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Ovarian toxicity of phthalates, bisphenol A and their substitutes

Research Project
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01.11.2021
 - 01.01.2023

This project aims at the identification and characterization of EDCs potentially inducing female reproductive toxicity, and ultimately leading to female infertility or contributing to female endocrine-metabolic diseases such as PCOS. The determination of the mechanisms how chemicals may lead to female infertility is, unfortunately, a neglected area of research. By addressing this issue, the proposed project on ovarian toxicity after exposure to EDCs complements the core project on male infertility and the core project on steroid disrupting effects of chemicals, offering synergies between SCAHT groups. The proposed experiments will also allow studying a potential susceptibility factor (SOD2) that might be relevant also for male infertility (impaired spermatozoa function) and metabolic diseases. Furthermore, we anticipate to identify the key events for the ovarian toxicity of those chemicals that will be studied in detail, allowing us to contribute to the establishment of new adverse outcome pathways.

Funding

Ovarian toxicity of phthalates, bisphenol A and their substitutes

Ressortforschung des Bundes (GrantsTool), 11.2021-12.2023 (26)
PI : Bouitbir, Jamal,Odermatt, Alex.

Members (2)

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Jamal Bouitbir

Principal Investigator
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Alex Odermatt

Principal Investigator