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Brainstem Circuits Controlling Movement

Research Project
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01.04.2018
 - 31.03.2022

One of the most important tasks of the nervous system is the generation of specific forms of movement as behavioral output, allowing animals or humans to interact with their surroundings appropriately according to motor plans and/or in response to influence from the environment. The motor system is broadly distributed across the nervous system, including areas close to actual motor program execution in the spinal cord, all the way up to regions of the nervous system involved in decision making and planning of motor acts. The brainstem is a key intermediary structure between higher motor centers and spinal circuits, and we have hypothesized that distinct subpopulations of brainstem neurons mediate selective motor programs. The goal of this work is to unravel key defining features of brainstem neurons involved in the regulation of diverse forms of movement, and to understand how a particular behavior is chosen over others. Our project will contribute to uncovering organizational principles of neuronal circuits in the motor output system of mice, as well as the contributions of these circuits to behavioral function.

Funding

Brainstem Circuits Controlling Movement

SNF Projekt (GrantsTool), 04.2018-03.2022 (48)
PI : Arber, Silvia.

Publications

Heindorf, Matthias, Arber, Silvia and Keller, Georg B. (2019) ‘Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback’, Neuron, 101(6), p. 1202. Available at: https://doi.org/10.1016/j.neuron.2019.02.042.

URLs
URLs

Takeoka, Aya and Arber, Silvia (2019) ‘Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury’, Cell reports, 27(1), pp. 71–85.e3. Available at: https://doi.org/10.1016/j.celrep.2019.03.010.

URLs
URLs

Arber, Silvia and Costa, Rui M. (2018) ‘Connecting neuronal circuits for movement’, Science, 360(6396), pp. 1403–1404. Available at: https://doi.org/10.1126/science.aat5994.

URLs
URLs

Ferreira-Pinto, Manuel J. et al. (2018) ‘Connecting Circuits for Supraspinal Control of Locomotion’, Neuron, 100(2), pp. 361–374. Available at: https://doi.org/10.1016/j.neuron.2018.09.015.

URLs
URLs

Heindorf, Matthias, Arber, Silvia and Keller, Georg B. (2018) ‘Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback’, Neuron, 99(5), pp. 1040–1054.e5. Available at: https://doi.org/10.1016/j.neuron.2018.07.046.

URLs
URLs

Pecho-Vrieseling, Eline et al. (2018) ‘Author Correction: Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons’, Nature neuroscience, 21(9), p. 1291. Available at: https://doi.org/10.1038/s41593-018-0201-6.

URLs
URLs

Pecho-Vrieseling, Eline et al. (2014) ‘Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons’, Nature neuroscience, 17(8), pp. 1064–72. Available at: https://doi.org/10.1038/nn.3761.

URLs
URLs

Members (8)

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Silvia Arber

Principal Investigator
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Ana Rita Costa Afonso

Project Member
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Keith Gunapala

Project Member
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Madhav Sridharan

Project Member
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Manuel Joao Neves Ferreira Pinto

Project Member
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Riccardo Schina

Project Member
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