PD Dr. med. habil. Marcus D'Souza

Papadopoulou, Athina, Pfister, Armanda, Tsagkas, Charidimos, Gaetano, Laura, Sellathurai, Shaumiya, D’Souza, Marcus, Cerdá-Fuertes, Nuria, Gugleta, Konstantin, Descoteaux, Maxime, Chakravarty, Mallar M., Fuhr, Peter, Kappos, Ludwig, Granziera, Cristina, Magon, Stefano, Sprenger, Till, & Hardmeier, Martin. (2024). Visual evoked potentials in multiple sclerosis: P100 latency and visual pathway damage including the lateral geniculate nucleus [Journal-article]. Clinical Neurophysiology, 161, 122–132. https://doi.org/10.1016/j.clinph.2024.02.020

Cagol, Alessandro, Benkert, Pascal, Melie-Garcia, Lester, Schaedelin, Sabine A., Leber, Selina, Tsagkas, Charidimos, Barakovic, Muhamed, Galbusera, Riccardo, Lu, Po-Jui, Weigel, Matthias, Ruberte, Esther, Radue, Ernst-Wilhelm, Yaldizli, Özgür, Oechtering, Johanna, Lorscheider, Johannes, D’Souza, Marcus, Fischer-Barnicol, Bettina, Muller, Stefanie, Achtnichts, Lutz, et al. (2024). Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS. Neurology, 102. https://doi.org/10.1212/wnl.0000000000207768

Papadopoulou, A., Pfister, A., Tsagkas, C., Gaetano, L., Sellathurai, S., D’Souza, M., Cerdá-Fuertes, N., Gugleta, K., Descoteaux, M., Chakravarty, M. M., Fuhr, P., Kappos, L., Granziera, C., Magon, S., Sprenger, T., & Hardmeier, M. (2024). Visual evoked potentials in multiple sclerosis: P100 latency and visual pathway damage including the lateral geniculate nucleus. Clinical Neurophysiology, 161, 122–132. https://doi.org/10.1016/j.clinph.2024.02.020

Cagol A., Fuertes N.C., Stoessel M., Barakovic M., Schaedelin S., D’Souza M, Wurfel J., Brandt A.U., Kappos L., Sprenger T, Naegelin Y, Kuhle J, Granziera C, & Papadopoulou A. (2023). Optical coherence tomography reflects clinically relevant gray matter damage in patients with multiple sclerosis. Journal of Neurology, 270(4), 2139–2148. https://doi.org/10.1007/s00415-022-11535-8

Abdelhak, Ahmed, Benkert, Pascal, Schaedelin, Sabine, Boscardin, W. John, Cordano, Christian, Oechtering, Johanna, Ananth, Kirtana, Granziera, Cristina, Melie-Garcia, Lester, Montes, Shivany Condor, Beaudry-Richard, Alexandra, Achtnichts, Lutz, Oertel, Frederike C., Lalive, Patrice H., Leppert, David, Müller, Stefanie, Henry, Roland G., Pot, Caroline, Matthias, Amandine, et al. (2023). Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis. JAMA Neurology, 80, 1317–1325. https://doi.org/10.1001/jamaneurol.2023.3997

Meier, Stephanie, Willemse, Eline A.J., Schaedelin, Sabine, Oechtering, Johanna, Lorscheider, Johannes, Melie-Garcia, Lester, Cagol, Alessandro, Barakovic, Muhamed, Galbusera, Riccardo, Subramaniam, Suvitha, Barro, Christian, Abdelhak, Ahmed, Thebault, Simon, Achtnichts, Lutz, Lalive, Patrice, Müller, Stefanie, Pot, Caroline, Salmen, Anke, Disanto, Giulio, et al. (2023). Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis. JAMA Neurology, 80, 287–297. https://doi.org/10.1001/jamaneurol.2022.5250

Reissenberger, Pamela, Serfözö, Peter, Piper, Diana, Juchler, Norman, Glanzmann, Sara, Gram, Jasmin, Hensler, Karina, Tonidandel, Hannah, Börlin, Elena, D’Souza, Marcus, Badertscher, Patrick, & Eckstein, Jens. (2023). Determine atrial fibrillation burden with a photoplethysmographic mobile sensor: the atrial fibrillation burden trial: detection and quantification of episodes of atrial fibrillation using a cloud analytics service connected to a wearable with photoplethysmographic sensor. European Heart Journal - Digital Health, 4, 402–410. https://doi.org/10.1093/ehjdh/ztad039

Lam KH, van Munster CEP, D’Souza M, Steinheimer S, Kamm CP, Burggraaff J, Johnson M, Zaykov Y, Dorn J, Dahlke F, Kappos L, Killestein J, & Uitdehaag B. (2022). Improving Detection of Change in Motor Functioning in Multiple Sclerosis Using Video-Assisted Composite Measures. International Journal of MS Care, 24(5), 230–234. https://doi.org/10.7224/1537-2073.2021-044

D’Souza M, Papadopoulou A, Girardey C, & Kappos L. (2021). Standardization and digitization of clinical data in multiple sclerosis. Nature Reviews. Neurology, 17(2), 119–125. https://doi.org/10.1038/s41582-020-00448-7

Papadopoulou A, Oertel F.C., Chien C., Kuchling J., Zimmermann H.G., Siebert N., Motamedi S., Souza M, Asseyer S., Bellmann-Strobl J., Ruprecht K., Chakravarty M.M., Scheel M., Magon S., Wuerfel J., Paul F, & Brandt A.U. (2021). Lateral geniculate nucleus volume changes after optic neuritis in neuromyelitis optica: A longitudinal study. NeuroImage. Clinical, 30, 102608. https://doi.org/10.1016/j.nicl.2021.102608

Steinheimer S, Dorn JF, Morrison C, Sarkar A, D’Souza M, Boisvert J, Bedi R, Burggraaff J, Kontschieder P, Dahlke F, Sellen A, Uitdehaag BMJ, Kappos L, & Kamm CP. (2020). Setwise comparison: efficient fine-grained rating of movement videos using algorithmic support - a proof of concept study. Disability and Rehabilitation, 42(18), 2640–2646. https://doi.org/10.1080/09638288.2018.1563832

D’Souza M, Heikkilä A, Lorscheider J, Haller V, Kravalis K, Gysin S, Fuertes NAC, Fricker E, Lam E, Higgins P, Tomic D, Papadopoulou A, & Kappos L. (2020). Electronic Neurostatus-EDSS increases the quality of expanded disability status scale assessments: Experience from two phase 3 clinical trials. Multiple Sclerosis Journal, 26(8), 993–996. https://doi.org/10.1177/1352458519845108

Kaufmann M, Salmen A, Barin L, Puhan MA, Calabrese P, Kamm CP, Gobbi C, Kuhle J, Manjaly ZM, Ajdacic-Gross V, Schafroth S, Bottignole B, Ammann S, Zecca C, D’Souza M, von Wyl V, & Swiss Multiple Sclerosis Registry (SMSR). (2020). Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories. Multiple Sclerosis and Related Disorders, 42, 102148. https://doi.org/10.1016/j.msard.2020.102148

D’Souza M, Papadopoulou A, Levy M, Jacob A, Yeaman MR, Kümpfel T, Marignier R, Paul F, & Brandt AU. (2020). Diagnostic procedures in suspected attacks in patients with neuromyelitis optica spectrum disorders: Results of an international survey. Multiple Sclerosis and Related Disorders, 41, 102027. https://doi.org/10.1016/j.msard.2020.102027

D’Souza M, Van Munster CEP, Dorn JF, Dorier A, Kamm CP, Steinheimer S, Dahlke F, Uitdehaag BMJ, Kappos L, & Johnson M. (2020). Autoencoder as a New Method for Maintaining Data Privacy While Analyzing Videos of Patients With Motor Dysfunction: Proof-of-Concept Study. Journal of Medical Internet Research, 22(5), e16669. https://doi.org/10.2196/16669

Burggraaff J, Dorn J, D’Souza M, Morrison C, Kamm CP, Kontschieder P, Tewarie P, Steinheimer S, Sellen A, Dahlke F, Kappos L, & Uitdehaag B. (2020). Video-Based Pairwise Comparison: Enabling the Development of Automated Rating of Motor Dysfunction in Multiple Sclerosis. Archives of Physical Medicine and Rehabilitation, 101(2), 234–241. https://doi.org/10.1016/j.apmr.2019.07.016

D’Souza, M., Van Munster, C. E. P., Dorn, J. F., Dorier, A., Kamm, C. P., Steinheimer, S., Dahlke, F., Uitdehaag, B. M. J., Kappos, L., & Johnson, M. (2019, October 13). Autoencoder as a New Method for Maintaining Data Privacy While Analyzing Videos of Patients With Motor Dysfunction: Proof-of-Concept Study (Preprint) [Posted-content]. JMIR Publications Inc. https://doi.org/10.2196/preprints.16669

van Munster CE, D’Souza M, Steinheimer S, Kamm CP, Burggraaff J, Diederich M, Kravalis K, Dorn J, Walsh L, Dahlke F, Kappos L, & Uitdehaag BM. (2019). Tasks of activities of daily living (ADL) are more valuable than the classical neurological examination to assess upper extremity function and mobility in multiple sclerosis. Multiple Sclerosis Journal, 25(12), 1673–1681. https://doi.org/10.1177/1352458518796690

D’Souza M, Steinheimer S, Dorn J, Morrison C, Boisvert J, Kravalis K, Burggraaff J, van Munster CE, Diederich M, Sellen A, Kamm CP, Dahlke F, Uitdehaag BM, & Kappos L. (2018). Reference videos reduce variability of motor dysfunction assessments in multiple sclerosis. Multiple sclerosis journal - experimental, translational and clinical, 4(3), 2055217318792399. https://doi.org/10.1177/2055217318792399

Parmar K, Stadelmann C, Rocca MA, Langdon D, D’Angelo E, D’Souza M, Burggraaff J, Wegner C, Sastre-Garriga J, Barrantes-Freer A, Dorn J, Uitdehaag BMJ, Montalban X, Wuerfel J, Enzinger C, Rovira A, Tintore M, Filippi M, Kappos L, et al. (2018). The role of the cerebellum in multiple sclerosis-150 years after Charcot. Neuroscience and Biobehavioral Reviews, 89, 85–98. https://doi.org/10.1016/j.neubiorev.2018.02.012

D’Souza M, Yaldizli Ö, John R, Vogt DR, Papadopoulou A, Lucassen E, Menegola M, Andelova M, Dahlke F, Schnyder F, & Kappos L. (2017). Neurostatus e-Scoring improves consistency of Expanded Disability Status Scale assessments: A proof of concept study. Multiple Sclerosis (Houndmills, Basingstoke, England), 23(4), 597–603. https://doi.org/10.1177/1352458516657439

Hauser SL, Bar-Or A, Comi G, Giovannoni G, Hartung HP, Hemmer B, Lublin F, Montalban X, Rammohan KW, Selmaj K, Traboulsee A, Wolinsky JS, Arnold DL, Klingelschmitt G, Masterman D, Fontoura P, Belachew S, Chin P, Mairon N, et al. (2017). Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis. The New England journal of medicine, 376(3), 221–234. https://doi.org/10.1056/nejmoa1601277

Montalban,Xavier, Hauser,Stephen L, Kappos,Ludwig, Arnold,Douglas L, Bar-Or,Amit, Comi,Giancarlo, de Seze,Jérôme, Giovannoni,Gavin, Hartung,Hans-Peter, Hemmer,Bernhard, Lublin,Fred, Rammohan,Kottil W, Selmaj,Krzysztof, Traboulsee,Anthony, Sauter,Annette, Masterman,Donna, Fontoura,Paulo, Belachew,Shibeshih, Garren,Hideki, et al. (2017). Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis. The New England journal of medicine, 376(3), 209–220. https://doi.org/10.1056/nejmoa1606468

Sarkar A., Morrison C., Dorn J.F., Bedi R., Steinheimer S., Boisvert J., Burggra J., D’Souza M., Kontschieder P., Bulo S.R., Walsh L., Kamm C.P., Zaykov Y., Sellen A., & Lindley S. (2016). Setwise comparison: Consistent, scalable, continuum labels for computer vision. 261–271. https://doi.org/10.1145/2858036.2858199

Schlaeger, Regina, Hardmeier, Martin, D’Souza, Marcus, Grize, Leticia, Schindler, Christian, Kappos, Ludwig, & Fuhr, Peter. (2016). Monitoring multiple sclerosis by multimodal evoked potentials : numerically versus ordinally scaled scoring systems. Clinical Neurophysiology, 127(3), 1864–1871. https://doi.org/10.1016/j.clinph.2015.11.041

Morrison C, D’Souza M, Huckvale K, Dorn JF, Burggraaff J, Kamm CP, Steinheimer SM, Kontschieder P, Criminisi A, Uitdehaag B, Dahlke F, Kappos L, & Sellen A. (2015). Usability and Acceptability of ASSESS MS: Assessment of Motor Dysfunction in Multiple Sclerosis Using Depth-Sensing Computer Vision. JMIR human factors, 2(1), e11. https://doi.org/10.2196/humanfactors.4129

Kappos L, D’Souza M, Lechner-Scott J, & Lienert C. (2015). On the origin of Neurostatus. (Patent No. 3). 4(3), Article 3. https://doi.org/10.1016/j.msard.2015.04.001

D’Souza M. (2015). MS tracking: basic and new tools/exergaming. Neurodegenerative disease management, 5(6 Suppl), 47–49. https://doi.org/10.2217/nmt.15.60

Kontschieder P, Dorn JF, Morrison C, Corish R, Zikic D, Sellen A, D’Souza M, Kamm CP, Burggraaff J, Tewarie P, Vogel T, Azzarito M, Glocker B, Chin P, Dahlke F, Polman C, Kappos L, Uitdehaag B, & Criminisi A. (2014). Quantifying progression of multiple sclerosis via classification of depth videos. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 17(Pt 2), 429–437. https://doi.org/10.1007/978-3-319-10470-6_54

Papadopoulou, A., Menegola, M., Kuhle, J., Ramagopalan, S. V., D’Souza, M., Sprenger, T., Radue, E. W., Kappos, L., & Yaldizli, O. (2014). Lesion-to-ventricle distance and other risk factors for the persistence of newly formed black holes in relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal, 20(3), 322–330. https://doi.org/10.1177/1352458513495583

Schlaeger, R, D’Souza, M, Schindler, C, Grize, L, Kappos, L, & Fuhr, P. (2014). Prediction of MS disability by multimodal evoked potentials : investigation during relapse or in the relapse-free interval? Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 125(9), 1889–1892. https://doi.org/10.1016/j.clinph.2013.12.117

Schlaeger, Regina, D’Souza, Marcus, Schindler, Christian, Grize, Leticia, Kappos, Ludwig, & Fuhr, Peter. (2014). Electrophysiological markers and predictors of the disease course in primary progressive multiple sclerosis. Multiple Sclerosis Journal, 20(1), 51–56. https://doi.org/10.1177/1352458513490543

D`Souza,Marcus, Papadopoulou,A, & Kappos,Ludwig. (2014). Bedeutung des EDSS für die Therapie-indikation bei Multipler Sklerose. 12(4), 6–9.

Schlaeger, R., D’Souza, M., Schindler, C., Grize, L., Dellas, S., Radue, E., Kappos, L., & Fuhr, P. (2012). Prediction of long-term disability in multiple sclerosis. Multiple Sclerosis Journal, 18(1), 31–38. https://doi.org/10.1177/1352458511416836

Schlaeger, Regina, D’Souza, Marcus, Schindler, Christian, Grize, Leticia, Kappos, Ludwig, & Fuhr, Peter. (2012). Combined evoked potentials as markers and predictors of disability in early multiple sclerosis. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 123(2), 406–410. https://doi.org/10.1016/j.clinph.2011.06.021

Grossman, P, Grossman, P, Kappos, L, Gensicke, H, D’Souza, M, Mohr, D C, Penner, I K, & Steiner, C. (2010). MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial. Neurology : Journal of the American Academy of Neurology, 75(13), 1141–1149. https://doi.org/10.1212/wnl.0b013e3181f4d80d

Papadopoulou, Athina, D’Souza, Marcus, Kappos, Ludwig, & Yaldizli, Ozgür. (2010). Dimethyl fumarate for multiple sclerosis. Expert Opinion on Investigational Drugs, 19(12), 1603–1612. https://doi.org/10.1517/13543784.2010.534778

D’Souza, Marcus, Gass, Achim, Lyrer, Philippe, Ott, Helmut-Werner, & Baumann, Thomas. (2008). Intravenous thrombolysis cancelled in acute right hemiparesis. Cerebrovascular Diseases, 26(6), 665–666. https://doi.org/10.1159/000172974

D’Souza, M, Kappos, L, & Czaplinski, A. (2008). Reconsidering clinical outcomes in Multiple Sclerosis : relapses, impairment, disability and beyond. Journal of the Neurological Sciences, 274(1-2), 76–79. https://doi.org/10.1016/j.jns.2008.08.023

Borgwardt SJ, McGuire PK, Aston J, Berger G, Dazzan P, Gschwandtner U, Pflüger M, D’Souza M, Radue EW, & Riecher-Rössler A. (2007). Structural brain abnormalities in individuals with an at-risk mental state who later develop psychosis. The British journal of psychiatry. Supplement, 51, s69–75. https://doi.org/10.1192/bjp.191.51.s69

Borgwardt SJ, Riecher-Rössler A, Dazzan P, Chitnis X, Aston J, Drewe M, Gschwandtner U, Haller S, Pflüger M, Rechsteiner E, D’Souza M, Stieglitz RD, Radü EW, & McGuire PK. (2007). Regional gray matter volume abnormalities in the at risk mental state. Biological psychiatry, 61(10), 1148–1156. https://doi.org/10.1016/j.biopsych.2006.08.009

Eng CM, Ashley GA, Burgert TS, Enriquez AL, D’Souza M, & Desnick RJ. (1997). Fabry disease: thirty-five mutations in the alpha-galactosidase A gene in patients with classic and variant phenotypes. Molecular medicine (Cambridge, Mass.), 3(3), 174–182.

Epplen C, Jäckel S, Santos EJ, D’Souza M, Poehlau D, Dotzauer B, Sindern E, Haupts M, Rüde KP, Weber F, Stöver J, Poser S, Gehler W, Malin JP, Przuntek H, & Epplen JT. (1997). Genetic predisposition to multiple sclerosis as revealed by immunoprinting. Annals of neurology, 41(3), 341–352. https://doi.org/10.1002/ana.410410309

Epplen C, Buitkamp J, Rumpf H, D’Souza M, & Epplen JT. (1995). Immunoprinting reveals different genetic bases for (auto)immuno diseases. Electrophoresis, 16(9), 1693–1697. https://doi.org/10.1002/elps.11501601281