[FG] Center for medical Image Analysis & NavigationHead of Research Unit Prof. Dr.Philippe Claude CattinOverviewMembersPublicationsProjects & CollaborationsProjects & Collaborations OverviewMembersPublicationsProjects & Collaborations Projects & Collaborations 38 foundShow per page10 10 20 50 REMEDY (Reducing Mistriage in Emergency Departments: A Path to Improved Triage Accuracy through Real-time Evaluation and Artificial Intelligence) Research Project | 4 Project MembersImported from Grants Tool 4707568 P-Study project - Comparing outcomes between Robotic, Laparoscopic and Open colorectal surgery: A multicenter study. Research Project | 1 Project MembersImported from Grants Tool 4708403 Transatlantic Capacity Building in Orthopaedic Sports Medicine Research Project | 3 Project MembersImported from Grants Tool 4708726 Virtual and Augmented Reality Platform in Surgery Research Project | 2 Project MembersImported from Grants Tool 4699240 Fluoroscopic Patient Referencing Research Project | 1 Project MembersNo Description available Accelerated Deep Learning Research Project | 2 Project MembersNo Description available Invention and development of a cell and organoid instrument prototype - MoLiBB Research Project | 1 Project MembersNo Description available Stop tip-toeing around toe-walking: towards a better understanding and more effective treatment of toe-walkers with cerebral palsy Research Project | 8 Project MembersBackground and Rationale: Walking is the most common and necessary form of movement for humans, as it ensures active participation in activities of daily life. In the initial stages of learning to walk, gait is rather unstable as well as variable. During this initial phase, children need to successfully perform the entire gait cycle that involves touch-down (characteristic heel-strike where the ankle is flexed), lift-off and swing phases. The characteristic heel-strike is critical to walking both effectively (stable) and efficiently (energy). Children that suffer from neuro-developmental disorders (e.g. cerebral palsy, CP) are often not able to heel-strike, they tend to keep walking with a forefoot or flatfoot pattern (i.e. toe-walking). Children that toe-walk often show poorer levels of static and dynamic stability, leading to a lower quality of life compared to typically developing children (TD). Current research suggests multifactorial adaptations in central and/or peripheral nervous as well as the musculoskeletal system contribute to and result from toe-walking. Current treatment mainly focuses on physically restoring the capability to heel-strike, however, adherence to walking with heel-strike is poor. From clinical experience, we hypothesize psychological factors (primarily fear-of-falling) as well as inadequate reflex control might contribute to toe-walking behavior. Currently, the interplay between the nervous-, musculoskeletal-, and psychological systems and their impact on resulting walking patterns are poorly understood. In order to sustain effective gait by means of effective interventions, it is therefore critical to understand the interplay among the mechanisms that underpin toe-walking adaptation. Overall Objectives & Specific Aims: The purpose of this study is to explore the interplay among nervous-, musculoskeletal-, and psychological systems and how they impact toe-walking behavior, and vice versa. Here, we will determine the effect of psychological factors (via the use of a custom-designed virtual reality environment) on static vs. dynamic stability, motor control and coordination (indirect assessment of central nervous system function), as well as reflex control (Hoffmann-reflex, H-reflex, performance of peripheral nervous system). In addition, we will also investigate the effect of restoring heel striking in toe-walkers based on the indices as mentioned above. Expected Results: It is expected that toe-walkers will show poorer stability during standing and walking, have a reduced H-reflex amplitude, reduced number of muscle synergies as well as increased fear-of-falling compared to TD. With the use of a custom-made virtual reality (VR) environment, the fear-of-falling in children will be increased. VR induced fear-of-falling will lead to poorer stability during standing and walking tasks in TD; in toe-walkers such reactions are present already without VR but worsen during VR conditions. By restoring (via the use of orthoses) heel-strike in toe-walkers stability during standing and walking tasks will be improved, number of muscle synergies will be increased, fear-of-falling will be reduced, and performance on VR induced fear-of-falling will be improved. Impact: Although development of heel-strike behavior takes place early in life, not all children demonstrate this feature during walking in daily life. Lack of heel-strike behavior is less efficient and leads to poorer quality of life. Management strategies to restore this critical feature of walking, have failed primarily due to the fact that although the capability might be restored, the adherence to walking with heel-strike is poor. By focusing on understanding the interplay between nervous-, musculoskeletal-, and psychological factors that might predispose individuals to toe-walking, we will provide solutions to design effective treatment strategies in the future. Deep learning to harmonize the MRI contrast over a scanner change in a longitudinal multiple sclerosis cohort study Research Project | 4 Project MembersNo Description available Unsupervised Tissue Classification Research Project | 2 Project MembersNo Description available 1234 1...4 OverviewMembersPublicationsProjects & Collaborations
Projects & Collaborations 38 foundShow per page10 10 20 50 REMEDY (Reducing Mistriage in Emergency Departments: A Path to Improved Triage Accuracy through Real-time Evaluation and Artificial Intelligence) Research Project | 4 Project MembersImported from Grants Tool 4707568 P-Study project - Comparing outcomes between Robotic, Laparoscopic and Open colorectal surgery: A multicenter study. Research Project | 1 Project MembersImported from Grants Tool 4708403 Transatlantic Capacity Building in Orthopaedic Sports Medicine Research Project | 3 Project MembersImported from Grants Tool 4708726 Virtual and Augmented Reality Platform in Surgery Research Project | 2 Project MembersImported from Grants Tool 4699240 Fluoroscopic Patient Referencing Research Project | 1 Project MembersNo Description available Accelerated Deep Learning Research Project | 2 Project MembersNo Description available Invention and development of a cell and organoid instrument prototype - MoLiBB Research Project | 1 Project MembersNo Description available Stop tip-toeing around toe-walking: towards a better understanding and more effective treatment of toe-walkers with cerebral palsy Research Project | 8 Project MembersBackground and Rationale: Walking is the most common and necessary form of movement for humans, as it ensures active participation in activities of daily life. In the initial stages of learning to walk, gait is rather unstable as well as variable. During this initial phase, children need to successfully perform the entire gait cycle that involves touch-down (characteristic heel-strike where the ankle is flexed), lift-off and swing phases. The characteristic heel-strike is critical to walking both effectively (stable) and efficiently (energy). Children that suffer from neuro-developmental disorders (e.g. cerebral palsy, CP) are often not able to heel-strike, they tend to keep walking with a forefoot or flatfoot pattern (i.e. toe-walking). Children that toe-walk often show poorer levels of static and dynamic stability, leading to a lower quality of life compared to typically developing children (TD). Current research suggests multifactorial adaptations in central and/or peripheral nervous as well as the musculoskeletal system contribute to and result from toe-walking. Current treatment mainly focuses on physically restoring the capability to heel-strike, however, adherence to walking with heel-strike is poor. From clinical experience, we hypothesize psychological factors (primarily fear-of-falling) as well as inadequate reflex control might contribute to toe-walking behavior. Currently, the interplay between the nervous-, musculoskeletal-, and psychological systems and their impact on resulting walking patterns are poorly understood. In order to sustain effective gait by means of effective interventions, it is therefore critical to understand the interplay among the mechanisms that underpin toe-walking adaptation. Overall Objectives & Specific Aims: The purpose of this study is to explore the interplay among nervous-, musculoskeletal-, and psychological systems and how they impact toe-walking behavior, and vice versa. Here, we will determine the effect of psychological factors (via the use of a custom-designed virtual reality environment) on static vs. dynamic stability, motor control and coordination (indirect assessment of central nervous system function), as well as reflex control (Hoffmann-reflex, H-reflex, performance of peripheral nervous system). In addition, we will also investigate the effect of restoring heel striking in toe-walkers based on the indices as mentioned above. Expected Results: It is expected that toe-walkers will show poorer stability during standing and walking, have a reduced H-reflex amplitude, reduced number of muscle synergies as well as increased fear-of-falling compared to TD. With the use of a custom-made virtual reality (VR) environment, the fear-of-falling in children will be increased. VR induced fear-of-falling will lead to poorer stability during standing and walking tasks in TD; in toe-walkers such reactions are present already without VR but worsen during VR conditions. By restoring (via the use of orthoses) heel-strike in toe-walkers stability during standing and walking tasks will be improved, number of muscle synergies will be increased, fear-of-falling will be reduced, and performance on VR induced fear-of-falling will be improved. Impact: Although development of heel-strike behavior takes place early in life, not all children demonstrate this feature during walking in daily life. Lack of heel-strike behavior is less efficient and leads to poorer quality of life. Management strategies to restore this critical feature of walking, have failed primarily due to the fact that although the capability might be restored, the adherence to walking with heel-strike is poor. By focusing on understanding the interplay between nervous-, musculoskeletal-, and psychological factors that might predispose individuals to toe-walking, we will provide solutions to design effective treatment strategies in the future. Deep learning to harmonize the MRI contrast over a scanner change in a longitudinal multiple sclerosis cohort study Research Project | 4 Project MembersNo Description available Unsupervised Tissue Classification Research Project | 2 Project MembersNo Description available 1234 1...4
REMEDY (Reducing Mistriage in Emergency Departments: A Path to Improved Triage Accuracy through Real-time Evaluation and Artificial Intelligence) Research Project | 4 Project MembersImported from Grants Tool 4707568
P-Study project - Comparing outcomes between Robotic, Laparoscopic and Open colorectal surgery: A multicenter study. Research Project | 1 Project MembersImported from Grants Tool 4708403
Transatlantic Capacity Building in Orthopaedic Sports Medicine Research Project | 3 Project MembersImported from Grants Tool 4708726
Virtual and Augmented Reality Platform in Surgery Research Project | 2 Project MembersImported from Grants Tool 4699240
Invention and development of a cell and organoid instrument prototype - MoLiBB Research Project | 1 Project MembersNo Description available
Stop tip-toeing around toe-walking: towards a better understanding and more effective treatment of toe-walkers with cerebral palsy Research Project | 8 Project MembersBackground and Rationale: Walking is the most common and necessary form of movement for humans, as it ensures active participation in activities of daily life. In the initial stages of learning to walk, gait is rather unstable as well as variable. During this initial phase, children need to successfully perform the entire gait cycle that involves touch-down (characteristic heel-strike where the ankle is flexed), lift-off and swing phases. The characteristic heel-strike is critical to walking both effectively (stable) and efficiently (energy). Children that suffer from neuro-developmental disorders (e.g. cerebral palsy, CP) are often not able to heel-strike, they tend to keep walking with a forefoot or flatfoot pattern (i.e. toe-walking). Children that toe-walk often show poorer levels of static and dynamic stability, leading to a lower quality of life compared to typically developing children (TD). Current research suggests multifactorial adaptations in central and/or peripheral nervous as well as the musculoskeletal system contribute to and result from toe-walking. Current treatment mainly focuses on physically restoring the capability to heel-strike, however, adherence to walking with heel-strike is poor. From clinical experience, we hypothesize psychological factors (primarily fear-of-falling) as well as inadequate reflex control might contribute to toe-walking behavior. Currently, the interplay between the nervous-, musculoskeletal-, and psychological systems and their impact on resulting walking patterns are poorly understood. In order to sustain effective gait by means of effective interventions, it is therefore critical to understand the interplay among the mechanisms that underpin toe-walking adaptation. Overall Objectives & Specific Aims: The purpose of this study is to explore the interplay among nervous-, musculoskeletal-, and psychological systems and how they impact toe-walking behavior, and vice versa. Here, we will determine the effect of psychological factors (via the use of a custom-designed virtual reality environment) on static vs. dynamic stability, motor control and coordination (indirect assessment of central nervous system function), as well as reflex control (Hoffmann-reflex, H-reflex, performance of peripheral nervous system). In addition, we will also investigate the effect of restoring heel striking in toe-walkers based on the indices as mentioned above. Expected Results: It is expected that toe-walkers will show poorer stability during standing and walking, have a reduced H-reflex amplitude, reduced number of muscle synergies as well as increased fear-of-falling compared to TD. With the use of a custom-made virtual reality (VR) environment, the fear-of-falling in children will be increased. VR induced fear-of-falling will lead to poorer stability during standing and walking tasks in TD; in toe-walkers such reactions are present already without VR but worsen during VR conditions. By restoring (via the use of orthoses) heel-strike in toe-walkers stability during standing and walking tasks will be improved, number of muscle synergies will be increased, fear-of-falling will be reduced, and performance on VR induced fear-of-falling will be improved. Impact: Although development of heel-strike behavior takes place early in life, not all children demonstrate this feature during walking in daily life. Lack of heel-strike behavior is less efficient and leads to poorer quality of life. Management strategies to restore this critical feature of walking, have failed primarily due to the fact that although the capability might be restored, the adherence to walking with heel-strike is poor. By focusing on understanding the interplay between nervous-, musculoskeletal-, and psychological factors that might predispose individuals to toe-walking, we will provide solutions to design effective treatment strategies in the future.
Deep learning to harmonize the MRI contrast over a scanner change in a longitudinal multiple sclerosis cohort study Research Project | 4 Project MembersNo Description available