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Characterization of the ELF for better PK/PD models of human lung infection

Research Project
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01.02.2021
 - 31.01.2023

The objective of this collaboration is knowledge generation of the composition of Epithelial Lining Fluid (ELF) of human (healthy volunteers and patients with bacterial pneumonia) and pre-clinical species. This knowledge will be used for constructing simulated ELF matrixes mimicking the most important components of the physiological fluids. An in vitro assay is consequently set up to assess the free fraction of drugs in these fluids. Finally, the data generated will be used to establish a machine learning tool to predict free fraction in ELF based on chemical descriptors and will be further used to develop advanced Physiologically Based PharmacoKinetic (PBPK) model including ELF as additional compartment and its validation for human dose prediction on marketed drugs.

Funding

Characterization of the ELF for better PK/PD models of human lung infection

Industriegelder, Sonstige Forschungskooperationen (GrantsTool), 02.2021-01.2023 (24)
PI : Bumann, Dirk.

Members (2)

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Dirk Bumann

Principal Investigator
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Uwe Sauer

Co-Investigator