Molecular Pharmacy (Ricklin)

Sommer-Plüss, Carla Johanna et al. (2025) ‘Determining Ligand Binding and Specificity Within the β2-Integrin Family with a Novel Assay Platform’, Biomolecules, 15(2), p. 238. Available at: https://doi.org/10.3390/biom15020238.

Fadda, Elisa et al. (2025) ‘Chemical glycobiology’, Beilstein Journal of Organic Chemistry, 21, pp. 8–9. Available at: https://doi.org/10.3762/bjoc.21.2.

Cramer, Jonathan et al. (2024) ‘Combating DC‐SIGN‐mediated SARS‐CoV‐2 dissemination by glycan‐mimicking polymers’, Archiv der Pharmazie, 357(4). Available at: https://doi.org/10.1002/ardp.202300396.

Varga, Norbert et al. (2024) ‘Strengthening an Intramolecular Non-Classical Hydrogen Bond to Get in Shape for Binding’, Angewandte Chemie - International Edition, 63(42). Available at: https://doi.org/10.1002/anie.202406024.

Ricklin, Daniel (2024) ‘Complement‐targeted therapeutics: Are we there yet, or just getting started?’, European Journal of Immunology [Preprint]. Available at: https://doi.org/10.1002/eji.202350816.

Nemli, Dilara D. et al. (2024) ‘Thermodynamics-Guided Design Reveals a Cooperative Hydrogen Bond in DC-SIGN-targeted Glycomimetics’, Journal of Medicinal Chemistry, 67(16), pp. 13813–13828. Available at: https://doi.org/10.1021/acs.jmedchem.4c00623.

Cori, Carmen R. and Hevey, Rachel (2024) ‘Total Synthesis of Core 3 & Core 4-Type Mucin Glycan Derivatives’, Helvetica Chimica Acta, 107(7), pp. 1–13. Available at: https://doi.org/10.1002/hlca.202400026.

Wagner, Beatrice et al. (2024) ‘Analogues of the pan-selectin antagonist rivipansel (GMI-1070)’, European Journal of Medicinal Chemistry, 272. Available at: https://doi.org/10.1016/j.ejmech.2024.116455.

Cramer, Jonathan et al. (2024) ‘Does size matter? – Comparing pyranoses with septanoses as ligands of the bacterial lectin FimH’, European Journal of Medicinal Chemistry, 268. Available at: https://doi.org/10.1016/j.ejmech.2024.116225.

Rysz, Marta et al. (2024) ‘Humanization of SLCO2B1 in Rats Increases rCYP3A1 Protein Expression but Not the Metabolism of Erlotinib to OSI-420’, Journal of Pharmacology and Experimental Therapeutics, 389(1), pp. 87–95. Available at: https://doi.org/10.1124/jpet.123.001884.

Kinzi, Jonny et al. (2024) ‘Impact of OATP2B1 on Pharmacokinetics of Atorvastatin Investigated in rSlco2b1-Knockout and SLCO2B1-Knockin Rats’, Drug Metabolism and Disposition, 52, pp. 957–965. Available at: https://doi.org/10.1124/dmd.124.001686.

van Beek, Anna E. et al. (2024) ‘Praziquantel and factor H recruitment differentially affect the susceptibility of Schistosoma mansoni to complement-mediated damage’, Frontiers in Immunology, 15. Available at: https://doi.org/10.3389/fimmu.2024.1474358.

Conti, Gabriele et al. (2023) ‘Tetra- and Hexavalent Siglec-8 Ligands Modulate Immune Cell Activation’, Angewandte Chemie - International Edition. 09.11.2023, 62(52). Available at: https://doi.org/10.1002/anie.202314280.

Rysz, Marta A. et al. (2023) ‘Simultaneous quantification of atorvastatin, erlotinib and OSI-420 in rat serum and liver microsomes using a novel liquid chromatography-mass spectrometry method’, Journal of Pharmaceutical and Biomedical Analysis, 236. Available at: https://doi.org/10.1016/j.jpba.2023.115716.

Scaglione, F. et al. (2023) ‘Nature of the Interaction of Alpha-D-Mannose and Escherichia coli Bacteria, and Implications for its Regulatory Classification. A Delphi Panel European Consensus Based on Chemistry and Legal Evidence’, Therapeutic Innovation and Regulatory Science, 57(6), pp. 1153–1166. Available at: https://doi.org/10.1007/s43441-023-00548-8.

Bechtler, Clément et al. (2023) ‘Optimized synthesis, polymer conjugation, and proof-of-concept studies of the gd-IgA1 epitope for antibody-scavenging therapies in IgA nephropathy’, Chemical Biology and Drug Design, 102(3), pp. 580–586. Available at: https://doi.org/10.1111/cbdd.14258.

Rabbani, S. et al. (2023) ‘108 Design and in vitro Evaluation of Collectin-11 Antagonists for the Treatment of Ischemia-Reperfusion Injuries’, Immunobiology, 228(5), p. 152559. Available at: https://doi.org/10.1016/j.imbio.2023.152559.

Bolten, Jan Stephan et al. (2023) ‘Nephrotoxicity of iopamidol is associated with mitochondrial impairment in human cell and teleost models’, Toxicology and Applied Pharmacology, 466(446), p. 116493. Available at: https://doi.org/10.1016/j.taap.2023.116493.

Lamers, Christina, Ricklin, Daniel and Lambris, John D (2023) ‘Complement-targeted therapeutics: An emerging field enabled by academic drug discovery’, American Journal of Hematology, 98(S4), pp. S82–S89. Available at: https://doi.org/10.1002/ajh.26875.

Minzer, Giulietta and Hevey, Rachel (2023) ‘Synthesis of Mucin O-Glycans Associated with Attenuation of Pathogen Virulence’, ChemistryOpen, 12(5), p. e202200134. Available at: https://doi.org/10.1002/open.202200134.

Wagner, B. et al. (2023) ‘A Structural-Reporter Group to Determine the Core Conformation of Sialyl Lewisx Mimetics’, Molecules, 28(6). Available at: https://doi.org/10.3390/molecules28062595.

Wang, Benjamin X. et al. (2023) ‘Host-derived O-glycans inhibit toxigenic conversion by a virulence-encoding phage in Vibrio cholerae’, EMBO Journal, 42(3), p. e111562. Available at: https://doi.org/10.15252/embj.2022111562.

Bechtler, Clément et al. (2023) ‘Complement-regulatory biomaterial coatings: Activity and selectivity profile of the factor H-binding peptide 5C6’, Acta Biomaterialia, 155, pp. 123–138. Available at: https://doi.org/10.1016/j.actbio.2022.10.055.

Cramer, Jonathan, Pang, Lijuan and Ernst, Beat (2023) ‘Antiadhesive Carbohydrates and Glycomimetics’, in Carbohydrate‐Based Therapeutics. wiley ( Carbohydrate‐Based Therapeutics), pp. 131–160. Available at: https://doi.org/10.1002/9783527831326.ch5.

Dubbu, Sateesh, Santhi, Jampani and Hevey, Rachel (2023) ‘Carbohydrate-Derived Dienes as Building Blocks for Pharmaceutically Relevant Molecules’, Helvetica Chimica Acta, 106(1), p. e202200135. Available at: https://doi.org/10.1002/hlca.202200135.

Golomingi, M. et al. (2023) ‘Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels’, Frontiers in Immunology, 14. Available at: https://doi.org/10.3389/fimmu.2023.1226832.

Hauswirth, Patrick et al. (2023) ‘Design and Characterization of Mutated Variants of the Oncotoxic Parvoviral Protein NS1’, Viruses, 15(1), pp. 1–19. Available at: https://doi.org/10.3390/v15010209.

Storani, A., Guerrero, S.A. and Iglesias, A.A. (2023) ‘Insights to improve the activity of glycosyl phosphorylases from Ruminococcus albus 8 with cello-oligosaccharides’, Frontiers in Chemistry, 11. Available at: https://doi.org/10.3389/fchem.2023.1176537.

Lamers, Christina et al. (2022) ‘Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors’, Nature Communications, 13(1), p. 5519. Available at: https://doi.org/10.1038/s41467-022-33003-7.

Krenev, Ilia A. et al. (2022) ‘In Vitro Modulation of Complement Activation by Therapeutically Prospective Analogues of the Marine Polychaeta Arenicin Peptides’, Marine Drugs, 20(10). Available at: https://doi.org/10.3390/md20100612.

Lamers, Christina et al. (2022) ‘Compstatins: the dawn of clinical C3-targeted complement inhibition’, Trends in Pharmacological Sciences, 43(8), pp. 629–640. Available at: https://doi.org/10.1016/j.tips.2022.01.004.

Bozzola, Tiago et al. (2022) ‘Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth’, ACS Chemical Biology, 17(7), pp. 1890–1900. Available at: https://doi.org/10.1021/acschembio.2c00321.

Li, Bojun et al. (2022) ‘Exploring the function of factor XIII free B subunit: Interactions with complement factors and a novel approach to identify potential binding partners’, Research and Practice in Thrombosis and Haemostasis, 6(5), p. e12766. Available at: https://doi.org/10.1002/rth2.12766.

Takagi, Julie et al. (2022) ‘Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity’, Nature Chemical Biology, 18(7), pp. 762–773. Available at: https://doi.org/10.1038/s41589-022-01035-1.

Girardi, Benedetta et al. (2022) ‘Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside’, ChemMedChem, 17(3), p. e202100514. Available at: https://doi.org/10.1002/cmdc.202100514.

Girardi, B. et al. (2022) ‘Front Cover: Selective Monovalent Galectin‐8 Ligands Based on 3‐Lactoylgalactoside (ChemMedChem 3/2022)’, ChemMedChem, 17(3). Available at: https://doi.org/10.1002/cmdc.202200044.

Mastellos, Dimitrios C et al. (2022) ‘From discovery to approval: A brief history of the compstatin family of complement C3 inhibitors’, Clinical Immunology, 235, p. 108785. Available at: https://doi.org/10.1016/j.clim.2021.108785.

Dätwyler, Philipp et al. (2022) ‘Prodrugs of E-selectin Antagonists with Enhanced Pharmacokinetic Properties’, ChemMedChem, 17(1), p. e202100634 (1 of 7). Available at: https://doi.org/10.1002/cmdc.202100634.

Arunasalam, Stefanie (2022) Development of a Human Macrophage Assay to assess DMPK Properties of New Drug Candidates. Masterarbeit.

Carere-Sigl, Anja et al. (2022) ‘FimH antagonists prevent biofilm formation on catheter surfaces’, Carbohydrate Chemistry, 45, pp. 519–536. Available at: https://doi.org/10.1039/9781839164538-00519.

Colombi, Alyssa (2022) Factor H binding peptides for protection of biomaterials from complement-mediated damage. Masterarbeit.

Csaba, Kevin (2022) Cloning, Expression, Purification and Characterisation of Ficolins. Masterarbeit.

Henn, Lilly (2022) In vitro assessment of polymer- or Sepharose-conjugated glycomimetic blood group antigens for enabling ABO incompatible organ transplantations. Masterarbeit.

Kocher, David (2022) Synthesis and evaluation of modified mannopyranoside-derivatives as potential collectin-11 inhibitors. Masterarbeit.

Leiggener Céline (2022) Integrin Receptor-Targeted Immune Modulation: Target Production, Bioassay Development and Evaluation of Inhibitors. Masterarbeit.

Meyer, Florian (2022) Development of novel complement inittiation pathway inhibitors by using protein engineering approaches. Masterarbeit.

Poletti, Fabio (2022) Development and Characterization of Macrocyclic Peptides as Modulator of the CD59-C5b-9 Interactionon Leukemia Cells to Potentiate Immunotherapy. Masterarbeit.

Romano, Annacarla (2022) Chemical synthesis for Carbohydrate-based Mimics as Ligands for Ficolins as Lectin-type Immune Receptors. Masterarbeit.

Roos, Noëmi Johanna et al. (2022) ‘Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines’, Food and Chemical Toxicology, 162, p. 112869. Available at: https://doi.org/10.1016/j.fct.2022.112869.

Tamburrino, Rahela Sara (2022) SYNTHESIS AND DEVELOPMENT OF BLOOD GROUP B ANTIGEN-DERIVATIVES TO ENABLE ABO-INCOMPATIBLE TRANSPLANTATION. Masterarbeit.

Tiric, Mateja (2022) From leech to therapeutic protein - Development of novel leads for complement pathway inhibition. Masterarbeit.

Vogt, Stephanie Anita (2022) Development and characterization of β2-integrin modulators as tool compounds to elucidate their role in immune modulation. Masterarbeit.

Pouw, Richard B and Ricklin, Daniel (2021) ‘Tipping the balance: intricate roles of the complement system in disease and therapy’, Seminars in Immunopathology, 43(6), pp. 757–771. Available at: https://doi.org/10.1007/s00281-021-00892-7.

Ricklin, Daniel and Pouw, Richard B (2021) ‘Complement & disease: out of the shadow into the spotlight’, Seminars in Immunopathology, 43(6), pp. 755–756. Available at: https://doi.org/10.1007/s00281-021-00897-2.

Wawrzinek, Robert et al. (2021) ‘A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN’, Journal of the American Chemical Society, 143(45), pp. 18977–18988. Available at: https://doi.org/10.1021/jacs.1c07235.

Hevey, Rachel et al. (2021) ‘Sweet turning bitter: Carbohydrate sensing of complement in host defence and disease’, British Journal of Pharmacology, 178(14), pp. 2802–2822. Available at: https://doi.org/10.1111/bph.15307.

Zwarthoff, Seline A et al. (2021) ‘C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases’, Proceedings of the National Academy of Sciences of the United States of America, 118(26), pp. 1–12. Available at: https://doi.org/10.1073/pnas.2102787118.

Schwardt, Oliver et al. (2021) ‘Therapeutic peptides as emerging options to restore misguided host defence and homeostasis: From teaching to concept to clinic’, Chimia, 75(6), pp. 495–499. Available at: https://doi.org/10.2533/chimia.2021.495.

Pozolotin, V.A. et al. (2021) ‘Evaluation of Antimicrobial Activity of the C3f Peptide, a Derivative of Human C3 Protein’, Russian Journal of Bioorganic Chemistry, 47(3), pp. 741–748. Available at: https://doi.org/10.1134/S1068162021030158.

Lamers, Christina, Plüss, Carla Johanna and Ricklin, Daniel (2021) ‘The Promiscuous Profile of Complement Receptor 3 in Ligand Binding, Immune Modulation, and Pathophysiology’, Frontiers in Immunology, 12, p. 662164. Available at: https://doi.org/10.3389/fimmu.2021.662164.

Carranza Valencia, Alejandra et al. (2021) ‘Comparison of pulmonary deposition of nebulized 99mtechnetium-diethylenetriamine-pentaacetic acid through 3 inhalation devices in healthy dogs’, Journal of Veterinary Internal Medicine, 35(2), pp. 1080–1087. Available at: https://doi.org/10.1111/jvim.16064.

Dopler, Arthur et al. (2021) ‘Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces’, Frontiers in Immunology, 12, p. 615748. Available at: https://doi.org/10.3389/fimmu.2021.615748.

Aliu, Butrint (2021) Development of therapeutic glycopolymers for the treatment of peripheral neuropathies and viral infections. Dissertation.

Bechtler, Clément and Lamers, Christina (2021) ‘Macrocyclization strategies for cyclic peptides and peptidomimetics’, RSC Medicinal Chemistry, 12(8), pp. 1325–1351. Available at: https://doi.org/10.1039/d1md00083g.

Bertschi, Jasmin (2021) The impact of monocytes on CD3/D28 activated T cells upon anti-C1q autoantibody encounter. Masterarbeit.

Blagojevic, Aleksandra (2021) Developing and analysing novel complement system pathway inhibitors by mimicking a leech protein. Masterarbeit.

Cavegn, Alessandra (2021) Investigating cellular mechanisms of AAV transport across the blood-brain barrier. Masterarbeit.

Conti, Gabriele (2021) Synthesis of glycomimetics of the natural Siglec-8 ligand and their pharmacodynamic characterization. Dissertation.

Cramer, Jonathan et al. (2021) ‘Poly-l-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses’, ChemMedChem, 16(15), pp. 2345–2353. Available at: https://doi.org/10.1002/cmdc.202100348.

Cramer, Jonathan et al. (2021) ‘Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2’, Journal of the American Chemical Society, 143(42), pp. 17465–17478. Available at: https://doi.org/10.1021/jacs.1c06778.

Gao, Chao et al. (2021) ‘Differential recognition of oligomannose isomers by glycan-binding proteins involved in innate and adaptive immunity’, Science Advances, 7(24), p. eabf6834. Available at: https://doi.org/10.1126/sciadv.abf6834.

Girardi, Benedetta (2021) Identification of potent and selective drug-like ligands for therapeutically relevant siglecs. Dissertation.

Hevey, Rachel (2021) ‘The role of fluorine in glycomimetic drug design’, Chemistry - A European Journal, 27(7), pp. 2240–2253. Available at: https://doi.org/10.1002/chem.202003135.

Jabeen, Iqra (2021) Discovery and Synthesis of CD59 Inhibitors to Potentiate Antibody based Leukemia Treatment. Masterarbeit.

Jeanguenat, Hannah (2021) Parasitic evasion: Investigating the interaction of Schistosoma mansoni with the human complement system. Masterarbeit.

Lal, Kanhaya et al. (2021) ‘Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia*’, Chemistry - A European Journal, 27(40), pp. 10341–10348. Available at: https://doi.org/10.1002/chem.202100252.

Nikci, Elira (2021) Integrin Receptor-Targeted Immune Modulation: Target Productioin, Bioassay Development and Evaluation of Inhibitors. Masterarbeit.

Palliparambil Sovichan, Mathew Ebin (2021) Production and Modification of a Drug-Like Complement System Inhibitor Derived from a Leech Protein. Masterarbeit. -.

Reiter, Maud et al. (2021) ‘A Perspective on Chemistry and Society: Swiss Women in Chemistry - Two Years Later ...’, Chimia, 75(12), pp. 1088–1090. Available at: https://doi.org/10.2533/chimia.2021.1088.

Schmidt, Yannik Tim (2021) Radiolabeling and Preclinical Evaluation of a New Class of Radiopharmaceuticals for Diagnosis and Therapy of CXCR4-Expressing Malignancies. Masterarbeit.

Sivanesan, Rojini (2021) Investigating and Comparing Complement Activation & Regulation on Different Human Endothelial Cells. Masterarbeit.

Tomašič, Tihomir et al. (2021) ‘Does targeting Arg98 of FimH lead to high affinity antagonists?’, European Journal of Medicinal Chemistry, 211, p. 113093. Available at: https://doi.org/10.1016/j.ejmech.2020.113093.

Trezzini, Elisa (2021) Discovery and synthesis of CD59 inhibitors to potentiate antibody-based leukemia treatment. Masterarbeit.

Tschanz, Marco (2021) Integrin Receptor-Targeted Immune Modulation: Discovery and Evaluation of Modulators. Masterarbeit.

Wicki, Amanda (2021) Harnessing epigenetic regulation to enhance cancer vaccine efficacy. Masterarbeit.

Wild, Milena Livia (2021) INVESTIGATING THE CIRCADIAN RHYTHM OF METASTATIC BREAST CANCER CELLS. Masterarbeit.

Kroezen, Blijke et al. (2020) ‘A Potent Mimetic of the Siglec-8 Ligand 6’-Sulfo-Sialyl Lewisx’, ChemMedChem, 15(18), pp. 1706–1719. Available at: https://doi.org/10.1002/cmdc.202000417.

Aliu, Butrint et al. (2020) ‘Selective inhibition of anti-MAG IgM autoantibody binding to myelin by an antigen-specific glycopolymer’, Journal of Neurochemistry, 154(5), pp. 486–501. Available at: https://doi.org/10.1111/jnc.15021.

Aliu, Butrint et al. (2020) ‘Selective inhibition of anti-MAG IgM autoantibody binding to myelin by an antigen-specific glycopolymer’, Journal of Neurochemistry, 154(5), pp. 486–501. Available at: https://doi.org/10.1111/jnc.15021.

Scharf, Birte et al. (2020) ‘Antiadhesive natural products against uropathogenic E. coli: What can we learn from cranberry extract?’, Journal of Ethnopharmacology, 257, p. 112889. Available at: https://doi.org/10.1016/j.jep.2020.112889.

Baas, Inge et al. (2020) ‘Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells’, Haematologica, 105(2), pp. e57–e60. Available at: https://doi.org/10.3324/haematol.2019.216028.

Chiesi, Davide (2020) Characterization of Small Compound Modulators of Protein Degradation Pathways as an Effective Means to Selective Targeting of Oncoproteins in Cancer Cells. Masterarbeit.

Ciullo, Lorella (2020) Development of CR3 Peptide Ligands using Phage Display Screening. Masterarbeit.

Cramer, Jonathan et al. (2020) ‘Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding’, RSC Chemical Biology, 1(4), pp. 281–287. Available at: https://doi.org/10.1039/d0cb00108b.

Gmür, Samira (2020) APPLICATION OF FLOW INDUCED DISPERSION ANALYSIS (FIDA) TO INVESTIGATE TNF-ALPHA/ANTI-TNF-ALPHA ANTIBODY BINDING, TNF-ALPHA MONOMER-TRIMER EQUILIBRIUM, AND COMPARISON WITH ESTABLISHED BIOSPECIFIC INTERACTION TECHNIQUES. Masterarbeit.

Hamid Mahmoud Hamid, Amal (2020) Synthesis, Characterization and Coating of FH-binding Peptides to Protect Biomedical Surfaces from Adverse Complement Attack. Masterarbeit.

Hevey, Rachel (2020) ‘Sugar-coating the search for new therapeutics’. medium.com. Available at: https://medium.com/sci-five-university-of-basel/sugar-coating-the-search-for-new-therapeutics-57effc2ae523.

Hughes, Sarah et al. (2020) ‘Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates’, Clinical Immunology, 214, p. 108391. Available at: https://doi.org/10.1016/j.clim.2020.108391.

Imholz, Juliana (2020) Target production and bioassay development for the assessment of beta2-integrin receptor modulators. Masterarbeit.

Julen, David (2020) Evaluation and Summarization of the Practical Course ‘Modern Drug Design’. Masterarbeit.