UNIverse - Public Research Portal
Project cover

Microfluidic sample preparation for high-resolution structure determination by cryogenic electron microscopy

Research Project
 | 
01.05.2021
 - 30.04.2023

Electron microscopy (EM) introduced a fast and lasting change to structural and cellular biology. Direct electron detector cameras and improved image processing algorithms now allow structure determination of large biomolecules by cryogenic EM (cryo-EM) at atomic resolution using a single particle approach. For the latter, only thousands to a few million particles must be imaged, to measure high-resolution structures. This amount of protein can be delivered by microfluidic technologies. I this project we explore to the potential of combining microfluidics and electron microscopy to study protein structures for drug discovery.

Funding

Microfluidic sample preparation for high-resolution structure determination by cryogenic electron microscopy

Industriegelder, Sonstige Forschungskooperationen (GrantsTool), 05.2021-04.2023 (24)
PI : Braun, Thomas.

Members (1)

Profile Photo

Thomas Braun

Principal Investigator