Charakterisierung der Mechanismen die zur Antibiotikatolerenz in Biofilmen von Vibrio cholerae führen
Research Project
|
01.09.2022
- 31.08.2025
Bacteria have the ability to form spatially structured multicellular communities, called biofilms. Biofilms are considered to be the dominant form of bacterial life on our planet and they are well-known to promote microbial survival under harmful environmental conditions. For example, biofilm-associated cells display increased tolerance towards stress treatment when compared to planktonic bacteria, which complicates biofilm removal in clinical settings. Thus, stress tolerance presents an important multicellular function of biofilms with clear fitness benefits, however, the underlying regulatory processes and biophysical mechanisms are unclear. In this proposal, we aim to close this gap by studying the emergent stress tolerance of biofilms formed by the major human pathogen Vibrio cholerae. More generally, this project will provide insights into biofilm development, intercellular communication, and the regulatory principles underlying bacterial communities.
