Cell and Developmental Biology (Schier)Head of Research Unit Prof. Dr. Alexander Schier, Prof. Dr.OverviewMembersPublicationsProjects & CollaborationsProjects & Collaborations OverviewMembersPublicationsProjects & Collaborations Projects & Collaborations 23 foundShow per page10 10 20 50 Schmidt Science Fellowship Research Project | 1 Project MembersImported from Grants Tool 4730599 SELFORGANIZE / Mechanisms of self-organized axis formation in vivo Research Project | 2 Project MembersImported from Grants Tool 4707034 10007179 - Mechanisms of Nodal morphogen interpretation Research Project | 1 Project MembersImported from Grants Tool 4722801 Enhancing transplant viability by using condensate modulators inspired by nature Research Project | 1 Project MembersImported from Grants Tool 4718162 Morphogen signaling and mechanotransduction in early killifish embryogenesis Research Project | 2 Project MembersImported from Grants Tool 4709749 MECHANISMS OF BODY-BRAIN COMMUNICATION IN ORGAN FUNCTION AND BEHAVIOR Research Project | 1 Project MembersImported from Grants Tool 4705266 The cis regulatory code of translational control during embryogenesis Research Project | 1 Project MembersImported from Grants Tool 4701316 The cis-regulatory code of Nodal morphogen interpretation Research Project | 1 Project MembersImported from Grants Tool 4701080 The functional and molecular evolution of thermosensation in nematode worms Research Project | 1 Project MembersImported from Grants Tool 4665048 DevBoundaries - Formation of tissue boundaries during zebrafish embryogenesis Research Project | 2 Project MembersDuring animal development, boundaries need to be established between cell types to guarantee the physical and functional integrity of tissues. However, the underlying mechanisms are poorly understood because it has been challenging to analyze the coordination of gene expression, cell proliferation and cell movement needed for boundary formation. I will probe the in vivo mechanisms of boundary formation using the zebrafish embryonic shield region as a model system. The shield contains overlapping progenitor cells that give rise to various midline structures whose boundaries form and sharpen during gastrulation. I will use imaging and genetic approaches to determine how shield cells differentiate and generate tissue boundaries. Aim 1: To characterize lineage, movement and differentiation of shield progenitors and their descendants, I will use in toto light-sheet imaging. This approach will generate a dynamic atlas detailing the cellular basis of boundary formation. Aim 2: To characterize the gene expression changes during the separation of shield progenitors and their descendants, I will use spatial transcriptomics. This aim will create a dynamic atlas detailing the transcriptomic basis of boundary formation. Aim 3: To define the molecular basis of boundary formation, I will disrupt candidate genes involved in boundary formation. This approach will determine if differentiation and morphogenesis are coupled during boundary formation and define molecular pathways that ensure robust boundary formation. Together, the proposed approaches will identify cellular and genetic mechanisms controlling boundary formation during embryogenesis. 123 123 OverviewMembersPublicationsProjects & Collaborations
Projects & Collaborations 23 foundShow per page10 10 20 50 Schmidt Science Fellowship Research Project | 1 Project MembersImported from Grants Tool 4730599 SELFORGANIZE / Mechanisms of self-organized axis formation in vivo Research Project | 2 Project MembersImported from Grants Tool 4707034 10007179 - Mechanisms of Nodal morphogen interpretation Research Project | 1 Project MembersImported from Grants Tool 4722801 Enhancing transplant viability by using condensate modulators inspired by nature Research Project | 1 Project MembersImported from Grants Tool 4718162 Morphogen signaling and mechanotransduction in early killifish embryogenesis Research Project | 2 Project MembersImported from Grants Tool 4709749 MECHANISMS OF BODY-BRAIN COMMUNICATION IN ORGAN FUNCTION AND BEHAVIOR Research Project | 1 Project MembersImported from Grants Tool 4705266 The cis regulatory code of translational control during embryogenesis Research Project | 1 Project MembersImported from Grants Tool 4701316 The cis-regulatory code of Nodal morphogen interpretation Research Project | 1 Project MembersImported from Grants Tool 4701080 The functional and molecular evolution of thermosensation in nematode worms Research Project | 1 Project MembersImported from Grants Tool 4665048 DevBoundaries - Formation of tissue boundaries during zebrafish embryogenesis Research Project | 2 Project MembersDuring animal development, boundaries need to be established between cell types to guarantee the physical and functional integrity of tissues. However, the underlying mechanisms are poorly understood because it has been challenging to analyze the coordination of gene expression, cell proliferation and cell movement needed for boundary formation. I will probe the in vivo mechanisms of boundary formation using the zebrafish embryonic shield region as a model system. The shield contains overlapping progenitor cells that give rise to various midline structures whose boundaries form and sharpen during gastrulation. I will use imaging and genetic approaches to determine how shield cells differentiate and generate tissue boundaries. Aim 1: To characterize lineage, movement and differentiation of shield progenitors and their descendants, I will use in toto light-sheet imaging. This approach will generate a dynamic atlas detailing the cellular basis of boundary formation. Aim 2: To characterize the gene expression changes during the separation of shield progenitors and their descendants, I will use spatial transcriptomics. This aim will create a dynamic atlas detailing the transcriptomic basis of boundary formation. Aim 3: To define the molecular basis of boundary formation, I will disrupt candidate genes involved in boundary formation. This approach will determine if differentiation and morphogenesis are coupled during boundary formation and define molecular pathways that ensure robust boundary formation. Together, the proposed approaches will identify cellular and genetic mechanisms controlling boundary formation during embryogenesis. 123 123
SELFORGANIZE / Mechanisms of self-organized axis formation in vivo Research Project | 2 Project MembersImported from Grants Tool 4707034
10007179 - Mechanisms of Nodal morphogen interpretation Research Project | 1 Project MembersImported from Grants Tool 4722801
Enhancing transplant viability by using condensate modulators inspired by nature Research Project | 1 Project MembersImported from Grants Tool 4718162
Morphogen signaling and mechanotransduction in early killifish embryogenesis Research Project | 2 Project MembersImported from Grants Tool 4709749
MECHANISMS OF BODY-BRAIN COMMUNICATION IN ORGAN FUNCTION AND BEHAVIOR Research Project | 1 Project MembersImported from Grants Tool 4705266
The cis regulatory code of translational control during embryogenesis Research Project | 1 Project MembersImported from Grants Tool 4701316
The cis-regulatory code of Nodal morphogen interpretation Research Project | 1 Project MembersImported from Grants Tool 4701080
The functional and molecular evolution of thermosensation in nematode worms Research Project | 1 Project MembersImported from Grants Tool 4665048
DevBoundaries - Formation of tissue boundaries during zebrafish embryogenesis Research Project | 2 Project MembersDuring animal development, boundaries need to be established between cell types to guarantee the physical and functional integrity of tissues. However, the underlying mechanisms are poorly understood because it has been challenging to analyze the coordination of gene expression, cell proliferation and cell movement needed for boundary formation. I will probe the in vivo mechanisms of boundary formation using the zebrafish embryonic shield region as a model system. The shield contains overlapping progenitor cells that give rise to various midline structures whose boundaries form and sharpen during gastrulation. I will use imaging and genetic approaches to determine how shield cells differentiate and generate tissue boundaries. Aim 1: To characterize lineage, movement and differentiation of shield progenitors and their descendants, I will use in toto light-sheet imaging. This approach will generate a dynamic atlas detailing the cellular basis of boundary formation. Aim 2: To characterize the gene expression changes during the separation of shield progenitors and their descendants, I will use spatial transcriptomics. This aim will create a dynamic atlas detailing the transcriptomic basis of boundary formation. Aim 3: To define the molecular basis of boundary formation, I will disrupt candidate genes involved in boundary formation. This approach will determine if differentiation and morphogenesis are coupled during boundary formation and define molecular pathways that ensure robust boundary formation. Together, the proposed approaches will identify cellular and genetic mechanisms controlling boundary formation during embryogenesis.
