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Dissecting the emergence of neuronal cell populations in the habenulae of the vertebrate brain (BIF Fellowship Jakob El Kholtei)

Research Project
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01.05.2020
 - 30.04.2022

The vertebrate brain displays an incredible number and diversity of neurons. Neural stem cells, or progenitor cells, give rise to this neuronal diversity through the process of neurogenesis. Despite many scientific efforts, we are yet to attain a comprehensive understanding of how these progenitors establish the myriad of neuronal cell types in the correct locations and quantities. By establishing and using genomic and optical lineage tracing tools in the zebrafish, I will study the dynamics of neural stem cells in the context of the vertebrate habenulae, a conserved forebrain region. Taking advantage of the comparably simple structure and limited size of the habenulae, I will reconstruct a comprehensive, spatially resolved lineage tree of a complete vertebrate brain region. By combining this approach with a molecular characterisation of habenular development using single-cell RNA-sequencing and sequential fluorescent in situ hybridisation, I aim to gain a comprehensive understanding of neurogenesis in this brain region. The method development involved in this project and the anticipated findings will significantly contribute toour understanding of vertebrate brain development.

Funding

Dissecting the emergence of neuronal cell populations in the habenulae of the vertebrate brain

Weitere ausländische Förderagenturen (GrantsTool), 05.2020-04.2022 (24)
PI : Schier, Alexander.
CI : El Kholtei, Jakob.

Members (2)

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Alexander Schier

Principal Investigator
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Jakob El Kholtei

Co-Investigator