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Zusammensetzung und Funktion von Vibrio cholerae Biofilmen auf humanen Makrophagen

Research Project
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01.08.2021
 - 31.08.2023

Cholera is a devastating diarrheal disease, caused by the bacterium Vibrio cholerae . Although V. cholerae induces an inflammatory response during infection, it is currently unclear how V. cholerae cells interact with the innate immune system. Focusing on the interaction of V. cholerae with macrophages, we discovered a surprising interaction process in preliminary work: V. cholerae cells form biofilms on the surface of macrophages, followed by macrophage death. In the proposed project, we will determine the key mechanisms underlying the formation, matrix composition, and function of biofilms on macrophages, and how macrophage death occurs during the interaction with V. cholerae . This project will provide a major new insight into the interaction mechanisms of V. cholerae with the human immune system.

Funding

Zusammensetzung und Funktion von Vibrio cholerae Biofilmen auf humanen Makrophagen

Weitere ausländische Förderagenturen (GrantsTool), 08.2021-08.2023 (25)
PI : Drescher, Knut.

Members (1)

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Knut Drescher

Principal Investigator