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Health economic analysis alongside DROPIT trial

Research Project
 | 
01.01.2023
 - 31.12.2027

Worldwide, proton pump inhibitors (PPIs) are frequently prescribed, and their use is continuingly increasing. PPI use is often inappropriate, they are prescribed for excessive durations or inadequate indications which contribute to adverse health outcomes. Reducing inappropriate PPIs could improve health and reduce human and financial costs. Limited studies have evaluated patient-focused deprescribing interventions to reduce inappropriate PPIs in the primary care setting. The involvement of general practitioners (GPs) and patients in deprescribing (to stop or reduce PPIs) is a necessity. Aims of the DROPIT trial: a) To investigate the effectiveness of an intervention for patients and GPs to deprescribe inappropriate PPIs in adults i) On the co-primary outcomes: - change from baseline in the dose of proton pump inhibitors (PPIs) at the 12-month follow-up - change from baseline in the Reflux Disease Questionnaire (RDQ) at the 12-month follow-up ii) Secondary outcomes: individual components of the co-primary outcomes, atypical gastrointestinal symptoms, diagnoses and conditions linked to PPI use, number and type of concurrent medications, medication adherence, prescribing of PPIs and alternative anti-reflux treatments, healthcare utilization, health-related quality of life, and side effects related to PPI deprescribing b) To evaluate the implementation of the intervention as well as GPs' and patients' intervention fidelity in a mixed-methods process evaluation c) To evaluate the cost-effectiveness of the trial intervention through health economic analyses. This part is in the responsibility of Uni basel, Research Group M. Schwenkglenks

Funding

Health economic analysis alongside DROPIT trial

Schweizerischer Nationalfonds (SNF), 01.2023-12.2027 (60)
PI : Schwenkglenks, Matthias.
CI : Barbier, Michaela.

Members (2)

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Matthias Schwenkglenks

Principal Investigator
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Michaela Barbier

Co-Investigator