UNIverse - Public Research Portal
Project cover

Home delivery: Bacterial sRNA mediated treatment of intestinal bowel disease (Freenovation Grant, Miro Plum and Maxim Kolesnikov)

Research Project
 | 
01.08.2021
 - 31.07.2023

Inflammatory bowel disease is characterized by persistent inflammation of the colon and represents an increasing problem worldwide. Existing treatments are broad-acting, unspecific and are limited to temporary relief of symptoms. Moreover, the disease is highly heterogeneous, with a variety of possible causes that range from genetic to environmental. In our project, we will engineer a bacterium that secretes anti-inflammatory RNA in extracellular vesicles. Such a "living pill" may pave the way for further applications that involve RNA dependent regulation.

Funding

Freenovation Grant

Industriegelder, Sonstige Forschungskooperationen (GrantsTool), 08.2021-07.2023 (24)
PI : Basler, Marek.

Members (3)

Profile Photo

Marek Basler

Principal Investigator
MALE avatar

Maxim Kolesnikov

Co-Investigator
MALE avatar

Miro Thorsten Wilhelm Plum

Co-Investigator