Synthetische Chemie (Baudoin)

Geraci, Andrea and Baudoin, Olivier (2025) ‘Fe-Catalyzed α-C(sp3)−H Amination of N-Heterocycles’, Angewandte Chemie - International Edition, 64(5). Available at: https://doi.org/10.1002/anie.202417414.

Huh, Soohee (2025) Palladium(0)-catalyzed C–H activation-based enantioselective reactions: synthesis of lower carbo[n]helicenes and planar chiral cyclophanes. Doctoral Thesis. University of Basel.

Huh, Soohee et al. (2025) ‘A C–H Arylation-Based Enantioselective Synthesis of Planar Chiral Cyclophanes’, Angewandte Chemie - International Edition [Preprint]. Available at: https://doi.org/10.1002/anie.202500653.

Vyhivskyi, Oleksandr (2025) Total synthesis of the diterpenes (+)-randainin D and (+)-barekoxide via photoredox-catalyzed deoxygenative allylation. Doctoral Thesis.

Tsitopoulou, Maria et al. (2024) ‘1,4-Pd Migration-Enabled Synthesis of Fused 4-Membered Rings’, Journal of the American Chemical Society. 05.07.2024, 146(28), pp. 18811–18816. Available at: https://doi.org/10.1021/jacs.4c04701.

Miyakoshi, Takeru et al. (2024) ‘Studies towards the Enantioselective Synthesis of Cryptowolinol via Pd0-Catalyzed C(sp3)-H Arylation/Parallel Kinetic Resolution’, Organic Letters, 26(15), pp. 2923–2927. Available at: https://doi.org/10.1021/acs.orglett.4c00386.

Geraci, A. (2024) Transition metal-catalyzed intermolecular C(sp³)-H animation reactions. Doctoral Thesis.

Morita, I. (2024) Development of an artificial peroxidase based on a human carbonic anhydrase protein . Doctoral Thesis.

Vyhivskyi, Oleksandr and Baudoin, Olivier (2024) ‘Total Synthesis of the Diterpenes (+)-Randainin D and (+)-Barekoxide via Photoredox-Catalyzed Deoxygenative Allylation’, Journal of the American Chemical Society [Preprint]. Available at: https://doi.org/10.1021/jacs.4c02224.

Kudashev, Anton et al. (2023) ‘Methylene C(sp³)−H Arylation Enables the Stereoselective Synthesis and Structure Revision of Indidene Natural Products’, Angewandte Chemie International Edition. 23.11.2023, 63(1). Available at: https://doi.org/10.1002/anie.202316103.

Moser, Daniel (2023) Diastereodivergent arene-forming aldol condensations and atroposelective pyridoannelations. Doctoral Thesis. University of Basel.

Baiyoumy, A. (2023) Development and application of an artificial allylic aminase for in vivo catalysis purposes. Doctoral Thesis.

Geraci, Andrea et al. (2023) ‘Iridium(III)-Catalyzed Intermolecular C(sp³)-H Amidation for the Synthesis of Chiral 1,2-Diamines’, Angewandte Chemie International Edition, 62(42), p. e202309263. Available at: https://doi.org/10.1002/anie.202309263.

Guo, Shu-Min et al. (2023) ‘A C-H activation-based enantioselective synthesis of lower carbo[n]helicenes’, Nature chemistry, 15, pp. 872–880. Available at: https://doi.org/10.1038/s41557-023-01174-5.

Kudashev, A. (2023) Exploiting ligand effects in development of new methods and total synthesis with Pd-catalyzed C(spᶟ)-H activation. Doctoral Thesis.

Martynova, Ekaterina A. et al. (2023) ‘Simple synthetic access to [Au(IBiox)Cl] complexes’, Dalton Transactions, 52(22), pp. 7558–7563. Available at: https://doi.org/10.1039/d3dt01357j.

Miyakoshi, T. (2023) N-Heterocycle synthesis via Pd(0)-catalysed C–H activation: kinetic resolution and Pd shift . Doctoral Thesis.

Salameh, Nihad et al. (2023) ‘A General Enantioselective C-H Arylation Using an Immobilized Recoverable Palladium Catalyst.’, ChemSusChem. 24.07.2023, 16(23). Available at: https://doi.org/10.1002/cssc.202300609.

Schmidt, T. (2023) Catalyst control over three- and fourfold stereogenicity. Doctoral Thesis.

Wheatley, Matthew et al. (2023) ‘Effect of α-Substitution on the Reactivity of C(sp³)-H Bonds in Pd⁰-Catalyzed C-H Arylation’, ACS Catalysis, 13, pp. 12563–12570. Available at: https://doi.org/10.1021/acscatal.3c03806.

Ferlin, Francesco et al. (2022) ‘C(sp³)−H Arylation Promoted by a Heterogeneous Palladium-N-Heterocyclic Carbene Complex in Batch and Continuous Flow’, ChemSusChem, 15(6), p. e202102736. Available at: https://doi.org/10.1002/cssc.202102736.

Guo, S. (2022) Palladium(0) Catalyzed Enantioselective C(sp2)–H Arylation Reactions: From Axial, Helical to Planar Chirality . Doctoral Thesis.

Miyakoshi, Takeru, Niggli, Nadja E. and Baudoin, Olivier (2022) ‘Remote Construction of N-Heterocycles via 1,4-Palladium Shift-Mediated Double C-H Activation’, Angewandte Chemie International Edition, 61(17), p. e202116101. Available at: https://doi.org/10.1002/anie.202116101.

Niggli, N.E. (2022) N-Heterocyclic Carbenes in Pd0-Catalyzed C(sp3)–H Activation. Doctoral Thesis.

Savary, D. (2022) C-H Functionalisation via Migratory Cross-Couplings and Enantioselective Pd0-Catalysed C(sp2)-H Arylation. Doctoral Thesis.

Zuccarello, M. (2022) Enantioselective Pd(0)-Catalyzed Activation of Secondary C(sp3)−H Bonds and Mechanistic Studies. Doctoral Thesis.

Antien, Kevin et al. (2021) ‘A New Dioxazolone for the Synthesis of 1,2-Aminoalcohols via Iridium(III)-Catalyzed C(sp; 3; )-H Amidation’, Angewandte Chemie International Edition, 60(42), pp. 22948–22955. Available at: https://doi.org/10.1002/anie.202110019.

Baudoin, Olivier (2021) ‘A Personal Account on Industrial Collaborations in the Field of C-H Activation’, Chimia, 75(11), pp. 967–971. Available at: https://doi.org/10.2533/chimia.2021.967.

Kudashev, Anton and Baudoin, Olivier (2021) ‘Site-Selective Pd-Catalyzed C(sp3)-H Arylation of Heteroaromatic Ketones’, Chemistry - A European Journal, 27(70), pp. 17688–17694. Available at: https://doi.org/10.1002/chem.202103467.

Melot, Romain et al. (2021) ‘Palladium(0)-Catalyzed Enantioselective Intramolecular Arylation of Enantiotopic Secondary C-H Bonds’, Angewandte Chemie International Edition, 60(13), pp. 7245–7250. Available at: https://doi.org/10.1002/anie.202014605.

Niggli, Nadja E. and Baudoin, Olivier (2021) ‘Design of Chiral NHC-Carboxylates as Potential Ligands for Pd-Catalyzed Enantioselective C-H Activation’, Helvetica Chimica Acta, 104(3), p. e2100015. Available at: https://doi.org/10.1002/hlca.202100015.

Savary, David and Baudoin, Olivier (2021) ‘Enantioselective Pd0-Catalyzed C(sp2)-H Arylation for the Synthesis of Chiral Warped Molecules’, Angewandte Chemie International Edition, p. 10.1002/anie.202013303. Available at: https://doi.org/10.1002/anie.202013303.

Thesmar, P. (2021) Pd(0)-Catalyzed C(sp3)-H Activation for the Synthesis of Natural Products and Cyclopropanes. Doctoral Thesis.

Vyhivskyi, Oleksandr et al. (2021) ‘Chiral Catalysts for Pd-0-Catalyzed Enantioselective C-H Activation’, Chemistry - A European Journal, 27(4), pp. 1231–1257. Available at: https://doi.org/10.1002/chem.202003225.

Baudoin, Olivier (2020) ‘Multiple Catalytic C-H Bond Functionalization for Natural Product Synthesis’, Angewandte Chemie (International ed. in English), p. 10.1002/anie.202001224. Available at: https://doi.org/10.1002/anie.202001224.

Baumgartner, Yann and Baudoin, Olivier (2020) ‘One-Pot Alkene Hydroboration/Palladium-Catalyzed Migratory Suzuki−Miyaura Cross-Coupling’, ACS Catalysis, 10, pp. 10508–10515. Available at: https://doi.org/10.1021/acscatal.0c02755.

Baumgartner, Y.L.G. (2020) Palladium-Catalysed Migratory Suzuki-Miyaura Cross-Coupling. Doctoral Thesis.

Carny, Tomas et al. (2020) ‘Synthesis of Amides and Esters by Palladium(0)-Catalyzed Carbonylative C(sp3)-H Activation’, Angewandte Chemie International Edition, 59(43), pp. 18980–18984. Available at: https://doi.org/10.1002/anie.202007922.

Clemenceau, Antonin et al. (2020) ‘Direct Synthesis of Cyclopropanes from gem-Dialkyl Groups through Double C-H Activation’, Journal of the American Chemical Society, 142(36), pp. 15355–15361. Available at: https://doi.org/10.1021/jacs.0c05887.

Nguyen, Qui-Hien et al. (2020) ‘Intermolecular Palladium(0)-Catalyzed Atropo-enantioselective C-H Arylation of Heteroarenes’, Journal of American Chemical Society, 142(5), pp. 2161–2167. Available at: https://doi.org/10.1021/jacs.9b12299.

Thesmar, Pierre et al. (2020) ‘Divergent Synthesis of Bioactive Dithiodiketopiperazine Natural Products Based on a Double C(sp3)−H Activation Strategy’, Chemistry - A European Journal, 26. Available at: https://doi.org/10.1002/chem.202003683.

Lin, Weilong, Zhang, Ke-Feng and Baudoin, Olivier (2019) ‘Regiodivergent enantioselective C-H functionalization of Boc-1,3-oxazinanes for the synthesis of beta(2)- and beta(3)-amino acids’, Nature Catalysis, 2(10), pp. 882–888. Available at: https://doi.org/10.1038/s41929-019-0336-1.

Melot, R. (2019) Asymmetric palladium (0)-catalyzed C(sp³)-H arylation and natural product synthesis. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-007177315.

Melot, Romain, Craveiro, Marcus V. and Baudoin, Olivier (2019) ‘Total Synthesis of (Nor)illudalane Sesquiterpenes Based on a C(sp3)-H Activation Strategy’, Journal of Organic Chemistry, 84(20), pp. 12933–12945. Available at: https://doi.org/10.1021/acs.joc.9b01669.

Melot, Romain et al. (2019) ‘Divergent Enantioselective Synthesis of (Nor)illudalane Sesquiterpenes via Pd-0-Catalyzed Asymmetric C(sp(3))-H Activation’, Organic Letters, 21(3), pp. 812–815. Available at: https://doi.org/10.1021/acs.orglett.8b04086.

Rocaboy, R. (2019) Palladium(0)/palladium(II) catalysed C(sp3)-H activation : from direct to remote functionalization. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-007149247.

Rocaboy, Ronan, Anastasiou, Ioannis and Baudoin, Olivier (2019) ‘Redox-Neutral Coupling between Two C(sp3)-H Bonds Enabled by 1,4-Palladium Shift for the Synthesis of Fused Heterocycles’, Angewandte Chemie International Edition, 58(41), pp. 14625–14628. Available at: https://doi.org/10.1002/anie.201908460.

Rocaboy, Ronan and Baudoin, Olivier (2019) ‘1,4-Palladium Shift/C(sp(3))-H Activation Strategy for the Remote Construction of Five-Membered Rings’, Organic Letters, 21(5), pp. 1434–1437. Available at: https://doi.org/10.1021/acs.orglett.9b00187.

Royal, Titouan and Baudoin, Olivier (2019) ‘Pd-catalyzed gamma-arylation of gamma,delta-unsaturated O-carbamates via an unusual haptotropic rearrangement’, Chemical Science, 10(8), pp. 2331–2335. Available at: https://doi.org/10.1039/c8sc05058a.

Thesmar, Pierre and Baudoin, Olivier (2019) ‘Efficient and Divergent Total Synthesis of (-)-Epicoccin G and (-)-Rostratin A Enabled by Double C(sp; 3; )-H Activation’, Journal of the American Chemical Society, 141, pp. 15779–15783. Available at: https://doi.org/10.1021/jacs.9b09359.

Rocaboy, Ronan, Dailler, David and Baudoin, Olivier (2018) ‘A Four-Step Synthesis of (±)-γ-Lycorane via Pd0-Catalyzed Double C(sp2)-H/C(sp3)-H Arylation’, Organic Letters, 20(3), pp. 772–775. Available at: https://doi.org/10.1021/acs.orglett.7b03909.

Rocaboy, Ronan et al. (2018) ‘Domino Pd0-Catalyzed C(sp3)-H Arylation/Electrocyclic Reactions via Benzazetidine Intermediates’, Angewandte Chemie International Edition, 57(37), pp. 12131–12135. Available at: https://doi.org/10.1002/anie.201807097.

Royal, T. (2018) Pd(0)-catalyzed arylation of O-carbamates via Negishi cross-coupling and intermolecular Pd(0)-catalyzed atroposelective Csp2-H bond activation. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-007074442.

Yang, Lei, Neuburger, Markus and Baudoin, Olivier (2018) ‘Chiral Bifunctional Phosphine-Carboxylate Ligands for Palladium(0)-Catalyzed Enantioselective C-H Arylation’, Angewandte Chemie International Edition, 57(5), pp. 1394–1398. Available at: https://doi.org/10.1002/anie.201712061.

Zhang, K.-F. (2018) Ligand-controlled selectivity in palladium(0)-catalyzed C(sp2)-C(sp3) Negishi cross-coupling reactions. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-006850206.

Zhang, Ke-Feng, Christoffel, Fadri and Baudoin, Olivier (2018) ‘Barbier-Negishi Coupling of Secondary Alkyl Bromides with Aryl and Alkenyl Triflates and Nonaflates’, Angewandte Chemie International Edition, 57(7), pp. 1982–1986. Available at: https://doi.org/10.1002/anie.201711990.

Baudoin, Olivier (2017) ‘Ring Construction by Palladium(0)-Catalyzed C(sp(3))-H Activation’, Accounts of Chemical Research, 50(4), pp. 1114–1123. Available at: https://doi.org/10.1021/acs.accounts.7b00099.

Dailler, D. (2017) Development and applications of palladium(0)-catalyzed-C(sp3)-H activation. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-006806222.

Dailler, David, Rocaboy, Ronan and Baudoin, Olivier (2017) ‘Synthesis of β-Lactams by Palladium(0)-Catalyzed C(sp3)−H Carbamoylation’, Angewandte Chemie International Edition, 56(25), pp. 7218–7222. Available at: https://doi.org/10.1002/anie.201703109.

Goutierre, Anne-Sophie et al. (2017) ‘Comparative Structural Analysis of Biarylphosphine Ligands in Arylpalladium Bromide and Malonate Complexes’, Organometallics, 36(1), pp. 129–135. Available at: https://doi.org/10.1021/acs.organomet.6b00535.

Holstein, Philipp M. et al. (2017) ‘Ferrocene derivatives of liquid chiral molecules allow assignment of absolute configuration by X-ray crystallography’, Tetrahedron: Asymmetry, 28(10), pp. 1321–1329. Available at: https://doi.org/10.1016/j.tetasy.2017.09.002.

Royal, Titouan, Baumgartner, Yann and Baudoin, Olivier (2017) ‘Enantioselective α-Arylation of O-Carbamates via Sparteine-Mediated Lithiation and Negishi Cross-Coupling’, Organic Letters, 19(1), pp. 166–169. Available at: https://doi.org/10.1021/acs.orglett.6b03472.

Yang, Lei et al. (2017) ‘Palladium(0)-catalyzed asymmetric C(sp3)-H arylation using a chiral binol-derived phosphate and an achiral ligand’, Chemical Science, 8(2), pp. 1344–1349. Available at: https://doi.org/10.1039/c6sc04006c.

Holstein, P.M. et al. (2016) ‘Synthesis of Strained γ-Lactams by Palladium(0)-Catalyzed C(sp3)-H Alkenylation and Application to Alkaloid Synthesis’, Angewandte Chemie - International Edition, 55(8), pp. 2805–2809. Available at: https://doi.org/10.1002/anie.201511457.

Baudoin, Olivier (2016) ‘Selectivity Control in the Palladium-catalyzed Cross-coupling of Alkyl Nucleophiles’, Chimia, 70(11), pp. 768–772. Available at: https://doi.org/10.2533/chimia.2016.768.

Dupuy, Stéphanie et al. (2016) ‘Terminal-Selective Functionalization of Alkyl Chains by Regioconvergent Cross-Coupling’, Angewandte Chemie International Edition, 55(47), pp. 14793–14797. Available at: https://doi.org/10.1002/anie.201608535.

Holstein, Philipp M. et al. (2016) ‘Synthesis of Strained γ-Lactams by Palladium(0)-Catalyzed C(sp3)−H Alkenylation and Application to Alkaloid Synthesis’, Angewandte Chemie, 128(8), pp. 2855–2859. Available at: https://doi.org/10.1002/ange.201511457.

Martin, Anthony, Vors, Jean-Pierre and Baudoin, Olivier (2016) ‘Synthesis of Conformationally Constrained Esters and Amines by Pd-Catalyzed α-Arylation of Hindered Substrates’, ACS Catalysis, 6(6), pp. 3941–3945. Available at: https://doi.org/10.1021/acscatal.6b00943.

Millet, A. and Baudoin, O. (2016) ‘Palladium-catalyzed β-Selective C(sp3)-H arylation of N-boc-piperidines’, Organic Syntheses, 92, pp. 76–90. Available at: https://doi.org/10.15227/orgsyn.92.0076.

Prieto, Alexis et al. (2016) ‘Electrophilic trifluoromethylation of carbonyl compounds and their nitrogen derivatives under copper catalysis’, Chemical Communications, 52(5), pp. 869–81. Available at: https://doi.org/10.1039/c5cc05954b.

Dailler, David, Danoun, Grégory and Baudoin, Olivier (2016) ‘Applications of Catalytic Organometallic C(sp3)-H Bond Functionalization’, in Dix-neuf, Pierre H.; Doucet, Henri (ed.) C-H bond activation and catalytic functionalization II. Cham: Springer International Publishing (Topics in Organometallic Chemistry), pp. 133–154. Available at: https://doi.org/10.1007/3418_2015_122.

Prieto, A. et al. (2015) ‘Copper-Catalyzed Trifluoromethylation of Aliphatic N-Arylhydrazones: A Concise Synthetic Entry to 2-Trifluoromethylindoles from Simple Aldehydes’, Advanced Synthesis and Catalysis, 357(13), pp. 2939–2943. Available at: https://doi.org/10.1002/adsc.201500237.

Holstein, P.M. et al. (2015) ‘Efficient Pd0-Catalyzed Asymmetric Activation of Primary and Secondary C-H Bonds Enabled by Modular Binepine Ligands and Carbonate Bases’, ACS Catalysis, 5(7), pp. 4300–4308. Available at: https://doi.org/10.1021/acscatal.5b00898.

Dailler, D. et al. (2015) ‘Divergent Synthesis of Aeruginosins Based on a C(sp3)£H Activation Strategy’, Chemistry - A European Journal, 21(26), pp. 9370–9379. Available at: https://doi.org/10.1002/chem.201501370.

Dailler, D., Danoun, G. and Baudoin, O. (2015) ‘A General and Scalable Synthesis of Aeruginosin Marine Natural Products Based on Two Strategic C(sp3)-H Activation Reactions’, Angewandte Chemie - International Edition, 54(16), pp. 4919–4922. Available at: https://doi.org/10.1002/anie.201500066.