Instrument to assess the Credibility of effect Modification ANalyses (ICEMAN)
Research Project |
Subgroup analyses can reveal differences in treatment effects between patient groups, but chance and analytical choices frequently produce misleading findings. ICEMAN helps researchers judge how credible these findings are.
The instrument has separate versions for randomized controlled trials and meta-analyses of randomized trials. It guides users through questions about prior hypotheses, earlier evidence, statistical support, and analytical choices. Users weigh these considerations to rate overall credibility from very low to high.
Stefan Schandelmaier led the development of ICEMAN with an international team. The team published the instrument in 2020. ICEMAN work toegtehr with Cochrane reviews and the GRADE approach.
Access the assessment forms, online tool, user manual, and reporting templates at iceman.help
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Funding
Development and validation of an instrument to assess the credibility of putative subgroup effects in randomized controlled trials and meta-analyses
SNF Schweizerischer Nationalfonds, 04.2016-03.2018 (24)
PI : Schandelmaier, Stefan.
Publications
Schandelmaier S et al. (2020) ‘Development of the instrument to assess the credibility of effect modification analyses (ICEMAN) in randomized controlled trials and meta-analyses’, CMAJ, 192(32), pp. E901–E906. Available at: https://doi.org/10.1503/cmaj.200077.
Members (1)
