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Pilot Study PIOMIC - Wound Healing Models

Research Project
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01.01.2018
 - 31.12.2018

The goal of this research proposal is to establish a cell culture-based experimental model system in a hypothesis-driven and explorative manner, which can be used for future evaluation of therapeutic variables and for pinpointing and investigating treatment-influenced biological processes. This information will provide the scientific rationale for the therapeutic application of the combined light/PM-ELF-MF exposure. First and foremost, the proposed research shall: clarify if the combined PM-ELF-MF/light exposure is manifesting in a biological response in cultured cells, focusing on the proliferation, migration and angiogenesis of fibroblasts, endothelial cells and keratinocytes estimate the contribution of waveforms to promote the biological effect by varying and/or excluding PM-ELF-MF and light signals during exposure elucidate redundant, additive or synergistic effects of the combined exposure approach compared to the separate exposure to either light or PM-ELF-MF reveal whether the enhanced healing process is promoted by affecting distinct cell types or rather by collective response of involved cells establish experimental conditions with solid response in order to tackle molecular pathways and mechanisms in more detail.

Funding

PIlot Study PIOMIC - Wound Healing Models

Piomic Medical AG, 01.2018-12.2018 (12)
PI : Schürmann, David.
CI : Schär, Primo Leo.

Members (2)

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David Schürmann

Principal Investigator
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Primo Leo Schär

Co-Investigator