownlee, Wallace J., Brunetti, Arturo, Cagol, Alessandro, Calabrese, Massimiliano, Castellaro, Marco, Christensen, Ronja, Cocozza, Sirio, Colato, Elisa, Collorone, Sara, Cortese, Rosa, et al. (2024). Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning: The Brain-Predicted Disease Duration Gap. Neurology, 103(10). https://doi.org/10.1212/WNL.0000000000209976

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Woelfle, Tim, Hirt, Julian, Janiaud, Perrine, Kappos, Ludwig, Ioannidis, John P.A., & Hemkens, Lars G. (2024). Benchmarking Human–AI collaboration for common evidence appraisal tools. Journal of Clinical Epidemiology, 175. https://doi.org/10.1016/j.jclinepi.2024.111533

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Geraldes, R., Arrambide, G., Banwell, B., Rovira, À., Cortese, R., Lassmann, H., Messina, S., Rocca, M. A., Waters, P., Chard, D., Gasperini, C., Hacohen, Y., Mariano, R., Paul, F., DeLuca, G. C., Enzinger, C., Kappos, L., Leite, M. I., Sastre-Garriga, J., et al. (2024). The influence of MOGAD on diagnosis of multiple sclerosis using MRI. Nature Reviews Neurology, 20(10), 620–635. https://doi.org/10.1038/s41582-024-01005-2

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Cagol, Alessandro, Ocampo-Pineda, Mario, Lu, Po-Jui, Weigel, Matthias, Barakovic, Muhamed, Melie-Garcia, Lester, Chen, Xinjie, Lutti, Antoine, Calabrese, Pasquale, Kuhle, Jens, Kappos, Ludwig, Sormani, Maria Pia, & Granziera, Cristina. (2024). Advanced Quantitative MRI Unveils Microstructural Thalamic Changes Reflecting Disease Progression in Multiple Sclerosis [Journal-article]. Neurology: Neuroimmunology and NeuroInflammation, 11(6). https://doi.org/10.1212/NXI.0000000000200299

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Müller, Jannis, Lu, Po-Jui, Cagol, Alessandro, Ruberte, Esther, Shin, Hyeong-Geol, Ocampo-Pineda, Mario, Chen, Xinjie, Tsagkas, Charidimos, Barakovic, Muhamed, Galbusera, Riccardo, Weigel, Matthias, Schaedelin, Sabine A., Wang, Yi, Nguyen, Thanh D., Spincemaille, Pascal, Kappos, Ludwig, Kuhle, Jens, Lee, Jongho, & Granziera, Cristina. (2024). Quantifying Remyelination Using χ-Separation in White Matter and Cortical Multiple Sclerosis Lesions [Journal-article]. Neurology, 103(6). https://doi.org/10.1212/WNL.0000000000209604

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Cortese, Rosa, Battaglini, Marco, Prados, Ferran, Gentile, Giordano, Luchetti, Ludovico, Bianchi, Alessia, Haider, Lukas, Jacob, Anu, Palace, Jacqueline, Messina, Silvia, Paul, Friedemann, Marignier, Romain, Durand-Dubief, Françoise, de Medeiros Rimkus, Carolina, Apostolos Pereira, Samira Luisa, Sato, Douglas Kazutoshi, Filippi, Massimo, Rocca, M.A., Cacciaguerra, Laura, et al. (2024). Grey Matter Atrophy and its Relationship with White Matter Lesions in Patients with Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Aquaporin-4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder, and Multiple Sclerosis. Annals of Neurology, 96(2), 276–288. https://doi.org/10.1002/ana.26951

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Greselin, Martina, Lu, Po-Jui, Melie-Garcia, Lester, Ocampo-Pineda, Mario, Galbusera, Riccardo, Cagol, Alessandro, Weigel, Matthias, de Oliveira Siebenborn, Nina, Ruberte, Esther, Benkert, Pascal, Müller, Stefanie, Finkener, Sebastian, Vehoff, Jochen, Disanto, Giulio, Findling, Oliver, Chan, Andrew, Salmen, Anke, Pot, Caroline, Bridel, Claire, et al. (2024). Contrast-Enhancing Lesion Segmentation in Multiple Sclerosis: A Deep Learning Approach Validated in a Multicentric Cohort [Journal-article]. Bioengineering, 11(8), 858. https://doi.org/10.3390/bioengineering11080858

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Sastre-Garriga, J., Vidal-Jordana, A., Toosy, A. T., Enzinger, C., Granziera, C., Frederiksen, J., Ciccarelli, O., Filippi, M., Montalban, X., Tintore, M., Pareto, D., Rovira, À., Rocca, M. A., De Stefano, N., Gasperini, C., Kappos, L., Palace, J., Vrenken, H., Barkhofghi, F., & Yousry, T. A. (2024). Value of Optic Nerve MRI in Multiple Sclerosis Clinical Management: A MAGNIMS Position Paper and Future Perspectives. Neurology, 103(3). https://doi.org/10.1212/wnl.0000000000209677

Kappos, L., Edan, G., Freedman, M. S., Hartung, H.-P., Montalbán, X., Barkhof, F., Koelbach, R., MacManus, D. G., & Wicklein, E.-M. (2024). Long-term clinical outcomes in patients with CIS treated with interferon beta-1b: results from the 15-year follow up of the BENEFIT trial. Journal of Neurology, 271(7), 4599–4609. https://doi.org/10.1007/s00415-024-12417-x

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Ciccarelli, O., Barkhof, F., Calabrese, M., De Stefano, N., Eshaghi, A., Filippi, M., Gasperini, C., Granziera, C., Kappos, L., Rocca, M. A., Rovira, À., Sastre-Garriga, J., Sormani, M. P., Tur, C., & Toosy, A. T. (2024). Using the Progression Independent of Relapse Activity Framework to Unveil the Pathobiological Foundations of Multiple Sclerosis [Journal-article]. Neurology, 103(1). https://doi.org/10.1212/WNL.0000000000209444

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Chitnis, T., Banwell, B., Kappos, L., Arnold, D. L., Gücüyener, K., Deiva, K., Saubadu, S., Hu, W., Benamor, M., Le-Halpere, A., Truffinet, P., & Tardieu, M. (2024). Teriflunomide in pediatric patients with relapsing multiple sclerosis: Open-label extension of TERIKIDS. Multiple Sclerosis Journal, 30(7), 833–842. https://doi.org/10.1177/13524585241242050

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Hirt, Julian, Dembowska, Kinga, Woelfle, Tim, Axfors, Cathrine, Granziera, Cristina, Kuhle, Jens, Kappos, Ludwig, Hemkens, Lars G., & Janiaud, Perrine. (2024). Clinical trial evidence of quality-of-life effects of disease-modifying therapies for multiple sclerosis: a systematic analysis. Journal of Neurology, 271(6), 3131–3141. https://doi.org/10.1007/s00415-024-12366-5

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Wendebourg, Maria Janina, Weigel, Matthias, Weidensteiner, Claudia, Sander, Laura, Kesenheimer, Eva, Naumann, Nicole, Haas, Tanja, Madoerin, Philipp, Braun, Nathalie, Neuwirth, Christoph, Weber, Markus, Jahn, Kathleen, Kappos, Ludwig, Granziera, Cristina, Schweikert, Kathi, Sinnreich, Michael, Bieri, Oliver, & Schlaeger, Regina. (2024). Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis [Journal-article]. European Journal of Neurology, 31(6). https://doi.org/10.1111/ene.16268

Khalil, Michael, Teunissen, Charlotte E., Lehmann, Sylvain, Otto, Markus, Piehl, Fredrik, Ziemssen, Tjalf, Bittner, Stefan, Sormani, Maria Pia, Gattringer, Thomas, Abu-Rumeileh, Samir, Thebault, Simon, Abdelhak, Ahmed, Green, Ari, Benkert, Pascal, Kappos, Ludwig, Comabella, Manuel, Tumani, Hayrettin, Freedman, Mark S., Petzold, Axel, et al. (2024). Neurofilaments as biomarkers in neurological disorders — towards clinical application. Nature Reviews Neurology, 20(5), 269–287. https://doi.org/10.1038/s41582-024-00955-x

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Papadopoulou, Athina, Pfister, Armanda, Tsagkas, Charidimos, Gaetano, Laura, Sellathurai, Shaumiya, D’Souza, Marcus, Cerdá-Fuertes, Nuria, Gugleta, Konstantin, Descoteaux, Maxime, Chakravarty, Mallar M., Fuhr, Peter, Kappos, Ludwig, Granziera, Cristina, Magon, Stefano, Sprenger, Till, & Hardmeier, Martin. (2024). Visual evoked potentials in multiple sclerosis: P100 latency and visual pathway damage including the lateral geniculate nucleus [Journal-article]. Clinical Neurophysiology, 161, 122–132. https://doi.org/10.1016/j.clinph.2024.02.020

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Fox, R. J., Cree, B. A. C., de Sèze, J., Gold, R., Hartung, H.-P., Jeffery, D., Kappos, L., Montalban, X., Weinstock-Guttman, B., Singh, C. M., Altincatal, A., Belviso, N., Avila, R. L., Ho, P.-R., Su, R., Engle, R., Sangurdekar, D., de Moor, C., Fisher, E., et al. (2024). Temporal Relationship between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients with Multiple Sclerosis. Neurology, 102(9). https://doi.org/10.1212/WNL.0000000000209357

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Woelfle, Tim, Hirt, Julian, Janiaud, Perrine, Kappos, Ludwig, Ioannidis, John P. A., & Hemkens, Lars G. (2024). Benchmarking Human-AI Collaboration for Common Evidence Appraisal Tools [Posted-content]. In medRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.04.21.24306137

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Weigel, M., Dechent, P., Galbusera, R., Bahn, E., Lu, P.-J., Kappos, L., Brück, W., Stadelmann, C., & Granziera, C. (2024). Cerebellar Ex Vivo Magnetic Resonance Imaging at its Feasibility Limit: Up to 77-Microns Isotropic Resolution using Low-Bandwidth Balanced Steady State Free Precession (LoBa-bSSFP) Sequences and 3T Standard Equipment [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.04.18.589707

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Hirt, Julian, Janiaud, Perrine, Düblin, Pascal, Nicoletti, Giovanni Jacopo, Dembowska, Kinga, Nguyen, Thao Vy Thi, Woelfle, Tim, Axfors, Cathrine, Yaldizli, Özgür, Granziera, Cristina, Kuhle, Jens, Kappos, Ludwig, & Hemkens, Lars G. (2024). Use of pragmatic randomized trials in multiple sclerosis: A systematic overview. Multiple Sclerosis Journal, 30(4-5), 463–478. https://doi.org/10.1177/13524585231221938

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Lazzarotto, A., Hamzaoui, M., Tonietto, M., Dubessy, A.-L., Khalil, M., Pirpamer, L., Ropele, S., Enzinger, C., Battaglini, M., Stromillo, M. L., De Stefano, N., Filippi, M., Rocca, M. A., Gallo, P., Gasperini, C., Stankoff, B., Bodini, B., Barkhof, F., Sastre-Garriga, J., et al. (2024). Time is myelin: early cortical myelin repair prevents atrophy and clinical progression in multiple sclerosis. Brain, 147(4), 1331–1343. https://doi.org/10.1093/brain/awae024

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Janiaud, Perrine, Zecca, Chiara, Salmen, Anke, Benkert, Pascal, Schädelin, Sabine, Orleth, Annette, Demuth, Lilian, Maceski, Aleksandra Maleska, Granziera, Cristina, Oechtering, Johanna, Leppert, David, Derfuss, Tobias, Achtnichts, Lutz, Findling, Oliver, Roth, Patrick, Lalive, Patrice, Uginet, Marjolaine, Müller, Stefanie, Pot, Caroline, et al. (2024). MultiSCRIPT-Cycle 1- A Pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in Multiple Sclerosis: a study protocol for a randomized clinical trial [Posted-content]. In medRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.03.22.24304720

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Cagol, Alessandro, Cortese, Rosa, Barakovic, Muhamed, Schaedelin, Sabine, Ruberte, Esther, Absinta, Martina, Barkhof, Frederik, Calabrese, Massimiliano, Castellaro, Marco, Ciccarelli, Olga, Cocozza, Sirio, De Stefano, Nicola, Enzinger, Christian, Filippi, Massimo, Jurynczyk, Maciej, Maggi, Pietro, Mahmoudi, Nima, Messina, Silvia, Montalban, Xavier, et al. (2024). Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis [Journal-article]. JAMA Neurology, 81(2), 143–153. https://doi.org/10.1001/jamaneurol.2023.4737

Kappos, Ludwig, Traboulsee, Anthony, Li, David K. B., Bar-Or, Amit, Barkhof, Frederik, Montalban, Xavier, Leppert, David, Baldinotti, Anna, Schneble, Hans-Martin, Koendgen, Harold, Sauter, Annette, Wang, Qing, & Hauser, Stephen L. (2024). Ocrelizumab exposure in relapsing–remitting multiple sclerosis: 10-year analysis of the phase 2 randomized clinical trial and its extension. Journal of Neurology, 271(2), 642–657. https://doi.org/10.1007/s00415-023-11943-4

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Derfuss, T., Bermel, R., Lin, C.-J., Hauser, S. L., Kappos, L., Vollmer, T., Comi, G., Giovannoni, G., Hartung, H.-P., Weber, M. S., Wang, J., Jessop, N., Chognot, C., Craveiro, L., & Bar-Or, A. (2024). Long-term analysis of infections and associated risk factors in patients with multiple sclerosis treated with ocrelizumab: pooled analysis of 13 interventional clinical trials [Journal-article]. Therapeutic Advances in Neurological Disorders, 17. https://doi.org/10.1177/17562864241277736

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Steinegger, L., Nierobisch, N., De Vere-Tyndall, A., Schreiner, B., Roth, P., Kappos, L., Kana, V., & Herwerth, M. (2024). Acute leukoencephalopathy associated with daratumumab treatment in POEMS syndrome: a case report. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1451693

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Abdelhak, Ahmed, Benkert, Pascal, Schaedelin, Sabine, Boscardin, W. John, Cordano, Christian, Oechtering, Johanna, Ananth, Kirtana, Granziera, Cristina, Melie-Garcia, Lester, Montes, Shivany Condor, Beaudry-Richard, Alexandra, Achtnichts, Lutz, Oertel, Frederike C., Lalive, Patrice H., Leppert, David, Müller, Stefanie, Henry, Roland G., Pot, Caroline, Matthias, Amandine, et al. (2023). Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis. JAMA Neurology, 80(12), 1317–1325. https://doi.org/10.1001/jamaneurol.2023.3997

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Hauser, S. L., Kappos, L., Montalban, X., Chognot, C., Jessop, N., Kadner, K., Pradhan, A., Incera, E., & Wolinsky, J. (2023). Safety of Ocrelizumab in Multiple Sclerosis: Updated Analysis in Patients with Relapsing and Primary Progressive Multiple Sclerosis. Multiple Sclerosis and Related Disorders, 80. https://doi.org/10.1016/j.msard.2023.105308

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Montalban, X., Vermersch, P., Arnold, D. L., Bar-Or, A., Cree, B. A. C., Cross, A., Havrdova, E. K., Kappos, L., Stuve, O., Wiendl, H., Wolinsky, J., Bolay, C. L., Hyvert, Y., Javor, A., Guehring, H., Tenenbaum, N., & Tomic, D. (2023). Design and Baseline Characteristics of Phase 3, Double-Blind, Randomised Trials Evaluating the Efficacy and Safety of Evobrutinib Versus Teriflunomide in Relapsing Multiple Sclerosis (evolutionRMS 1 and 2) [Elsevier B.V.]. 80. https://doi.org/10.1016/j.msard.2023.105328

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Woelfle, Tim, Pless, Silvan, Reyes, Óscar, Wiencierz, Andrea, Kappos, Ludwig, Granziera, Cristina, & Lorscheider, Johannes. (2023). Smartwatch-derived sleep and heart rate measures complement step counts in explaining established metrics of MS severity. Multiple Sclerosis and Related Disorders, 80. https://doi.org/10.1016/j.msard.2023.105104

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Müller, Jannis, Cagol, Alessandro, Lorscheider, Johannes, Tsagkas, Charidimos, Benkert, Pascal, Yaldizli, Özgür, Kuhle, Jens, Derfuss, Tobias, Sormani, Maria Pia, Thompson, Alan, Granziera, Cristina, & Kappos, Ludwig. (2023). Harmonizing Definitions for Progression Independent of Relapse Activity inMultiple Sclerosis A Systematic Review. JAMA Neurology, 80(11), 1232–1245. https://doi.org/10.1001/jamaneurol.2023.3331

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Galbusera, Riccardo, Bahn, Erik, Weigel, Matthias, Schaedelin, Sabine, Franz, Jonas, Lu, Po-Jui, Barakovic, Muhamed, Melie-Garcia, Lester, Dechent, Peter, Lutti, Antoine, Sati, Pascal, Reich, Daniel S., Nair, Govind, Brück, Wolfgang, Kappos, Ludwig, Stadelmann, Christine, & Granziera, Cristina. (2023). Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis. Brain Pathology, 33(6). https://doi.org/10.1111/bpa.13136

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Hauser S.L., Kappos L., Bar-Or A., Wiendl H., Paling D., Williams M., Gold R., Chan A., Milo R., Das Gupta A., Karlsson G., Sullivan R., Graham G., Merschhemke M., Haring D.A., & Vermersch P. (2023). The Development of Ofatumumab, a Fully Human Anti-CD20 Monoclonal Antibody for Practical Use in Relapsing Multiple Sclerosis Treatment. Neurology and Therapy, 12(5), 1491–1515. https://doi.org/10.1007/s40120-023-00518-0

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Hauser, S. L., Zielman, R., Das Gupta, A., Xi, J., Stoneman, D., Karlsson, G., Robertson, D., Cohen, J. A., & Kappos, L. (2023). Efficacy and safety of four-year ofatumumab treatment in relapsing multiple sclerosis: The ALITHIOS open-label extension. Multiple Sclerosis Journal, 29(11-12), 1452–1464. https://doi.org/10.1177/13524585231195346

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Cagol A, Fuertes NC, Stoessel M, Barakovic M, Schaedelin S, D’Souza M, Würfel J, Brandt AU, Kappos L, Sprenger T, Naegelin Y, Kuhle J, Granziera C, & Papadopoulou A. (2023). Optical coherence tomography reflects clinically relevant gray matter damage in patients with multiple sclerosis. Journal of Neurology, 270(4), 2139–2148. https://doi.org/10.1007/s00415-022-11535-8

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Diouf I., Malpas C.B., Sharmin S., Roos I., Horakova D., Havrdova E.K., Patti F., Shaygannejad V., Ozakbas S., Izquierdo G., Eichau S., Onofrj M., Lugaresi A., Alroughani R., Prat A., Girard M., Duquette P., Terzi M., Boz C., et al. (2023). Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis. European Journal of Neurology, 30(4), 1014–1024. https://doi.org/10.1111/ene.15706

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Hauser S.L., Bar-Or A., Weber M.S., Kletzl H., Gunther A., Manfrini M., Model F., Mercier F., Petry C., Wing Q., Koendgen H., Smith T., & Kappos L. (2023). Association of Higher Ocrelizumab Exposure With Reduced Disability Progression in Multiple Sclerosis. Neurology: Neuroimmunology and NeuroInflammation, 10(2). https://doi.org/10.1212/NXI.0000000000200094

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Kuhle J, Chitnis T., Banwell B., Tardieu M., Arnold DL, Rawlings A.M., Geertsen S.S., Lublin AL, Saubadu S., Truffinet P., & Kappos L. (2023). Plasma neurofilament light chain in children with relapsing MS receiving teriflunomide or placebo: A post hoc analysis of the randomized TERIKIDS trial. Multiple Sclerosis Journal, 29(3), 385–394. https://doi.org/10.1177/13524585221144742

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Woelfle T, Bourguignon L, Lorscheider J, Kappos L, Naegelin Y, & Jutzeler CR. (2023). Wearable Sensor Technologies to Assess Motor Functions in People With Multiple Sclerosis: Systematic Scoping Review and Perspective. Journal of Medical Internet Research, 25, e44428. https://doi.org/10.2196/44428

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Woelfle T, Pless S, Reyes O, Wiencierz A, Feinstein A, Calabrese P, Gugleta K, Kappos L, Lorscheider J, & Naegelin Y. (2023). Reliability and acceptance of dreaMS, a software application for people with multiple sclerosis: a feasibility study. Journal of Neurology, 270(1), 262–271. https://doi.org/10.1007/s00415-022-11306-5

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Chang I, Kappos L, Giovannoni G, Calabresi PA, Sandrock A, Cheng W, Xiao S, Riester K, Belachew S, Deykin A, & Zhu B. (2022). Overall Disability Response Score: An integrated endpoint to assess disability improvement and worsening over time in patients with multiple sclerosis. Multiple Sclerosis Journal, 28(14), 2263–2273. https://doi.org/10.1177/13524585221114997

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URLs

Meaton I, Altokhis A, Allen CM, Clarke MA, Sinnecker T, Meier D, Enzinger C, Calabrese M, De Stefano N, Pitiot A, Giorgio A, Schoonheim MM, Paul F, Pawlak MA, Schmidt R, Granziera C, Kappos L, Montalban X, Rovira À, et al. (2022). Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis. Multiple Sclerosis Journal, 28(14), 2212–2220. https://doi.org/10.1177/13524585221118677

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URLs

Woelfle, T., Bourguignon, L., Lorscheider, J., Kappos, L., Naegelin, Y., & Jutzeler, C. R. (2022, November 18). Wearable Sensor Technologies to Assess Motor Functions in People With Multiple Sclerosis: Systematic Scoping Review and Perspective (Preprint) [Posted-content]. JMIR Publications Inc. https://doi.org/10.2196/preprints.44428

URLs
URLs