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Development of a Swiss surveillance database for molecular epidemiology of multi-drug resistant pathogens

Research Project
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01.01.2018
 - 31.12.2020

Background: Multi-drug resistant (MDR) bacterial pathogens clearly pose an important challenge to our society at multiple levels: in humans, MDR pathogens are increasingly detected and associated with significant morbidity, mortality and health care costs. Similarly, in veterinary medicine, MDR bacteria lead to a high economic burden and constitute a reservoir for dangerous zoonoses representing a serious public health concern. The spread of many bacterial pathogens is complex, and understanding the most imprtant routes of transmission is a precondition for effective countermeasures. A better understanding of transmission events and dynamics between compartments (animals and humans) would be a critical guide to containment. We anticipate that a shared surveillance database between human and vertinary medicine coupled to state-of-the-art automated phylogenetic analysis will enable a more complete and detailed surveillance of MDR pathogens and actionable results for public health policy. Objective of the project: The main goal is to connect human and veterinary micrbiology laboratories through a shared framework for near real-time molecular epidemiology of MDR bacterial pathogens, which will allow to perform transmission and outbreak surveillance between different species and the environment. Specific aims include: - Implementation of an active surveillance system using MRSA as a proof-of-concept, which can be expanded to many other one-health related MDR pathogens. - Continuous development of a highly flexible surveillance tool, which allows to incorporate molecular epidemiological data from whole genome sequencing (WGS) and imprtant metadata information. - Development of a semi-automated modelling tool to assess transmission rates between geographic locations, hospitals, communities, and species over time and space. - Preparation for expansion with different other species including carbapenemase-producing Enterobacteriacea - Connection to international databases for global surveillance

Funding

Development of a Swiss surveillance database for molecular epidemiology of multi-drug resistant pathogens

SNF Schweizerischer Nationalfonds, 09.2017-08.2020 (36)
PI : Egli, Adrian.

Members (7)

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Adrian Egli

Principal Investigator
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Richard Neher

Co-Investigator
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Dominique Blanc

Co-Investigator
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Gilbert Greub

Co-Investigator
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Ioannis Xenarios

Co-Investigator
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Jacques Schrenzel

Co-Investigator
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