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OPERAM: Optimising PharmacothERApy in the Multimorbid elderly

Research Project
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01.05.2015
 - 30.04.2020

The overall aim of OPERAM (OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly) is to optimise existing pharmacological and non-pharmacological therapy primarily in order to reduce avoidable hospital admissions among the elderly population aged ≥70 years with multimorbidity. Specifically, the OPERAM consortium aims at: Creating new evidence to prevent avoidable hospital admissions through optimising pharmacotherapy in the multimorbid elderly by performing a multi-centre cluster randomised clinical trial (RCT) to assess the impact of a structured medication review Obtaining evidence-based data comparing pharmacological and non-pharmacological interventions to prevent common causes of avoidable hospital admissions in the elderly with multimorbidity, and rank these interventions according to their effectiveness and safety using network meta-analyses (NMA) Identify the most cost-effective pharmacological and non-pharmacological interventions to prevent avoidable hospital admissions in the multimorbid elderly

Funding

OPERAM: Optimising PharmacothERApy in the Multimorbid elderly

Horizon 2020 (GrantsTool), 05.2015-04.2020 (60)
PI : Schwenkglenks, Matthias.
CI : Szucs, Thomas.

Publications

Blum, Manuel R et al. (2021) ‘Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): Cluster randomised controlled trial’, The BMJ, 374, p. n1585. Available at: https://doi.org/10.1136/bmj.n1585.

Bhadhuri, Arjun et al. (2020) ‘Measurement properties of EQ-5D-3L and EQ-5D-5L in recording self-reported health status in older patients with substantial multimorbidity and polypharmacy’, Health and quality of life outcomes, 18(1), p. 317. Available at: https://doi.org/10.1186/s12955-020-01564-0.

URLs
URLs

Adam, Luise et al. (2019) ‘Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial’, BMJ open, 9(6), p. e026769. Available at: https://doi.org/10.1136/bmjopen-2018-026769.

URLs
URLs

Members (3)

MALE avatar

Matthias Schwenkglenks

Principal Investigator
FEMALE avatar

Zanfina Ademi

Co-Investigator
MALE avatar

Thomas Szucs

Co-Investigator