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[FG] Gebhard Caroline & Wildi Karin

Publications

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Corpataux, Noé et al. (2026) ‘Effect of age and sex on cardiac magnetic resonance native T1 mapping and synthetic extracellular volume’, International Journal of Cardiology, 442. Available at: https://doi.org/10.1016/j.ijcard.2025.133818.

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Tobias Zimmermann et al. (2026) ‘The cTnI/cTnT Ratio in Myocardial Injury A Multicohort and Experimental Synthesis’, Journal of the American College of Cardiology [Preprint].

Haider, Achi et al. (2025) ‘Sex-specific cardiac ageing and sympathetic compensation: a translational study’, European Heart Journal [Preprint]. Available at: https://doi.org/10.1093/eurheartj/ehaf922.

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Amacher, Simon A. et al. (2025) ‘Sex differences in advance directives and their clinical translation among critically ill adults: results from the ADVISE study’, Annals of Intensive Care, 15. Available at: https://doi.org/10.1186/s13613-025-01518-z.

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Amacher, Simon A. et al. (2025) ‘Sex disparities in ICU care and outcomes after cardiac arrest: a Swiss nationwide analysis’, Critical Care, 29(1). Available at: https://doi.org/10.1186/s13054-025-05262-5.

Grzonka, Pascale et al. (2025) ‘Central nervous system infections rarely underlie presumed delirium in ICU admissions: insights from the Swiss ICU registry’, Critical Care, 29. Available at: https://doi.org/10.1186/s13054-025-05485-6.

Grzonka, Pascale et al. (2025) ‘Unveiling the clinical spectrum of herpes simplex virus CNS infections in adults: a systematic review’, Systematic Reviews, 14. Available at: https://doi.org/10.1186/s13643-025-02797-0.

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Levy, Bruno et al. (2025) ‘Association between mean hemodynamic variables during the first 24 h and outcomes in cardiogenic shock: identification of clinically relevant thresholds’, Critical Care, 29. Available at: https://doi.org/10.1186/s13054-025-05356-0.

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Mikail, Nidaa et al. (2025) ‘Age modulates the link between stress-related neural activity and mortality’, Nature Communications, 16. Available at: https://doi.org/10.1038/s41467-025-64802-3.

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Reid, G. et al. (2025) ‘Harnessing the angiogenic potential of adipose-derived stromal vascular fraction cells with perfusion cell seeding’, Stem Cell Research and Therapy , 16(1). Available at: https://doi.org/10.1186/s13287-025-04286-6.

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See Hoe, Louise E. et al. (2025) ‘Cardiac Mitochondrial and Electrophysiological Changes in Transplanted Ovine Hearts Following Preservation by Hypothermic Oxygenated Perfusion’, Transplantation, 109. Available at: https://doi.org/10.1097/tp.0000000000005490.

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Fuentes Artiles, Rubén, Gebhard, Caroline E. and Gebhard, Catherine (2025) ‘Integrating gender medicine into modern healthcare: Progress and barriers’, European Journal of Clinical Investigation, 55. Available at: https://doi.org/10.1111/eci.70089.

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Berger, Sebastian et al. (2025) ‘Risk stratification for violent behavior in critically ill patients: Current assessment tools’, Intensive and Critical Care Nursing, 89. Available at: https://doi.org/10.1016/j.iccn.2025.103957.

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Wildi, K. et al. (2025) ‘Possible Misdiagnosis of Myocardial Infarction Using Regulatory-Approved and Close-to-Bioequivalent Upper Limits of Normal for Cardiac Troponin’, Journal of the American Heart Association , 14(10). Available at: https://doi.org/10.1161/jaha.124.040468.

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Sileo, Antonio et al. (2025) ‘Toward Origami-Inspired In Vitro Cardiac Tissue Models’, ACS Biomaterials Science & Engineering, 11(3), pp. 1583–1597. Available at: https://doi.org/10.1021/acsbiomaterials.4c01594.

Amacher, Simon A. et al. (2025) ‘Can the large language model ChatGPT-4omni predict outcomes in adult patients with status epilepticus?’, Epilepsia, 66, pp. 674–685. Available at: https://doi.org/10.1111/epi.18215.

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Baumann, Sira M. et al. (2025) ‘Advance directives in the intensive care unit: An eight-year vanguard cohort study’, Journal of Critical Care, 85. Available at: https://doi.org/10.1016/j.jcrc.2024.154918.

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Koechlin, Luca et al. (2025) ‘Diagnostic and Prognostic Performance of High-Sensitivity Cardiac Troponin T vs I’, Journal of the American College of Cardiology, 85(4), pp. 381–385. Available at: https://doi.org/10.1016/j.jacc.2024.10.076.

Baumann, Sira M. et al. (2025) ‘Prevalence, clinical impact and associated patient-centred outcomes of advance directives in Swiss intensive care units: Results from the retrospective ADVISE Study’, Swiss Medical Weekly, 155. Available at: https://doi.org/10.57187/s.4625.

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Sileo, A. et al. (2025) ‘Asymmetric biphasic electric stimulation supports cardiac maturation and functionality’, 16. Available at: https://doi.org/10.1177/20417314251393556.

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Berger, Sebastian et al. (2024) ‘Violence against healthcare professionals in intensive care units: a systematic review and meta-analysis of frequency, risk factors, interventions, and preventive measures’, Critical Care, 28(1). Available at: https://doi.org/10.1186/s13054-024-04844-z.

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Karnik, Varun et al. (2024) ‘Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation’, Intensive Care Medicine Experimental, 12(1). Available at: https://doi.org/10.1186/s40635-024-00669-w.

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Roffler, Sereina et al. (2024) ‘Intra-abdominal pressure, renal resistive index, sublingual microcirculation and total body water for guidance of volume resuscitation to avoid acute kidney injury during shock therapy’, Renal Replacement Therapy, 10. Available at: https://doi.org/10.1186/s41100-024-00589-1.

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Wildi, Karin et al. (2024) ‘An appraisal of lung computer tomography in very early anti-inflammatory treatment of two different ovine ARDS phenotypes’, Scientific Reports, 14(1). Available at: https://doi.org/10.1038/s41598-024-52698-w.

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Zimmermann, Tobias et al. (2024) ‘Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis’, Critical Care, 28(1). Available at: https://doi.org/10.1186/s13054-024-04996-y.

Sato, Kei et al. (2024) ‘A novel echocardiographic parameter considering left ventricular afterload during V-A ECMO support’, European Journal of Clinical Investigation, 54(10). Available at: https://doi.org/10.1111/eci.14263.

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Sato, Kei et al. (2024) ‘Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors’, European Journal of Clinical Investigation, 54(10). Available at: https://doi.org/10.1111/eci.14259.

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Nielsen, Frederik M. et al. (2024) ‘Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial’, JAMA, 331(14), pp. 1185–1194. Available at: https://doi.org/10.1001/jama.2024.2934.

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Ledergerber, Katrin et al. (2024) ‘Impact of Additional Administration of von Willebrand Factor Concentrates to Thrombocyte Transfusion in Perioperative Bleeding in Cardiac Surgery’, Transfusion Medicine and Hemotherapy, 51(1), pp. 22–31. Available at: https://doi.org/10.1159/000530810.

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Sato, Kei et al. (2024) ‘A novel speckle-tracking echocardiography parameter assessing left ventricular afterload’, European Journal of Clinical Investigation, 54(2). Available at: https://doi.org/10.1111/eci.14106.

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Gebhard, Caroline E. et al. (2024) ‘Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020’, Eurosurveillance, 29(2). Available at: https://doi.org/10.2807/1560-7917.es.2024.29.2.2300200.

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Gebhard, Caroline E et al. (2024) ‘Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020’, Eurosurveillance, 29(2). Available at: https://doi.org/10.2807/1560-7917.es.2024.29.2.2300200.

Gebhard, Catherine and Gebhard, Caroline E. (2024) ‘The Impact of Sex and Gender on Cardiological and Intensive Medical Care’, Zeitschrift fur Medizinische Ethik, 70, pp. 173–194. Available at: https://doi.org/10.30965/29498570-20240069.

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Arslani, Ketina et al. (2023) ‘Temporal trends in mortality and provision of intensive care in younger women and men with acute myocardial infarction or stroke’, Critical Care, 27(1). Available at: https://doi.org/10.1186/s13054-022-04299-0.

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Baumann, Sira M. et al. (2023) ‘Sex-related differences in adult patients with status epilepticus: a seven-year two-center observation’, Critical Care, 27(1). Available at: https://doi.org/10.1186/s13054-023-04592-6.

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Rozencwajg, Sacha et al. (2023) ‘Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation’, Scientific Reports, 13(1). Available at: https://doi.org/10.1038/s41598-023-30226-6.

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Wildi, Karin et al. (2023) ‘Application of anti-inflammatory treatment in two different ovine Acute Respiratory Distress Syndrome injury models: a preclinical randomized intervention study’, Scientific Reports, 13(1). Available at: https://doi.org/10.1038/s41598-023-45081-8.

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Merdji, Hamid et al. (2023) ‘Sex and gender differences in intensive care medicine’, Intensive Care Medicine, 49(10), pp. 1155–1167. Available at: https://doi.org/10.1007/s00134-023-07194-6.

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See Hoe, Louise E. et al. (2023) ‘Donor heart ischemic time can be extended beyond 9 hours using hypothermic machine perfusion in sheep’, Journal of Heart and Lung Transplantation, 42(8), pp. 1015–1029. Available at: https://doi.org/10.1016/j.healun.2023.03.020.

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Gysi, B. et al. (2023) ‘Impact of biological and sociocultural factors: Sex and gender-related differences in COVID-19 diagnoses and outcomes’, Atemwegs- und Lungenkrankheiten, 49, pp. 294–303. Available at: https://doi.org/10.5414/ATX02684.

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Lott, Nicola et al. (2023) ‘Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?’, Nature Reviews Endocrinology, 19(4), pp. 217–231. Available at: https://doi.org/10.1038/s41574-022-00780-6.

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Leng, Albert et al. (2023) ‘Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutics’, Cells, 12(5). Available at: https://doi.org/10.3390/cells12050816.

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Knobel, Demian et al. (2023) ‘Does the age of packed red blood cells, donor sex or sex mismatch affect the sublingual microcirculation in critically ill intensive care unit patients? A secondary interpretation of a retrospective analysis’, Journal of Clinical Monitoring and Computing, 37(1), pp. 179–188. Available at: https://doi.org/10.1007/s10877-022-00877-3.

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Deschamps J et al. (2023) ‘Venous Doppler to Assess Congestion: A Comprehensive Review of Current Evidence and Nomenclature’, Ultrasound in Medicine and Biology, 49(1), pp. 3–17. Available at: https://doi.org/10.1016/j.ultrasmedbio.2022.07.011.

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Wildi, Karin (2023) ‘The Significance of Different Phenotypes in Acute Respiratory Distress Syndrome (ARDS) for Effective Treatment’, Scientific Reports, pp. 45081–45088. Available at: https://doi.org/10.14264/cafc64b.

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Dyer WB et al. (2022) ‘Recovery of organ-specific tissue oxygen delivery at restrictive transfusion thresholds after fluid treatment in ovine haemorrhagic shock’, Intensive Care Medicine Experimental , 10(1), p. 12. Available at: https://doi.org/10.1186/s40635-022-00439-6.

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Li Bassi, G. et al. (2022) ‘Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis’, Critical Care, 26(1). Available at: https://doi.org/10.1186/s13054-022-03983-5.

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Deforth M et al. (2022) ‘Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms.’, Diagnostic and prognostic research, 6(1), p. 22. Available at: https://doi.org/10.1186/s41512-022-00135-9.

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Denault A et al. (2022) ‘Perioperative Doppler ultrasound assessment of portal vein flow pulsatility in high-risk cardiac surgery patients: a multicentre prospective cohort study’, British Journal of Anaesthesia, 129(5), pp. 659–669. Available at: https://doi.org/10.1016/j.bja.2022.07.053.

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Gebhard, Caroline E. et al. (2022) ‘Sex versus gender-related characteristics: which predicts clinical outcomes of acute COVID-19?’, Intensive Care Medicine, 48(11), pp. 1652–1655. Available at: https://doi.org/10.1007/s00134-022-06836-5.

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Doyle BJ et al. (2022) ‘Design, development and preliminary assessment in a porcine model of a novel peripheral intravenous catheter aimed at reducing early failure rates.’, The journal of vascular access, p. 11297298221127760. Available at: https://doi.org/10.1177/11297298221127760.

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Gebhard, Caroline E. et al. (2022) ‘Différences entre les sexes dans le COVID-19’, Primary and hospital care médecine interne générale [Preprint]. Available at: https://doi.org/10.4414/phc-f.2022.10542.

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Gebhard, Cathrine et al. (2022) ‘Médecine de genre cardiovasculaire: comment le cœur et le cerveau interagissent-ils?’, Primary and hospital care médecine interne générale [Preprint]. Available at: https://doi.org/10.4414/phc-f.2022.10544.

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Wildi K et al. (2022) ‘Validation of Messenger Ribonucleic Acid Markers Differentiating Among Human Acute Respiratory Distress Syndrome Subgroups in an Ovine Model of Acute Respiratory Distress Syndrome Phenotypes’, Frontiers in Medicine, 9, p. 961336. Available at: https://doi.org/10.3389/fmed.2022.961336.

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Wildi K et al. (2022) ‘Differential Protein Expression among Two Different Ovine ARDS Phenotypes—A Preclinical Randomized Study’, Metabolites, 12(7). Available at: https://doi.org/10.3390/metabo12070655.

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Arslani K et al. (2022) ‘Sex disparities in patients with suspected COVID-19 presenting at an emergency department in Switzerland’, Swiss Medical Weekly, 152(19-20), p. w30167. Available at: https://doi.org/10.4414/smw.2022.w30167.

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Caroline E. Gebhard et al. (2022) ‘Geschlechterspezifische Unterschiede bei der COVID-19-Erkrankung’, Primary and Hospital Care Allgemeine Innere Medizin [Preprint]. 01.01.2022. Available at: https://doi.org/10.4414/phc-d.2022.10542.

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Catherine Gebhard et al. (2022) ‘Kardiovaskuläre Gendermedizin: Wie interagieren Herz und Gehirn?’, Primary and Hospital Care Allgemeine Innere Medizin [Preprint]. Available at: https://doi.org/10.4414/phc-d.2022.10544.

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Gebhard CE et al. (2022) ‘Prone positioning as a potential risk factor for deep vein thrombosis in covid-19 patients: A hypothesis generating observation’, Journal of Clinical Medicine, 11(1). Available at: https://doi.org/10.3390/jcm11010103.

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Wendel-Garcia, Pedro David et al. (2022) ‘Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry’, Critical Care, 26(1), p. 199. Available at: https://doi.org/10.1186/s13054-022-04065-2.

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Dyer WB et al. (2021) ‘An Ovine Model of Hemorrhagic Shock and Resuscitation, to Assess Recovery of Tissue Oxygen Delivery and Oxygen Debt, and Inform Patient Blood Management’, Shock, 56(6), pp. 1080–1091. Available at: https://doi.org/10.1097/shk.0000000000001805.

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Heinsar S et al. (2021) ‘An innovative ovine model of severe cardiopulmonary failure supported by veno-arterial extracorporeal membrane oxygenation’, Scientific Reports, 11(1), p. 20458. Available at: https://doi.org/10.1038/s41598-021-00087-y.

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Li Bassi G. et al. (2021) ‘An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients’, Critical Care, 25(1). Available at: https://doi.org/10.1186/s13054-021-03518-4.

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See Hoe LE et al. (2021) ‘A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death’, Intensive Care Medicine Experimental , 9(1), p. 60. Available at: https://doi.org/10.1186/s40635-021-00425-4.

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Wildi K et al. (2021) ‘The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?’, Journal of Intensive Care, 9(1), p. 14. Available at: https://doi.org/10.1186/s40560-021-00528-w.

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Millar JE et al. (2021) ‘Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: An experimental ovine study’, Physiological Reports, 9(19), p. e15048. Available at: https://doi.org/10.14814/phy2.15048.

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Wildi K et al. (2021) ‘Design and Rationale of a Prospective International Follow-Up Study on Intensive Care Survivors of COVID-19: The Long-Term Impact in Intensive Care Survivors of Coronavirus Disease-19–AFTERCOR’, Frontiers in Medicine, 8, p. 738086. Available at: https://doi.org/10.3389/fmed.2021.738086.

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Livingstone SA et al. (2021) ‘Coagulation Dysfunction in Acute Respiratory Distress Syndrome and Its Potential Impact in Inflammatory Subphenotypes’, Frontiers in Medicine, 8, p. 723217. Available at: https://doi.org/10.3389/fmed.2021.723217.

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Zaiser AS et al. (2021) ‘Adverse events of percutaneous microaxial left ventricular assist devices—a retrospective, single-centre cohort study’, Journal of Clinical Medicine, 10(16). Available at: https://doi.org/10.3390/jcm10163710.

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Knobel, D. et al. (2021) Does the Age of Packed Red Blood Cells, Donor Sex or Sex Mismatch Affect the Sublingual Microcirculation in Critically Ill Intensive Care Unit Patients? — A Secondary Interpretation of a Retrospective Analysis. Research Square Platform LLC. Available at: https://doi.org/10.21203/rs.3.rs-665862/v1.

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Gebhard, Caroline E. et al. (2021) Understanding the Impact of Sociocultural Gender on Post-acute Sequelae of COVID-19: a Bayesian Approach, medRxiv (Cold Spring Harbor Laboratory). Cold Spring Harbor Laboratory (medRxiv (Cold Spring Harbor Laboratory)). Available at: https://doi.org/10.1101/2021.06.30.21259757.

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Malinovska A et al. (2021) ‘Femoral and popliteal venous Doppler during prone and supine position in COVID-19 patients: a potential diagnostic tool to detect abnormal right ventricular function’, Canadian Journal of Anesthesia. Springer, 68(5). Available at: https://doi.org/10.1007/s12630-021-01918-2.

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Schjørring OL et al. (2021) ‘Lower or higher oxygenation targets for acute hypoxemic respiratory failure’, New England Journal of Medicine, 384(14), pp. 1301–1311. Available at: https://doi.org/10.1056/nejmoa2032510.

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Wildi K et al. (2021) ‘Correction to: The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?’, 9(1). Available at: https://doi.org/10.1186/s40560-021-00534-y.

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Zellweger NM et al. (2021) ‘Haemophagocytic lymphohistiocytosis and liver failure-induced massive hyperferritinaemia in a male COVID-19 patient’, Swiss Medical Weekly, 151(3-4), p. w20420. Available at: https://doi.org/10.4414/smw.2021.20420.

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Azzam MA et al. (2021) ‘A proposed algorithm for combining transcranial Doppler ultrasound monitoring with cerebral and somatic oximetry: a case report.’, Canadian journal of anaesthesia = Journal canadien d’anesthesie, 68(1), pp. 130–136. Available at: https://doi.org/10.1007/s12630-020-01832-z.

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Menter T et al. (2021) ‘Case Report: Co-occurrence of Myocarditis and Thrombotic Microangiopathy Limited to the Heart in a COVID-19 Patient’, Frontiers in Cardiovascular Medicine. Frontiers Media SA, 8. Available at: https://doi.org/10.3389/fcvm.2021.695010.

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Sia YT, Gebhard CE and Denault AY (2021) ‘Reversal of Acute Right Ventricular Failure Early Post Left Ventricular Assist Device Placement by Intratracheal Milrinone Administration: Case Report’, Chest. Elsevier Inc., 159(1). Available at: https://doi.org/10.1016/j.chest.2020.01.059.

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Todorov, Atanas et al. (2021) ‘Gender differences in the provision of intensive care: a Bayesian approach’, Intensive Care Medicine, 47(5), pp. 577–587. Available at: https://doi.org/10.1007/s00134-021-06393-3.

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Millar, J.E. et al. (2020) Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2020.12.02.408682.

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Li Bassi G et al. (2020) ‘Design and rationale of the COVID-19 Critical Care Consortium international, multicentre, observational study’, BMJ Open, 10(12), p. e041417. Available at: https://doi.org/10.1136/bmjopen-2020-041417.

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Denault AY et al. (2020) Doppler Interrogation of the Femoral Vein in the Critically Ill Patient: The Fastest Potential Acoustic Window to Diagnose Right Ventricular Dysfunction?, Critical Care Explorations. 10. Lippincott Williams and Wilkins, p. e0209. Available at: https://doi.org/10.1097/cce.0000000000000209.

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Reinhold, Simona et al. (2020) ‘Protein delivery in intermittent and continuous enteral nutrition with a protein-rich formula in critically ill patients - A protocol for the prospective randomized controlled proof-of-concept Protein Bolus Nutrition (Pro BoNo) study’, Trials, 21. Available at: https://doi.org/10.1186/s13063-020-04635-1.

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Marzolini, C. et al. (2020) Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2020.07.05.20146878.

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Li Bassi, G. et al. (2020) The COVID-19 Critical Care Consortium observational study: Design and rationale of a prospective, international, multicenter, observational study. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2020.05.29.20115253.

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Gebhard, Caroline E et al. (2018) ‘Hockey Games and the Incidence of ST-Elevation Myocardial Infarction’, Canadian Journal of Cardiology, 34(6), pp. 744–751. Available at: https://doi.org/10.1016/j.cjca.2017.12.028.

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Gebhard, Catherine et al. (2018) ‘Weather and risk of ST-elevation myocardial infarction revisited: Impact on young women’, PLoS ONE, 13(4), p. e0195602. Available at: https://doi.org/10.1371/journal.pone.0195602.

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