Development, standardisation and digitisation of clinical rating scales for recording and quantifying neurological symptoms, including algorithm-based feedback systems. The focus is on neuroimmunological (MS, NMOSD) and neurodegenerative (Huntington's disease) disorders. Further, development of telemedical applications in neurology for assessing clinical symptoms; to perform physical examination in home environment (to compensate for reduced mobility, pandemic and planning DCTs). In addition, use of AI-based methods to analyse the data obtained from the systems we develop. Further implementing new strategies in QMS and supporting validation of software used in the medical field.

Approved Research Projects

2017-2019 "Development of an eEDSS App"; research grant from Fonds zur Förderung von Innovations-Transfer Universitätsspital Basel
2017-2019 "Evaluation of the reliability and validity of the Modified Manual Muscle Test for persons with MS"; (co-applicant) research grand from the Swiss Multiple Sclerosis Society
2011-2013 "Development and validation of an electronic data capturing system for EDSS assessments in MS: Neurostatus e-Scoring"; research grant form MS-Fonds, Department of Neurology, University Hospital Basel
2010-2012 "Characterization of lymphocyte subsets in patients with MS treated with oral fingolimod"; research grand from the Swiss Multiple Sclerosis Society
2007-2013 "Development of electronic / audiovisual and web-based teaching and certify-cation tools for Training of Neurologists in international therapeutic studies in MS"; research grant form MS-Fonds, Department of Neurology, University Hospital Basel

Collaborations

National Collaborations

- Innovation Management Basel USB

- FHNW Muttenz Life Sciences und Wirtschaftsinformatik

International Collaborations

- Research Group of Prof. F. Paul, Experimental and Clinical Research Center (ECRC), Charité Universitätsmedizin, Berlin, Germany

- Matthew Johnson, Microsoft Research, Cambridge, United Kingdom

Ongoing Research Projects

"Development and validation of a video-assisted assessment comparing HCPs with Neurologists to capture disability in MS, the Neurostatus-SMARTCARE"; collaborative research project with RC2NB, supported by Novartis Pharma AG (ethic approval given)
"Digitalisation and standardisation of the dataflow at the outpatient clinics; eCapture – a pilot project"; collaborative research project with ICT at the University Hospital Basel (in planing stage)
"Development of an e-learning platform”; research grant from Roche, Merck and Sanofi (in planing stage)
“Development of a new clinical progression marker in MS”; research grant form Novartis Pharma AG (ethic approval given)
2013 - paused; "Validation of a Kinect-based Motion Capturing device for a quantitative analyse of disability in MS"; Collaborative research project with Microsoft research Cambridge, UK, and support from Novartis Pharma AG (ethic approval given)

[FG] D'Souza Marcus

Head of Research Unit

PD Dr. med. habil. Marcus D'Souza

Projects & Collaborations