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Optimising paediatric dosing regimens based on a clinical data warehouse SwissPKcdw

Research Project
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01.01.2019
 - 31.12.2021

The project will build the SwissPharmacoKinetics clinical data warehouse SwissPK cdw , with encoded clinical, pharmacokinetic, physiological and genetic data from Swiss Children's Hospitals (real-world data). Within the project the collaborating groups will focus on the patients with highest need for optimised dosage regimens, namely the paediatric patients, and will include a pre-defined list of 1-3 drugs. The long-term goal beyond the funding period is to establish a dynamic, steadily growing CDW for any drug and any patient cohort. It is aim to significantly extend based on analytical evidence the current expert-opinio-only recommendations for drug dosage in paediatrics and to identify covariates which best predict the pharmacokinetics in children, including physiological factors, genetic polymorphisms in ADMET-relevant genes, disease-related factors and co-medication.

Funding

Optimising paediatric dosing regimens based on a clinical data warehouse SwissPKcdw

Swiss Personalized Health Network (GrantsTool), 01.2019-12.2021 (36)
PI : Meyer zu Schwabedissen, Henriette.
CI : Bielicki, Julia Anna.

Publications

Goers, Roland et al. (2021) ‘SwissPKcdw – A clinical data warehouse for the optimization of pediatric dosing regimens’, CPT: Pharmacometrics and Systems Pharmacology, 10(12), pp. 1578–1587. Available at: https://doi.org/10.1002/psp4.12723.

Paioni, Paolo et al. (2021) ‘Gentamicin population pharmacokinetics in pediatric patients—a prospective study with data analysis using the saemix package in r’, Pharmaceutics, 13(10), p. 1596. Available at: https://doi.org/10.3390/pharmaceutics13101596.

URLs
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Members (4)

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Henriette Meyer zu Schwabedissen

Principal Investigator
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Julia Anna Bielicki

Co-Investigator
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Roland Goers

Project Member
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Romy Tilen

Project Member